Fabrication of sustainable modified fenugreek gum block copolymer in oral controlled drug delivery system: synthesis, toxicity, in vitro and in vivo pharmacokinetics

Fabrication of sustainable modified fenugreek gum block copolymer in oral controlled drug delivery system: synthesis, toxicity, in vitro and in vivo pharmacokinetics | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Fabrication of sustainable modified fenugreek gum block copolymer in oral controlled drug delivery system: synthesis, toxicity, in vitro and in vivo pharmacokinetics Baburao N. Chandakavathe, Raghavendra Kulkarni, Ashwin Mali, Amol Muthal, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6231237/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 26 Jul, 2025 Read the published version in Journal of Pharmaceutical Innovation → Version 1 posted You are reading this latest preprint version Abstract This study was planned to develop Fenugreek polymer which was modified by grafting with acrylamide using ceric ammonium nitrate. The copolymer was characterized with the help of instrumental data. Nifedipine tablets were prepared including pure gum, graft copolymer and HPMC K100M. In vitro release studies showed that the tablets F1-F5 released 94.72% to 92.24% within 5 h, while tablet formulations F6-F10 extended the release up to 12 h and the release was retarded with increase in concentration of copolymer in the range of 95.84% to 88.39% of drug release. Tablets F8 demonstrated optimum drug release which was 94.19% in 12 h. In vivo pharmacokinetic studies of F8 in rabbits showed an area under the curve of 6050.45 (ng/mL)×h as compared with marketed nifedipine tablets (6723.88 (ng/mL)×h). The acrylamide copolymer retarded the drug release and hence can be explored for the preparation of extended-release formulations for the administration. Fenugreek gum Grafting Acrylamide in vitro drug release in vivo pharmacokinetic study Full Text Additional Declarations No competing interests reported. Supplementary Files supplimentarymaterial.docx Cite Share Download PDF Status: Published Journal Publication published 26 Jul, 2025 Read the published version in Journal of Pharmaceutical Innovation → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6231237","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":434417706,"identity":"7b449e10-bda2-46f9-ad6e-f9b6e1e6206c","order_by":0,"name":"Baburao N. 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