[Association of natural killer T cells with staging of endometriosis].

Guo Saiqun, Saiqun Guo, Ying Zhang, Lifeng Wang, Wenshan Qiu
Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2012 · vol. 32(9) , pp. 1322–4 · PMID:22985574 · W2396585529
article OA: closed CC0 ⤵ 4 in-corpus citations
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Abstract

OBJECTIVE: To investigate the role of natural killer T cells (NKT) in the pathogenesis and staging of endometriosis (EMT). METHODS: Sixty EMT cases of stages I to IV were enrolled as the observation group, and 20 healthy volunteers served as the control group. NKT percentages in the peripheral blood and peritoneal effusions were detected by flow cytometry, and the levels of interferon-γ (IFN-γ) and interleukin-4 (IL-4) were examined using ELISA. RESULTS: Compared with the control group, EMT group showed significantly lowered NKT percentages and IFN-γ and IL-4 levels in both the peripheral blood and peritoneal effusions (PII>III>IV (P0.06, P<0.05). CONCLUSION: As a protective factor against EMT, NKT, together with its cytokines IFN-γ and IL-4, play an important role in EMT and is closely correlated with EMT staging.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Natural Killer T-Cells Case-Control Studies Endometriosis Endometriosis Female Flow Cytometry Humans Interferon-gamma Interferon-gamma Interleukin-4 Interleukin-4 Natural Killer T-Cells

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