papillary renal neoplasm with reverse polarity (PRNRP) and renal clear cell carcinoma: a case report of image-pathology-molecular multidimensional diagnosis and nephron sparing surgery practice

papillary renal neoplasm with reverse polarity (PRNRP) and renal clear cell carcinoma: a case report of image-pathology-molecular multidimensional diagnosis and nephron sparing surgery practice | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report papillary renal neoplasm with reverse polarity (PRNRP) and renal clear cell carcinoma: a case report of image-pathology-molecular multidimensional diagnosis and nephron sparing surgery practice Yuxuan Liu, Yanchen Wang, Lihui Guan, Shuping Sun, Huimin Sun, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6707949/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 5 You are reading this latest preprint version Abstract papillary renal neoplasm with reverse polarity (PRNRP) is a new pathological type of renal tumor, and its incidence is low. It is considered to be an indolent renal tumor at present. It is rare for PRNRP to co-occur with other tumors in the same kidney. Like other renal tumors, patients with PRNRP do not have any specific clinical manifestations. During surgery, we resected a solid and a cystic lesion in the left kidney simultaneously, and performed two partial nephrectomy on the ipsilateral kidney at one time, both with good surgical results. The postoperative pathological results were as follows: 1. Solid lesions are PRNRP.; 2. Cystic lesions are RCCC. (RCCC). Here, we present a case of PRNRP concurrent with RCCC and review the literature. papillary renal neoplasm with reverse polarity (PRNRP) ipsilateral double primary renal cell carcinoma GATA3 Full Text Additional Declarations No competing interests reported. Supplementary Files Supplementarymaterials.zip Cite Share Download PDF Status: Under Review Version 1 posted Reviewers invited by journal 23 Jun, 2025 Editor invited by journal 27 May, 2025 Editor assigned by journal 26 May, 2025 Submission checks completed at journal 26 May, 2025 First submitted to journal 20 May, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6707949","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":475230372,"identity":"9e58a5c7-341e-4467-9787-b5be76e62843","order_by":0,"name":"Yuxuan Liu","email":"","orcid":"","institution":"Shandong Second Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yuxuan","middleName":"","lastName":"Liu","suffix":""},{"id":475230373,"identity":"12a4229a-25b6-4b95-85ca-6a89a256709b","order_by":1,"name":"Yanchen Wang","email":"","orcid":"","institution":"WeiFang People’s 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