Evaluation on the application of GnRHa in patients with endometriosis after conservative surgery

Objective To investigate the clinical effect and security of gonadotropin-releasing hormone agonist(GnRHa) for patients with endometriosis after conservative surgery. Methods Sixty patients of uterine endometriosis in our hospital were randomly divided into the experimental group and the control group. The two groups of patients were treated with conservative surgery, while patients of the experimental group were given triptorelin treatment. The clinical efficacy of the two groups was compared and the occurrence of side reactions was observed during the treatment. The 1-year, 2-year, 3-year cumulative pregnancy rate and recurrence rate were observed in the 3-year follow-up. Results The clinical efficacy, the 1-year, 2-year, 3-year cumulative pregnancy rate of the experimental group were significantly higher than those of the control group(P0.05); 1-year, 2-year, 3-year cumulative recurrence rate of the experimental group were significantly lower than those of the control group(P0.05). There were mild adverse reactions such as hot flashes, vaginal dryness, and loss of libido during treatment in the experimental group, which were tolerated by all patients. Conclusion GnRHa applied to patients with endometriosis after conservative surgery can significantly improve the clinical efficacy, promote pregnancy, reduce the relapse rate, and is of high security, which is worthy of clinical application.