Dose-effect research on the effect of Oxytocin on high intensity focused ultrasound ablation of adenomysis

Objective:To explore the effectsand safety of differentdose of oxytocin on high intensity focused ultrasound(HIFU)ablation of adenomysis.Methods 129 patientswith adenomyosis from three hospitalswere treated with ultrasound-guided HIFU.The patientswere randomly assigned in 0.32U/min oxytocin group,0.48U/min oxytocin group,or control group. To compare energy, sonication time required to ablate 1cm3 of adenomyosis, side-effects between three groups. Results The non-perfused volume(NPV)ratio of the two groups with using oxytocin are significantly higher than without one.The sonication time required to ablate 1cm3 and EEFare below.There are no significantly difference inNPVratio,EEF, sonication time required to ablate1cm3 between the twogroups with oxytocin. Conclusion Oxytocin could significantly decrease the energy for ablating adenomysis with HIFU, enhance the treatment efficiency. It can not increase benefit to increase the doses of Oxytocin.