Transplantation of mesenchymal stem cells improves age-related ovarian dysfunction via regulating the local renin-angiotensin system

Abstract Background: the context and purpose of the study Methods: how the study was performed and statistical tests used Results: the main findings Conclusions: Age-related reproductive aging is a natural and irreversible physiological process, and delaying childbearing is increasingly common all over the world. Transplantation of umbilical cord-derived mesenchymal stem cells (MSCs) is considered a new and effective therapy to restore ovarian function, but the relevant mechanisms remain unclear. In recent years, it has been found that there is a local renin-angiotensin system (RAS) in human ovary and it plays a key role.In our research, local RAS of ovary, which is independent of circulating RAS, is affected by age and related to ovarian function. Furthermore, the in vivo(mice) and in vitro (KGN cells) experiments were designed to confirm that transplantation of MSCs improves age-related ovarian dysfunction by the local RAS. Together, our findings indicate that a novel possible mechanism to explain how stem cells restore age-related ovarian dysfunction.