Magnetic Particle Imaging in Human Subjects

Magnetic Particle Imaging in Human Subjects | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Magnetic Particle Imaging in Human Subjects Erica Mason, Olivia Sehl, Marcela Weyhmiller, Bryanna Davison, and 16 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8825005/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Magnetic Particle Imaging (MPI) is a tracer-based medical imaging modality that detects magnetic nanoparticles with no background tissue signal. MPI acquires quantitative, high-sensitivity tomographic images of shelf-stable magnetic tracers that safely produce signals in vivo for weeks or even months. These features can fill capability gaps in medical imaging for applications benefiting from tracer specificity with an extended imaging window. Despite two decades of preclinical validation and multiple published human-scale imagers, MPI has not previously been demonstrated in human subjects. Here we report MPI imaging in two subjects following subcutaneous administration of magnetic tracer in the scalp and foot. Our results showed quantitative and longitudinal visualization of lymphatic drainage for up to six months, with supporting validation in a mouse model. Imaging in human subjects required the development and verification of a novel clinical imager, including magnetostimulation threshold testing of all magnetic fields used in imaging sequences. To understand MPI in the context of existing medical imaging technologies, we benchmarked MPI imaging performance against SPECT using lymphatic system phantom models. These findings demonstrate that MPI can translate from animals to human subjects, and establish MPI as a new tool for longitudinal tracer imaging in medicine. The addition of MPI to the clinical imaging toolbox could enable new approaches and capabilities for diagnosis, real-time interventions, and treatment monitoring across a broad range of clinical applications. Health sciences/Medical research/Translational research Health sciences/Health care/Medical imaging Physical sciences/Engineering/Biomedical engineering Physical sciences/Engineering/Electrical and electronic engineering Physical sciences/Physics/Techniques and instrumentation/Imaging techniques Full Text Additional Declarations Yes there is potential Competing Interest. At the time of the study, all authors employed by Magnetic Insight, Inc. were stockholders in the company. Magnetic Insight, Inc. is no longer in business at the time of manuscript submission. Supplementary Files SV1.mp4 Supplementary Video SV1 SV2.mp4 Supplementary Video SV2 Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8825005","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":606236525,"identity":"8e043312-786e-4dcf-bc79-ed3e3e724ce8","order_by":0,"name":"Erica Mason","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABAUlEQVRIiWNgGAWjYFACxgZkNrMciD7wgBQtxmAtCSTYyJwINgGfFn7pw40ffjBsk5dv7z3AXLjDOn1+2OGHQFvs5HQbsGuR7EtsluxhuG244cy5BOaZZ9JzN95OMwBqSTY2O4Bdi8EZxjYGHobbjBskcgyYedsO526cnQDSciBxGw4t9kAtjH8YbtvPnwHRkm44O/0DXi0GPIxtzEBbEhtuQLQkyEvn4LdF4gxjs7SMwe3kDWfOGBye2ZZuuEE6p+BAggFuv/D3sD/8+Kbitu389h7Dx4Vt1vLys9M3f/hQYSeHSwvUeRDqMJh9AEmEIGAGEfINRKoeBaNgFIyCEQMAUK1gwY+AWEsAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0001-7002-3599","institution":"Magnetic Insight, Inc.","correspondingAuthor":true,"prefix":"","firstName":"Erica","middleName":"","lastName":"Mason","suffix":""},{"id":606236526,"identity":"aec2f83e-fce2-41db-87ce-1942fc7ac8b1","order_by":1,"name":"Olivia Sehl","email":"","orcid":"","institution":"Magnetic Insight, Inc. and Western University, Robarts Research Institute","correspondingAuthor":false,"prefix":"","firstName":"Olivia","middleName":"","lastName":"Sehl","suffix":""},{"id":606236527,"identity":"f5e9a2e8-a1b8-45e8-b751-0b1a13d8f138","order_by":2,"name":"Marcela Weyhmiller","email":"","orcid":"","institution":"Magnetic Insight, Inc.","correspondingAuthor":false,"prefix":"","firstName":"Marcela","middleName":"","lastName":"Weyhmiller","suffix":""},{"id":606236528,"identity":"f84b791e-34ae-4cfc-8323-94ba8e979dd7","order_by":3,"name":"Bryanna Davison","email":"","orcid":"","institution":"Magnetic Insight, Inc.","correspondingAuthor":false,"prefix":"","firstName":"Bryanna","middleName":"","lastName":"Davison","suffix":""},{"id":606236529,"identity":"1c0b6ba9-de11-4869-84d8-4ede8c562a85","order_by":4,"name":"Eli Mattingly","email":"","orcid":"","institution":"Magnetic Insight, Inc.","correspondingAuthor":false,"prefix":"","firstName":"Eli","middleName":"","lastName":"Mattingly","suffix":""},{"id":606236530,"identity":"fee26ca2-59e5-4d17-99bf-d4f8b1fa8ede","order_by":5,"name":"Justin Konkle","email":"","orcid":"https://orcid.org/0000-0003-1198-049X","institution":"Magnetic Insight, Inc.","correspondingAuthor":false,"prefix":"","firstName":"Justin","middleName":"","lastName":"Konkle","suffix":""},{"id":606236531,"identity":"a7307773-9619-4b39-bda6-ef9ea3084d19","order_by":6,"name":"Toby Sanders","email":"","orcid":"","institution":"Magnetic Insight, Inc.","correspondingAuthor":false,"prefix":"","firstName":"Toby","middleName":"","lastName":"Sanders","suffix":""},{"id":606236532,"identity":"4ab6ac85-e787-47fa-970b-8b0410c21eab","order_by":7,"name":"A. 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