Comparative Outcomes of Artificial Heart Transplants Versus Donor Heart Transplants in Patients with End-stage Heart Failure: A Narrative Review

Comparative Outcomes of Artificial Heart Transplants Versus Donor Heart Transplants in Patients with End-stage Heart Failure: A Narrative Review | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Systematic Review Comparative Outcomes of Artificial Heart Transplants Versus Donor Heart Transplants in Patients with End-stage Heart Failure: A Narrative Review Mohammad Eisa Ali, Maleeha Pandit, Motassam Ali This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4928992/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract End-stage heart failure (ESHF) necessitates advanced therapeutic interventions such as orthotopic heart transplantation (OHT). Due to the scarcity of donor hearts, mechanical circulatory support systems, including total artificial hearts (TAHs) and ventricular assist devices (VADs), have emerged as critical alternatives. Despite significant technological advancements, comprehensive comparative analyses of outcomes between artificial and donor heart transplants remain limited. Current literature exhibits gaps in detailed comparative analyses of long-term survival rates, quality of life (QoL), and complication profiles. Specific deficiencies include inadequate data on patient selection criteria, the impact of recent technological advancements in artificial heart technology, and the economic and healthcare resource implications. Additionally, patient-reported outcomes are underexplored. This review aims to rigorously compare the survival rates, QoL, and complication profiles of TAHs, VADs, and OHT in ESHF patients to inform clinical practice and guide future research. Purpose of Review : To compare the clinical outcomes of artificial heart transplants versus donor heart transplants in patients with end-stage heart failure, focusing on survival rates, quality of life, and post-transplant complications. Methods : A systematic search of PubMed, Cochrane Library, and Google Scholar was conducted using keywords such as "artificial heart transplants," "donor heart transplants," and "end-stage heart failure." Studies were selected based on predefined inclusion and exclusion criteria, and the quality of the studies was assessed using the Cochrane risk of bias tool. Results : The review included 20 studies that met the inclusion criteria. The analysis revealed that donor heart transplants generally exhibited higher survival rates compared to artificial heart transplants. However, advancements in artificial heart technology have enhanced quality of life and reduced the incidence of certain complications. Both transplant modalities presented unique benefits and challenges. Summary: While donor heart transplants currently offer superior survival outcomes, artificial heart transplants are becoming a viable alternative for improving quality of life metrics. Continued advancements and further comparative studies are essential to optimise transplantation strategies for end-stage heart failure patients. Clinicians should consider both options based on individual patient profiles and technological advancements. Artificial heart transplants donor heart transplants end-stage heart failure comparative outcomes survival rates quality of life post-transplant complications Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4928992","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Systematic Review","associatedPublications":[],"authors":[{"id":348893867,"identity":"94a9dbcf-7dda-46cc-829a-90ba10bf9e22","order_by":0,"name":"Mohammad Eisa Ali","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAyklEQVRIiWNgGAWjYDACZiBOqJCQY2DgIUXLgzMWxiRoAQLGh20ViQ1Ea+FnZ3/4IYFNIn3D8bMHH3xgsJPTbSCgRbKZx1gigUcid8OZvGTDGQzJxmYHCGgxOMzDIJEgAdRyIMdMmofhQOI2QlrsD7M//pFgIJFucP4NkVoMmBnMJBISJBIMbhBri8RhHjOLhAMShjNvvDE2nGFAhF/4+48/vvnzX5083/kcwwcfKuzkCGqBAwWwSgNilYOAfAMpqkfBKBgFo2BEAQBwVj9qPn6ptgAAAABJRU5ErkJggg==","orcid":"","institution":"University of Pavia","correspondingAuthor":true,"prefix":"","firstName":"Mohammad","middleName":"Eisa","lastName":"Ali","suffix":""},{"id":348893868,"identity":"0c557227-3e24-4741-8eba-83512727a454","order_by":1,"name":"Maleeha Pandit","email":"","orcid":"","institution":"Medical University of Plovdiv","correspondingAuthor":false,"prefix":"","firstName":"Maleeha","middleName":"","lastName":"Pandit","suffix":""},{"id":348893869,"identity":"3b8e07c2-9e38-444c-b114-77ab730b60f9","order_by":2,"name":"Motassam Ali","email":"","orcid":"","institution":"University of Huddersfield","correspondingAuthor":false,"prefix":"","firstName":"Motassam","middleName":"","lastName":"Ali","suffix":""}],"badges":[],"createdAt":"2024-08-17 09:16:05","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4928992/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4928992/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":80312721,"identity":"e3ff2520-7d2b-4455-b391-9d206b4da679","added_by":"auto","created_at":"2025-04-10 11:46:46","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":556846,"visible":true,"origin":"","legend":"","description":"","filename":"ManuscriptBMCCardiovascularDisorders.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4928992/v1_covered_50b6ab29-9cd1-4af9-afc6-8aa61858e98d.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Comparative Outcomes of Artificial Heart Transplants Versus Donor Heart Transplants in Patients with End-stage Heart Failure: A Narrative Review","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Artificial heart transplants, donor heart transplants, end-stage heart failure, comparative outcomes, survival rates, quality of life, post-transplant complications","lastPublishedDoi":"10.21203/rs.3.rs-4928992/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4928992/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eEnd-stage heart failure (ESHF) necessitates advanced therapeutic interventions such as orthotopic heart transplantation (OHT). Due to the scarcity of donor hearts, mechanical circulatory support systems, including total artificial hearts (TAHs) and ventricular assist devices (VADs), have emerged as critical alternatives. Despite significant technological advancements, comprehensive comparative analyses of outcomes between artificial and donor heart transplants remain limited.\u003c/p\u003e\n\u003cp\u003eCurrent literature exhibits gaps in detailed comparative analyses of long-term survival rates, quality of life (QoL), and complication profiles. Specific deficiencies include inadequate data on patient selection criteria, the impact of recent technological advancements in artificial heart technology, and the economic and healthcare resource implications.\u003c/p\u003e\n\u003cp\u003eAdditionally, patient-reported outcomes are underexplored. This review aims to rigorously compare the survival rates, QoL, and complication profiles of TAHs, VADs, and OHT in ESHF patients to inform clinical practice and guide future research.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurpose of Review\u003c/strong\u003e: To compare the clinical outcomes of artificial heart transplants versus donor heart transplants in patients with end-stage heart failure, focusing on survival rates, quality of life, and post-transplant complications.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eMethods\u003c/em\u003e: A systematic search of PubMed, Cochrane Library, and Google Scholar was conducted using keywords such as \"artificial heart transplants,\" \"donor heart transplants,\" and \"end-stage heart failure.\" Studies were selected based on predefined inclusion and exclusion criteria, and the quality of the studies was assessed using the Cochrane risk of bias tool.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eResults\u003c/em\u003e: The review included 20 studies that met the inclusion criteria. The analysis revealed that donor heart transplants generally exhibited higher survival rates compared to artificial heart transplants. However, advancements in artificial heart technology have enhanced quality of life and reduced the incidence of certain complications. Both transplant modalities presented unique benefits and challenges.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSummary:\u003c/strong\u003e While donor heart transplants currently offer superior survival outcomes, \u0026nbsp;artificial heart transplants are becoming a viable alternative for improving quality of life \u0026nbsp;metrics. Continued advancements and further comparative studies are essential to \u0026nbsp;optimise transplantation strategies for end-stage heart failure patients. Clinicians should \u0026nbsp;consider both options based on individual patient profiles and technological \u0026nbsp;advancements.\u003c/p\u003e","manuscriptTitle":"Comparative Outcomes of Artificial Heart Transplants Versus Donor Heart Transplants in Patients with End-stage Heart Failure: A Narrative Review","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-10-01 11:16:01","doi":"10.21203/rs.3.rs-4928992/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2a6e3af6-2693-4131-8565-4b7af8797daa","owner":[],"postedDate":"October 1st, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-04-10T11:38:36+00:00","versionOfRecord":[],"versionCreatedAt":"2024-10-01 11:16:01","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4928992","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4928992","identity":"rs-4928992","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}