Symptom clusters of patients with advanced thyroid cancer: a prospective cross-sectional study

Symptom clusters of patients with advanced thyroid cancer: a prospective cross-sectional study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Symptom clusters of patients with advanced thyroid cancer: a prospective cross-sectional study Ming Cai, Juxiang Gou This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4793744/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 25 Sep, 2024 Read the published version in Endocrine → Version 1 posted 9 You are reading this latest preprint version Abstract Purpose To investigate and analyze the symptom clusters of patients with advanced thyroid cancer and provide a basis for developing targeted symptom management measures. Methods Patients who visited a multidisciplinary outpatient service for advanced thyroid cancer at a tertiary A hospital in Sichuan Province from April 2022 to April 2023 were selected using convenience sampling. A cross-sectional survey was conducted using the M.D. Anderson Symptom Inventory-Thyroid Cancer module (MDASI-THY). Symptom clusters were extracted by exploratory factor analysis. Results Disturbed sleep had the highest incidence (75.7%) and severity (3.0 points), while mood distress had the highest incidence (63.5%) and severity (2.0 points) of symptom interference. Three symptom clusters were identified: mood-fatigue-sleep, digestive tract-sensation, and thyroid cancer-specific symptom clusters. Conclusion Patients with advanced thyroid cancer have multiple symptom clusters that seriously affect their daily lives. Health care professionals should conduct targeted observation and preventive treatment to reduce the burden of symptoms on patients. symptom advanced thyroid cancer symptom cluster symptom interference mood sleep Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 25 Sep, 2024 Read the published version in Endocrine → Version 1 posted Editorial decision: Revision requested 17 Aug, 2024 Reviews received at journal 15 Aug, 2024 Reviewers agreed at journal 15 Aug, 2024 Reviews received at journal 11 Aug, 2024 Reviewers agreed at journal 06 Aug, 2024 Reviewers invited by journal 06 Aug, 2024 Editor assigned by journal 25 Jul, 2024 Submission checks completed at journal 25 Jul, 2024 First submitted to journal 24 Jul, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4793744","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":341496317,"identity":"8519a283-5e59-4d0a-b64a-ee79e9fc710f","order_by":0,"name":"Ming Cai","email":"","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":false,"prefix":"","firstName":"Ming","middleName":"","lastName":"Cai","suffix":""},{"id":341496318,"identity":"e340a521-0d5e-432a-82a4-e7cb27b52c51","order_by":1,"name":"Juxiang Gou","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA6UlEQVRIiWNgGAWjYJACAwYGCSDF2HDgg4GNHSlamBsPzihISybFMvbmwzwfDjE2EFIn795jUMzbZiFvzr+w4bCNwQFmBvbDRzfg02J45oyBMc8ZCcOdMx42HM4xuMPHwJOWdgOvlhk5QC0VEowbbhwEaXnGzCDBY0aEFgMJe7AWC4PDjA2EtMhLQGxJ3HC+seEwAzFaDHiOFRjOOSORvOEGY8PBHoO0ZDZCfpFvb95m8LatznbD+eOPP/z4Y2PHz374GH5bDjCwGYBZEgkQETZ8ysG2NDAwPwCz+A8QUjsKRsEoGAUjFQAAZapP0Qp4XDYAAAAASUVORK5CYII=","orcid":"","institution":"West China Hospital of Sichuan University","correspondingAuthor":true,"prefix":"","firstName":"Juxiang","middleName":"","lastName":"Gou","suffix":""}],"badges":[],"createdAt":"2024-07-24 08:44:19","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4793744/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4793744/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s12020-024-04051-4","type":"published","date":"2024-09-25T15:58:16+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":65628598,"identity":"ce0b688b-5744-495b-b1fc-22bad4a8adf8","added_by":"auto","created_at":"2024-09-30 16:19:20","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":217209,"visible":true,"origin":"","legend":"","description":"","filename":"Symptomclustersofpatientswithadvancedthyroidcanceraprospectivecrosssectionalstudy.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4793744/v1_covered_d2e4243f-37a6-42e0-9640-a1ada10bafbf.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Symptom clusters of patients with advanced thyroid cancer: a prospective cross-sectional study","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"endocrine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"endo","sideBox":"Learn more about [Endocrine](https://www.springer.com/journal/12020)","snPcode":"12020","submissionUrl":"https://submission.nature.com/new-submission/12020/3","title":"Endocrine","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"symptom, advanced thyroid cancer, symptom cluster, symptom interference, mood, sleep","lastPublishedDoi":"10.21203/rs.3.rs-4793744/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4793744/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose\u003c/h2\u003e \u003cp\u003eTo investigate and analyze the symptom clusters of patients with advanced thyroid cancer and provide a basis for developing targeted symptom management measures.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003ePatients who visited a multidisciplinary outpatient service for advanced thyroid cancer at a tertiary A hospital in Sichuan Province from April 2022 to April 2023 were selected using convenience sampling. 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