Magnetic Graphene oxide incorporated alginate hydrogel beads as a potential Nanocarrier

Magnetic Graphene oxide incorporated alginate hydrogel beads as a potential Nanocarrier | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Magnetic Graphene oxide incorporated alginate hydrogel beads as a potential Nanocarrier somayeh Sadighian, Abolfazl Kordloo, Mohammad Reza Heydari, Akram Khanmohammadi, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8117697/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This research aims to synthesize pH responsive magnetic graphene oxide (MGO) incorporated alginate hydrogel beads for controlled drug delivery using ionotropic gelation. MGO was prepared using hydrothermal method which was embedded in alginate beads. FTIR, XRD, FESEM, TEM, VSM, TGA, and BET characterization showed that the material had a porous structure with a surface area of 145 m²/g and pore radius of 3.5 nm, superparamagnetic behavior of 28.1 emu/g, and was thermally stable up to 350°C. A model drug quercetin was loaded with 25.8% efficiency and showed pH dependent release (83% at pH 7.4 in 200 min, 45% at pH 2.1). Stability tests showed the unattached quercetin had less than 3% weight loss in the range of pH 2.0 to 12.0. The HFF-2 cells showed greater than 80% viability at 140 µg/mL with strong anti-cancer effects on Caco-2 cells with decreased viability less than 50% at 200 µg/mL. The results obtained demonstrates that the magnetic hydrogel beads have biocompatibility and act as nanocarriers for targeted delivery of therapeutics. magnetite controlled drug delivery GO Caco-2 cells quercetin Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8117697","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":554326145,"identity":"81b11e34-bb8e-4775-a165-1143cc542535","order_by":0,"name":"somayeh 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","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"magnetite, controlled drug delivery, GO, Caco-2 cells, quercetin","lastPublishedDoi":"10.21203/rs.3.rs-8117697/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8117697/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThis research aims to synthesize pH responsive magnetic graphene oxide (MGO) incorporated alginate hydrogel beads for controlled drug delivery using ionotropic gelation. MGO was prepared using hydrothermal method which was embedded in alginate beads. FTIR, XRD, FESEM, TEM, VSM, TGA, and BET characterization showed that the material had a porous structure with a surface area of 145 m\u0026sup2;/g and pore radius of 3.5 nm, superparamagnetic behavior of 28.1 emu/g, and was thermally stable up to 350\u0026deg;C. A model drug quercetin was loaded with 25.8% efficiency and showed pH dependent release (83% at pH 7.4 in 200 min, 45% at pH 2.1). Stability tests showed the unattached quercetin had less than 3% weight loss in the range of pH 2.0 to 12.0. The HFF-2 cells showed greater than 80% viability at 140 \u0026micro;g/mL with strong anti-cancer effects on Caco-2 cells with decreased viability less than 50% at 200 \u0026micro;g/mL. The results obtained demonstrates that the magnetic hydrogel beads have biocompatibility and act as nanocarriers for targeted delivery of therapeutics.\u003c/p\u003e","manuscriptTitle":"Magnetic Graphene oxide incorporated alginate hydrogel beads as a potential Nanocarrier","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-12-04 13:07:43","doi":"10.21203/rs.3.rs-8117697/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"6af2fef1-f40e-4d48-9b26-70b0acf2638f","owner":[],"postedDate":"December 4th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-01-03T15:09:01+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-04 13:07:43","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8117697","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8117697","identity":"rs-8117697","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}