Factors Causing Infertility in Women Diagnosed with Endometriosis

Andrés Alejandro Lepe Rosales, José Armando López Rodríguez, Alejandro Arias Mendoza, Araceli López Medina, Erika Mora González, Rocía Alvídrez Rodríguez
2022 · doi:10.5281/zenodo.7229254 · W4306905823
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Endometriosis causes infertility through oxidative stress, altered estrogen production via aromatase P450 dysregulation, and the impact of specific interleukins, alongside pelvic, ovarian, and genetic factors.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper discusses mechanisms proposed to explain infertility in women diagnosed with endometriosis, framing endometriosis as ectopic endometrial glands and stroma that is commonly associated with dysmenorrhea and infertility in more than 50% of affected women. It highlights several multifactorial contributors, including oxidative stress-related alterations in oocyte recovery and maturation, dysregulation of aromatase P450 affecting steroidogenesis and estrogen levels, and involvement of multiple interleukins such as TNF-α, IL-1β, IL-6, IL-8, and IL-10. It also describes other proposed links involving pelvic cavity, ovarian, and genetic factors, while noting that the exact mechanisms are not certain. This paper is centrally about endometriosis — it focuses on factors and biological theories underlying endometriosis-associated infertility.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a pathology that commonly prevails in more than 50% of women as a cause of dysmenorrhea and infertility and we can define it as the presence of endometrial glands and stroma outside of it, that is, ectopic endometrial tissue that is mostly located in the ovaries, Douglas pouch, uterosacral ligaments and other anatomical sites. Infertility associated with endometriosis is a multifactorial disease and there is no certainty about the mechanisms by which it is developed, however there are several theories that could provide an explanation. Oxidative stress is one of the factors that contribute to infertility where a chain of events is created that culminates in the alteration of the number of oocyte recovery and the number of mature oocytes. Dysregulation of aromatase P450 production in steroidogenesis causes a decrease in estrogen production altering follicular and oocyte development. There are also interleukins associated with infertility of which TNF-α, interleukin-1β, IL-6, IL-8, IL-10 and others stand out. On the other hand, there are several biological explanations that are related to the causal link between endometriosis and infertility, some of them include factors of the pelvic cavity, ovarian and genetic factors.
Full text 1,840 characters · extracted from oa-doi-fallback · click to expand
Factors Causing Infertility in Women Diagnosed with Endometriosis Authors/Creators - 1. Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México. - 2. Universidad Anáhuac. México. - 3. Escuela Superior de Medicina del Instituto Politécnico Nacional - 4. Universidad Autónoma de Ciudad Juárez. Ciudad Juarez, Chihuahua, México - 5. Universidad Anáhuac. México - 6. Universidad Autónoma de Chihuahua. Chihuahua, México. Description Endometriosis is a pathology that commonly prevails in more than 50% of women as a cause of dysmenorrhea and infertility and we can define it as the presence of endometrial glands and stroma outside of it, that is, ectopic endometrial tissue that is mostly located in the ovaries, Douglas pouch, uterosacral ligaments and other anatomical sites. Infertility associated with endometriosis is a multifactorial disease and there is no certainty about the mechanisms by which it is developed, however there are several theories that could provide an explanation. Oxidative stress is one of the factors that contribute to infertility where a chain of events is created that culminates in the alteration of the number of oocyte recovery and the number of mature oocytes. Dysregulation of aromatase P450 production in steroidogenesis causes a decrease in estrogen production altering follicular and oocyte development. There are also interleukins associated with infertility of which TNF-α, interleukin-1β, IL-6, IL-8, IL-10 and others stand out. On the other hand, there are several biological explanations that are related to the causal link between endometriosis and infertility, some of them include factors of the pelvic cavity, ovarian and genetic factors. Files 16.pdf Files (432.7 kB) | Name | Size | Download all | |---|---|---| | md5:ffeffa12d5028f071bd5d0d645f6f3ac | 432.7 kB | Preview Download |

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisdysmenorrheainfertility

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK