Factors Influencing AVF Dysfunction in Patients with Maintenance Hemodialysis: A retrospective study

ABSTRACT Objective To explore factors influencing primary dysfunction of autologous arteriovenous fistula (AVF) in patients with maintenance hemodialysis (MHD). Methods This is a retrospectively study. One hundred and twenty-one patients who underwent anastomosis for AVF in our hospital Between 1st January 2016 and 31st December 2018 were selected. Seventy-seven patients satisfied the inclusion criteria and were included in the final analyses. Patients were divided into two groups based on the function of vascular access. The comparisons of complete blood count and other blood biochemical parameters were made between two groups. Factors influencing AVF dysfunction were analyzed by multivariate Cox proportional hazard regression model for patients with End stage renal disease (ESRD). Results There were significant differences in total cholesterol (TC), low density lipoprotein (LDL) and serum phosphorus levels between patency and dysfunction group (P<0.05) of AVFs. Further multivariate COX proportional risk regression showed that hypercholesterolemia and hyperphosphatemia were independent risk factors for AVF dysfunction. Conclusions Hypercholesterolemia and hyperphosphatemia are independent risk factors for primary AVF dysfunction in patients with MHD.