TRANSCRIPTIONAL ACTIVATOR
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Abstract
It is intended to provide a novel transcriptional activator GCX-1 which is specific to a reproductive organ and seemingly plays an important role in the hypothalamus-pituitary-gonad axis. A novel gene GCX-1 (SEQ ID NO:2) overexpressed in the ovarian is isolated from a rat ovarian granulocyte cDNA library. By examining an abnormality in this gene and its gene product (SEQ ID NO:1) or an abnormality in the production thereof or developing a drug acting on its transcriptional activation region, it is possible to clarify causes of diseases induced by abnormalities in reproductive organs (for example, infertility, polycystic ovary diseases, endometriosis, pubertas praecox and osteoporosis) and treat these diseases.
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- europepmc
- last seen: 2026-07-07T06:07:59.301721+00:00