Evaluation of the effect of oral taurine supplementation on fasting levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind randomized controlled trial

Abstract Background: Taurine (Tau) is involved in many biochemical functions such as regulation of glucose and lipid metabolism, enhancement of energy expenditure, anti-inflammatory effects and appetite control. The most important effect of Tau in obesity is its direct effect on adipose tissue. Some evidence has shown an impaired FGF ( Fbroblast Growth Factor)19 and 21 biosynthesis in obesity. Besides the effects of eicosapentaenoic acid on serum FGF21 concentrations, the effect of other nutrients on FGFs is not clear. Since obesity as an important health problem is rising around the world and on the other side, taurine (Tau) biosynthesis is reduced by adipose tissue-derived factors in obesity, the effects of Tau and a weight loss diet on obesity need to be investigated further. Methods: We will conduct a 8 weeks’ double-blind, parallel-group, randomized controlled clinical trial to investigate the effect of Tau supplementation on fasting serum levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in 50 obese women aged between 18 to 49 on a weight-loss diet. Discussion: We will determine the other advantages of a weight loss diet on new metabolic risk factors. Since Tau may regulate adipose tissue-derived factors and a weight loss diet can promote the useful effects of Tau supplementation; for the first time, the effects of a weight loss diet along with Tau supplementation on these variables will be assessed.