Randomised controlled trial of educational package on management of menorrhagia in primary care: the Anglia menorrhagia education study

Guy Fender, Andrew Prentice, T. Gorst, Richard M. Nixon, S W Duffy, Nicholas Day, S. K. Smith
In: BMJ · 1999 · vol. 318(7193) , pp. 1246–1250 · doi:10.1136/bmj.318.7193.1246 · PMID:10231255 · W2043217106
article OA: bronze CC0 ⤵ 5 in-corpus citations
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This randomized controlled trial found that an educational intervention in primary care practices significantly reduced menorrhagia referrals and increased tranexamic acid use compared to controls.

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Abstract

OBJECTIVE: To determine whether an educational package could influence the management of menorrhagia, increase the appropriateness of choice of non-hormonal treatment, and reduce referral rates from primary to secondary care. DESIGN: Randomised controlled trial. SETTING: General practices in East Anglia. SUBJECTS: 100 practices (348 doctors) in primary care were recruited and randomised to intervention (54) and control (46). INTERVENTIONS: An educational package based on principles of "academic detailing" with independent academics was given in small practice based interactive groups with a visual presentation, a printed evidence based summary, a graphic management flow chart, and a follow up meeting at 6 months. OUTCOME MEASURES: All practices recorded consultation details, treatments offered, and outcomes for women with regular heavy menstrual loss (menorrhagia) over 1 year. RESULTS: 1001 consultation data sheets for menorrhagia were returned. There were significantly fewer referrals (20% v 29%; odds ratio 0. 64; 95% confidence interval 0.41 to 0.99) and a significantly higher use of tranexamic acid (odds ratio 2.38; 1.61 to 3.49) in the intervention group but no overall difference in norethisterone treatment compared with controls. There were more referrals when tranexamic acid was given with norethisterone than when it was given alone. Those practices reporting fewer than 10 cases showed the highest increase in prescribing of tranexamic acid. CONCLUSIONS: The educational package positively influenced referral for menorrhagia and treatment with appropriate non-hormonal drugs.

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