Synthesis and Antibacterial Screening of Cefradine Schiff Bases and Their Metal Salts

2023 · doi:10.32388/0vars0
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Abstract

A series of Schiff bases(3-8) were synthesized by the reaction of cefradine with six different aldehydes/ketones. These Schiff bases(3-8) were treated with different bases/salt (NaOH, KOH, Ca(OH)2, Ba(OH)2, Ag(NO)3) to get their metal salts. Structures of the products were ascertained by spectroscopic data. The synthesized compounds were tested for biological activities against _Staphylococcus aureus_(gram positive bacterium) and _Escherichia coli_(gram negative bacterium). In general low activities of most of the synthesized compounds were observed in comparison to cefradine which can be linked to unavailability of free amino group of cefradine by its involvement in synthesis of imine derivatives.
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License: CC-BY-4.0