IL‐7 and IL‐8 inhibit gamete interaction in the zona‐free hamster egg sperm penetration assay
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Interleukin-7 and interleukin-8 were found to inhibit sperm penetration of hamster eggs in vitro in a dose-dependent manner, suggesting a potential role in subfertility.
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Abstract
Current thought in reproductive endocrinology suggests hat endometriosis-associated subfertility may be the result of an adverse influence of activated immunocompetent cells on fertilization and embryo development. Inflammatory ediators such as interleukin-1 and tumour necrosis actor have been implicated in the pathophysiology of this process. The purpose of this study was to assess the effect of two recently characterized cytokines, interleukin-7 (IL-7 ) and interleukin-8 (IL-8), on gamete interaction in the perm penetration assay (SPA). Donor sperm were preincubated or 4 h with 0.5, 5, 50, or 500 ng ml(-1) of human ecombinant IL-7 or IL-8. Sperm penetration was determined by an experienced gametologist by the presence of decondensed sperm heads or pronuclei formation. A dose-dependent inhibition of gamete interaction was observed following coincubation with either IL-7 or IL-8. These data offer the possibility that IL-7 and IL-8 may play a role in the pathogenesis of immunocompetent cell-associated subfertility.
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References (6)
- Altered maturation and function of peritoneal macrophages: Possible role in pathogenesis of endometriosis via openalex
- Heterologous transplantation of activated murine peritoneal macrophages inhibits gamete interaction in vivo: a paradigm for endometriosis-associated subfertility via openalex
- W1994731573 via openalex
- W2010639752 via openalex
- W2123884323 via openalex
- W2414329918 via openalex
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- europepmc
- last seen: 2026-09-27T09:11:36.575535+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:11:49.821429+00:00
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