Association between GPx-1 Polymorphisms and Personality Traits in Healthy Chinese-Han Subjects

Abstract Purpose: Glutathione Peroxidase 1 (GPx1) is the most abundantly expressed of the glutathione peroxidase (GPx) family. The impact of GPx1 polymorphisms has been rarely explored in the field of personality traits. Therefore, we analyzed relationships between GPx-1 polymorphisms and personality traits in healthy Chinese-Han subjects. Methods: 493 Chinese-Han participants (male=234, female=259) were recruited. Personality traits were assessed by Tridimensional Personality Questionnaire (TPQ). GPx-1 gene polymorphisms were detected through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The results indicated that the GPx-1 polymorphisms rs1050450 and rs1800668 were associated with the personality trait novelty seeking (NS). Our data found a correlation between rs1800668 and NS2 (X2=7.392, P=0.025). While the results showed the rs1050450 was significantly associated with NS4 (X2=6.059, P=0.048). Regarding sex stratification, there was a significant difference in the NS2 score (X2=8.232, P=0.016) among women for rs1800668. There was no difference in TPQ scores among the different genotypic groups in males. Additionally, no sex effect was observed for either genotype for rs1050450. Conclusion: Our results suggested that GPx-1 may be a potential gene that influenced personality.