A Scale-Up of Fluidized Bed Granulation Process for Calcium-Tryptophan

A Scale-Up of Fluidized Bed Granulation Process for Calcium-Tryptophan | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A Scale-Up of Fluidized Bed Granulation Process for Calcium-Tryptophan Hyeong-seok Han, Woo Chang Sung, Jun-Woo Kim, Kyochan Kim, Donghyun Lee This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4474607/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 03 Sep, 2024 Read the published version in Korean Journal of Chemical Engineering → Version 1 posted 4 You are reading this latest preprint version Abstract The importance of tryptophan in both human and animal nutrition continues to drive its demand and market growth. The fluidized bed granulation is one of the crucial processes for industrial production of tryptophan from microbial fermentation, particularly as the simplified process of evaporation and granulation to efficiently generate commercial granular products. In this study, solid flow analysis for scaling up fluidized bed granulators in the manufacturing of calcium-tryptophan granules was conducted in terms of solid flow characteristics of the granules, flow regime within the granulator, and design considerations of the granulator. Based on the established scale-up case of calcium-tryptophan granules, it was founded that the flow regime of bubbling fluidization occurred similarly in both pilot and plant scale fluidized bed granulator. Then, the desired height (transport disengaging height, TDH) and entrainment rate (to secure the capacity of entrained particle recovery equipment such as cyclones or bag filters) were determined to obtain basic design data for scale-up of the fluidized bed granulation. Fluidized bed granulation amino acid calcium-tryptophan granule solid flow analysis Full Text Cite Share Download PDF Status: Published Journal Publication published 03 Sep, 2024 Read the published version in Korean Journal of Chemical Engineering → Version 1 posted Reviewers agreed at journal 29 May, 2024 Reviewers invited by journal 29 May, 2024 Editor assigned by journal 28 May, 2024 First submitted to journal 24 May, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4474607","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":308042158,"identity":"7e260321-6e5a-40f0-98fe-bb5a6a9def8a","order_by":0,"name":"Hyeong-seok Han","email":"","orcid":"","institution":"CJ CheilJedang Pharmaceutical Business Division: HK inno.N Corp","correspondingAuthor":false,"prefix":"","firstName":"Hyeong-seok","middleName":"","lastName":"Han","suffix":""},{"id":308042159,"identity":"b0b48434-7dec-427e-b5a0-cff9c3ea123a","order_by":1,"name":"Woo Chang Sung","email":"","orcid":"","institution":"Sung Kyun Kwan University: Sungkyunkwan University","correspondingAuthor":false,"prefix":"","firstName":"Woo","middleName":"Chang","lastName":"Sung","suffix":""},{"id":308042160,"identity":"7aef5d6b-5d71-4091-9da6-32a9fb883cc1","order_by":2,"name":"Jun-Woo Kim","email":"","orcid":"","institution":"CJ CheilJedang Pharmaceutical Business Division: HK inno.N Corp","correspondingAuthor":false,"prefix":"","firstName":"Jun-Woo","middleName":"","lastName":"Kim","suffix":""},{"id":308042161,"identity":"52f88e7e-510b-4b5b-a728-291649786feb","order_by":3,"name":"Kyochan Kim","email":"","orcid":"","institution":"CJ CheilJedang Pharmaceutical Business Division: HK inno.N Corp","correspondingAuthor":false,"prefix":"","firstName":"Kyochan","middleName":"","lastName":"Kim","suffix":""},{"id":308042162,"identity":"8d0cf259-bb5d-4ebe-8fb6-8ad9b8be8154","order_by":4,"name":"Donghyun Lee","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAqklEQVRIiWNgGAWjYDCCG8wNDAwVDAYSIA4PcVoYgVrOkKyFsY0ULXy3GxsffJxXZyw5I4Hxwds2IrRI3jnYbDhz22EzaYkEZsO5xGgxuJHYJs277YCNnEQCmzQvkVraf/+dUwfSwv6bWC1tzIwNzCCHsTETpUXyRmKzZM+xw8aSPQ+bJeecI0IL343kgx9+1NQZzjgOZLwpI0ILEgDF6SgYBaNgFIwC6gAA5mM4bTXoTCwAAAAASUVORK5CYII=","orcid":"","institution":"Sungkyunkwan University","correspondingAuthor":true,"prefix":"","firstName":"Donghyun","middleName":"","lastName":"Lee","suffix":""}],"badges":[],"createdAt":"2024-05-24 23:55:32","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4474607/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4474607/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s11814-024-00269-0","type":"published","date":"2024-09-03T16:05:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":64185664,"identity":"4dc12c13-73a2-457a-b294-e13ae0fb117e","added_by":"auto","created_at":"2024-09-09 16:20:21","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":426269,"visible":true,"origin":"","legend":"","description":"","filename":"KoreanJHanFLD07.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4474607/v1_covered_bd729b5c-d833-4441-ab6c-3d68c2e9ed4d.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eA Scale-Up of Fluidized Bed Granulation Process for Calcium-Tryptophan\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"korean-journal-of-chemical-engineering","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"kjce","sideBox":"Learn more about [Korean Journal of Chemical Engineering](http://link.springer.com/journal/11814)","snPcode":"11814","submissionUrl":"https://www.editorialmanager.com/kjce/default2.aspx","title":"Korean Journal of Chemical Engineering","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Subscription","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Fluidized bed granulation, amino acid, calcium-tryptophan granule, solid flow analysis","lastPublishedDoi":"10.21203/rs.3.rs-4474607/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4474607/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe importance of tryptophan in both human and animal nutrition continues to drive its demand and market growth. 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