Unlocking the Potential of Liquid Biopsy: A Paradigm Shift in Endometrial Cancer Care

Endometrial cancer is one of the most prevalent gynecologic malignancies in devel-oped countries, with its incidence steadily increasing each year. Early diagnosis is crucial for a favorable prognosis; however certain patients experience recurrence and distant metastasis after surgery, similar to advanced cancer patients, with limited treatment options. Therefore, effective strategies for early screening, diagnosis, pre-dicting local recurrence, and guiding rapid treatment interventions are essential for improving survival rates and prognosis. Liquid biopsy, a method known for being non-invasive, safe, and effective, has attracted widespread attention for cancer diag-nosis and treatment. Although its clinical application in endometrial cancer is less es-tablished than in other cancers, research on biomarkers using liquid biopsy in endo-metrial cancer patients is currently in progress. This review examines the latest ad-vancements in non-invasive biomarkers identified through liquid biopsy and provides a comprehensive overview of their clinical applications in endometrial cancer. Addi-tionally, it discusses the challenges and future prospects of liquid biopsy, offering valuable insights into the diagnosis and personalized treatment of endometrial cancer.