Short (seven days) versus standard (fourteen days) oestrogen administration in a programmed frozen embryo transfer cycle: a retrospective cohort study

Short (seven days) versus standard (fourteen days) oestrogen administration in a programmed frozen embryo transfer cycle: a retrospective cohort study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Short (seven days) versus standard (fourteen days) oestrogen administration in a programmed frozen embryo transfer cycle: a retrospective cohort study Wen-Jing Jiang, Jing-Yan Song, Zhen-Gao Sun This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1368931/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 21 Mar, 2022 Read the published version in Journal of Ovarian Research → Version 1 posted 7 You are reading this latest preprint version Abstract Research question: What influence does seven days of oestrogen administration versus fourteen days have on the reproductive outcomes of frozen-thawed embryo transfer (FET) in programmed endometrial preparation cycles? Design: In a retrospective study, conducted at a university-affiliated tertiary hospital, a total of 2628 infertile patients (4142 FET cycles) were divided into one of two groups between January 2014 and December 2020: group A (n=1406, seven days of oestrogen before progesterone (P4) supplementation) and group B (n=2716, fourteen days of oestrogen before P4 supplementation). The primary outcome was cumulative live birth rate (CLBR). Secondary outcomes were other pregnancy-related outcomes, maternal and neonatal complications. Results: No significant difference in CLBR was observed when comparing seven versus fourteen days of oestrogen administration before starting P4 supplementation (47.6% vs. 48.8%, P=0.537). Furthermore, multivariable logistic regression analysis revealed that oestrogen administration in programmed FET cycles (7 days vs. 14 days) was not significantly associated with CLBR (OR 1.04, 95% CI 0.89-1.23). The risks of maternal and neonatal complications were comparable between the two groups. Conclusions: Variation in the duration of oestradiol supplementation before P4 initiation does not impact FET reproductive outcomes. For infertile women who desire to conceive as soon as feasible, short (seven days) oestrogen administration in a programmed FET cycle may be a suitable alternative. Endometrial preparation oestrogen frozen-thawed embryo transfer cumulative live birth rate maternal and neonatal complications Figures Figure 1 Figure 2 introduction In recent years, with the rapid development of assisted reproductive technology (ART) and the continuous progress of vitrification technology, FET technology has become the mainstream. FET plays an important role in preventing ovarian hyperstimulation syndrome, preserving the remaining embryos, increasing the cumulative pregnancy rate, and reducing ectopic pregnancy 1 . Studies have found that the clinical pregnancy rate of FET is similar to or even higher than that of fresh embryo transfer 2 . Before undergoing FET, the endometrium is mostly prepared clinically using natural cycles, programmed cycles, and ovulation induction cycle protocols 3 . Endometrial preparation and its synchrony with embryonic developmental stages are essential factors to ensure the maximization of endometrial receptivity and the quality of embryo implantation 4 . Programmed cycles offer greater flexibility for scheduling transfer without reducing live birth rates compared to natural and ovulation induction cycles, and are therefore more widely used clinically 5 6 . Previous studies have confirmed that different routes of oestrogen administration in programmed cycles do not affect the clinical outcome of patients 7-9 . However, these studies did not address whether the timing of exposure to oestrogen during the endometrial preparation phase would have an impact on clinical outcomes. In studies of non-genetically tested embryo transfer, it has been shown that prolonged exposure to oestrogen, i.e., > 32 days, will result in significantly lower live birth rates and increased miscarriage rates after autologous frozen-thawed blastocyst transfer 10 . However, in a study of euploid embryos, Sekhon et al. did not find a link between exposure time to oestrogen and clinical outcomes (pregnancy and miscarriage rates) 11 . In addition, the optimal duration of oestrogen when preparing the endometrium in a programmed cycle has not yet been defined. Therefore, this study retrospectively assessed the relationship between oestrogen duration and reproductive outcomes in programmed cycle frozen embryo transfer, in order to provide more options for patients who wish to become pregnant as soon as possible. materials and methods Study design Between January 2014 and December 2020, individuals treated at the authors' reproductive clinic completed autologous in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) cycles and had supernumerary embryos cryopreserved for future FET were included in this single-centre retrospective cohort study. The study was authorized by the local institutional review board (Reproductive Ethics Committee of The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, approval no. SDTCM/E2110-03, dated 11 October 2021) and was undertaken at a public tertiary referral university hospital. Eligibility criteria This study only included patients who had autologous programmed cycle FETs after performing a freeze-all strategy or after failed fresh embryo transfer attempts. This study was excluded for the following patients: (1) patients aged ≥ 45 years at the time of oocyte retrieval, (2) patients previously diagnosed with congenital or acquired uterine abnormalities, (3) patients undergoing blastocyst biopsy for preimplantation genetic testing (PGT) or preimplantation genetic diagnosis (PGD), (4) patients who underwent in vitro maturation (IVM), (5) patients who had ≥ 3 embryos transferred, (6) patients who used embryos derived from previous stimulation cycles (i.e., cryopreserved oocytes and/or donor oocytes), (7) patients who were unable to achieve an endometrial thickness of 8 mm within 7 or 14 days of initiating oestrogen supplementation, and (8) patients who required oestrogen administration beyond the standard oral regimen used. Additionally, natural cycle FETs that did not involve the administration of oestrogen or P4 were excluded. The included patients were divided into one of two groups: Group A (7 days of oestrogen prior to P4 supplementation) and Group B (14 days of oestrogen prior to P4 supplementation). Patient assignment to treatment was based simply on endometrial thickness meeting criteria above 7 mm and no follicular luteinization occurring before FET. Ovarian stimulation and laboratory procedures As previously described, the ovarian stimulation protocols used in 'fresh' cycles leading to oocyte retrieval and embryo cryopreservation were routine procedures at our centre 12 13 . For ovarian stimulation, either gonadotrophin-releasing hormone agonist (GnRH-a) or GnRH antagonist (GnRH-ant) protocols were employed. Cumulus oocyte complexes was collected by transvaginal ultrasound (TVUS)-guided needle aspiration 35-36 hours following hCG or GnRH-a combined hCG (dual trigger) administration. After ovum pick up, oocytes were fertilized using either conventional insemination (standard IVF) or ICSI, as indicated. Fertilization was determined 16-18 hours after insemination and was judged normal when two clearly distinguishable pronuclei containing nuclei were present. Under ultrasound supervision, embryo transfer was carried out using a routine approach. The number of embryos transferred was determined on an individual basis, taking into account the patient's age, previous failed attempts, and embryo quality. Only surplus embryos or blastocysts of good quality were cryopreserved utilizing the previously described fast freezing procedure 14 . Good quality Day 3 embryos were characterized as those that reached at least the six-cell stage with < 20% fragmentation. Good quality Day 5 blastocysts were defined as having a full blastocoel cavity with trophectoderm and inner cell mass quality scores of AA, AB, BA or BB. Frozen embryo transfer protocol In a subsequent cycle, patients were administered hormones for endometrial preparation prior to FET. For scheduling purposes, patients with irregular ovulation or anovulation underwent suppression of their hypothalamic-pituitary-ovarian axis with oral contraceptive pills for a minimum of 21 days. There were no medical contraindications for pre-treatment with oral contraceptives. On day 3 of vaginal bleeding (after withdrawal of oral contraceptives) or spontaneous menses, Patients performed a baseline TVUS and serum oestrogen, P4, luteinizing hormone, follicle stimulating hormone, and β-hCG monitoring to establish that they were in the early follicular phase of their menstrual cycle and to rule out pregnancy. Patients then began oral oestrogen (France; DELPHARM Lille S.A.S.), 2 mg three times daily for 1 or 2 weeks, depending on the grouping (Group A or Group B). The purpose of oral oestrogen administration was to stimulate endometrial growth while preventing the formation of a dominant follicle. We used TVUS to assess the patients' endometrium on a regular basis, with the first ultrasound performed within 7 days of initiating oestrogen administration. Before commencing P4 supplementation, ultrasonography was performed to confirm that the endometrial thickness was more than 7 mm, and serum P4 was evaluated to rule out premature ovulation. Once the FET's time has been determined, P4 in the form of intramuscular (Zhejiang Xianju Pharmaceutical Co., Ltd) or a combination of oral (Dydrogesterone; Abbott Biologicals B.V.) and vaginal (8% Crinone; Merck-Serono) administration was administered daily. Patient preference dictated the method of P4 supplementation. There were no medical indications to choose one regimen over the other. 3 to 5 days prior to FET, patients received intramuscular P4 or a combination of oral and vaginal P4. The vitrified-warming embryo or blastocyst was selected for transfer on the fourth or sixth day of P4 administration based on morphological grading according to the Gardner and Schoolcraft scale. Daily oestrogen and P4 medication were maintained after FET until a negative pregnancy test was reported. If a pregnancy was established, hormone treatment was maintained until the anticipated luteal-placental shift in oestrogen and P4 production, which occurred at approximately 8 to 9 weeks of gestation. Assessment of pregnancy outcomes The primary outcome was the cumulative live birth rate (CLBR), which was defined as the delivery of a liveborn (>24 weeks of gestation) using embryos obtained from the same ovarian stimulation cycle. Positive pregnancy rate, pregnancy loss rate, ectopic pregnancy rate, ongoing pregnancy rate, and live birth rate were secondary outcomes. Preeclampsia, gestational diabetes, gestational hypertension, preterm delivery, low birth weight, infants born small or large for gestational age, and congenital anomalies were among the maternal and neonatal outcomes monitored in pregnancies that lasted longer than 24 weeks. All secondary outcomes are described in Supplementary TABLE S1 . Statistical analysis Patients were categorized into two groups: Group A (7 days of oestrogen prior to P4 supplementation) and Group B (14 days of oestrogen prior to P4 supplementation). The distribution of the observations was investigated for continuous variables. The mean values and standard deviation (SD) within each group of interest were employed in the case of normal distribution (Shapiro-Wilk test). Whereas if distribution was not normal, the median and interquartile range (IQR) were reported. Categorical variables, including numerator and denominator values, are presented as either number of cases or percentages. Depending on the normality of the distribution, continuous variables were compared using an independent t-test or a Mann-Whitney U-test. The chi-squared or Fisher's exact test was used to compare categorical variables. Two-tailed alpha of 0.05 were employed in all statistical tests. All analyses were performed using SPSS 26 (SPSS Inc., Chicago, IL, USA). To identify characteristics that may be associated with the CLBR, multivariable logistic regression analysis was performed with the CLBR as the dependent variable and duration of oestrogen administration in FET cycles (7 days versus 14 days) as the main independent variable. The potential predictors considered for the analysis were female age, body mass index (BMI), basal follicle stimulating hormone, anti-müllerian hormone, ovarian stimulation protocol, ovulation trigger, number of oocytes retrieved, embryo transfer stage, number of embryos transferred, assisted hatching, physicians of embryo transfer, and endometrial thickness prior to FET. All variables were entered into the logistic regression model simultaneously or separately. The likelihood of CLBR is presented as an odds ratio (OR) with 95% confidence interval (CI). Additionally, we performed subgroup analyses of CLBR taking into account all confounding variables, including duration of oestrogen administration in FET cycles. In our study, we also used binary multivariate logistic regression analysis to assess the association between duration of oestrogen administration and pregnancy outcomes per FET after adjusting for 7 confounding variables such as female age (<37 yrs., ≥37 yrs.), BMI (<24 kg/m 2 , ≥24 kg/m 2 ), number of transferred embryos (single embryo transfer (SET), double embryo transfer (DET)), Day of FET (day 3, day 5), assisted hatching (yes, no), physicians of embryo transfer (A, B, C, and D) and endometrial thickness before FET. We calculated crude OR and adjusted OR with 95% CI. Results Baseline characteristics of the study population In total, 2628 patients (4142 FET cycles) were included in this study ( FIGURE 1 ) and were divided into two groups. Group A (n= 1406) used 7 days of oestrogen for endometrial preparation and Group B (n = 2716) used 14 days of oestrogen for endometrial preparation. Baseline characteristics are presented in TABLE 1 . Overall, there were no statistical differences between the two groups, except for a slightly longer duration of infertility in the group A than those in the group B: (3.5 (2, 4) versus 3.3 (2, 4), respectively, P=0.023). Ovarian stimulation and embryological characteristics The characteristics of the ovarian stimulation cycles were comparable for the two groups ( TABLE 1 ) in terms of the number of days of ovarian stimulation, total gonadotropin dose administered, serum oestradiol, progesterone, and luteinizing hormone concentrations on trigger day, method of fertilization, ovulation trigger protocol, as well as number of oocytes retrieved. A higher percentage of GnRH-ant protocol use was noted in group A patients (18.8% vs. 15.2% for group A and group B patients, respectively; P = 0.008). There were no significant differences between the two groups referring to embryological characteristics ( TABLE 1 ), except for more available and high-quality embryos were observed in group B (5.1 (2, 7) vs. 5.5 (3, 8) for group A and group B, P=0.026 and 1.8 (0, 3) vs. 2.1 (0, 3) for group A and group B, P=0.013, respectively). Characteristics of the FET cycles These several characteristics were not balanced and comparable between the two groups on the day of FET (day 3, day 5), number of frozen-thawed embryos transferred (SET, DET), and physicians TABLE 1 BASELINE CHARACTERISTICS, OVARIAN STIMULATION OUTCOMES AND cycle features of FETs Characteristic Seven Days (Group A) Fourteen Days (Group B) P-value Patients 942 1686 FET cycles 1406 2716 Female age at oocyte retrieval (years; mean (SD)) 31.0 (4.3) 31.2 (4.6) 0.480 Etiology of infertility 0.542 Tubal factor 509 (54.0) 923 (54.7) Male factor 257 (27.3) 448 (26.6) PCOS 126 (13.4) 206 (12.2) Endometriosis 50 (5.3) 109 (6.5) Duration of infertility (years; mean (IQR)) 3.5 (2, 4) 3.3 (2, 4) 0.023 Nulliparous 491 (52.1) 885 (52.5) 0.856 Gravidity (median (IQR)) 0 (0, 1) 1 (0, 1) 0.808 Parity (median (IQR)) 0 (0, 0) 0 (0, 0) 0.261 BMI (kg/m 2 ; mean (SD)) 23.9 (3.9) 23.7 (4.0) 0.529 AMH (ng/ml; median (IQR)) 3.3 (1.8, 5.5) 3.3 (1.8, 5.5) 0.890 Basic FSH (mIU/ml; mean (SD)) 6.7 (2.4) 6.8 (2.3) 0.258 Basic LH (mIU/ml; mean (SD)) 6.0 (4.2) 6.1 (4.9) 0.950 Basic oestradiol (pg/ml; median (IQR)) 27.5 (20.8, 38.0) 26.9 (20.8, 37.9) 0.642 Ovarian stimulation protocol 0.019 GnRH-a long protocol 765 (81.2) 1429 (84.8) GnRH-ant protocol 177 (18.8) 257 (15.2) No of days of COS (mean (SD)) 11.6 (2.7) 11.6 (2.7) 0.781 Total Gn dose administered (IU; mean (SD)) 2530.5 (983) 2509.2 (975.9) 0.647 Serum LH on trigger day (mIU/ml; median (IQR)) 1.3 (0.8, 2.2) 1.3 (0.8, 2.3) 0.439 Serum estradiol on trigger day (pg/ml; median (IQR)) 4800 (2956, 4901) 4800 (2858, 4936) 0.055 Serum progesterone on trigger day (ng/ml; median (IQR)) 1.2 (0.9, 1.8) 1.3 (0.9, 1.8) 0.819 Ovulation trigger protocol 0.056 hCG 875 (92.9) 1597 (94.7) GnRH-a and hCG (dual trigger) 67 (7.1) 89 (5.3) Method of fertilization 0.693 IVF 685 (72.7) 1238 (73.4) ICSI 257 (27.3) 448 (26.6) No of oocytes retrieved (mean (SD)) 16.5 (8.0) 16.9 (8.5) 0.413 2PN fertilization (median (IQR)) 9 (6, 13) 10 (6, 14) 0.127 No of embryos available for transfer (mean (IQR)) 5.1 (2, 7) 5.5 (3, 8) 0.026 Blastocysts available for transfer 101 (10.7) 213 (12.6) 0.147 No of high-quality embryos (mean (IQR)) 1.8 (0, 3) 2.1 (0, 3) 0.013 Ovarian stimulation cycle outcomes 0.356 Cycle with fresh embryo transfer 116 (12.3) 229 (13.6) Cycle with freeze-all strategy 826 (87.7) 1457 (86.4) Day of FET < 0.001 Day 3 1305 (92.8) 2287 (84.2) Day 5 101 (7.2) 429 (15.8) No of frozen thawed embryos transferred < 0.001 SET 288 (20.5) 807 (29.7) DET 1118 (79.5) 1909 (70.3) Assisted hatching 0.277 Yes 191 (13.6) 403 (14.8) No 1215 (86.4) 2313 (85.2) Endometrial thickness prior to FET (mm; mean (SD)) 10.4 (1.9) 10.3 (1.9) 0.281 Physicians of embryo transfer 0.002 Physician A 657 (46.7) 1111 (40.9) Physician B 265 (18.9) 520 (19.1) Physician C 276 (19.6) 605 (22.3) Physician D 208 (14.8) 480 (17.7) Abbreviation: FET, frozen embryo transfer; IQR, interquartile range; BMI, body mass index; AMH, anti-müllerian hormone; FSH, follicle stimulating hormone; LH, luteinizing hormone; GnRH-a, gonadotropin releasing hormone agonist; GnRH-ant, gonadotropin releasing hormone antagonist; IVF, in-vitro fertilization; ICSI, intracytoplasmic sperm injection; 2PN, double pronuclear fertilization; Gn, gonadotropin; IU, international units; SET, single embryo transfer; DET, double embryo transfer. Data are presented as numbers (%) unless otherwise noted. TABLE 2 Pregnancy and birth outcomes Seven Days (Group A) Fourteen Days (Group B) Relative Risk (95% CI) P-value Patients 942 1686 FET cycles 1406 2716 Positive pregnancy per embryo transfer 657 (46.7) 1228 (45.2) 0.97 (0.92 to 1.03) 0.355 Clinical pregnancy per embryo transfer 622 (44.2) 1113 (41.0) 1.08 (1.00 to 1.16) 0.044 Biochemical pregnancy loss per positive pregnancy 35 (5.3) 115 (9.4) 0.57 (0.39 to 0.82) 0.002 Clinical pregnancy loss per clinical pregnancy 129 (20.7) 222 (19.9) 1.04 (0.86 to 1.26) 0.693 Total pregnancy loss per positive pregnancy 164 (25.0) 337 (27.4) 0.91 (0.78 to 1.07) 0.245 Ectopic pregnancy per positive pregnancy 9 (1.4) 32 (2.6) 0.53 (0.25 to 1.10) 0.080 Ongoing pregnancy per embryo transfer 486 (34.6) 862 (31.7) 1.09 (0.99 to 1.19) 0.067 Live birth per embryo transfer 484 (34.4) 859 (31.6) 1.25 (0.99 to 1.57) 0.069 Cumulative live birth per patient 448 (47.6) 823 (48.8) 0.97 (0.90 to 1.06) 0.537 Data are presented as numbers (%). Table 3 Crude and adjusted odds ratio (OR) for Oestrogen priming of FET s and other potential confounders for Cumulative live birth rate (CLBR). Variable Crude OR (95% CI) Adjusted OR (95% CI) Oestrogen priming in FET cycles Seven days Reference Reference Fourteen days 1.05 (0.90 to 1.23) 1.04 (0.89 to 1.23) Female age at oocyte retrieval < 37 yrs. Reference Reference ≥ 37 yrs. 0.60 (0.47 to 0.76) 0.65 (0.50 to 0.83) Body mass index (BMI) 10 mIU/ml 0.87 (0.63 to 1.21) 1.03 (0.73 to 1.45) Anti-müllerian hormone < 1.2 mIU/ml Reference Reference ≥ 1.2mIU/ml 1.41 (1.11to 1.79) 1.41 (1.10 to 1.80) Ovarian stimulation protocol GnRH-a long protocol Reference Reference GnRH-ant protocol 0.97 (0.79to 1.19) 1.09 (0.86 to 1.37) Ovulation trigger hCG Reference Reference GnRH-a and hCG (dual trigger) 1.04 (0.76 to 1.44) 0.99 (0.69 to 1.42) No of oocytes retrieved ≤ 9 Reference Reference 10-15 1.37 (1.09 to 1.72) 1.30 (1.02 to 1.65) ≥ 16 1.58 (1.28 to 1.95) 1.46 (1.17 to 1.83) Embryo transfer stage D3 Reference Reference D5 1.38 (1.10 to 1.74) 1.57 (1.16 to 2.13) No of embryos transferred SET Reference Reference DET 0.92 (0.77 to 1.09) 1.12 (0.89 to 1.40) Assisted hatching No Reference Reference Yes 1.03 (0.83 to 1.29) 0.97 (0.78 to 1.22) Physicians of embryo transfer Physician A Reference Reference Physician B 1.12 (0.92 to 1.37) 1.13 (0.93 to 1.39) Physician C 0.93 (0.75 to 1.16) 0.95 (0.77 to 1.18) Physician D 1.01 (0.81 to 1.26) 1.02 (0.81 to 1.28) Endometrial thickness prior to FET < 8mm Reference Reference ≥ 8mm 1.29 (1.00 to 1.65) 1.25 (0.97 to 1.61) TABLE 4 Relationship between endometrial preparation Duration and pregnancy outcomes Per FEt in different models. Pregnancy outcomes Oestrogen priming in FET cycles Crude model a Adjusted model b OR (95% CI) P value OR (95% CI) P value Positive pregnancy Fourteen days Reference Reference Seven days 0.98 (0.86 to 1.11) 0.751 0.99 (0.87 to 1.13) 0.863 Clinical pregnancy Fourteen days Reference Reference Seven days 0.88 (0.77 to 0.99) 0.045 0.89 (0.78 to 1.02) 0.088 Live birth Fourteen days Reference Reference Seven days 0.88 (0.77 to 1.01) 0.069 0.91 (0.79 to 1.05) 0.183 BMI = body mass index; OR = odds ratio; CI = confidence interval; FET = frozen-thawed embryo transfer. a No adjustments for other covariates. b Adjusted for female age (<37 yrs., ≥37 yrs.), BMI (<24 kg/m 2 , ≥24 kg/m 2 ), number of transferred embryos (SET, DET), Day of FET (day 3, day 5), assisted hatching (yes, no), physicians of embryo transfer (A, B, C, and D) and endometrial thickness before FET. of embryo transfer (A, B, C, and D) (P<0.001, P<0.001, and P=0.002, respectively). Nevertheless, other characteristics of the programmed cycles, such as endometrial thickness or whether to perform assisted hatching or not, did not differ between the two study groups. ( TABLE 1 ) Pregnancy and birth outcomes As shown in TABLE 2 , the primary outcome of CLBR in the group A was non-inferior to the group B (47.6% vs. 48.8%, relative risk (RR) 0.97, 95% CI 0.90-1.06, P=0.537). Moreover, no significant difference was found in the ongoing pregnancy and live birth rates between the group A and the group B (34.6% vs. 31.7%, RR 1.09, 95% CI 0.99-1.19, P=0.067; 34.4% vs. 31.6%, RR 1.25, 95% CI 0.99-1.57, P=0.069, respectively). In the group A, 622 of 1406 FETs (44.2%) had a higher clinical pregnancy rate compared with 1113 out of 2716 (41.0%) in the group B (RR 1.08, 95% CI 1.00-1.16, p=0.044). Additionally, biochemical pregnancy loss per positive hCG test was approximately 80% higher in the group B than the group A (9.4% vs. 5.3%, P=0.002). The positive pregnancy rate, clinical pregnancy loss rate, and ectopic pregnancy rate did not differ significantly between the two groups. Nonetheless, binary multivariate logistic regression analysis revealed that oestrogen administration in the programmed FET cycle (7 days vs. 14 days) was not a significant independent factor of positive pregnancy rate (OR 0.99, 95% CI 0.87-1.13, P=0.863), clinical pregnancy rate (OR 0.89, 95% CI 0.78-1.02, P=0.088), and live birth rate (OR 0.91, 95% CI 0.79-1.05, P=0.183). ( TABLE 4 ) The detailed results of secondary outcomes on maternal and perinatal complications are presented in Supplementary TABLE S2 . Multivariable regression and subgroup analyses of CLBR As shown in TABLE 3 , multivariable logistic regression analysis, allowing adjustment for relevant confounders, revealed that oestrogen administration in programmed FET cycles (7 days vs. 14 days) was not significantly associated with CLBR in the adjusted models (OR 1.04, 95% CI 0.89-1.23). We also performed subgroup analyses of CLBR. ( FIGURE 2 ) The CLBR was significantly higher in the group A compared with those in the group B when FET procedure operations were performed by physician B (57.5% for group A vs. 47.4% for group B, P=0.021), a result that deserves cautious interpretation due to the heterogeneity of this subgroup. Discussion With this large retrospective study, we analyzed the effect of 7 and 14 days of oestrogen administration in programmed cycles on pregnancy outcomes in FET. The results of the study found that the clinical pregnancy rate and live birth rate as well as the cumulative live birth rate in infertile patients who underwent FET by programmed cycle preparation of the endometrium were not affected by the duration of oestrogen administration. The number of days of oestrogen use did not alter the reproductive outcome of FET, which shows that endometrial receptivity is not affected by shorter oestrogen exposure time. We therefore conclude that physicians can be flexible in scheduling FET procedures when endometrial thickness is appropriate, without being limited by the number of days of oestrogen administration. Numerous studies have shown that the expression of endometrial genes and implantation factors are affected during implantation at higher oestrogen concentrations 15 , and genes highly expressed during the implantation window of the natural cycle are down-regulated 16-18 , such as endometrial integrin β3 subunit and leukaemia inhibitory factor (LIF) 16 19 . When the appropriate concentration of oestrogen acts on the endometrium, it can make the endometrium more synchronized with the embryo 15 . However, compared with natural cycles, programmed cycles have similar reproductive outcomes although serum oestrogen levels are higher 5 20 . In recent years, with the increasing number of FET cycles, it is particularly urgent to study the correlation between the duration of oestrogen administration in the proliferative phase and endometrial content. In the study of donor oocyte transfer cycles, some scholars believe that a shorter duration of oestrogen can negatively affect the cycle outcome, leading to an increase in the rate of early pregnancy loss 10 21 . Younis et al 22 found that the duration of oestrogen administration should be controlled at 12-19 days for optimal pregnancy rates. Borini et al. 10 also found that donor oocyte transfer cycles resulted in the best reproductive outcome when the timing of oestrogen administration was controlled in the range of 11-40 days. However, some scholars believe that long-term use of oestrogen will lead to adverse pregnancy outcomes in donor oocyte transfer cycles. Michalas et al. 23 found in their study that the optimal duration of oestrogen administration was 6-11 days before progesterone addition, after which the clinical pregnancy rate decreased significantly with prolonged oestrogen exposure. Alternatively, Navot et al. 21 found a significant increase in the incidence of breakthrough bleeding in patients when oestrogen was administered for more than 40 days. At present, few studies have addressed the effect of the number of days of continuous oestrogen administration on receiving autologous oocyte-derived frozen embryo transfer. Ying et al. 24 found that biochemical and clinical pregnancy rates were significantly higher in the later oestrogen initiation group compared with the early oestrogen initiation group, however, ongoing pregnancy rates were not significantly different between groups. However, this study did not observe the effect of duration of oestrogen on live birth rate. Sekho et al concluded that the duration of oestrogen administration before FET was not associated with embryo implantation rate, clinical pregnancy rate, early pregnancy loss rate, and live birth rate 11 . In contrast, Bourdon et al. found in a large retrospective analysis involving 1377 autologous IVF transfers with frozen blastocysts that continuous oestrogen administration for more than 28 days before FET significantly reduced live birth rates, and that fetal birth weight and Z-score decreased with prolonged oestrogen exposure when oestrogen was administered for more than 36 days 10 . The strength of this study is the large sample size included. To date, our study provides the largest duration of oestrogen administration in programmed cycles and clinical outcomes of FET. The limitation of our study is that it is a retrospective study, conducted in a single centre, IVF/ICSI administration protocol only involves GnRH-a long protocol and GnRH-ant protocol, and FET procedure is performed by different senior doctors. Our study does not exclude the possible effects of the oestrogen administration route, although the available studies suggest that the oestrogen administration route does not affect the clinical outcome of patients 7-9 . In addition, progesterone is not administered in the same way in patients. Now, the route of clinical progesterone administration is intramuscular injection, oral and vaginal administration, or a combination regimen. Current studies suggest that the mode of progesterone administration does not affect pregnancy rates 25-27 . Despite these limitations, our study still provides valuable data with reference for clinicians to use flexible programmed cycle protocols. Conclusion In conclusion, our study showed that oestrogen administration for 7 days and for 14 days did not affect the reproductive outcome of FET. There was no association between duration of oestrogen use and live birth rate. This provides a more flexible option for the administration regimen of FET oestrogen under programmed cycles, and, without affecting clinical outcomes, reduces patient time and economic costs to some extent. However, because this study still has some limitations and contradicts some previous findings, more prospective clinical trials need to be designed to further evaluate the effect of the number of days of oestrogen administration in programmed cycles on the clinical outcomes of FET. In addition, previous studies have found that there is a correlation between oestrogen exposure time and delivery, premature delivery rate and fetal weight 10 11 , but there are few relevant studies, and more detailed prospective studies involving obstetric follow-up content need to be designed to further explore their relationship and provide a reference for clinical practice. Declarations Author’s contributions SJY and SZG conceived of the study; JWJ responsible for data collection and thesis writing; SJY and JWJ responsible for data curation and supervision; SZG responsible for the revision of articles and enrolment of patient. All authors have read and approved the manuscript. Funding statement This study was funded by the National Natural Science Foundation of China (81874484). Disclaimer The authors are fully responsible for the content of this manuscript, and the views and opinions described in the publication reflect solely those of the authors. Competing interest’s statement The author has not signed any contract with any funding unit that may bias the research results. All authors declare that they have no competing interests. References 1. Zech J, Brandao A, Zech M, et al. Elective frozen-thawed embryo transfer (FET) in women at risk for ovarian hyperstimulation syndrome. Reprod Biol 2018;18(1):46-52. doi: 10.1016/j.repbio.2017.12.004 [published Online First: 2017/12/28] 2. Roque M, Lattes K, Serra S, et al. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. Fertil Steril 2013;99(1):156-62. doi: 10.1016/j.fertnstert.2012.09.003 [published Online First: 2012/10/09] 3. Kajihara T, Brosens JJ, Ishihara O. The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy. Med Mol Morphol 2013;46(2):61-8. doi: 10.1007/s00795-013-0018-z [published Online First: 2013/02/06] 4. Wallach EE, Younis JS, Simon A, et al. Endometrial preparation: lessons from oocyte donation. Fertility and Sterility 1996;66(6):873-84. doi: 10.1016/s0015-0282(16)58677-4 5. Ghobara T, Gelbaya TA, Ayeleke RO. Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev 2017;7:CD003414. doi: 10.1002/14651858.CD003414.pub3 [published Online First: 2017/07/05] 6. Groenewoud ER, Cohlen BJ, Al-Oraiby A, et al. A randomized controlled, non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer. Hum Reprod 2016;31(7):1483-92. doi: 10.1093/humrep/dew120 [published Online First: 2016/05/15] 7. Corroenne R, El Hachem H, Verhaeghe C, et al. Endometrial preparation for frozen-thawed embryo transfer in an artificial cycle: transdermal versus vaginal estrogen. Sci Rep 2020;10(1):985. doi: 10.1038/s41598-020-57730-3 [published Online First: 2020/01/24] 8. Scheffer JB, Scheffer BB, Aguiar APS, et al. A comparison of the effects of three different estrogen used for endometrium preparation on the outcome of day 5 frozen embryo transfer cycle. JBRA Assist Reprod 2021;25(1):104-08. doi: 10.5935/1518-0557.20200059 [published Online First: 2020/09/30] 9. Kahraman S, Cetinkaya CP, Sahin Y, et al. Transdermal versus oral estrogen: clinical outcomes in patients undergoing frozen-thawed single blastocyst transfer cycles without GnRHa suppression, a prospective randomized clinical trial. J Assist Reprod Genet 2019;36(3):453-59. doi: 10.1007/s10815-018-1380-5 [published Online First: 2018/12/07] 10. Bourdon M, Santulli P, Kefelian F, et al. Prolonged estrogen (E2) treatment prior to frozen-blastocyst transfer decreases the live birth rate. Hum Reprod 2018;33(5):905-13. doi: 10.1093/humrep/dey041 [published Online First: 2018/03/13] 11. Sekhon L, Feuerstein J, Pan S, et al. Endometrial preparation before the transfer of single, vitrified-warmed, euploid blastocysts: does the duration of estradiol treatment influence clinical outcome? Fertil Steril 2019;111(6):1177-85 e3. doi: 10.1016/j.fertnstert.2019.02.024 [published Online First: 2019/04/29] 12. Li L, Gao D-D, Zhang Y, et al. Comparison of Stimulated Cycles with Low Dose r-FSH versus Hormone Replacement Cycles for Endometrial Preparation Prior to Frozen-Thawed Embryo Transfer in Young Women with Polycystic Ovarian Syndrome: A Single-Center Retrospective Cohort Study from China. Drug design, development and therapy 2021;15:2805-13. doi: 10.2147/DDDT.S317545 13. Gao DD, Li L, Zhang Y, et al. Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer? Front Med (Lausanne) 2021;8:691428. doi: 10.3389/fmed.2021.691428 [published Online First: 2021/11/02] 14. Song J, Xiang S, Sun Z. Frozen embryo transfer at the cleavage stage can be performed within the first menstrual cycle following the freeze-all strategy without adversely affecting the live birth rate: A STROBE-compliant retrospective study. Medicine 2019;98(38):e17329. doi: 10.1097/md.0000000000017329 15. Kassab A, Sabatini L, Tozer A, et al. The correlation between basal serum follicle-stimulating hormone levels before embryo cryopreservation and the clinical outcome of frozen embryo transfers. Fertil Steril 2009;92(4):1269-75. doi: 10.1016/j.fertnstert.2008.08.077 [published Online First: 2008/10/22] 16. Chen QJ, Sun XX, Li L, et al. Effects of ovarian stimulation on endometrial integrin beta3 and leukemia inhibitory factor expression in the peri-implantation phase. Fertil Steril 2008;89(5 Suppl):1357-63. doi: 10.1016/j.fertnstert.2007.03.073 [published Online First: 2007/08/08] 17. Creus M, Ordi J, Fabregues F, et al. The effect of different hormone therapies on integrin expression and pinopode formation in the human endometrium: a controlled study. Hum Reprod 2003;18(4):683-93. doi: 10.1093/humrep/deg177 [published Online First: 2003/03/28] 18. Liu Y, Lee KF, Ng EH, et al. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril 2008;90(6):2152-64. doi: 10.1016/j.fertnstert.2007.10.020 [published Online First: 2008/01/15] 19. Diamanti-Kandarakis E, Baillargeon JP, Iuorno MJ, et al. A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills. J Clin Endocrinol Metab 2003;88(5):1927-32. doi: 10.1210/jc.2002-021528 [published Online First: 2003/05/03] 20. Groenewoud ER, Cantineau AE, Kollen BJ, et al. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update 2017;23(2):255-61. doi: 10.1093/humupd/dmw046 [published Online First: 2017/01/08] 21. NAVOT D, BERGH PA, BERGH PA, et al. An Insight into Early Reproductive Processes through the in Vivo Model of Ovum Donation. Journal of Clinical Endocrinology and Metabolism 1991;72:408-14. 22. YOUNIS JS, MORDEL N, LEWIN A, et al. Artificial Endometrial Preparation for Oocyte Donation: The Effect of Estrogen Stimulation on Clinical Outcome. Journal of Assisted Reproduction and Genetics 1992;9:222-27. 23. Brown SG, Costello S, Kelly MC, et al. Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid. Hum Reprod 2017;32(10):1995-2006. doi: 10.1093/humrep/dex269 [published Online First: 2017/09/25] 24. Ying Y, Wu Y, Liu S, et al. The timing for initiating estrogen stimulation in artificial cycle for frozen-thawed embryo transfer can be flexible. Reprod Health 2021;18(1):181. doi: 10.1186/s12978-021-01229-1 [published Online First: 2021/09/11] 25. Deng Y, Ou Z, Liang Y, et al. [Efficacy of vaginal administration of Crinone versus Utrogestan combined with oral dydrogesterone tablets for luteal support in PGT freeze-thaw embryo transfer cycles]. Nan Fang Yi Ke Da Xue Xue Bao 2021;41(7):1062-66. doi: 10.12122/j.issn.1673-4254.2021.07.14 [published Online First: 2021/07/27] 26. Liu Y, Wu Y. Progesterone Intramuscularly or Vaginally Administration May Not Change Live Birth Rate or Neonatal Outcomes in Artificial Frozen-Thawed Embryo Transfer Cycles. Front Endocrinol (Lausanne) 2020;11:539427. doi: 10.3389/fendo.2020.539427 [published Online First: 2020/12/22] 27. Ozer G, Yuksel B, Yucel Cicek OS, et al. Oral dydrogesterone vs. micronized vaginal progesterone gel for luteal phase support in frozen-thawed single blastocyst transfer in good prognosis patients. J Gynecol Obstet Hum Reprod 2021;50(5):102030. doi: 10.1016/j.jogoh.2020.102030 [published Online First: 2020/12/04] Additional Declarations No competing interests reported. Supplementary Files SupplementaryTables.docx Cite Share Download PDF Status: Published Journal Publication published 21 Mar, 2022 Read the published version in Journal of Ovarian Research → Version 1 posted Editorial decision: Major revision 03 Mar, 2022 Reviews received at journal 27 Feb, 2022 Reviewers agreed at journal 24 Feb, 2022 Reviewers invited by journal 24 Feb, 2022 Editor assigned by journal 21 Feb, 2022 Submission checks completed at journal 21 Feb, 2022 First submitted to journal 17 Feb, 2022 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1368931","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":85336612,"identity":"728a255b-4094-4bd3-a947-5315c9aa20ef","order_by":0,"name":"Wen-Jing Jiang","email":"","orcid":"","institution":"Shandong University of Traditional Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Wen-Jing","middleName":"","lastName":"Jiang","suffix":""},{"id":85336613,"identity":"70b087e9-6235-4624-85b2-222d138c4997","order_by":1,"name":"Jing-Yan Song","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA9ElEQVRIie3PsWoCQRCA4TkG7ppJbD3wIcYqBETzKCcHqY6QB1A5EKzuAQz6HCHlLAtnY7LtQSpJa7GWQoqoGEnjnmXA/buB+ZhdAJ/vH8YAgSQAuB/EcocaUV5L4ETU9PmxFRdyAfkdkKzucPXgJnfRu8jqbRix0UoTG4IKArvJzpP74imR/nKBLGWi5vxJwSzH+OXV8TDJWPqTElkVLOsdwZaEeOMiZn0kumGF+IPCZlJDqsOVAXJJoIiFqJ4crgjGy5DVlFNqkhq7/2Ky9mo7GaW3Rn9Z+93t9RZjZTcOckynf4Ygr93fNepesuXz+XxX2g+TalzZs5RdZQAAAABJRU5ErkJggg==","orcid":"","institution":"Shandong University of Traditional Chinese Medicine","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Jing-Yan","middleName":"","lastName":"Song","suffix":""},{"id":85336614,"identity":"45d594f6-8e1d-435d-9b51-4224ce400988","order_by":2,"name":"Zhen-Gao Sun","email":"","orcid":"","institution":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhen-Gao","middleName":"","lastName":"Sun","suffix":""}],"badges":[],"createdAt":"2022-02-17 10:14:18","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1368931/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1368931/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s13048-022-00967-5","type":"published","date":"2022-03-21T20:49:29+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":18438043,"identity":"003f67ec-66f2-47fe-b35c-cac895bbd013","added_by":"auto","created_at":"2022-02-21 15:02:43","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":315211,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eThe flow chart of study enrolment.\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-1368931/v1/bc331e757f8ce686c1a40089.jpg"},{"id":18438057,"identity":"3cd7cabe-fdb1-4382-9517-e9262a158bab","added_by":"auto","created_at":"2022-02-21 15:02:43","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":1461298,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eSubgroup analysis of CLBR in patients treated with oestrogen for 7 days and 14 days for endometrial preparation in programmed FET cycles.\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Figure2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-1368931/v1/712bae7cfaf18c6d18bb344e.jpg"},{"id":19451292,"identity":"9d45ea35-e4fa-4e77-a57e-2e844dbfe07b","added_by":"auto","created_at":"2022-03-21 20:49:37","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":885674,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1368931/v1/95ae2647-1645-4f1f-af55-698a84f10146.pdf"},{"id":18438030,"identity":"a2bf05ae-61eb-449c-9c96-b7f4b0e2a5e5","added_by":"auto","created_at":"2022-02-21 15:02:43","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":19721,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTables.docx","url":"https://assets-eu.researchsquare.com/files/rs-1368931/v1/e93cafd9022b3b0ebef712c6.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Short (seven days) versus standard (fourteen days) oestrogen administration in a programmed frozen embryo transfer cycle: a retrospective cohort study","fulltext":[{"header":"introduction","content":"\u003cp\u003eIn recent years, with the rapid development of assisted reproductive technology (ART) and the continuous progress of vitrification technology, FET technology has become the mainstream. FET plays an important role in preventing ovarian hyperstimulation syndrome, preserving the remaining embryos, increasing the cumulative pregnancy rate, and reducing ectopic pregnancy\u0026nbsp;\u003csup\u003e1\u003c/sup\u003e. Studies have found that the clinical pregnancy rate of FET is similar to or even higher than that of fresh embryo transfer\u0026nbsp;\u003csup\u003e2\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eBefore undergoing FET, the endometrium is mostly prepared clinically using natural cycles, programmed cycles, and ovulation induction cycle protocols\u0026nbsp;\u003csup\u003e3\u003c/sup\u003e. Endometrial preparation and its synchrony with embryonic developmental stages are essential factors to ensure the maximization of endometrial receptivity and the quality of embryo implantation\u0026nbsp;\u003csup\u003e4\u003c/sup\u003e. Programmed cycles offer greater flexibility for scheduling transfer without reducing live birth rates compared to natural and ovulation induction cycles, and are therefore more widely used clinically\u0026nbsp;\u003csup\u003e5 6\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003ePrevious studies have confirmed that different routes of oestrogen administration in programmed cycles do not affect the clinical outcome of patients\u0026nbsp;\u003csup\u003e7-9\u003c/sup\u003e. However, these studies did not address whether the timing of exposure to oestrogen during the endometrial preparation phase would have an impact on clinical outcomes. In studies of non-genetically tested embryo transfer, it has been shown that prolonged exposure to oestrogen, i.e., \u0026gt; 32 days, will result in significantly lower live birth rates and increased miscarriage rates after autologous frozen-thawed blastocyst transfer\u0026nbsp;\u003csup\u003e10\u003c/sup\u003e. However, in a study of euploid embryos, Sekhon et al. did not find a link between exposure time to oestrogen and clinical outcomes (pregnancy and miscarriage rates)\u0026nbsp;\u003csup\u003e11\u003c/sup\u003e. In addition, the optimal duration of oestrogen when preparing the endometrium in a programmed cycle has not yet been defined.\u003c/p\u003e\n\u003cp\u003eTherefore, this study retrospectively assessed the relationship between oestrogen duration and reproductive outcomes in programmed cycle frozen embryo transfer, in order to provide more options for patients who wish to become pregnant as soon as possible.\u003c/p\u003e"},{"header":"materials and methods","content":"\u003cp\u003e\u003cstrong\u003eStudy design\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBetween January 2014 and December 2020, individuals treated at the authors\u0026apos; reproductive clinic completed autologous in vitro fertilization (IVF) /\u0026nbsp;intracytoplasmic sperm injection (ICSI) cycles and had supernumerary embryos cryopreserved for future FET were included in this single-centre retrospective cohort study. The study was authorized by the local institutional review board (Reproductive Ethics Committee of The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, approval no. SDTCM/E2110-03, dated 11 October 2021) and was undertaken at a public tertiary referral university hospital.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEligibility criteria\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study only included patients who had autologous programmed cycle FETs after performing a freeze-all strategy or after failed fresh embryo transfer attempts. This study was excluded for the following patients: (1)\u0026nbsp;patients aged \u0026ge; 45 years at the time of oocyte retrieval, (2) patients previously diagnosed with congenital or acquired uterine abnormalities, (3) patients undergoing blastocyst biopsy for preimplantation genetic testing (PGT) or preimplantation genetic diagnosis (PGD), (4) patients who underwent in vitro maturation (IVM), (5) patients who had \u0026ge; 3 embryos transferred, (6) patients who used embryos derived from previous stimulation cycles (i.e., cryopreserved oocytes and/or donor oocytes), (7) patients who were unable to achieve an endometrial thickness of 8 mm within 7 or 14 days of initiating oestrogen supplementation, and (8) patients who required oestrogen administration beyond the standard oral regimen used. Additionally, natural cycle FETs that did not involve the administration of oestrogen or P4 were excluded. The included patients were divided into one of two groups: Group A (7 days of oestrogen prior to P4 supplementation) and Group B (14 days of oestrogen prior to P4 supplementation). Patient assignment to treatment was based simply on endometrial thickness meeting criteria above 7 mm and no follicular luteinization occurring before FET.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eOvarian stimulation and laboratory procedures\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAs previously described, the ovarian stimulation protocols used in \u0026apos;fresh\u0026apos; cycles leading to oocyte retrieval and embryo cryopreservation were routine procedures at our centre\u0026nbsp;\u003csup\u003e12 13\u003c/sup\u003e. For ovarian stimulation, either gonadotrophin-releasing hormone agonist (GnRH-a) or GnRH antagonist (GnRH-ant) protocols were employed. Cumulus oocyte complexes was collected by transvaginal ultrasound (TVUS)-guided needle aspiration 35-36 hours following hCG or GnRH-a combined hCG (dual trigger) administration. After ovum pick up, oocytes were fertilized using either conventional insemination (standard IVF) or ICSI, as indicated. Fertilization was determined 16-18 hours after insemination and was judged normal when two clearly distinguishable pronuclei containing nuclei were present. Under ultrasound supervision, embryo transfer was carried out using a routine approach. The number of embryos transferred was determined on an individual basis, taking into account the patient\u0026apos;s age, previous failed attempts, and embryo quality. Only surplus embryos or blastocysts of good quality were cryopreserved utilizing the previously described fast freezing procedure\u0026nbsp;\u003csup\u003e14\u003c/sup\u003e. Good quality Day 3 embryos were characterized as those that reached at least the six-cell stage with \u0026lt; 20% fragmentation. Good quality Day 5 blastocysts were defined as having a full blastocoel cavity with trophectoderm and inner cell mass quality scores of AA, AB, BA or BB.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFrozen embryo transfer protocol\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn a subsequent cycle, patients were administered hormones for endometrial preparation prior to FET. For scheduling purposes, patients with irregular ovulation or anovulation underwent suppression of their hypothalamic-pituitary-ovarian axis with oral contraceptive pills for a minimum of 21 days. There were no medical contraindications for pre-treatment with oral contraceptives. On day 3 of vaginal bleeding (after withdrawal of oral contraceptives) or spontaneous menses, Patients performed a baseline TVUS and serum oestrogen, P4, luteinizing hormone, follicle stimulating hormone, and \u0026beta;-hCG monitoring to establish that they were in the early follicular phase of their menstrual cycle and to rule out pregnancy.\u003c/p\u003e\n\u003cp\u003ePatients then began oral oestrogen (France; DELPHARM Lille S.A.S.), 2 mg three times daily for 1 or 2 weeks, depending on the grouping (Group A or Group B). The purpose of oral oestrogen administration was to stimulate endometrial growth while preventing the formation of a dominant follicle. We used TVUS to assess the patients\u0026apos; endometrium on a regular basis, with the first ultrasound performed within 7 days of initiating oestrogen administration. Before commencing P4 supplementation, ultrasonography was performed to confirm that the endometrial thickness was more than 7 mm, and serum P4 was evaluated to rule out premature ovulation.\u003c/p\u003e\n\u003cp\u003eOnce the FET\u0026apos;s time has been determined, P4 in the form of intramuscular (Zhejiang Xianju Pharmaceutical Co., Ltd) or a combination of oral (Dydrogesterone; Abbott Biologicals B.V.) and vaginal (8% Crinone; Merck-Serono) administration was administered daily. Patient preference dictated the method of P4 supplementation. There were no medical indications to choose one regimen over the other. 3 to 5 days prior to FET, patients received intramuscular P4 or a combination of oral and vaginal P4. The vitrified-warming embryo or blastocyst was selected for transfer on the fourth or sixth day of P4 administration based on morphological grading according to the Gardner and Schoolcraft scale. Daily oestrogen and P4 medication were maintained after FET until a negative pregnancy test was reported. If a pregnancy was established, hormone treatment was maintained until the anticipated luteal-placental shift in oestrogen and P4 production, which occurred at approximately 8 to 9 weeks of gestation.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAssessment of pregnancy outcomes\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe primary outcome was the cumulative live birth rate (CLBR), which was defined as the delivery of a liveborn (\u0026gt;24 weeks of gestation) using embryos obtained from the same ovarian stimulation cycle. Positive pregnancy rate, pregnancy loss rate, ectopic pregnancy rate, ongoing pregnancy rate, and live birth rate were secondary outcomes. Preeclampsia, gestational diabetes, gestational hypertension, preterm delivery, low birth weight, infants born small or large for gestational age, and congenital anomalies were among the maternal and neonatal outcomes monitored in pregnancies that lasted longer than 24 weeks. All secondary outcomes are described in Supplementary \u003cstrong\u003eTABLE S1\u003c/strong\u003e.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePatients were categorized into two groups: Group A (7 days\u0026nbsp;of oestrogen prior to P4 supplementation) and Group B (14 days of oestrogen prior to P4 supplementation). The distribution of the observations was investigated for continuous variables. The mean values and standard deviation (SD) within each group of interest were employed in the case of normal distribution (Shapiro-Wilk test). Whereas if distribution was not normal, the median and interquartile range (IQR) were reported. Categorical variables, including numerator and denominator values, are presented as either number of cases or percentages. Depending on the normality of the distribution, continuous variables were compared using an independent t-test or a Mann-Whitney U-test. The chi-squared or Fisher\u0026apos;s exact test was used to compare categorical variables. Two-tailed alpha of 0.05 were employed in all statistical tests. All analyses were performed using SPSS 26 (SPSS Inc., Chicago, IL, USA).\u003c/p\u003e\n\u003cp\u003eTo identify characteristics that may be associated with the CLBR, multivariable logistic regression analysis was performed with the CLBR as the dependent variable and duration of oestrogen administration in FET cycles (7 days versus 14 days) as the main independent variable. The potential predictors considered for the analysis were female age, body mass index (BMI), basal follicle stimulating hormone, anti-m\u0026uuml;llerian hormone, ovarian stimulation protocol,\u0026nbsp;ovulation trigger, number of oocytes retrieved, embryo transfer stage, number of embryos transferred, assisted hatching, physicians of embryo transfer, and endometrial thickness prior to FET. All variables were entered into the logistic regression model simultaneously or separately. The likelihood of CLBR is presented as an odds ratio (OR) with 95% confidence interval (CI). Additionally, we performed subgroup analyses of CLBR taking into account all confounding variables, including duration of oestrogen administration in FET cycles. In our study, we also used binary multivariate logistic regression analysis to assess the association between duration of oestrogen administration and pregnancy outcomes per FET after adjusting for 7 confounding variables such as female age (\u0026lt;37 yrs., \u0026ge;37 yrs.), BMI (\u0026lt;24 kg/m\u003csup\u003e2\u003c/sup\u003e, \u0026ge;24 kg/m\u003csup\u003e2\u003c/sup\u003e), number of transferred embryos (single embryo transfer (SET), double embryo transfer (DET)), Day of FET (day 3, day 5), assisted hatching (yes, no), physicians of embryo transfer (A, B, C, and D) and endometrial thickness before FET. We calculated crude OR and adjusted OR with 95% CI.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBaseline characteristics of the study population\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eIn total, 2628 patients (4142 FET cycles) were included in this study\u0026nbsp;(\u003cstrong\u003eFIGURE 1\u003c/strong\u003e) and were divided into two groups. Group A (n= 1406) used 7 days of oestrogen for endometrial preparation and Group B (n = 2716) used 14 days of oestrogen for endometrial preparation.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBaseline characteristics are presented in \u003cstrong\u003eTABLE 1\u003c/strong\u003e. Overall, there were no statistical differences between the two groups, except for a slightly longer duration of infertility in the group A than those in the group B: (3.5 (2, 4) versus 3.3 (2, 4), respectively, P=0.023).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eOvarian stimulation and embryological characteristics\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eThe characteristics of the ovarian stimulation cycles were comparable for the two groups (\u003cstrong\u003eTABLE 1\u003c/strong\u003e) in terms of the number of days of ovarian stimulation, total gonadotropin dose administered, serum oestradiol, progesterone, and luteinizing hormone concentrations\u0026nbsp;on trigger day, method of fertilization, ovulation trigger protocol, as well as number of oocytes retrieved. A higher percentage of GnRH-ant protocol use was noted in group A patients (18.8% vs. 15.2% for group A and group B patients, respectively; P = 0.008). There were no significant differences between the two groups referring to embryological characteristics (\u003cstrong\u003eTABLE 1\u003c/strong\u003e), except for more available and high-quality embryos were observed in group B (5.1 (2, 7) vs. 5.5 (3, 8) for group A and group B, P=0.026 and 1.8 (0, 3) vs. 2.1 (0, 3) for group A and group B, P=0.013, respectively).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eCharacteristics of the FET cycles\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eThese several characteristics were not balanced and comparable between the two groups on the day of FET (day 3, day 5), number of frozen-thawed embryos transferred (SET, DET), and physicians\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width:98.18%;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width:100.0%;border:none;border-bottom: solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:27.6pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 19px; background-color: rgb(255, 255, 255);\"\u003eTABLE 1 BASELINE CHARACTERISTICS, OVARIAN STIMULATION OUTCOMES\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e \u003cstrong\u003e\u003c/strong\u003e\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 19px;;background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eAND cycle features of FETs\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:22.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eCharacteristic\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:22.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eSeven Days (Group A)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:22.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eFourteen Days (Group B)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:22.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eP-value\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 115%;;background-color: rgb(255, 255, 255);\"\u003ePatients\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e942\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e1686\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 115%;;background-color: rgb(255, 255, 255);\"\u003eFET cycles\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 115%;;background-color: rgb(255, 255, 255);\"\u003e1406\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 115%;;background-color: rgb(255, 255, 255);\"\u003e2716\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eFemale age at oocyte retrieval (years; mean (SD))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e31.0 (4.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e31.2 (4.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.480\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eEtiology of infertility\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.542\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eTubal factor\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e509 (54.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e923 (54.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eMale factor\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e257 (27.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e448 (26.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePCOS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e126 (13.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e206 (12.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eEndometriosis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e50 (5.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e109 (6.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eDuration of infertility (years; mean (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e3.5 (2, 4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e3.3 (2, 4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.023\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eNulliparous\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e491 (52.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e885 (52.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.856\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eGravidity (median (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0 (0, 1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1 (0, 1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.808\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eParity (median (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0 (0, 0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0 (0, 0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.261\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBMI (kg/m\u003csup\u003e2\u003c/sup\u003e; mean (SD))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e23.9 (3.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e23.7 (4.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.529\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eAMH (ng/ml; median (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e3.3 (1.8, 5.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e3.3 (1.8, 5.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.890\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBasic FSH (mIU/ml; mean (SD))\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e6.7 (2.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e6.8 (2.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.258\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBasic LH (mIU/ml; mean (SD))\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e6.0 (4.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e6.1 (4.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.950\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBasic\u003c/span\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eoestradiol (pg/ml; median (IQR))\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e27.5 (20.8, 38.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e26.9 (20.8, 37.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.642\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eOvarian stimulation protocol\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.019\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eGnRH-a long protocol\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e765 (81.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1429 (84.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eGnRH-ant protocol\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e177 (18.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e257 (15.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eNo of days of COS (mean (SD))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e11.6 (2.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e11.6 (2.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.781\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eTotal Gn dose administered (IU; mean (SD))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e2530.5 (983)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e2509.2 (975.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.647\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSerum LH on trigger day (mIU/ml; median (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.3 (0.8, 2.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.3 (0.8, 2.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.439\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSerum estradiol on trigger day (pg/ml; median (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e4800 (2956, 4901)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e4800 (2858, 4936)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.055\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSerum progesterone on trigger day (ng/ml; median (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.2 (0.9, 1.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.3 (0.9, 1.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.819\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eOvulation trigger protocol\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.056\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ehCG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e875 (92.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1597 (94.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eGnRH-a and hCG (dual trigger)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e67 (7.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e89 (5.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:23.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eMethod of fertilization\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.693\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eIVF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e685 (72.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1238 (73.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eICSI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e257 (27.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e448 (26.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eNo of oocytes retrieved (mean (SD))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e16.5 (8.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e16.9 (8.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.413\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e2PN fertilization (median (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e9 (6, 13)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e10 (6, 14)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.127\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eNo of embryos available for transfer (mean (IQR))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e5.1 (2, 7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e5.5 (3, 8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.026\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBlastocysts available for transfer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e101 (10.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e213 (12.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.147\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eNo of high-quality embryos (mean (IQR))\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.8 (0, 3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e2.1 (0, 3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.013\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eOvarian stimulation cycle outcomes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.356\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eCycle with fresh embryo transfer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e116 (12.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e229 (13.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eCycle with freeze-all strategy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e826 (87.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1457 (86.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eDay of FET\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026lt; 0.001\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eDay 3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1305 (92.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e2287 (84.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eDay 5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e101 (7.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e429 (15.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eNo of frozen thawed embryos transferred\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026lt; 0.001\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSET\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e288 (20.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e807 (29.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eDET\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1118 (79.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1909 (70.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eAssisted hatching\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.277\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e191 (13.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e403 (14.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1215 (86.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e2313 (85.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eEndometrial thickness prior to FET (mm; mean (SD))\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e10.4 (1.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e10.3 (1.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.281\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysicians of embryo transfer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e0.002\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysician A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e657 (46.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1111 (40.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysician B\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e265 (18.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e520 (19.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysician C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e276 (19.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e605 (22.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.54%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysician D\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.18%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e208 (14.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.6%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e480 (17.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.68%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:22.1pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" style=\"width: 100%;border: none;padding: 0in 5.4pt;height: 92.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 15px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eAbbreviation: FET, frozen embryo transfer; IQR, interquartile range; BMI, body mass index; AMH, anti-m\u0026uuml;llerian hormone; FSH, follicle stimulating hormone; LH, luteinizing hormone; GnRH-a,\u003c/span\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003cspan style=\"font-size: 15px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003egonadotropin releasing hormone agonist; GnRH-ant,\u003c/span\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e \u003c/span\u003e\u003cspan style=\"font-size: 15px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003egonadotropin releasing hormone antagonist; IVF, in-vitro fertilization; ICSI, intracytoplasmic sperm injection; 2PN, double pronuclear fertilization; Gn, gonadotropin; IU, international units; SET, single embryo transfer; DET, double embryo transfer.\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 15px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eData are presented as numbers (%) unless otherwise noted.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable id=\"isPasted\" style=\"width: 7.8e+2pt;border: none;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width:779.7pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255);\"\u003eTABLE 2 Pregnancy and birth outcomes\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:23.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:23.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eSeven Days (Group A)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:23.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eFourteen Days (Group B)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:23.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eRelative Risk (95% CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:23.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eP-value\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003ePatients\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e942\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e1686\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:20.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eFET cycles\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:20.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e1406\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:20.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e2716\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:20.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:20.4pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:21.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePositive pregnancy per embryo transfer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:21.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e657 (46.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1228 (45.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:21.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.97 (0.92 to 1.03)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.9pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.355\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eClinical pregnancy\u003csup\u003e\u0026nbsp;\u003c/sup\u003eper embryo transfer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e622 (44.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1113 (41.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.08 (1.00 to 1.16)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.044\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:21.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBiochemical pregnancy loss\u0026nbsp;per positive pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:21.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e35 (5.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e115 (9.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:21.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.57 (0.39 to 0.82)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.002\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:21.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eClinical pregnancy loss per clinical pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:21.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e129 (20.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e222 (19.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:21.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.04 (0.86 to 1.26)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.45pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.693\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eTotal pregnancy loss per positive pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e164 (25.0)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e337 (27.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.91 (0.78 to 1.07)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.245\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:21.3pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eEctopic pregnancy per positive pregnancy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:21.3pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e9 (1.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.3pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e32 (2.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:21.3pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.53 (0.25 to 1.10)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.3pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.080\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:20.95pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eOngoing pregnancy per embryo transfer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:20.95pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e486 (34.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:20.95pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e862 (31.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:20.95pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.09 (0.99 to 1.19)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:20.95pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.067\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;padding:0in 5.4pt 0in 5.4pt;height:21.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eLive birth per embryo transfer\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;padding:0in 5.4pt 0in 5.4pt;height:21.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e484 (34.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;padding:0in 5.4pt 0in 5.4pt;height:21.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e859 (31.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;padding:0in 5.4pt 0in 5.4pt;height:21.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.25 (0.99 to 1.57)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;padding:0in 5.4pt 0in 5.4pt;height:21.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.069\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:276.5pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:.3in;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eCumulative live birth per patient\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:155.9pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:.3in;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e448 (47.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:146.0pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:.3in;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e823 (48.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:130.45pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:.3in;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.97 (0.90 to 1.06)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:70.85pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:.3in;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003e0.537\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"5\" style=\"width:779.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:36.8pt;\"\u003e\n \u003cp style='margin:0in;text-align:left;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"font-size: 15px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eData are presented as numbers (%).\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable id=\"isPasted\" style=\"width:673.75pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" style=\"width:673.75pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:42.55pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eTable 3 Crude and adjusted odds ratio (OR) for Oestrogen priming of FET\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003c/strong\u003e\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 115%;;background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003es\u0026nbsp;and other potential confounders for Cumulative live birth rate (CLBR).\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eVariable\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eCrude OR (95% CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eAdjusted OR (95% CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eOestrogen priming in FET cycles\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSeven days\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eFourteen days\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.05 (0.90 to 1.23)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.04 (0.89 to 1.23)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eFemale age at oocyte retrieval\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026lt; 37 yrs.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026ge; 37 yrs.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.60 (0.47 to 0.76)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.65 (0.50 to 0.83)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eBody mass index (BMI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026lt; 24 kg/m\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026ge; 24 kg/m\u003csup\u003e2\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.94 (0.81 to 1.10)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.93 (0.79 to 1.09)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eFSH on menstrual cycle days 2-3\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026le; 10 mIU/ml\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026gt; 10 mIU/ml\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.87 (0.63 to 1.21)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.03 (0.73 to 1.45)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eAnti-m\u0026uuml;llerian hormone\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026lt; 1.2 mIU/ml\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026ge; 1.2mIU/ml\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.41 (1.11to 1.79)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.41 (1.10 to 1.80)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eOvarian stimulation protocol\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eGnRH-a long protocol\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eGnRH-ant protocol\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.97 (0.79to 1.19)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.09 (0.86 to 1.37)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eOvulation trigger\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ehCG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eGnRH-a and hCG (dual trigger)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.04 (0.76 to 1.44)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.99 (0.69 to 1.42)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eNo of oocytes retrieved\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026le; 9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e10-15\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.37 (1.09 to 1.72)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.30 (1.02 to 1.65)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026ge; 16\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.58 (1.28 to 1.95)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.46 (1.17 to 1.83)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eEmbryo transfer stage\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eD3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eD5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.38 (1.10 to 1.74)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:16.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.57 (1.16 to 2.13)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eNo of embryos transferred\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSET\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eDET\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.92 (0.77 to 1.09)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.12 (0.89 to 1.40)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eAssisted hatching\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.03 (0.83 to 1.29)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.97 (0.78 to 1.22)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003ePhysicians of embryo transfer\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysician A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysician B\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.12 (0.92 to 1.37)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.13 (0.93 to 1.39)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysician C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.93 (0.75 to 1.16)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.95 (0.77 to 1.18)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003ePhysician D\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.01 (0.81 to 1.26)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.02 (0.81 to 1.28)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;;background-color: rgb(255, 255, 255);\"\u003eEndometrial thickness prior to FET\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026lt; 8mm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:287.9pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;text-indent:24.0pt;'\u003e\u003cspan style=\"font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026ge; 8mm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:199.7pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.29 (1.00 to 1.65)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:186.15pt;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.7pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e1.25 (0.97 to 1.61)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable id=\"isPasted\" style=\"width:98.62%;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"width:100.0%;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:24.25pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eTABLE 4 Relationship between endometrial preparation Duration and pregnancy outcomes Per FEt in different models.\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 19.82%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003ePregnancy outcomes\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:25.74%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003eOestrogen priming in FET cycles\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:27.26%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:150%;;background-color: rgb(255, 255, 255);\"\u003eCrude model \u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:27.2%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.65pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:150%;;background-color: rgb(255, 255, 255);\"\u003eAdjusted model \u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 19.82%;border: none;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 25.74%;border: none;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.4%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt dashed windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003eOR (95% CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.86%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt dashed windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:150%;;background-color: rgb(255, 255, 255);\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003c/strong\u003e\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:150%;;background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;value\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.3%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt dashed windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003eOR (95% CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.9%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt dashed windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size:16px;line-height:150%;;background-color: rgb(255, 255, 255);\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003c/strong\u003e\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height:150%;;background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;value\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 19.82%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003ePositive pregnancy\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 25.74%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eFourteen days\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.4%;border: none;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.86%;border: none;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.3%;border: none;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.9%;border: none;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 19.82%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 25.74%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSeven days\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.4%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.98 (0.86 to 1.11)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.86%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.751\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.3%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.99 (0.87 to 1.13)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.9%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.863\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 19.82%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003eClinical pregnancy\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 25.74%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eFourteen days\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.4%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.86%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.3%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.9%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 19.82%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 25.74%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSeven days\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.4%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.88 (0.77 to 0.99)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.86%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.045\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.3%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.89 (0.78 to 1.02)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.9%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.088\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 19.82%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:16px;line-height: 150%;;background-color: rgb(255, 255, 255);\"\u003eLive birth\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 25.74%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eFourteen days\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.4%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.86%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.3%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eReference\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.9%;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 19.82%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 25.74%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eSeven days\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.4%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.88 (0.77 to 1.01)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.86%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.069\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.3%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.91 (0.79 to 1.05)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 9.9%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:150%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 150%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e0.183\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"6\" style=\"width: 100%;border: none;padding: 0in 5.4pt;height: 82.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eBMI = body mass index; OR = odds ratio; CI = confidence interval; FET = frozen-thawed embryo transfer.\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003csup\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;No adjustments for other covariates.\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Times New Roman\",serif;line-height:115%;'\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003csup\u003e\u003cspan style=\"font-size:16px;line-height:115%;;background-color: rgb(255, 255, 255);\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003cspan style=\"font-size: 16px; line-height: 115%; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u0026nbsp;Adjusted for female age (\u0026lt;37 yrs., \u0026ge;37 yrs.), BMI (\u0026lt;24 kg/m\u003csup\u003e2\u003c/sup\u003e, \u0026ge;24 kg/m\u003csup\u003e2\u003c/sup\u003e), number of transferred embryos (SET, DET), Day of FET (day 3, day 5), assisted hatching (yes, no), physicians of embryo transfer (A, B, C, and D) and endometrial thickness before FET.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp id=\"isPasted\"\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eof embryo transfer (A, B, C, and D) (P\u0026lt;0.001, P\u0026lt;0.001, and P=0.002, respectively). Nevertheless, other characteristics of the programmed cycles, such as endometrial thickness or whether to perform assisted hatching or not, did not differ between the two study groups. (\u003cstrong\u003eTABLE 1\u003c/strong\u003e)\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003ePregnancy and birth outcomes\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eAs shown in \u003cstrong\u003eTABLE 2\u003c/strong\u003e, the primary outcome of CLBR in the group A was non-inferior to the group B (47.6% vs. 48.8%, relative risk (RR) 0.97, 95% CI 0.90-1.06, P=0.537). Moreover, no significant difference was found in the ongoing pregnancy and live birth rates between the group A and the group B (34.6% vs. 31.7%, RR 1.09, 95% CI 0.99-1.19, P=0.067; 34.4% vs. 31.6%, RR 1.25, 95% CI 0.99-1.57, P=0.069, respectively). In the group A, 622 of 1406 FETs (44.2%) had a higher clinical pregnancy rate compared with 1113 out of 2716 (41.0%) in the group B (RR 1.08, 95% CI 1.00-1.16, p=0.044). Additionally, biochemical pregnancy loss per positive hCG test was approximately 80% higher in the group B than the group A (9.4% vs. 5.3%, P=0.002). The positive pregnancy rate, clinical pregnancy loss rate, and ectopic pregnancy rate did not differ significantly between the two groups. Nonetheless, binary multivariate logistic regression analysis revealed that oestrogen administration in the programmed FET cycle (7 days vs. 14 days) was not a significant independent factor of positive pregnancy rate (OR 0.99, 95% CI 0.87-1.13, P=0.863), clinical pregnancy rate (OR 0.89, 95% CI 0.78-1.02, P=0.088), and live birth rate (OR 0.91, 95% CI 0.79-1.05, P=0.183). (\u003cstrong\u003eTABLE 4\u003c/strong\u003e) The detailed results of secondary outcomes on maternal and perinatal complications are presented in Supplementary\u003cstrong\u003e\u0026nbsp;TABLE S2\u003c/strong\u003e.\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eMultivariable regression and subgroup analyses of CLBR\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eAs shown in \u003cstrong\u003eTABLE 3\u003c/strong\u003e, multivariable logistic regression analysis, allowing adjustment for relevant confounders, revealed that oestrogen administration in programmed FET cycles (7 days vs. 14 days) was not significantly associated with CLBR in the adjusted models (OR 1.04, 95% CI 0.89-1.23).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);\"\u003eWe also performed subgroup analyses of CLBR. (\u003cstrong\u003eFIGURE 2\u003c/strong\u003e) The CLBR was significantly higher in the group A compared with those in the group B when FET procedure operations were performed by physician B (57.5% for group A vs. 47.4% for group B, P=0.021), a result that deserves cautious interpretation due to the heterogeneity of this subgroup.\u003c/span\u003e\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eWith this large retrospective study, we analyzed the effect of 7 and 14 days of oestrogen administration in programmed cycles on pregnancy outcomes in FET. The results of the study found that the clinical pregnancy rate and live birth rate as well as the cumulative live birth rate in infertile patients who underwent FET by programmed cycle preparation of the endometrium were not affected by the duration of oestrogen administration. The number of days of oestrogen use did not alter the reproductive outcome of FET, which shows that endometrial receptivity is not affected by shorter oestrogen exposure time. We therefore conclude that physicians can be flexible in scheduling FET procedures when endometrial thickness is appropriate, without being limited by the number of days of oestrogen administration.\u003c/p\u003e\n\u003cp\u003eNumerous studies have shown that the expression of endometrial genes and implantation factors are affected during implantation at higher oestrogen concentrations\u0026nbsp;\u003csup\u003e15\u003c/sup\u003e, and genes highly expressed during the implantation window of the natural cycle are down-regulated\u003csup\u003e16-18\u003c/sup\u003e, such as endometrial integrin \u0026beta;3 subunit and leukaemia inhibitory factor (LIF)\u0026nbsp;\u003csup\u003e16 19\u003c/sup\u003e. When the appropriate concentration of oestrogen acts on the endometrium, it can make the endometrium more synchronized with the embryo\u0026nbsp;\u003csup\u003e15\u003c/sup\u003e. However, compared with natural cycles, programmed cycles have similar reproductive outcomes although serum oestrogen levels are higher\u0026nbsp;\u003csup\u003e5 20\u003c/sup\u003e. In recent years, with the increasing number of FET cycles, it is particularly urgent to study the correlation between the duration of oestrogen administration in the proliferative phase and endometrial content.\u003c/p\u003e\n\u003cp\u003eIn the study of donor oocyte transfer cycles, some scholars believe that a shorter duration of oestrogen can negatively affect the cycle outcome, leading to an increase in the rate of early pregnancy loss\u0026nbsp;\u003csup\u003e10 21\u003c/sup\u003e. Younis et al\u0026nbsp;\u003csup\u003e22\u003c/sup\u003e found that the duration of oestrogen administration should be controlled at 12-19 days for optimal pregnancy rates. Borini et al.\u0026nbsp;\u003csup\u003e10\u003c/sup\u003e also found that donor oocyte transfer cycles resulted in the best reproductive outcome when the timing of oestrogen administration was controlled in the range of 11-40 days. However, some scholars believe that long-term use of oestrogen will lead to adverse pregnancy outcomes in donor oocyte transfer cycles. Michalas et al.\u0026nbsp;\u003csup\u003e23\u003c/sup\u003e found in their study that the optimal duration of oestrogen administration was 6-11 days before progesterone addition, after which the clinical pregnancy rate decreased significantly with prolonged oestrogen exposure. Alternatively, Navot et al.\u0026nbsp;\u003csup\u003e21\u003c/sup\u003e found a significant increase in the incidence of breakthrough bleeding in patients when oestrogen was administered for more than 40 days.\u003c/p\u003e\n\u003cp\u003eAt present, few studies have addressed the effect of the number of days of continuous oestrogen administration on receiving autologous oocyte-derived frozen embryo transfer. Ying et al.\u0026nbsp;\u003csup\u003e24\u003c/sup\u003e found that biochemical and clinical pregnancy rates were significantly higher in the later oestrogen initiation group compared with the early oestrogen initiation group, however, ongoing pregnancy rates were not significantly different between groups. However, this study did not observe the effect of duration of oestrogen on live birth rate. Sekho et al concluded that the duration of oestrogen administration before FET was not associated with embryo implantation rate, clinical pregnancy rate, early pregnancy loss rate, and live birth rate\u0026nbsp;\u003csup\u003e11\u003c/sup\u003e. In contrast, Bourdon et al. found in a large retrospective analysis involving 1377 autologous IVF transfers with frozen blastocysts that continuous oestrogen administration for more than 28 days before FET significantly reduced live birth rates, and that fetal birth weight and Z-score decreased with prolonged oestrogen exposure when oestrogen was administered for more than 36 days\u0026nbsp;\u003csup\u003e10\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eThe strength of this study is the large sample size included. To date, our study provides the largest duration of oestrogen administration in programmed cycles and clinical outcomes of FET. The limitation of our study is that it is a retrospective study, conducted in a single centre, IVF/ICSI administration protocol only involves GnRH-a long protocol and GnRH-ant protocol, and FET procedure is performed by different senior doctors. Our study does not exclude the possible effects of the oestrogen administration route, although the available studies suggest that the oestrogen administration route does not affect the clinical outcome of patients\u0026nbsp;\u003csup\u003e7-9\u003c/sup\u003e. In addition, progesterone is not administered in the same way in patients. Now, the route of clinical progesterone administration is intramuscular injection, oral and vaginal administration, or a combination regimen. Current studies suggest that the mode of progesterone administration does not affect pregnancy rates\u0026nbsp;\u003csup\u003e25-27\u003c/sup\u003e. Despite these limitations, our study still provides valuable data with reference for clinicians to use flexible programmed cycle protocols.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, our study showed that oestrogen administration for 7 days and for 14 days did not affect the reproductive outcome of FET. There was no association between duration of oestrogen use and live birth rate. This provides a more flexible option for the administration regimen of FET oestrogen under programmed cycles, and, without affecting clinical outcomes, reduces patient time and economic costs to some extent. However, because this study still has some limitations and contradicts some previous findings, more prospective clinical trials need to be designed to further evaluate the effect of the number of days of oestrogen administration in programmed cycles on the clinical outcomes of FET. In addition, previous studies have found that there is a correlation between oestrogen exposure time and delivery, premature delivery rate and fetal weight \u003csup\u003e10 11\u003c/sup\u003e, but there are few relevant studies, and more detailed prospective studies involving obstetric follow-up content need to be designed to further explore their relationship and provide a reference for clinical practice.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAuthor\u0026rsquo;s contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSJY and SZG conceived of the study; JWJ responsible for data collection and thesis writing; SJY and JWJ responsible for data curation and supervision; SZG responsible for the revision of articles and enrolment of patient. All authors have read and approved the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was funded by the National Natural Science Foundation of China (81874484).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors are fully responsible for the content of this manuscript, and the views and opinions described in the publication reflect solely those of the authors.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interest\u0026rsquo;s statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe author has not signed any contract with any funding unit that may bias the research results. All authors declare that they have no competing interests.\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e1. Zech J, Brandao A, Zech M, et al. Elective frozen-thawed embryo transfer (FET) in women at risk for ovarian hyperstimulation syndrome. \u003cem\u003eReprod Biol\u003c/em\u003e 2018;18(1):46-52. doi: 10.1016/j.repbio.2017.12.004 [published Online First: 2017/12/28]\u003c/p\u003e\n\u003cp\u003e2. Roque M, Lattes K, Serra S, et al. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. \u003cem\u003eFertil Steril\u003c/em\u003e 2013;99(1):156-62. doi: 10.1016/j.fertnstert.2012.09.003 [published Online First: 2012/10/09]\u003c/p\u003e\n\u003cp\u003e3. Kajihara T, Brosens JJ, Ishihara O. The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy. \u003cem\u003eMed Mol Morphol\u003c/em\u003e 2013;46(2):61-8. doi: 10.1007/s00795-013-0018-z [published Online First: 2013/02/06]\u003c/p\u003e\n\u003cp\u003e4. Wallach EE, Younis JS, Simon A, et al. Endometrial preparation: lessons from oocyte donation. \u003cem\u003eFertility and Sterility\u003c/em\u003e 1996;66(6):873-84. doi: 10.1016/s0015-0282(16)58677-4\u003c/p\u003e\n\u003cp\u003e5. Ghobara T, Gelbaya TA, Ayeleke RO. Cycle regimens for frozen-thawed embryo transfer. \u003cem\u003eCochrane Database Syst Rev\u003c/em\u003e 2017;7:CD003414. doi: 10.1002/14651858.CD003414.pub3 [published Online First: 2017/07/05]\u003c/p\u003e\n\u003cp\u003e6. Groenewoud ER, Cohlen BJ, Al-Oraiby A, et al. A randomized controlled, non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer. \u003cem\u003eHum Reprod\u003c/em\u003e 2016;31(7):1483-92. doi: 10.1093/humrep/dew120 [published Online First: 2016/05/15]\u003c/p\u003e\n\u003cp\u003e7. Corroenne R, El Hachem H, Verhaeghe C, et al. Endometrial preparation for frozen-thawed embryo transfer in an artificial cycle: transdermal versus vaginal estrogen. \u003cem\u003eSci Rep\u003c/em\u003e 2020;10(1):985. doi: 10.1038/s41598-020-57730-3 [published Online First: 2020/01/24]\u003c/p\u003e\n\u003cp\u003e8. Scheffer JB, Scheffer BB, Aguiar APS, et al. A comparison of the effects of three different estrogen used for endometrium preparation on the outcome of day 5 frozen embryo transfer cycle. \u003cem\u003eJBRA Assist Reprod\u003c/em\u003e 2021;25(1):104-08. doi: 10.5935/1518-0557.20200059 [published Online First: 2020/09/30]\u003c/p\u003e\n\u003cp\u003e9. Kahraman S, Cetinkaya CP, Sahin Y, et al. Transdermal versus oral estrogen: clinical outcomes in patients undergoing frozen-thawed single blastocyst transfer cycles without GnRHa suppression, a prospective randomized clinical trial. \u003cem\u003eJ Assist Reprod Genet\u003c/em\u003e 2019;36(3):453-59. doi: 10.1007/s10815-018-1380-5 [published Online First: 2018/12/07]\u003c/p\u003e\n\u003cp\u003e10. Bourdon M, Santulli P, Kefelian F, et al. Prolonged estrogen (E2) treatment prior to frozen-blastocyst transfer decreases the live birth rate. \u003cem\u003eHum Reprod\u003c/em\u003e 2018;33(5):905-13. doi: 10.1093/humrep/dey041 [published Online First: 2018/03/13]\u003c/p\u003e\n\u003cp\u003e11. Sekhon L, Feuerstein J, Pan S, et al. Endometrial preparation before the transfer of single, vitrified-warmed, euploid blastocysts: does the duration of estradiol treatment influence clinical outcome? \u003cem\u003eFertil Steril\u003c/em\u003e 2019;111(6):1177-85 e3. doi: 10.1016/j.fertnstert.2019.02.024 [published Online First: 2019/04/29]\u003c/p\u003e\n\u003cp\u003e12. Li L, Gao D-D, Zhang Y, et al. Comparison of Stimulated Cycles with Low Dose r-FSH versus Hormone Replacement Cycles for Endometrial Preparation Prior to Frozen-Thawed Embryo Transfer in Young Women with Polycystic Ovarian Syndrome: A Single-Center Retrospective Cohort Study from China. \u003cem\u003eDrug design, development and therapy\u003c/em\u003e 2021;15:2805-13. doi: 10.2147/DDDT.S317545\u003c/p\u003e\n\u003cp\u003e13. Gao DD, Li L, Zhang Y, et al. Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer? \u003cem\u003eFront Med (Lausanne)\u003c/em\u003e 2021;8:691428. doi: 10.3389/fmed.2021.691428 [published Online First: 2021/11/02]\u003c/p\u003e\n\u003cp\u003e14. Song J, Xiang S, Sun Z. Frozen embryo transfer at the cleavage stage can be performed within the first menstrual cycle following the freeze-all strategy without adversely affecting the live birth rate: A STROBE-compliant retrospective study. \u003cem\u003eMedicine\u003c/em\u003e 2019;98(38):e17329. doi: 10.1097/md.0000000000017329\u003c/p\u003e\n\u003cp\u003e15. Kassab A, Sabatini L, Tozer A, et al. The correlation between basal serum follicle-stimulating hormone levels before embryo cryopreservation and the clinical outcome of frozen embryo transfers. \u003cem\u003eFertil Steril\u003c/em\u003e 2009;92(4):1269-75. doi: 10.1016/j.fertnstert.2008.08.077 [published Online First: 2008/10/22]\u003c/p\u003e\n\u003cp\u003e16. Chen QJ, Sun XX, Li L, et al. Effects of ovarian stimulation on endometrial integrin beta3 and leukemia inhibitory factor expression in the peri-implantation phase. \u003cem\u003eFertil Steril\u003c/em\u003e 2008;89(5 Suppl):1357-63. doi: 10.1016/j.fertnstert.2007.03.073 [published Online First: 2007/08/08]\u003c/p\u003e\n\u003cp\u003e17. Creus M, Ordi J, Fabregues F, et al. The effect of different hormone therapies on integrin expression and pinopode formation in the human endometrium: a controlled study. \u003cem\u003eHum Reprod\u003c/em\u003e 2003;18(4):683-93. doi: 10.1093/humrep/deg177 [published Online First: 2003/03/28]\u003c/p\u003e\n\u003cp\u003e18. Liu Y, Lee KF, Ng EH, et al. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. \u003cem\u003eFertil Steril\u003c/em\u003e 2008;90(6):2152-64. doi: 10.1016/j.fertnstert.2007.10.020 [published Online First: 2008/01/15]\u003c/p\u003e\n\u003cp\u003e19. Diamanti-Kandarakis E, Baillargeon JP, Iuorno MJ, et al. A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills. \u003cem\u003eJ Clin Endocrinol Metab\u003c/em\u003e 2003;88(5):1927-32. doi: 10.1210/jc.2002-021528 [published Online First: 2003/05/03]\u003c/p\u003e\n\u003cp\u003e20. Groenewoud ER, Cantineau AE, Kollen BJ, et al. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. \u003cem\u003eHum Reprod Update\u003c/em\u003e 2017;23(2):255-61. doi: 10.1093/humupd/dmw046 [published Online First: 2017/01/08]\u003c/p\u003e\n\u003cp\u003e21. NAVOT D, BERGH PA, BERGH PA, et al. An Insight into Early Reproductive Processes through the in Vivo Model of Ovum Donation. \u003cem\u003eJournal of Clinical Endocrinology and Metabolism\u003c/em\u003e 1991;72:408-14.\u003c/p\u003e\n\u003cp\u003e22. YOUNIS JS, MORDEL N, LEWIN A, et al. Artificial Endometrial Preparation for Oocyte Donation: The Effect of Estrogen Stimulation on Clinical Outcome. \u003cem\u003eJournal of Assisted Reproduction and Genetics\u003c/em\u003e 1992;9:222-27.\u003c/p\u003e\n\u003cp\u003e23. Brown SG, Costello S, Kelly MC, et al. Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid. \u003cem\u003eHum Reprod\u003c/em\u003e 2017;32(10):1995-2006. doi: 10.1093/humrep/dex269 [published Online First: 2017/09/25]\u003c/p\u003e\n\u003cp\u003e24. Ying Y, Wu Y, Liu S, et al. The timing for initiating estrogen stimulation in artificial cycle for frozen-thawed embryo transfer can be flexible. \u003cem\u003eReprod Health\u003c/em\u003e 2021;18(1):181. doi: 10.1186/s12978-021-01229-1 [published Online First: 2021/09/11]\u003c/p\u003e\n\u003cp\u003e25. Deng Y, Ou Z, Liang Y, et al. [Efficacy of vaginal administration of Crinone versus Utrogestan combined with oral dydrogesterone tablets for luteal support in PGT freeze-thaw embryo transfer cycles]. \u003cem\u003eNan Fang Yi Ke Da Xue Xue Bao\u003c/em\u003e 2021;41(7):1062-66. doi: 10.12122/j.issn.1673-4254.2021.07.14 [published Online First: 2021/07/27]\u003c/p\u003e\n\u003cp\u003e26. Liu Y, Wu Y. Progesterone Intramuscularly or Vaginally Administration May Not Change Live Birth Rate or Neonatal Outcomes in Artificial Frozen-Thawed Embryo Transfer Cycles. \u003cem\u003eFront Endocrinol (Lausanne)\u003c/em\u003e 2020;11:539427. doi: 10.3389/fendo.2020.539427 [published Online First: 2020/12/22]\u003c/p\u003e\n\u003cp\u003e27. Ozer G, Yuksel B, Yucel Cicek OS, et al. Oral dydrogesterone vs. micronized vaginal progesterone gel for luteal phase support in frozen-thawed single blastocyst transfer in good prognosis patients. \u003cem\u003eJ Gynecol Obstet Hum Reprod\u003c/em\u003e 2021;50(5):102030. doi: 10.1016/j.jogoh.2020.102030 [published Online First: 2020/12/04]\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"journal-of-ovarian-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"jovr","sideBox":"Learn more about [Journal of Ovarian Research](http://ovarianresearch.biomedcentral.com)","snPcode":"13048","submissionUrl":"https://submission.nature.com/new-submission/13048/3","title":"Journal of Ovarian Research","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Endometrial preparation, oestrogen, frozen-thawed embryo transfer, cumulative live birth rate, maternal and neonatal complications","lastPublishedDoi":"10.21203/rs.3.rs-1368931/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1368931/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Research question: What influence does seven days of oestrogen administration versus fourteen days have on the reproductive outcomes of frozen-thawed embryo transfer (FET) in programmed endometrial preparation cycles?\nDesign: In a retrospective study, conducted at a university-affiliated tertiary hospital, a total of 2628 infertile patients (4142 FET cycles) were divided into one of two groups between January 2014 and December 2020: group A (n=1406, seven days of oestrogen before progesterone (P4) supplementation) and group B (n=2716, fourteen days of oestrogen before P4 supplementation). The primary outcome was cumulative live birth rate (CLBR). Secondary outcomes were other pregnancy-related outcomes, maternal and neonatal complications.\nResults: No significant difference in CLBR was observed when comparing seven versus fourteen days of oestrogen administration before starting P4 supplementation (47.6% vs. 48.8%, P=0.537). Furthermore, multivariable logistic regression analysis revealed that oestrogen administration in programmed FET cycles (7 days vs. 14 days) was not significantly associated with CLBR (OR 1.04, 95% CI 0.89-1.23). The risks of maternal and neonatal complications were comparable between the two groups.\nConclusions: Variation in the duration of oestradiol supplementation before P4 initiation does not impact FET reproductive outcomes. For infertile women who desire to conceive as soon as feasible, short (seven days) oestrogen administration in a programmed FET cycle may be a suitable alternative.","manuscriptTitle":"Short (seven days) versus standard (fourteen days) oestrogen administration in a programmed frozen embryo transfer cycle: a retrospective cohort study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-02-21 15:02:41","doi":"10.21203/rs.3.rs-1368931/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2022-03-03T17:10:57+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2022-02-27T17:12:22+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"bee7da62-e4c3-41cd-9ea7-554c27231179","date":"2022-02-24T20:18:16+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2022-02-24T18:51:44+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2022-02-22T03:16:27+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2022-02-21T08:41:18+00:00","index":"","fulltext":""},{"type":"submitted","content":"Journal of Ovarian Research","date":"2022-02-17T10:11:01+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"journal-of-ovarian-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"jovr","sideBox":"Learn more about [Journal of Ovarian Research](http://ovarianresearch.biomedcentral.com)","snPcode":"13048","submissionUrl":"https://submission.nature.com/new-submission/13048/3","title":"Journal of Ovarian Research","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"d4f47ec0-68eb-45a2-b766-e5eac36b4e4f","owner":[],"postedDate":"February 21st, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2022-03-21T20:49:29+00:00","versionOfRecord":{"articleIdentity":"rs-1368931","link":"https://doi.org/10.1186/s13048-022-00967-5","journal":{"identity":"journal-of-ovarian-research","isVorOnly":false,"title":"Journal of Ovarian Research"},"publishedOn":"2022-03-21 20:49:29","publishedOnDateReadable":"March 21st, 2022"},"versionCreatedAt":"2022-02-21 15:02:41","video":"","vorDoi":"10.1186/s13048-022-00967-5","vorDoiUrl":"https://doi.org/10.1186/s13048-022-00967-5","workflowStages":[]},"version":"v1","identity":"rs-1368931","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1368931","identity":"rs-1368931","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}