Benign endometrioid tumours of the ovary and the Müllerian concept of ovarian epithelial tumours

Hughesdon PE, P. E. Hughesdon
Histopathology · 1984 · vol. 8(6) , pp. 977–990 · doi:10.1111/j.1365-2559.1984.tb02415.x · PMID:6526392 · W2048216530
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This paper explores a Müllerian interpretation of ovarian epithelial tumors, suggesting benign endometrioid tumors likely arise from inactive neoplastic areas and share features with senile endometrium or "serous" adenofibromas.

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Abstract

The difficulties of a consistent Müllerian interpretation of the epithelial ovarian tumours include their inconstant hormonal responsiveness, the doubtful nature of the clear cell tumour and the apparent rarity of benign endometrioid forms. The reported frequency figures for the different types of endometrioid tumour suggest that their nature is made evident by proliferation. The appearance of indolent forms is explored by a study of inactive neoplastic areas associated with endometrioid carcinomas, or with proliferating endometrioid tumours or arising in endometriosis. These jointly suggest that most such tumours are identical with inactive 'serous' adenofibromas of glandular pattern and have senile endometrium as their prototype. Increasing proliferation develops more overt endometrioid forms which, if luxuriant, may be associated with corpus carcinoma. The endometrium of pregnancy is probably the prototype of the clear cell tumour, with a corresponding range of cell types. There is tenuous evidence that tumours may respond to steroid hormones if they arise in endometriosis and a difficulty of deducing such an origin is noted. The term 'serous' may be generic and comprise several different tissue types.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Adenofibroma Endometriosis Ovarian Neoplasms Adenocarcinoma Adenofibroma Adult Aged Endometriosis Female Humans Middle Aged Ovarian Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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