Clinical value of serum CA125 and CA19-9 detection for the diagnosis of epithelial ovarian cancer and endometriosis.

Objective To explore the expression of CA125 and CA19-9 in epithelial ovarian cancer and endometriosis and discuss its clini- cal significance. Methods The expression of CA125 and CA19-9 of 153 patients who admitted to the first affiliated hospital and the fourth affiliated hospital of China medical university from september 2003 to September 2008 were retrospectively reviewed. Results Serum CA125 and CA19-9 levels in epithelial ovarian cancer significantly increased in endometriosis and benign ovarian tumor (P 0. 05;P 0. 01); serum CA125 and CA19-9 levels in endometriosis significantly increased in benign ovarian tumor (P 0. 05) . Combined detection of CA125 and CA19-9 has a significantly higher sensitivity for the diagnosis of epithelial ovarian cancer than single detection of CA125 and CA19-9. In case of CA125 was at the range of 70~140 U/ml,the CA125 level in endometriosis patients is higher than that in epithelial ovarian cancer patients (P 0. 05). In case of CA125 140 U/ml,CA125 level in epithelial ovarian cancer patients is higher than that in the endometriosis patients (P 0. 01). Conclusion Combined detection of serum CA125 and CA19-9 has a high sensitivity for the diagnosis of epithelial ovarian cancer and endometriosis. CA125 is useful for distinguishing epithelial ovarian cancer from endometriosis.