Quantitative evaluation the rationality of the use of FOLFOX regimen in patients with metastatic colorectal cancer based on AHP weighted TOPSIS method

Quantitative evaluation the rationality of the use of FOLFOX regimen in patients with metastatic colorectal cancer based on AHP weighted TOPSIS method | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Quantitative evaluation the rationality of the use of FOLFOX regimen in patients with metastatic colorectal cancer based on AHP weighted TOPSIS method Jian Zou, Jia-yun Zhong, Rui Zou, Dan Huang, Yu Liu, Yan-xin Liu, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3301383/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose Adopts Analytic Hierarchy Process (AHP) and Technique for Order Preference by Similarity to Ideal Situation (TOPSIS) to assess and rank different indicators of evaluation index and evaluate the rationality of the use of FOLFOX regimen in patients with metastatic CRC. Methods The evaluation criteria for the rationality of the use of FOLFOX regimen was established with reference to the dispensatory and application guidelines by using AHP weight, and TOPSIS method was adopts to retrospectively analyze and evaluate the rationality of the use of FOLFOX regimen in 176 cases in the medical records of our hospital from July to December 2022. Results Established evaluation criteria included 3 primary indexes (indication, medication process, management indicator) and 18 secondary parameters. Chemotherapy regimens selection, therapeutic evaluation and discontinuation of drug indications ranked top 3 secondary parameters (relative weight coefficient were 0.08352, 0.06257, 0.06217, respectively). The primary inappropriate types and scores of FOLFOX regimen were preconditioning, dose selection and therapeutic evaluation (deducted scores were 429.44, 416.97, 306.59 respectively). Among 176 cases, 49 cases (27.84%) had a relative proximity ( C i ) equal to 100%, 87 cases (49.43%) 100%-80%, 29 cases (16.48%) 80%-60% and 11 cases (6.25%) below to 60%. The major problems were vomiting risk was not assessed (16.13%), insufficient dose of cytotoxic agents (15.66%) and treatment effects were not evaluated according to WHO standards (11.52%). Conclusions The evaluation criteria of the rationality of clinical application of FOLFOX regimen were established by AHP-TOPSIS method. The evaluation results obtained by this method were quantifiable, scientific and credible. The phenomenon of irrational use of these drugs in our hospital is relatively common, and the management should be strengthened in clinical application. Implications for cancer survivors AHP weighted TOPSIS method can quantitatively evaluate the rationality of anti-cancer drugs by integrating multiple indicators. Quantitative evaluation FOLFOX regimen AHP TOPSIS Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3301383","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":229604302,"identity":"5087b510-6849-47e9-81a1-882559e9111d","order_by":0,"name":"Jian Zou","email":"","orcid":"","institution":"The People’s Hospital of Pengzhou","correspondingAuthor":false,"prefix":"","firstName":"Jian","middleName":"","lastName":"Zou","suffix":""},{"id":229604303,"identity":"d9d6bf37-94cd-4497-a7c2-07b138334f2f","order_by":1,"name":"Jia-yun Zhong","email":"","orcid":"","institution":"The People’s Hospital of 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cancer based on AHP weighted TOPSIS method","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Quantitative evaluation, FOLFOX regimen, AHP, TOPSIS","lastPublishedDoi":"10.21203/rs.3.rs-3301383/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3301383/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose\u003c/h2\u003e \u003cp\u003eAdopts Analytic Hierarchy Process (AHP) and Technique for Order Preference by Similarity to Ideal Situation (TOPSIS) to assess and rank different indicators of evaluation index and evaluate the rationality of the use of FOLFOX regimen in patients with metastatic CRC.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eThe evaluation criteria for the rationality of the use of FOLFOX regimen was established with reference to the dispensatory and application guidelines by using AHP weight, and TOPSIS method was adopts to retrospectively analyze and evaluate the rationality of the use of FOLFOX regimen in 176 cases in the medical records of our hospital from July to December 2022.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eEstablished evaluation criteria included 3 primary indexes (indication, medication process, management indicator) and 18 secondary parameters. Chemotherapy regimens selection, therapeutic evaluation and discontinuation of drug indications ranked top 3 secondary parameters (relative weight coefficient were 0.08352, 0.06257, 0.06217, respectively). The primary inappropriate types and scores of FOLFOX regimen were preconditioning, dose selection and therapeutic evaluation (deducted scores were 429.44, 416.97, 306.59 respectively). Among 176 cases, 49 cases (27.84%) had a relative proximity (\u003cem\u003eC\u003c/em\u003e\u003csub\u003e\u003cem\u003ei\u003c/em\u003e\u003c/sub\u003e) equal to 100%, 87 cases (49.43%) 100%-80%, 29 cases (16.48%) 80%-60% and 11 cases (6.25%) below to 60%. The major problems were vomiting risk was not assessed (16.13%), insufficient dose of cytotoxic agents (15.66%) and treatment effects were not evaluated according to WHO standards (11.52%).\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eThe evaluation criteria of the rationality of clinical application of FOLFOX regimen were established by AHP-TOPSIS method. The evaluation results obtained by this method were quantifiable, scientific and credible. The phenomenon of irrational use of these drugs in our hospital is relatively common, and the management should be strengthened in clinical application.\u003c/p\u003e\u003ch2\u003eImplications for cancer survivors\u003c/h2\u003e \u003cp\u003eAHP weighted TOPSIS method can quantitatively evaluate the rationality of anti-cancer drugs by integrating multiple indicators.\u003c/p\u003e","manuscriptTitle":"Quantitative evaluation the rationality of the use of FOLFOX regimen in patients with metastatic colorectal cancer based on AHP weighted TOPSIS method","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2023-09-01 08:11:52","doi":"10.21203/rs.3.rs-3301383/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"eb8f545e-9583-404f-b7d5-5f21f3e42546","owner":[],"postedDate":"September 1st, 2023","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-10-09T00:59:19+00:00","versionOfRecord":[],"versionCreatedAt":"2023-09-01 08:11:52","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3301383","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3301383","identity":"rs-3301383","version":["v1"]},"buildId":"J0_U0BvcaRcwD8yVFaRlm","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}