Pregabalin induces pathological changes in cerebrum and cerebellum of Albino Rats

Background: Pregabalin (PGB) used as analgesic in remedy of neurogenic pains of persistent diseases, is taken into consideration as one of the maximum abused anti-epileptic pills and it's been proved that it induces addictive behaviors. The current study investigated the impact of PGB management on cerebral cortex and cerebellar cortex, in each acute and chronic toxicity. Seventy- male and non-pregnant female albino rats’ 6- to 8-week-vintage divided into three principal corporations of 24 rats each had been studied. Group 1 was the control group, group 2 represented the acute toxicity group, and group three represented the hronic toxicity group. Rats had been sacrificed and examined. Result: Cerebral cortex tissue of acute toxicity group displayed astrocytosis and dystrophic changes, while the chronic toxicity group showed degeneration, necrosis and inflammatory cell infiltrates. The cerebellum of chronic toxicity group showed affection of Purkinje cells. Conclusion: Acute and chronic intoxication with pregabalin adversely altered the structure and thus the function of the cerebral cortex and cerebellum.