Plasma protein and blood volume restitution after hemorrhage in conscious pregnant and ovarian steroid-replaced rats

M. L. Blair, Deanne Mickelsen
In: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2005 · vol. 290(2) , pp. R425–R434 · doi:10.1152/ajpregu.00011.2005 · PMID:16166212 · W2054666993
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This study found that plasma protein restitution after hemorrhage is significantly augmented during midgestation in rats, but not early pregnancy, and this enhancement is not solely due to elevated estradiol.

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Abstract

We have previously shown that both plasma protein restitution and plasma volume restitution are significantly enhanced in female rats hemorrhaged during the proestrus phase of the estrous cycle. Estradiol and progesterone levels are markedly elevated during proestrus and also increase during pregnancy. The present studies were therefore designed to determine whether the ability to restore plasma protein and blood volume after hemorrhage is augmented during pregnancy and by chronically elevated estradiol levels. The response to moderate hemorrhage (22-23% blood loss) was evaluated in conscious pregnant rats during early and midgestation and compared with that of virgin female rats studied during metestrus. At 22 h posthemorrhage, plasma volume had increased to greater than basal levels, and blood volume was restored to 93 +/- 1% (metestrus), 91 +/- 2% (early pregnancy), and 98 +/- 2% (midgestation) of control (P > 0.05). Animals hemorrhaged during metestrus or early pregnancy restored the same amount of protein to the plasma as had been removed, whereas those hemorrhaged during midgestation restored nearly 50% more plasma protein than had been removed (P < 0.01). In ovariectomized animals with chronic steroid replacement that maintained plasma progesterone at metestrus levels (15 +/- 2 ng/ml) but raised plasma estradiol to twofold that of midgestation (22 +/- 3 pg/ml), the blood volume and plasma protein restitution responses to hemorrhage did not differ from those of ovariectomized animals with no steroid replacement. In summary, posthemorrhage restoration of plasma protein content is significantly augmented during midgestation, but not during early pregnancy. This augmented response cannot be attributed to chronic elevation of plasma estradiol levels alone.

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SciLite annotations

organisms 7
rattus sp. rattus sp. rattus sp. rattus sp. multicellular animals multicellular animals multicellular animals
chemicals 9
steroid estradiol progesterone estradiol steroid progesterone estradiol steroid estradiol

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