Use of a gonadotropin-releasing hormone antagonist for endometrial maturation and synchronization in an ovum recipient

ObjectiveTo report the novel use of hMG and the GnRH antagonist for endometrial preparation and synchronization in a woman participating in an ovum donation program who was resistant to endometrial preparation with estrogen replacement.DesignCase report.SettingTertiary fertility center.Patient(s)The patient had inadequate endometrial maturation, as determined by pelvic ultrasound (thickness of <5 mm), after estrogen replacement. Ovarian hyperstimulation with hMG and a GnRH antagonist resulted in an endometrial thickness of 7.5 mm. Synchronization with a ovum donor resulted in a delivered twin gestation.Intervention(s): Late follicular transvaginal ultrasound.Main outcome measure(s)Appropriate endometrial maturation and pregnancy.Result(s)Appropriate endometrial maturation.Conclusion(s)For women with inadequate endometrial maturation with simple estrogen replacement, ovarian hyperstimulation with hMG and a GnRH antagonist can yield appropriate endometrial maturation for pregnancy through ovum donation.