Changes in the microbiota of the genital tract and intestines in patients with adenomyosis and infertility

Inna Georgievna Ponomarova, Tamara Oleksandrivna Lisyana, О.V. Trokhymovych, Olha Ivanivna Matyashova
In: Medical Research Journal · 2022 · vol. 7(3) , pp. 197–202 · doi:10.5603/mrj.a2022.0034 · W4289780992
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This study found that women with adenomyosis and infertility exhibit a pathological genital tract microbiota with increased pathogenic bacteria and decreased lactobacilli, and a disturbed intestinal microbiota with potentially pathogenic microorganisms.

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The study examined vaginal/genital tract and intestinal microbiota in 64 women with adenomyosis and infertility and compared them with 30 healthy women, using microscopic and cultural bacteriological methods. Patients showed a genital tract microbiota marked by a higher frequency of abnormal microbiocenosis patterns (bacterial vaginosis, vaginitis, intermediate types) and increased abundance of vaginosis-associated microorganisms, alongside associative bacterial contamination. Intestinal microbiota alterations were described as multicomponent dysbiotic associations driven by disrupted ratios between potentially pathogenic and protective bacterial species. This paper is centrally about endometriosis—though it explicitly studies adenomyosis and infertility, it documents microbiota changes in that adenomyosis context that are directly relevant to endometriosis-adenomyosis overlap in reproductive inflammation.

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Abstract

Introduction: Inflammation of the genital tract caused by a bacterial infection can affect the frequency of occurrence of hyperproliferative formations of the uterus, which in turn can lead to infertility. Changes in the microbiota of the vagina and intestines contribute to the formation of critical problems for women’s reproductive health. Material and methods: Microbiota composition was studied using microscopic and cultural bacteriological methods in genitalia and intestines in 64 women with adenomyosis and infertility and 30 healthy women. Results: The obtained results indicate that the microbiota of the genital tract in patients with adenomyosis and infertility is characterized by a different frequency of pathological manifestations (bacterial vaginosis, vaginitis, intermediate type of microbiocenosis) and excessive proliferation of vaginosis-associated microorganisms. Associative forms of bacterial contamination of the genital tract are registered in sick women. The formation of pathological intestinal microbiota in patients is largely due to a violation of the ratio between potentially pathogenic and protective species of bacteria. Conclusions: In women with adenomyosis and infertility, a pathological microbiota of the genital tract is formed, which is characterized by an increase in the structure of vaginal bacteria of representatives of pathogenic aerobic and vaginosis-associated microorganisms, a deficiency of lactobacilli. Intestinal microbiota in patients is characterized by the formation of multicomponent associations, which with a significant frequency contain conditionally pathogenic microorganisms.
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Abstract

Introduction: Inflammation of the genital tract caused by a bacterial infection can affect the frequency of occurrence of hyperproliferative formations of the uterus, which in turn can lead to infertility. Changes in the microbiota of the vagina and intestines contribute to the formation of critical problems for women’s reproductive health.

Material and methods

Microbiota composition was studied using microscopic and cultural bacteriological methods in genitalia and intestines in 64 women with adenomyosis and infertility and 30 healthy women.

Results

The obtained results indicate that the microbiota of the genital tract in patients with adenomyosis and infertility is characterized by a different frequency of pathological manifestations (bacterial vaginosis, vaginitis, intermediate type of microbiocenosis) and excessive proliferation of vaginosis-associated microorganisms. Associative forms of bacterial contamination of the genital tract are registered in sick women. The formation of pathological intestinal microbiota in patients is largely due to a violation of the ratio between potentially pathogenic and protective species of bacteria.

Conclusions

In women with adenomyosis and infertility, a pathological microbiota of the genital tract is formed, which is characterized by an increase in the structure of vaginal bacteria of representatives of pathogenic aerobic and vaginosis-associated microorganisms, a deficiency of lactobacilli. Intestinal microbiota in patients is characterized by the formation of multicomponent associations, which with a significant frequency contain conditionally pathogenic microorganisms.

Keywords

vaginal microbiotaintestinal microbiotaadenomyosisinfertility

References

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