Formulation and Evaluation of Pioglitazone Hydrochloride and Teneligliptin combined Nano suspension for diabetes

Formulation and Evaluation of Pioglitazone Hydrochloride and Teneligliptin combined Nano suspension for diabetes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Formulation and Evaluation of Pioglitazone Hydrochloride and Teneligliptin combined Nano suspension for diabetes Archana Yelmate, Sapna Bende, Kranti Satpute, Mahesh Sonkamble This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7977001/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Many recently developed drugs exhibit reduced water solubility, which causes problems with bioavailability. The application of conventional methods for improving solubility remains limited, particularly when a drug has low solubility in both aqueous and non-aqueous solvents. Nano suspension technology has therefore shown to be a novel and profitable method of increasing the bioavailability of poorly soluble drugs. In the present study, we combined the anti-diabetic effect of pioglitazone hydrochloride and Teneligliptin preparing a hybrid Nano suspension with high efficiency, low toxicity, and enhanced efficacy to achieve the purpose of synergism and enhanced clinical beneficial. The Prepared Nanosuspension was evaluated for different parameters like Appearance, Redispersibiility, Viscosity, pH, Drug content. The results of stability study were confirmed that the prepared pioglitazone hydrochloride and Teneligliptin Nano suspension is stable during the stability study. Thus, it can be concluded that the combined Nano suspension method was commercially feasible and cost effective. Drug delivery systems Diabetes mellitus Nano suspension Pioglitazone Hydrochloride Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7977001","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":545675684,"identity":"89161d5a-2242-40d4-8651-6c2550cc89cf","order_by":0,"name":"Archana 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The application of conventional methods for improving solubility remains limited, particularly when a drug has low solubility in both aqueous and non-aqueous solvents. Nano suspension technology has therefore shown to be a novel and profitable method of increasing the bioavailability of poorly soluble drugs. In the present study, we combined the anti-diabetic effect of pioglitazone hydrochloride and Teneligliptin preparing a hybrid Nano suspension with high efficiency, low toxicity, and enhanced efficacy to achieve the purpose of synergism and enhanced clinical beneficial. The Prepared Nanosuspension was evaluated for different parameters like Appearance, Redispersibiility, Viscosity, pH, Drug content. The results of stability study were confirmed that the prepared pioglitazone hydrochloride and Teneligliptin Nano suspension is stable during the stability study. 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