Categorizing weight growth using the 2023 Postnatal Growth Charts for Preterm Infants to inform morbidity risks for very preterm infants

Categorizing weight growth using the 2023 Postnatal Growth Charts for Preterm Infants to inform morbidity risks for very preterm infants | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Categorizing weight growth using the 2023 Postnatal Growth Charts for Preterm Infants to inform morbidity risks for very preterm infants Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Jing Zhang, Maria Fe Villosis, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6230166/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 9 You are reading this latest preprint version Abstract Objective To categorize and correlate growth with morbidity outcomes in infants born before 32 weeks of gestation. Study Design This retrospective study categorized weight growth by correlating mean growth velocity (GV) with growth trajectory percentile ( \(\:\varDelta\:GTP\) ) changes, as measured using 2023 Postnatal Growth Charts for Preterm Infants. The associations between weight categories and morbidities of prematurity were assessed. Results Weight gain of infants without morbidities was categorized into three groups based on \(\:\varDelta\:GTP\) : insufficient ( \(\:\varDelta\:GTP\) < -5%, 10%, > 20 g/kg/day). The proportions of infants with and without morbidities in these categories were evaluated across two distinct cohorts, revealing similar patterns. Both insufficient and excessive growth were associated with bronchopulmonary dysplasia, while only insufficient growth was associated with retinopathy of prematurity. Conclusion Weight growth categorization using 2023 Postnatal Growth Charts for Preterm Infants informs morbidity risks. Health sciences/Medical research/Outcomes research Health sciences/Health care/Paediatrics Full Text Additional Declarations There is NO conflict of interest to disclose. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: revise 08 Apr, 2025 Review # 2 received at journal 05 Apr, 2025 Review # 1 received at journal 31 Mar, 2025 Reviewer # 2 agreed at journal 25 Mar, 2025 Reviewer # 1 agreed at journal 22 Mar, 2025 Reviewers invited by journal 18 Mar, 2025 Submission checks completed at journal 17 Mar, 2025 Editor assigned by journal 14 Mar, 2025 First submitted to journal 14 Mar, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6230166","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":430461165,"identity":"9b8b3968-6c2c-4e09-8194-6aad24997efa","order_by":0,"name":"Fu-Sheng 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Clarke","email":"","orcid":"","institution":"pediatrix","correspondingAuthor":false,"prefix":"","firstName":"Reese","middleName":"","lastName":"Clarke","suffix":""}],"badges":[],"createdAt":"2025-03-15 03:45:16","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6230166/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6230166/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":79298018,"identity":"76f4a1d7-9588-4d9e-9cd6-8d62c8c65b48","added_by":"auto","created_at":"2025-03-26 17:52:40","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":813920,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript20250314JofPerinatol.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6230166/v1_covered_caf81388-0b83-418f-b851-5133e5cb027a.pdf"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e conflict of interest to disclose.","formattedTitle":"Categorizing weight growth using the 2023 Postnatal Growth Charts for Preterm Infants to inform morbidity risks for very preterm infants","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"journal-of-perinatology","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"jp","sideBox":"Learn more about [Journal of Perinatology](http://www.nature.com/jp/)","snPcode":"41372","submissionUrl":"https://mts-jper.nature.com/cgi-bin/main.plex","title":"Journal of Perinatology","twitterHandle":"@jperinatology","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-6230166/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6230166/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eObjective\u003c/h2\u003e \u003cp\u003eTo categorize and correlate growth with morbidity outcomes in infants born before 32 weeks of gestation.\u003c/p\u003e\u003ch2\u003eStudy Design\u003c/h2\u003e \u003cp\u003eThis retrospective study categorized weight growth by correlating mean growth velocity (GV) with growth trajectory percentile (\u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:\\varDelta\\:GTP\\)\u003c/span\u003e\u003c/span\u003e) changes, as measured using 2023 Postnatal Growth Charts for Preterm Infants. The associations between weight categories and morbidities of prematurity were assessed.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eWeight gain of infants without morbidities was categorized into three groups based on \u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:\\varDelta\\:GTP\\)\u003c/span\u003e\u003c/span\u003e: insufficient (\u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:\\varDelta\\:GTP\\)\u003c/span\u003e\u003c/span\u003e \u0026lt; -5%, \u0026lt;\u0026thinsp;15 g/kg/day), satisfactory (\u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:\\varDelta\\:GTP\\)\u003c/span\u003e\u003c/span\u003e between \u0026minus;\u0026thinsp;5% and 10%, 15\u0026ndash;20 g/kg/day), and excessive (\u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:\\varDelta\\:GTP\\)\u003c/span\u003e\u003c/span\u003e \u0026gt; 10%, \u0026gt;\u0026thinsp;20 g/kg/day). The proportions of infants with and without morbidities in these categories were evaluated across two distinct cohorts, revealing similar patterns. Both insufficient and excessive growth were associated with bronchopulmonary dysplasia, while only insufficient growth was associated with retinopathy of prematurity.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eWeight growth categorization using 2023 Postnatal Growth Charts for Preterm Infants informs morbidity risks.\u003c/p\u003e","manuscriptTitle":"Categorizing weight growth using the 2023 Postnatal Growth Charts for Preterm Infants to inform morbidity risks for very preterm infants","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-03-26 17:36:33","doi":"10.21203/rs.3.rs-6230166/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"revise","date":"2025-04-08T08:50:51+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"This content is not available.","date":"2025-04-05T23:58:21+00:00","index":2,"fulltext":"This content is not available."},{"type":"editorInvitedReview","content":"This content is not available.","date":"2025-03-31T18:09:54+00:00","index":1,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2025-03-25T18:28:55+00:00","index":2,"fulltext":"This content is not available."},{"type":"reviewerAgreed","content":"This content is not available.","date":"2025-03-22T22:22:55+00:00","index":1,"fulltext":"This content is not available."},{"type":"reviewersInvited","content":"","date":"2025-03-18T11:30:21+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-03-17T13:05:08+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-03-15T03:44:01+00:00","index":"","fulltext":""},{"type":"submitted","content":"Journal of Perinatology","date":"2025-03-15T03:44:01+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"journal-of-perinatology","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"jp","sideBox":"Learn more about [Journal of Perinatology](http://www.nature.com/jp/)","snPcode":"41372","submissionUrl":"https://mts-jper.nature.com/cgi-bin/main.plex","title":"Journal of Perinatology","twitterHandle":"@jperinatology","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"b1dc543b-fc7c-4af0-a71e-67b72daea8eb","owner":[],"postedDate":"March 26th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":45846570,"name":"Health sciences/Medical research/Outcomes research"},{"id":45846571,"name":"Health sciences/Health care/Paediatrics"}],"tags":[],"updatedAt":"2025-07-21T15:47:52+00:00","versionOfRecord":[],"versionCreatedAt":"2025-03-26 17:36:33","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6230166","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6230166","identity":"rs-6230166","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}