Study of cell apoptosis and cell proliferation in ectopic human endometrium

Objective To study the relation between cell proliferation and cell apoptosis in endometrium and endometriosisMethods Eutopic and ectopic human endometrium during the menstrual cycle were obtained from 61 patients.PCNA was examined by immunohistochemical mothod.Apoptosis cells were detected by TUNEL mothod from 34 patients.Results Apoptotic cells appeared as scatted grandular in secretory phase.The staining of PCNA protein in cytoplasm of glandular cells was mainly seen in proliferative phase.It rarely appeared in secretory phase and absent during menstruation.It appeared higher in endometriosis.Conclusion Apoptosis of endometrial cell is ralated to endometrium shedding.In order to extend its lifecycle,endometriotic cells decreased apoptosis and proliferated overly.