ProteoDisco: A flexible R approach to generate customized protein databases for extended search space of novel and variant proteins in proteogenomic studies
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CC-BY-4.0
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ProteoDisco is an R package that enables the flexible creation of custom protein databases by incorporating genomic variants, fusion genes, and transcriptomic variants for proteogenomic studies.
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Abstract
Summary We present an R-based open-source software termed ProteoDisco that allows for flexible incorporation of genomic variants, fusion-genes and (aberrant) transcriptomic variants from standardized formats into protein variant sequences. ProteoDisco allows for a flexible step-by-step workflow allowing for in-depth customization to suit a myriad of research approaches in the field of proteogenomics, on all organisms for which a reference genome and transcript annotations are available. Availability and Implementation ProteoDisco (R package version ≥ 0.99) is available from https://github.com/ErasmusMC-CCBC/ProteoDisco/ . Contact [email protected] Supplementary information Supplementary table, figures and data files available.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
- last seen: 2026-05-24T02:00:01.246996+00:00
License: CC-BY-4.0