Repetitive stability study of Remdesivir/Cyclodextrin complex on ISS

Repetitive stability study of Remdesivir/Cyclodextrin complex on ISS | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Repetitive stability study of Remdesivir/Cyclodextrin complex on ISS György Dormán, Balázs Buchholcz, István Puskás, Pál Szabó, Erzsébet Varga, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3969779/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 04 Feb, 2025 Read the published version in Scientific Reports → Version 1 posted 3 You are reading this latest preprint version Abstract Stability assessment of drugs in space is particularly important for future missions., In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and reproducibility of the data. Therefore, we investigated the stability of an anti-Covid drug formulation, Remdesivir (RDV) sulfobutylether-beta-cyclodextrin (SBECD) complex, in two separate flight experiments on the International Space Station (ISS). While HPLC/MS studies revealed no degradation of the cyclodextrin excipient in any of the samples investigated in both missions, RDV purity analysis of the RDV/SBECD complex after the first mission revealed different stabilities and altered degradation in space and on Earth. This latter interesting finding was not supported by the second mission, where no differences in the drug stabilities were identified. This anomaly highlighted the importance of standardization together with increased control of the variable parameters during the entire space missions and the terrestrial control experiments. Biological sciences/Drug discovery Physical sciences/Astronomy and planetary science Physical sciences/Chemistry Remdesivir sulfobutylether-beta-cyclodextrin in-space drug stability space medicinal chemistry space environment chemical degradation reproducibility standardization Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryMaterialDormanDarvas.docx Cite Share Download PDF Status: Published Journal Publication published 04 Feb, 2025 Read the published version in Scientific Reports → Version 1 posted Editor invited by journal 20 Mar, 2024 Submission checks completed at journal 20 Mar, 2024 First submitted to journal 19 Feb, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3969779","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":281795024,"identity":"19e4d2cc-1ae1-4aef-9d30-64802c403a05","order_by":0,"name":"György Dormán","email":"","orcid":"","institution":"Innostudio, Inc","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"György","middleName":"","lastName":"Dormán","suffix":""},{"id":281795025,"identity":"ac957c24-c57d-464f-9039-185532ce10ec","order_by":1,"name":"Balázs Buchholcz","email":"","orcid":"","institution":"Innostudio, Inc","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Balázs","middleName":"","lastName":"Buchholcz","suffix":""},{"id":281795026,"identity":"f8ca5f95-9fe1-4466-a26a-e76b121c7385","order_by":2,"name":"István Puskás","email":"","orcid":"","institution":"Cyclolab Cyclodextrin Research \u0026 Development Laboratory Ltd","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"István","middleName":"","lastName":"Puskás","suffix":""},{"id":281795027,"identity":"e1ba23cc-6c51-4513-a2c1-4c6b0803d4ca","order_by":3,"name":"Pál Szabó","email":"","orcid":"","institution":"Research Centre for Natural Science and National Drug Research and Development Laboratory, Magyar Tudósok körútja 2., Budapest, H-1117, Hungary","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Pál","middleName":"","lastName":"Szabó","suffix":""},{"id":281795028,"identity":"77ecf3c3-f6d1-4a54-8b5e-262effe158d2","order_by":4,"name":"Erzsébet Varga","email":"","orcid":"","institution":"Cyclolab Cyclodextrin Research \u0026 Development Laboratory Ltd","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Erzsébet","middleName":"","lastName":"Varga","suffix":""},{"id":281795029,"identity":"0f06a840-347d-47ca-b3b1-19b84149652f","order_by":5,"name":"Lajos Szente","email":"","orcid":"","institution":"Cyclolab Cyclodextrin Research \u0026 Development Laboratory Ltd","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lajos","middleName":"","lastName":"Szente","suffix":""},{"id":281795030,"identity":"3e5761fc-4043-44ed-b4a8-d1af5d84f313","order_by":6,"name":"György M. 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