Compound capable of inhibiting zinc ion metalloproteinases

The invention discloses a 1,2,3-trihydroxy benzene and derivant or pharmacy acceptable salt for zinc ion metal-prolease inhibition, which is characterized by the following: theses compounds is used for selective depressant of zinc ion metal-prolease (such as MT1-MMP, gelatinase A, B and collagenase, matrilysins, metal-elastase and stromelysin-1) these depressants can adjust physiological and pathology course with MMPs, ADAMs, ADAM-TS such as vessel rebirth, wound healing, organ transplantation, fecundation course and reactivation capability, rebuilding bone and ache, which is used for treating cancer, cardiovascular disease, arthritis, periodontal disease, multiple sclerosis, inflammation, adenomyosis, cornea ulcer, bacterial meningitis, diabetic syndrome, kidney disease, nerve retrogression disease, AIDS, bleb, anaphylaxis, adenomyosis, osteoporosis, asthma and so on theses blocking agents can be used for antisenescence, antibiosis, commercial manufacture addition agent of cell epimatrix, collagen product, cosmetics and make-up preparation, which can used for animals and other living bodies.