Bioinformatics analysis of next generation sequencing data reveals novel biomarkers and signaling pathways associated with recurrent implantation failure

Bioinformatics analysis of next generation sequencing data reveals novel biomarkers and signaling pathways associated with recurrent implantation failure | bioRxiv /* */ /* */ <!-- <!-- /*! * yepnope1.5.4 * (c) WTFPL, GPLv2 */ (function(a,b,c){function d(a){return"[object Function]"==o.call(a)}function e(a){return"string"==typeof a}function f(){}function g(a){return!a||"loaded"==a||"complete"==a||"uninitialized"==a}function h(){var a=p.shift();q=1,a?a.t?m(function(){("c"==a.t?B.injectCss:B.injectJs)(a.s,0,a.a,a.x,a.e,1)},0):(a(),h()):q=0}function i(a,c,d,e,f,i,j){function k(b){if(!o&&g(l.readyState)&&(u.r=o=1,!q&&h(),l.onload=l.onreadystatechange=null,b)){"img"!=a&&m(function(){t.removeChild(l)},50);for(var d in y[c])y[c].hasOwnProperty(d)&&y[c][d].onload()}}var j=j||B.errorTimeout,l=b.createElement(a),o=0,r=0,u={t:d,s:c,e:f,a:i,x:j};1===y[c]&&(r=1,y[c]=[]),"object"==a?l.data=c:(l.src=c,l.type=a),l.width=l.height="0",l.onerror=l.onload=l.onreadystatechange=function(){k.call(this,r)},p.splice(e,0,u),"img"!=a&&(r||2===y[c]?(t.insertBefore(l,s?null:n),m(k,j)):y[c].push(l))}function j(a,b,c,d,f){return q=0,b=b||"j",e(a)?i("c"==b?v:u,a,b,this.i++,c,d,f):(p.splice(this.i++,0,a),1==p.length&&h()),this}function k(){var a=B;return a.loader={load:j,i:0},a}var l=b.documentElement,m=a.setTimeout,n=b.getElementsByTagName("script")[0],o={}.toString,p=[],q=0,r="MozAppearance"in l.style,s=r&&!!b.createRange().compareNode,t=s?l:n.parentNode,l=a.opera&&"[object Opera]"==o.call(a.opera),l=!!b.attachEvent&&!l,u=r?"object":l?"script":"img",v=l?"script":u,w=Array.isArray||function(a){return"[object Array]"==o.call(a)},x=[],y={},z={timeout:function(a,b){return b.length&&(a.timeout=b[0]),a}},A,B;B=function(a){function b(a){var a=a.split("!"),b=x.length,c=a.pop(),d=a.length,c={url:c,origUrl:c,prefixes:a},e,f,g;for(f=0;f<d;f++)g=a[f].split("="),(e=z[g.shift()])&&(c=e(c,g));for(f=0;f<b;f++)c=x[f](c);return c}function g(a,e,f,g,h){var i=b(a),j=i.autoCallback;i.url.split(".").pop().split("?").shift(),i.bypass||(e&&(e=d(e)?e:e[a]||e[g]||e[a.split("/").pop().split("?")[0]]),i.instead?i.instead(a,e,f,g,h):(y[i.url]?i.noexec=!0:y[i.url]=1,f.load(i.url,i.forceCSS||!i.forceJS&&"css"==i.url.split(".").pop().split("?").shift()?"c":c,i.noexec,i.attrs,i.timeout),(d(e)||d(j))&&f.load(function(){k(),e&&e(i.origUrl,h,g),j&&j(i.origUrl,h,g),y[i.url]=2})))}function h(a,b){function c(a,c){if(a){if(e(a))c||(j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}),g(a,j,b,0,h);else if(Object(a)===a)for(n in m=function(){var b=0,c;for(c in a)a.hasOwnProperty(c)&&b++;return b}(),a)a.hasOwnProperty(n)&&(!c&&!--m&&(d(j)?j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}:j[n]=function(a){return function(){var b=[].slice.call(arguments);a&&a.apply(this,b),l()}}(k[n])),g(a[n],j,b,n,h))}else!c&&l()}var h=!!a.test,i=a.load||a.both,j=a.callback||f,k=j,l=a.complete||f,m,n;c(h?a.yep:a.nope,!!i),i&&c(i)}var i,j,l=this.yepnope.loader;if(e(a))g(a,0,l,0);else if(w(a))for(i=0;i (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0];var j=d.createElement(s);var dl=l!='dataLayer'?'&l='+l:'';j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;j.type='text/javascript';j.async=true;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-M677548'); Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search New Results Bioinformatics analysis of next generation sequencing data reveals novel biomarkers and signaling pathways associated with recurrent implantation failure View ORCID Profile Basavaraj Vastrad , View ORCID Profile Chanabasayya Vastrad doi: https://doi.org/10.1101/2025.02.13.638207 Basavaraj Vastrad 1 Department of Pharmaceutical Chemistry, K.L.E. College of Pharmacy , Gadag 582101, Karnataka, India Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Basavaraj Vastrad Chanabasayya Vastrad 2 Biostatistics and Bioinformatics , Chanabasava Nilaya, Bharthinagar, Dharwad 580001, Karnataka, India Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Chanabasayya Vastrad For correspondence: channu.vastrad{at}gmail.com Abstract Full Text Info/History Metrics Preview PDF Abstract Recurrent implantation failure (RIF) is a cases in which women have had three fruitless in vitro fertilization (IVF) bid with positive quality embryos. The RIF originates from uterine endometrium microbiota has been implicated in reproductive failure, and poor prognosis and lacks effective treatment. Efforts have been made to elucidate the molecular pathogenesis of RIF. To identify key genes and signaling pathways in RIF, the next genetation sequencing data GSE243550 was downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) between RIF and normal controls samples were identified using t-tests in the limma R bioconductor package. Using the DEGs, we further performed a series of gene ontology (GO) and REACTOME pathway enrichment analyses. Protein-protein interaction network was derived using the IMex interactome database and visualized using Cytoscape software. The most significant modules from the PPI network were selected for GO and pathway enrichment analysis. A miRNA-hub gene regulatory network and TF-hub gene regulatory network were constructed depending on key hub genes and visualized using Cytoscape software. A receiver operating characteristic curve (ROC) analysis was plotted to diagnose RIF. In total, 958 DEGs were identified, of which 479 were up regulated genes and 479 were down regulated genes. GO and REACTOME pathway enrichment analysis results revealed that the upregulated genes were mainly enriched in multicellular organismal process, membrane, small molecule binding and extracellular matrix organization, whereas downregulated genes were mainly enriched in organonitrogen compound metabolic process, intracellular anatomical structure, catalytic activity and translation. Through analyzing the PPI network, we screened hub genes APP, HSP90AA1, CAND1, CUL1, HSP90AB1, SIRT7, SRC, CDKN1A, ISG15 and RPS16 by the Cytoscape software. The regulatory network analysis revealed that microRNAs (miRNAs) include hsa-miR-574-3p and hsa-mir-208a-3p, and transcription factors (TFs) include SREBF1 and RELA might be involved in the development of RIF. Receiver operating characteristic curve analysis demonstrated that the hub genes screened for RIF were of good diagnostic significance. Overall, these results thus highlight a range of novel signaling pathways and genes that are linked to the incidence and progression of RIF, providing a list of important diagnostic and prognostic molecular markers that have the potential to aid in the clinical diagnosis and treatment of RIF. Introduction Successful implantation involves the synchronized and interdependent crosstalk between the embryo and endometrium, which is the essential point for a fruitful pregnancy [ 1 ]. At present, in vitro fertilization-embryo transfer (IVF-ET) is considered the key approach for treating infertility with improvements in laboratory procedures and ovarian stimulation [ 2 ]. Recurrent implantation failure (RIF) is the failure to achieve a clinical pregnancy after transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman < 40 years of age [ 3 ]. RIF affects only 10% women undergoing IVF-ET, which places a great difficulty on the economy of health and reduces quality of life [ 4 ]. The pathological manifestations of RIF are characterized by attachment and migration process, with a negative urine or blood test for human chorionic gonadotropin (hCG) or failure to form an intrauterine gestational sac with positive hCG [ 5 ]. Regarding the pathogenesis of RIF, the most widely discussed factors include the hyperparathyroidism [ 6 ], insulin resistance [ 7 ], obesity [ 8 ], preeclampsia [ 9 ], male factor [ 10 ], endometriosis [ 11 ], polycystic ovarian syndrome [ 12 ], inflammatory factors [ 13 ], autoimmunity [ 14 ], endometrial cancer [ 15 ], endometrial receptivity [ 16 ], psychosocial consequences [ 17 ], inherited thrombophilia [ 18 ], prothrombotic genetic variants [ 19 ], chromosomal abnormalities [ 20 ], viral infections [ 21 ], hyperprolactinaemia [ 22 ], immunomodulation [ 23 ], embryo aneuploidy [ 24 ], endometrial microbiome [ 25 ], uterine fibroids [ 26 ], sperm DNA damage [ 27 ], oxidative stress [ 28 ] and Male factor infertility [ 29 ]. Studies have revealed that the progression of RIF is related to genetic factors [ 30 ]. Therefore, molecular changes in the occurrence and development of RIF and are effective ways to explore the molecular pathogenesis of RIF. Despite improvement in diagnosis and treatment, the prognosis of RIF patients remains poor, which has become an active topic of clinical and basic research. Genetic mutations [ 31 ], epigenetic alterations [ 32 ] and aberrant molecular signaling pathways [ 33 ] are involved in the processes of RIF. In particular, the new molecular characteristics can be applied in early risk assessment, the identification of better specific biomarkers, and the improvement of clinic treatment and survival. In the treatment of RIF, early diagnosis is of great significance, so it is necessary to dig out more RIF biomarkers. New biomarkers such as KIR and LILRB [ 34 ], ERAP/HLA-C and KIR [ 35 ], KIR2DL4 [ 36 ], STAT3, IL-1β, IL-6 and TNF-α [ 37 ], and MTHFR and TS [ 38 ] have also been widely concerned and studied. Previous reports on this topic have focused on identification of potential signaling pathways such as Wnt4/β-catenin signaling pathway [ 39 ], NF-κB signaling pathway [ 40 ], JAK/STAT3 signaling pathway [ 41 ], Met/PI3K/Akt signaling pathway [ 42 ] and ADCY1/cAMP signalling pathway [ 43 ]. The identification of novel biomarkers and signaling pathways may be helpful to improve the clinical outcome of RIF patients. With the rapid advancement of bioinformatics and next generation sequencing (NGS) technology, plenty of clinical and genetic data are disclosed, which provides rich resources for basic and clinical investigation of various diseases and disorders [ 44 – 45 ]. Through various public databases, we can further investigation the molecular pathogenesis of RIF and explore novel RIF biomarkers and potential therapeutic targets of RIF. At present, NGS dataset GSE243550 downloaded from Gene Expression Omnibus (GEO) ( https://www.ncbi.nlm.nih.gov/geo ) [ 46 ] database can be used to detect genes transcription expression levels and to provide the technical support for monitoring mRNA expression and cell function prediction in RIF. Non-biased bioinformatics analyses, including identification of DEGs, gene ontology (GO) and REACTOME pathway enrichment analyses, and protein–protein interaction (PPI) network and module analysis, and miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis were conducted, and the findings were further validated by receiver operating characteristic (ROC) curve analysis. Based on the obtained results, we propose novel biomarkers as potential targets for the diagnosis and treatment of RIF Materials and Methods Next generation sequencing (NGS) data source GSE243550 NGS dataset was downloaded from the GEO database. The GSE243550 dataset was generated utilizing the GPL24676 [Illumina NovaSeq 6000 (Homo sapiens)] platform and contained 20 RIF samples and 20 normal control samples. Identification of DEGs The statistically significant DEGs were selected by moderated t test approach with limma [ 47 ] package of R bioconductor. We screened DEGs between RIF and normal control samples by utilizing limma package with a adjust p 0.1343 for up regulated genes and log (Fold Change) < - 0.1554 for down regulated genes. We adjusted p-value to correct the false positive error caused by the multiple tests and determined it by the Benjamini & Hochberg method [ 48 ], which is one of the suitable tools to reduce the false discovery rate. The DEGs are presented as volcano plot, generated using ggplot2 package of R bioconductor. The gplot package of R bioconductor was used to construct a heatmap of the DEGs. GO and pathway enrichment analyses of DEGs In order to further investigation the role of DEGs in the occurrence and advancement of RIF, the GO ( http://www.geneontology.org ) [ 49 ] and REACTOME pathway ( https://reactome.org/ ) [ 50 ] enrichment analyses were carried out through online tool g:Profiler ( http://biit.cs.ut.ee/gprofiler/ ) [ 51 ]. A p < 0.05 was marked as the threshold value. Through GO enrichment analysis, biological processes (BP), cellular components (CC) and the molecular functions (MF) associated in various genes were interpreted. REACTOME pathway enrichment analysis was conducted to explore the role of DEGs in different signaling pathway in the homo sapiens. Construction of the PPI network and module analysis IMex interactome ( https://www.imexconsortium.org/ ) [ 52 ], an open source online tool, was used to construct a PPI network, and Cytoscape (version 3.10.3) ( http://www.cytoscape.org/ ) [ 53 ] software was implemented to complete visualization. To screen the hub genes that might be associated in RIF, we applied the Network Analyzer plug-in, using different parameters such as node degree [ 54 ], betweenness [ 55 ], stress [ 56 ] and closeness [ 57 ]. In addition, PEWCC plug-in [ 58 ] in cytoscape was used to identify the significant modules of the PPI network. Construction of the miRNA-hub gene regulatory network The hub genes obtained from PPI network were uploaded to miRNet ( https://www.mirnet.ca/ ) [ 59 ] to construct miRNA-hub gene regulatory network. The miRNA-hub gene regulatory network was constructed based on the TarBase, miRTarBase, miRecords, miRanda, miR2Disease, HMDD, PhenomiR, SM2miR, PharmacomiR, EpimiR, starBase, TransmiR, ADmiRE, and TAM 2.0 databases via the miRNet platform. The Cytoscape (version 3.10.3) [ 53 ] software was used to visualize the miRNA-hub gene regulatory network. Construction of the TF-hub gene regulatory network The hub genes obtained from PPI network were uploaded to NetworkAnalyst ( https://www.networkanalyst.ca/ ) [ 60 ] to construct TF-hub gene regulatory network. The TF-hub gene regulatory network was constructed based on the JASPAR database via the NetworkAnalyst platform. The Cytoscape (version 3.10.3) [ 53 ] software was used to visualize the TF-hub gene regulatory network. Receiver operating characteristic curve (ROC) analysis To verify the sensitivity and specificity of the hub gene expression obtained from the PPI network analysis for the diagnosis of RIF, we plotted the receiver operator characteristic (ROC) curve analysis and calculated the corresponding area under the curve (AUC) of hub genes based on the RIF data. The ROC curve was created to quantitatively determine the sensitivity and specificity of hub genes using pROC package of R bioconductor [ 61 ]. AUC > 0.8 was considered the excellent diagnostic value. Results Identification of DEGs The RIF NGS dataset GSE243550 was downloaded from the GEO database. After screening with the threshold of an adjusted p 0.1343 for up regulated genes and log (Fold Change) < −0.1554 for down regulated genes, a total of 958 (479 up regulated and 479 down regulated genes) DEGs were screened from GSE243550 using the “limma” package in R bioconductor ( Table 1 ), respectively. As shown in Fig.1 and Fig.2 , the volcano plot and heatmap analyses were used to visualize the DEGs. Download figure Open in new tab Fig. 1. Volcano plot of differentially expressed genes. Genes with a significant change of more than two-fold were selected. Green dot represented up regulated significant genes and red dot represented down regulated significant genes. Download figure Open in new tab Fig. 2. Heat map of differentially expressed genes. Legend on the top left indicate log fold change of genes. (A1 – A20 = RIF samples; B1 – B20= Normal control samples) View this table: View inline View popup Table 1 The statistical metrics for key differentially expressed genes (DEGs). GO and pathway enrichment analyses of DEGs GO and REACTOME pathway enrichment analyses were performed to better understand the biological functions of the identified DEGs using the online tool g:Profiler. The top significant GO terms for each of the subsections (BP, CC, and MF) ( Table 2 ) and top REACTOME pathways ( Table 3 ) were clustered with the threshold of adjusted p < 0.05. In the BP, the DEGs were significantly enriched in multicellular organismal process, regulation of biological process, organonitrogen compound metabolic process and metabolic process. Under the term of CC, DEGs were principally associated with the membrane, cytoplasm, intracellular anatomical structure and cytosol. Among the MF, DEGs were mainly enriched in small molecule binding, carbohydrate derivative binding, catalytic activity and hydrolase activity. Additionally, DEGs were significantly enriched in REACTOME pathways, including extracellular matrix organization, RHO GTPase cycle, translation and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. View this table: View inline View popup Table 2 The enriched GO terms of the up and down regulated differentially expressed genes. View this table: View inline View popup Table 3 The enriched pathway terms of the up and down regulated differentially expressed genes. Construction of the PPI network and module analysis The PPI network of DEGs was established by the IMex interactome database to analyze the interaction between the DEGs and visualized by Cytoscape software ( Fig.3 ). PPI network consist of 6316 nodes and 15825 edges. To identify the hub genes from the PPI network, the Network Analyzer plug in of Cytoscape software was used. And according to the node degree, betweenness, stress and closeness algorithms, we selected the top hub genes as potential hub genes ( Table 4 ), including APP, HSP90AA1, CAND1, CUL1, HSP90AB1, SIRT7, SRC, CDKN1A, ISG15 and RPS16. Two significant modules were identified by the PEWCC. A total of 44 nodes and 177 edges were included in Module 1 ( Fig. 4A ), and a total of 40 nodes and 141 edges were included in Module 2 ( Fig. 4B ). Module 1 was mainly enriched in regulation of biological process, membrane, membrane trafficking, RHO GTPase cycle, cytoplasm, small molecules, nervous system development, multicellular organismal process and transport of small molecules. Module 2 was mainly enriched in translation, cellular responses to stimuli, organonitrogen compound metabolic process, viral infection pathways and cellular responses to stress. Download figure Open in new tab Fig. 3. PPI network of DEGs. Up regulated genes are marked in green; down regulated genes are marked in red. Download figure Open in new tab Fig. 4. Modules selected from the PPI network. (A) The most significant module was obtained from PPI network with 44 nodes and 177 edges for up regulated genes (B) The most significant module was obtained from PPI network with 40 nodes and 141 edges for down regulated genes. Up regulated genes are marked in parrot green; down regulated genes are marked in red. View this table: View inline View popup Table 4 Topology table for up and down regulated genes. Construction of the miRNA-hub gene regulatory network The miRNet database was used to anticipate and visualize the miRNA - hub gene regulatory network of hub genes. The miRNA - hub gene regulatory network consisted of 5139 (miRNA: 4751 and hub gene: 388) nodes and 73061 edges ( Fig.5 ). CLTC was found to be regulated by 688 miRNAs (ex: hsa-miR-574-3p), CAND1 was found to be regulated by 604 miRNAs (ex: hsa-mir-382-5p), HSP90AB1 was found to be regulated by 548 miRNAs (ex: hsa-miR-218-1-3p), HSP90AA1 was found to be regulated by 538 miRNAs (ex: hsa-mir-548ad-5p), APP was found to be regulated by 511 miRNAs (ex: hsa-mir-31-5p), CDKN1A was found to be regulated by 919 miRNAs (ex: hsa-mir-208a-3p), RPS16 was found to be regulated by 222 miRNAs (ex: hsa-mir-216b-5p), GABARAP was found to be regulated by 205 miRNAs (ex: hsa-miR-218-5p), MAP1LC3B was found to be regulated by 199 miRNAs (ex: hsa-mir-6132) and SRC was found to be regulated by 155 miRNAs (ex: hsa-mir-205-5p) ( Table 5 ). Download figure Open in new tab Fig. 5. Hub gene - miRNA regulatory network. The light pink color diamond nodes represent the key miRNAs; up regulated genes are marked in green; down regulated genes are marked in red. View this table: View inline View popup Table 5 MiRNA - hub gene and TF – hub gene topology table. Construction of the TF-hub gene regulatory network The NetworkAnalyst database was used to anticipate and visualize the TF - hub gene regulatory network of hub genes. The TF - hub gene regulatory network consisted of 5139 (TF: 97 and hub gene: 386) nodes and 3209 edges ( Fig.6 ). APP was found to be regulated by 16 TFs (ex: SREBF1), HSP90AA1 was found to be regulated by 13 TFs (ex: ARID3A), YWHAB was found to be regulated by 10 TFs (ex: GATA3), CUL5 was found to be regulated by 9 TFs (ex: IRF2), DDX5 was found to be regulated by 8 TFs (ex: BRCA1), CDKN1A was found to be regulated by 14 TFs (ex: RELA), MAP1LC3A was found to be regulated by 14 TFs (ex: TFAP2C), HRAS was found to be regulated by 14 TFs (ex: MAX), EMD was found to be regulated by 10 TFs (ex: SPIB) and ISG15 was found to be regulated by 10 TFs (ex: NR2E3) ( Table 5 ). Download figure Open in new tab Fig. 6. Hub gene - TF regulatory network. The violet color triangle nodes represent the key TFs; up regulated genes are marked in dark green; down regulated genes are marked in dark red. Receiver operating characteristic curve (ROC) analysis ROC curves analysis were performed and the corresponding area under the ROC curve (AUC) was determined to validate the diagnostic value of these 10 hub genes obtained from the PPI network analysis. The larger the area under the ROC curve (AUC), the more the capability of the hub genes to diagnose RIF with excellent specificity and sensitivity. The diagnostic value of hub genes in RIF samples and normal control samples are as follow: APP (AUC:0.910), HSP90AA1 (AUC:0.923), CAND1 (AUC:0.907), CUL1 (AUC:0.901), HSP90AB1 (AUC:0.914), SIRT7 (AUC:0.926), SRC (AUC:0.944), CDKN1A (AUC:0.938), ISG15 (AUC:0.883) and RPS16 (AUC:0.938) ( Fig.7 ). Download figure Open in new tab Fig. 7. ROC curve analyses of hub genes. A) APP B) HSP90AA1 C) CAND1 D) CUL1 E) HSP90AB1 F) SIRT7 G) SRC H) CDKN1A I) ISG15 J) RPS16. Discussion RIF is a collapse to accomplish a clinical pregnancy after transfer of at least four good-quality embryos in a woman under the age of 40 years [ 62 ]. Therefore, sensitive and specific biomarkers of RIF are crucially needed to be identified. In the current investigation, bioinformatics and NGS technology are promising methods to analyze the essential genes and signaling pathways, which might provide novel clues for diagnosis, therapy, and prognosis of RIF. Methodologies related to bioinformatics analyses were used to search the NGS dataset of RIF, and 958 (479 up regulated and 479 down regulated genes) DEGs between RIF and normal control samples were identified based on the GEO database. Recent studies have shown that HBA2 [ 63 ], HLA-DRB5 [ 64 ], DIO2 [ 65 ] and TNC (tenascin C) [ 66 ] play important roles in psychosocial consequences. HBA2 [ 67 ], FOLR1 [ 68 ], DIO2 [ 69 ], TNC (tenascin C) [ 70 ] and HAP1 [ 71 ] are altered expressed in viral infections. HBA2 [ 72 ], DIO2 [ 73 ], TNC (tenascin C) [ 74 ], GAST (gastrin) [ 75 ], C2CD4B [ 76 ] and CES1 [ 77 ] were shown to be involved in the oxidative stress. Several studies have shown that FOLR1 [ 78 ], MSLN (mesothelin) [ 78 ] and TNC (tenascin C) [ 79 ] might contribute to the pathogenesis of endometriosis and could be a potential biomarker for predicting disease progression and therapeutic effects in endometriosis patients. CALCR (calcitonin receptor) [ 80 ], DIO2 [ 81 ], TNC (tenascin C) [ 82 ], HAP1 [ 83 ] and CES1 [ 84 ] participates in the pathophysiological progression of inflammation. DIO2 [ 85 ] and S100P [ 86 ] might be implicated in the recurrent spontaneous abortion. DIO2 [ 87 ] might serve as molecular marker for insulin resistance. DIO2 [ 88 ], TNC (tenascin C) [ 89 ] and CES1 [ 90 ] have been reported its expression in the obesity. DIO2 [ 91 ], MSLN (mesothelin) [ 92 ] and S100P [ 93 ] plays a role in diagnosis of endometrial cancer. DIO2 [ 94 ], TNC (tenascin C) [ 95 ], GAST (gastrin) [ 96 ] and S100P [ 97 ] have been known to be involved in autoimmunity progression. TNC (tenascin C) [ 70 ] has a significant prognostic potential in preeclampsia. TNC (tenascin C) [ 98 ] is molecular marker for the diagnosis and prognosis of polycystic ovary syndrome. Altered expression of TNC (tenascin C) [ 99 ] and GAST (gastrin) [ 100 ] significantly correlates with immunomodulation. TNC (tenascin C) [ 101 ] might be a potential prognostic marker or therapeutic target for uterine fibroids. Recently, increasing evidence demonstrated that GAST (gastrin) [ 102 ] was over-expressed in hyperparathyroidism. Studies had shown that GAST (gastrin) [ 103 ] was associated with gestational diabetes. Abnormal regulation of HAP1 [ 104 ] is associated with chromosomal abnormalities. HAP1 [ 105 ] plays an indispensable role in DNA damage. The results of this investigation suggest that DEGs might play a key role in the pathogenesis of RIF. GO term and REACTOME pathway enrichment analyses were used to explore the molecular mechanisms involved in the occurrence and development of RIF as well as to determine the potential role of DEGs in the occurrence and development of RIF. Signaling pathways include extracellular matrix organization [ 106 ], autophagy [ 107 ] and viral infections [ 21 ] were responsible for RIF. Recent studies have found that NRCAM (neuronal cell adhesion molecule) [ 108 ], JAG1 [ 109 ], CD4 [ 110 ], MMP2 [ 111 ], CDK6 [ 112 ], SEZ6L2 [ 113 ], SEMA4A [ 114 ], CDKN2C [ 115 ], EPHA4 [ 116 ], ADAM9 [ 117 ], ITPR1 [ 118 ], CAT (catalase) [ 119 ], JAK1 [ 120 ], IGF1R [ 121 ], PTEN (phosphatase and tensin homolog) [ 122 ], CHD4 [ 123 ], APP (amyloid beta precursor protein) [ 124 ], SRSF1 [ 125 ], LRP2 [ 126 ], NFAT5 [ 127 ], CLEC16A [ 128 ], CAPN5 [ 129 ], HPSE (heparanase) [ 130 ], CLDN4 [ 131 ], ANXA1 [ 132 ], ISG15 [ 133 ], CDKN1A [ 134 ], MIF (macrophage migration inhibitory factor) [ 135 ], ACE (angiotensin I converting enzyme) [ 136 ], GPX1 [ 137 ], UCP2 [ 138 ], TOB1 [ 139 ], KLF15 [ 140 ], FKBP1B [ 141 ], GDF15 [ 142 ], ADGRG3 [ 143 ], IRF7 [ 144 ], TOM1 [ 145 ], CXCR3 [ 146 ], IRF5 [ 147 ], SLIRP (SRA stem-loop interacting RNA binding protein) [ 148 ] and PIK3IP1 [ 149 ] have been proved to be related to the pathogenesis of autoimmunity. Studies have revealed that NRCAM (neuronal cell adhesion molecule) [ 150 ], LOXL1 [ 151 ], CCND1 [ 152 ], CYP1B1 [ 153 ], CD4 [ 154 ], TNFRSF21 [ 155 ], TUBB2B [ 156 ], PCDH10 [ 157 ], MMP2 [ 158 ], CDK6 [ 159 ], FOXF2 [ 160 ], PIAS1 [ 161 ], FURIN (furin, paired basic amino acid cleaving enzyme) [ 162 ], USP46 [ 163 ], ADAM9 [ 164 ], DDX5 [ 165 ], ABCA1 [ 166 ], SLC11A2 [ 167 ], JAK1 [ 168 ], RBFOX2 [ 169 ], IGF1R [ 170 ], PTEN (phosphatase and tensin homolog) [ 171 ], CHD4 [ 172 ], MSH3 [ 173 ], PCDHGB7 [ 174 ], KDM4A [ 175 ], IGF2R [ 176 ], PRKAR1A [ 177 ], YAP1 [ 178 ], SOS1 [ 179 ], ARID1A [ 180 ], CHD7 [ 181 ], EIF4G2 [ 182 ], ATM (ATM serine/threonine kinase) [ 183 ], PEG10 [ 184 ], FAM83B [ 185 ], FOLH1 [ 186 ], EPM2AIP1 [ 187 ], TRIM22 [ 188 ], HPSE (heparanase) [ 189 ], CLDN4 [ 190 ], NUPR1 [ 191 ], ISG15 [ 192 ], CDKN1A [ 193 ], ALDH2 [ 194 ], KSR1 [ 195 ], MIF (macrophage migration inhibitory factor) [ 196 ], ACE (angiotensin I converting enzyme) [ 197 ], GPX1 [ 91 ], PTGIS (prostaglandin I2 synthase) [ 198 ], ATP5F1D [ 199 ], RPIA (ribose 5-phosphate isomerase A) [ 200 ], BNIP3 [ 201 ], FLOT1 [ 202 ], HSF1 [ 203 ], SIRT7 [ 204 ], GDF15 [ 205 ], FXYD3 [ 206 ], MGST1 [ 207 ], MT2A [ 208 ], MT1A [ 208 ], ROMO1 [ 209 ], PFKFB3 [ 210 ], FOXA2 [ 211 ], SNHG25 [ 212 ], ABHD11 [ 213 ], CXCR3 [ 214 ], FAM83H [ 215 ], EMX2 [ 216 ], ESRRA (estrogen related receptor alpha) [ 217 ] and CCDC124 [ 218 ] can contribute to endometrial cancer. NRCAM (neuronal cell adhesion molecule) [ 219 ], BMP7 [ 220 ], SLC24A4 [ 221 ], KIF26B [ 222 ], ANPEP (alanylaminopeptidase, membrane) [ 223 ], HSD11B1 [ 224 ], ADCYAP1R1 [ 225 ], CD4 [ 226 ], NNAT (neuronatin) [ 227 ], TUBB2A [ 228 ], SYT7 [ 229 ], ADAM22 [ 230 ], LSAMP (limbic system associated membrane protein) [ 231 ], TNFRSF19 [ 232 ], TNFRSF21 [ 233 ], LTBP1 [ 234 ], MMP2 [ 235 ], SEZ6L2 [ 236 ], PIAS1 [ 237 ], ADGRL1 [ 238 ], HSP90AA1 [ 239 ], KCNC2 [ 240 ], SCARB2 [ 241 ], FURIN (furin, paired basic amino acid cleaving enzyme) [ 242 ], AGTR2 [ 243 ], SLC6A9 [ 244 ], EPHA4 [ 245 ], PSAP (prosaposin) [ 246 ], USP46 [ 247 ], UHMK1 [ 248 ], ADAM9 [ 249 ], SLC1A3 [ 250 ], ITPR1 [ 118 ], LRRC4C [ 251 ], CAT (catalase) [ 252 ], UNC13B [ 253 ], TUSC3 [ 254 ], ABCA1 [ 255 ], LRPAP1 [ 256 ], WNK3 [ 257 ], ADGRB3 [ 258 ], JAK1 [ 259 ], MAP6 [ 260 ], IGF1R [ 261 ], ATRN (attractin) [ 262 ], CLTC (clathrin heavy chain) [ 263 ], EPHA5 [ 264 ], MSH3 [ 265 ], BACE1 [ 266 ], AGO1 [ 267 ], APP (amyloid beta precursor protein) [ 268 ], CCDC88A [ 269 ], RBMX (RNA binding motif protein X-linked) [ 270 ], ATRX (ATRX chromatin remodeler) [ 271 ], PPP3CA [ 272 ], ALDH5A1 [ 273 ], MSI2 [ 274 ], PJA2 [ 275 ], YAP1 [ 276 ], HFE (homeostatic iron regulator) [ 277 ], KIDINS220 [ 278 ], SPAST (spastin) [ 279 ], AKAP11 [ 280 ], ARID1A [ 281 ], ARHGEF11 [ 282 ], ATM (ATM serine/threonine kinase) [ 283 ], PRSS12 [ 284 ], SCRN1 [ 285 ], MAPK10 [ 286 ], ALDH18A1 [ 287 ], NFAT5 [ 288 ], ITPR2 [ 289 ], GOLGB1 [ 290 ], LAMP2 [ 291 ], TSPAN5 [ 292 ], TTC3 [ 293 ], HSP90B1 [ 294 ], ASAH1 [ 295 ], VCP (valosin containing protein) [ 296 ], DLG3 [ 297 ], GPC5 [ 298 ], CLEC16A [ 128 ], M6PR [ 299 ], AADAT (aminoadipate aminotransferase) [ 300 ], HSPA4 [ 301 ], GFM1 [ 302 ], CAPN5 [ 303 ], ANG (angiogenin) [ 304 ], ANXA1 [ 305 ], RPS6KA5 [ 306 ], ALDH2 [ 307 ], TSPO (translocator protein) [ 308 ], MIF (macrophage migration inhibitory factor) [ 309 ], ACE (angiotensin I converting enzyme) [ 310 ], GPX1 [ 311 ], FBXL16 [ 312 ], UCP2 [ 313 ], CLCF1 [ 314 ], PRSS57 [ 315 ], DDAH2 [ 316 ], ARL6IP1 [ 317 ], MVP (major vault protein) [ 318 ], FLOT1 [ 319 ], STYXL1 [ 320 ], ATG4D [ 321 ], TNK1 [ 322 ], MRPL43 [ 323 ], CAPN10 [ 324 ], SHARPIN (SHANK associated RH domain interactor) [ 325 ], HINT2 [ 326 ], PEX10 [ 327 ], HSF1 [ 328 ], SIRT7 [ 329 ], ACAT1 [ 330 ], PPP3CC [ 331 ], ANG (angiogenin) [ 332 ], ADH1B [ 333 ], GDF15 [ 334 ], CEBPD (CCAAT enhancer binding protein delta) [ 335 ], RGS10 [ 336 ], ELK4 [ 337 ], IRF7 [ 338 ], TOM1 [ 339 ], CXCR3 [ 340 ], SNHG7 [ 341 ], ZNF787 [ 342 ], ARHGEF28 [ 343 ], HS1BP3 [ 344 ], GPR18 [ 345 ], UXT (ubiquitously expressed prefoldin like chaperone) [ 346 ], SNRPE (small nuclear ribonucleoprotein polypeptide E) [ 347 ], VPS51 [ 348 ], COQ8A [ 349 ], HDAC11 [ 350 ] and PCGF1 [ 351 ] are expected to be potential therapeutic targets for psychosocial consequences. BMP7 [ 352 ], HSD11B1 [ 353 ], CD4 [ 354 ], PIAS1 [ 355 ], ADAM9 [ 356 ], CAT (catalase) [ 357 ], ABCA1 [ 358 ], JAK1 [ 359 ], IGF1R [ 360 ], PTEN (phosphatase and tensin homolog) [ 361 ], BACE1 [ 362 ], APP (amyloid beta precursor protein) [ 363 ], IGF2R [ 364 ], HFE (homeostatic iron regulator) [ 365 ], ARHGEF11 [ 366 ], ATM (ATM serine/threonine kinase) [ 367 ], COL6A3 [ 368 ], NFAT5 [ 369 ], EPM2AIP1 [ 370 ], ARG2 [ 371 ], ALDH2 [ 372 ], TSPO (translocator protein) [ 373 ], MIF (macrophage migration inhibitory factor) [ 374 ], ACE (angiotensin I converting enzyme) [ 375 ], UCP2 [ 376 ], KLF15 [ 377 ], VEGFB (vascular endothelial growth factor B) [ 378 ], MSRB1 [ 379 ], CAPN10 [ 380 ], HSF1 [ 381 ], ADH1B [ 382 ], GDF15 [ 383 ], SOD3 [ 384 ], RGS10 [ 385 ], AGPAT2 [ 386 ], PFKFB3 [ 387 ], FOXA2 [ 388 ]. IRF7 [ 389 ] and CXCR3 [ 390 ] have been linked to the development of insulin resistance. Studies have shown that BMP7 [ 352 ], F13A1 [ 391 ], LOXL1 [ 392 ], HSD11B1 [ 393 ]. CCND1 [ 394 ], WNT16 [ 395 ], CYP1B1 [ 396 ], JAG1 [ 397 ], CD4 [ 354 ], NNAT (neuronatin) [ 398 ], UBB (ubiquitin B) [ 399 ], STRA6 [ 400 ], COL18A1 [ 401 ], MMP2 [ 402 ], CDK6 [ 403 ], PIAS1 [ 355 ], ADGRL1 [ 404 ], KCNC2 [ 405 ], SCARB2 [ 406 ], CDKN2C [ 407 ], RGN (regucalcin) [ 408 ], USP22 [ 409 ], LAMA1 [ 410 ], PRCP (prolylcarboxypeptidase) [ 411 ], CAT (catalase) [ 357 ], LDB1 [ 412 ], ABCA1 [ 358 ], EPHA3 [ 413 ], IGF1R [ 414 ], PTEN (phosphatase and tensin homolog) [ 415 ], ATRN (attractin) [ 416 ], AMPD2 [ 417 ], BACE1 [ 362 ], APP (amyloid beta precursor protein) [ 418 ], IGF2R [ 419 ], MSI2 [ 420 ], PRKAR1A [ 421 ], SRSF1 [ 422 ], YAP1 [ 423 ], SOS1 [ 424 ], KIDINS220 [ 425 ], ARID1A [ 426 ], ARHGEF11 [ 427 ], LRP2 [ 428 ], COL6A3 [ 429 ], NFAT5 [ 369 ], LAMP2 [ 430 ], ARHGAP21 [ 431 ], ARMCX3 [ 432 ], LANCL1 [ 433 ], CAP1 [ 434 ], ND2 [ 435 ], M6PR [ 436 ], GSTM4 [ 437 ], CAPN5 [ 438 ], HPSE (heparanase) [ 439 ], ARG2 [ 440 ], ANXA1 [ 441 ], ALDH2 [ 442 ], TSPO (translocator protein) [ 443 ], MIF (macrophage migration inhibitory factor) [ 374 ], ACE (angiotensin I converting enzyme) [ 444 ], GPX1 [ 445 ], MPST (mercaptopyruvatesulfurtransferase) [ 446 ], UCP2 [ 376 ], KLF15 [ 447 ], CDKN1C [ 448 ], ND3 [ 449 ], PFKP (phosphofructokinase, platelet) [ 450 ], HRAS (HRas proto-oncogene, GTPase) [ 451 ], VEGFB (vascular endothelial growth factor B) [ 452 ], MVP (major vault protein) [ 453 ], CAPN10 [ 454 ], HSF1 [ 455 ], SIRT7 [ 456 ], ACAT1 [ 457 ]. TKT (transketolase) [ 458 ], ADH1B [ 382 ], GDF15 [ 459 ], CEBPD (CCAAT enhancer binding protein delta) [ 460 ], SOD3 [ 384 ], PPP1R3G [ 461 ], AGPAT2 [ 462 ], PFKFB3 [ 387 ], FOXA2 [ 463 ], IRF7 [ 389 ], CXCR3 [ 390 ], IRF5 [ 464 ], PNPLA2 [ 465 ], EMD (emerin) [ 466 ], ESRRA (estrogen related receptor alpha) [ 467 ] and HDAC11 [ 468 ] plays an important role in the development of obesity. Findings have shown that BMP7 [ 469 ], HSD11B1 [ 470 ], MRC2 [ 471 ], CYP1B1 [ 472 ], CRISPLD2 [ 473 ], CD4 [ 474 ], PCDH10 [ 475 ], MMP2 [ 476 ], CDK6 [ 477 ], AGTR2 [ 478 ], CAT (catalase) [ 479 ], EPHA3 [ 480 ], IGF1R [ 481 ], PTEN (phosphatase and tensin homolog) [ 482 ], MSI2 [ 483 ], YAP1 [ 484 ], ARID1A [ 485 ], MAT2A [ 486 ], GSTM4 [ 487 ], ANG (angiogenin) [ 488 ], CLDN4 [ 489 ], ANXA1 [ 490 ], CDKN1A [ 491 ], ALDH2 [ 492 ], TSPO (translocator protein) [ 493 ], MIF (macrophage migration inhibitory factor) [ 494 ]. ACE (angiotensin I converting enzyme) [Kowalczyńska et al. 2014], GPX1 [ 495 ], PTGIS (prostaglandin I2 synthase) [ 496 ], KLF15 [ 497 ], HSF1 [ 498 ], GDF15 [ 499 ], PFKFB3 [ 500 ], FOXA2 [ 501 ], CXCR3 [ 502 ] and EMX2 [ 503 ] expression is regulated in endometriosis. Recently, increasing evidence demonstrated that BMP7 [ 504 ], F13A1 [ 505 ], HSD11B1 [ 506 ], CYP1B1 [ 507 ], CD4 [ 508 ], MMP2 [ 509 ], CORIN (corin, serine peptidase) [ 510 ], CAT (catalase) [ 511 ], ABCA1 [ 512 ], JAK1 [ 513 ], IGF1R [ 514 ], PTEN (phosphatase and tensin homolog) [ 515 ], ATRX (ATRX chromatin remodeler) [ 516 ], YAP1 [ 517 ], ARID1A [ 518 ], HSD17B6 [ 519 ], LIFR (LIF receptor subunit alpha) [ 520 ], MTM1 [ 521 ], CAPN5 [ 522 ], CDKN1A [ 523 ], TSPO (translocator protein) [ 524 ], MIF (macrophage migration inhibitory factor) [ 525 ], ACE (angiotensin I converting enzyme) [ 375 ], GPX1 [ 526 ], UCP2 [ 527 ], CDKN1C [ 528 ], BNIP3 [ 529 ], VEGFB (vascular endothelial growth factor B) [ 530 ], CAPN10 [ 531 ], SLC18A2 [ 532 ], GDF15 [ 533 ], MAP1LC3A [ 534 ], IRF7 [ 535 ] and SNHG7 [ 536 ] were alerted expressed in polycystic ovary syndrome. BMP7 [ 537 ], F13A1 [ 538 ], ANPEP (alanylaminopeptidase, membrane) [ 223 ], LOXL1 [ 539 ], HSD11B1 [ 540 ], WNT16 [ 541 ], CYP1B1 [ 542 ], CRISPLD2 [ 543 ], JAG1 [ 544 ], CD4 [ 545 ], NNAT (neuronatin) [ 546 ], TGFB3 [ 547 ], STRA6 [ 548 ], TNFRSF21 [ 233 ], CD109 [ 549 ], PIK3R3 [ 550 ], ABCC4 [ 551 ], MMP2 [ 552 ], MAFB (MAF bZIP transcription factor B) [ 553 ], VANGL2 [ 554 ], SEMA4A [ 555 ], PIAS1 [ 355 ], TNFSF11 [ 556 ], HSP90AA1 [ 557 ], RGN (regucalcin) [ 558 ], AGTR2 [ 559 ], USP22 [ 560 ], EPHA4 [ 561 ], HSP90AB1 [ 562 ], PSAP (prosaposin) [ 563 ], PRCP (prolylcarboxypeptidase) [ 564 ], NR2C2 [ 565 ], ADAM9 [ 566 ], ITPR1 [ 567 ], DDX5 [ 568 ], CAT (catalase) [ 569 ], ABCA1 [ 570 ], ZMPSTE24 [ 571 ], JAK1 [ 359 ], RRM2B [ 572 ], ITGB1 [ 573 ], IGF1R [ 574 ], SLC39A10 [ 575 ], ARHGAP24 [ 576 ], PTEN (phosphatase and tensin homolog) [ 577 ], UBR3 [ 578 ], CLTC (clathrin heavy chain) [ 579 ], MSH3 [ 580 ], TP53BP1 [ 581 ], BACE1 [ 582 ], APP (amyloid beta precursor protein) [ 124 ], ASAP1 [ 583 ], UFL1 [ 584 ], ATRX (ATRX chromatin remodeler) [ 585 ], FBN2 [ 586 ], MSI2 [ 420 ], YAP1 [ 587 ], HFE (homeostatic iron regulator) [ 588 ], SLC26A6 [ 589 ], KIDINS220 [ 590 ], ARID1A [ 591 ], PAG1 [ 592 ], EIF4G2 [ 593 ], COL6A3 [ 594 ], COL4A5 [ 595 ], NFAT5 [ 596 ], TTC3 [ 597 ], EXTL2 [ 598 ], ARMCX3 [ 599 ], STAT2 [ 600 ], CAP1 [ 601 ], VCP (valosin containing protein) [ 602 ], CUL1 [ 603 ], UBA1 [ 604 ], TNKS (tankyrase) [ 605 ], GPC5 [ 606 ], ST3GAL2 [ 607 ], MAT2A [ 608 ], TRIM22 [ 609 ], HSPA4 [ 301 ], CAPN5 [ 610 ], ANG (angiogenin) [ 611 ], HPSE (heparanase) [ 612 ], ARG2 [ 613 ], NUPR1 [ 614 ], ANXA1 [ 615 ], ISG15 [ 616 ], CDKN1A [ 134 ], ALDH2 [ 617 ], TSPO (translocator protein) [ 308 ], KSR1 [ 618 ], MIF (macrophage migration inhibitory factor) [ 619 ], ACE (angiotensin I converting enzyme) [ 620 ], GPX1 [ 621 ], MPST (mercaptopyruvatesulfurtransferase) [ 622 ], FBXL16 [ 312 ], UCP2 [ 623 ], TOB1 [ 624 ], KLF15 [ 625 ], NAPRT (nicotinatephosphoribosyltransferase) [ 626 ], BNIP3 [ 627 ], ARL6IP1 [ 317 ], MACROD1 [ 628 ], VEGFB (vascular endothelial growth factor B) [ 629 ], ABCA3 [ 630 ], MSRB1 [ 631 ], MVP (major vault protein) [ 632 ], TNK1 [ 633 ], RPL38 [ 634 ], DAPK3 [ 635 ], HINT2 [ 636 ], HSF1 [ 637 ], SIRT7 [ 638 ], ACAT1 [ 457 ], PPP3CC [ 639 ], GLTP (glycolipid transfer protein) [ 640 ], ANG (angiogenin) [ 641 ], CEBPD (CCAAT enhancer binding protein delta) [ 642 ], MAFF (MAF bZIP transcription factor F) [ 643 ], ADH1C [ 644 ], MT2A [ 645 ], SOD3 [ 384 ], ASCL2 [ 646 ], ROMO1 [ 647 ], RGS10 [ 648 ], ELK4 [ 337 ], JPH4 [ 649 ], PFKFB3 [ 650 ], FOXA2 [ 651 ], IRF7 [ 652 ], CXCR3 [ 390 ], IRF5 [ 653 ], SNHG7 [ 341 ], PNPLA2 [ 654 ], HMGB2 [ 655 ], TMUB1 [ 656 ], COX6C [ 657 ], FAM83H [ 658 ], TCFL5 [ 659 ], GPR18 [ 660 ], RNASEH2A [ 661 ], HDAC11 [ 662 ] and PCGF1 [ 351 ] be a potential therapeutic targets for inflammation. Studies had shown that BMP7 [ 663 ], JAG1 [ 664 ], ANXA1 [ 665 ] and KLF15 [ 497 ] were associated with endometrial receptivity. The dysregulation of cellular processes that involve genes include BMP7 [ 666 ], CD4 [ 667 ], ABCA1 [ 668 ], YAP1 [ 669 ], GOT2 [ 670 ], ARMH4 [ 671 ], ISG15 [ 672 ], TSPO (translocator protein) [ 673 ], MIF (macrophage migration inhibitory factor) [ 674 ], UCP2 [ 675 ], GDF15 [ 676 ], SOD3 [ 677 ] and CXCR3 [ 678 ] have been linked to the development of immunomodulation. A recent study also showed that BMP7 [ 679 ], CYP1B1 [ 680 ], CD4 [ 681 ], NNAT (neuronatin) [ 682 ], SYT7 [ 683 ], STRA6 [ 684 ], MMP2 [ 685 ], SEMA4A [ 686 ], PIAS1 [ 687 ], RGN (regucalcin) [ 688 ], USP22 [ 689 ], ADAM9 [ 690 ], CAT (catalase) [ 691 ], ABCA1 [ 692 ], JAK1 [ 693 ], RRM2B [ 572 ], ITGB1 [ 573 ], IGF1R [ 694 ], CHD4 [ 695 ], ATRN (attractin) [ 696 ], BACE1 [ 697 ], KDM4A [ 698 ], APP (amyloid beta precursor protein) [ 699 ], ARL6 [ 700 ], YAP1 [ 701 ], SOS1 [ 702 ], HFE (homeostatic iron regulator) [ 703 ], SLC26A6 [ 704 ], SPAST (spastin) [ 705 ], ARID1A [ 706 ], EIF4G2 [ 707 ], ATM (ATM serine/threonine kinase) [ 708 ], GPX8 [ 709 ], SCARA3 [ 710 ], LAMP2 [ 711 ], FSCN1 [ 712 ], AIG1 [ 713 ], TTC3 [ 597 ], LANCL1 [ 714 ], ASAH1 [ 715 ], CAP1 [ 716 ], GRK3 [ 717 ], VCP (valosin containing protein) [ 718 ], MAT2A [ 719 ], STARD4 [ 720 ], CHD3 [ 721 ], ANG (angiogenin) [ 722 ], ARG2 [ 723 ], ANXA1 [ 724 ], ISG15 [ 725 ], ALDH2 [ 726 ], MIF (macrophage migration inhibitory factor) [ 727 ], ACE (angiotensin I converting enzyme) [ 728 ], GPX1 [ 621 ], UCP2 [ 729 ], KLF15 [ 730 ], CDKN1C [ 731 ], CDKN2D [ 732 ], BNIP3 [ 733 ], MSRB1 [ 734 ], NOL3 [ 735 ], NUDT1 [ 736 ], TXK (TXK tyrosine kinase) [ 737 ], MSRB2 [ 738 ], ATG4D [ 739 ], DAPK3 [ 740 ], HINT2 [ 741 ], HSF1 [ 742 ], SIRT7 [ 743 ], TKT (transketolase) [ 744 ], ANG (angiogenin) [ 745 ], GDF15 [ 746 ], CEBPD (CCAAT enhancer binding protein delta) [ 747 ], PAGE4 [ 748 ], MAFF (MAF bZIP transcription factor F) [ 749 ], MT2A [ 750 ], MGST1 [ 751 ], SOD3 [ 752 ], MT1A [ 753 ], ROMO1 [ 647 ], RGS10 [ 754 ], AGPAT2 [ 755 ], NOXA1 [ 756 ], PFKFB3 [ 757 ], FOXA2 [ 758 ], IRF7 [ 759 ], CXCR3 [ 760 ], PNPLA2 [ 761 ], HMGB2 [ 762 ], NOL3 [ 763 ], EMD (emerin) [ 764 ], COX6C [ 657 ], SLC25A23 [ 765 ] and HDAC11 [ 662 ] improves oxidative stress. Several studies suggested that F13A1 [ 766 ], CCND1 [ 767 ], JAG1 [ 768 ], CD4 [ 226 ], MMP2 [ 769 ], CDK6 [ 770 ], RARB (retinoic acid receptor beta) [ 771 ], PIAS1 [ 772 ], HSP90AA1 [ 773 ], SCARB2 [ 774 ], FURIN (furin, paired basic amino acid cleaving enzyme) [ 775 ], AGTR2 [ 776 ], USP22 [ 777 ], ADAR (adenosine deaminase RNA specific) [ 778 ], HSP90AB1 [ 562 ], PRCP (prolylcarboxypeptidase) [ 779 ], ADAM9 [ 780 ], SLC1A3 [ 781 ], DDX5 [ 782 ], CAT (catalase) [ 569 ], ABCA1 [ 783 ], RAB14 [ 784 ], ZMPSTE24 [ 785 ], JAK1 [ 786 ], IGF1R [ 787 ], PTEN (phosphatase and tensin homolog) [ 788 ], CLTC (clathrin heavy chain) [ 789 ], MSH3 [ 790 ], MOV10 [ 791 ], APP (amyloid beta precursor protein) [ 792 ], CCDC88A [ 793 ], RBMX (RNA binding motif protein X-linked) [ 794 ], UFL1 [ 795 ], ATRX (ATRX chromatin remodeler) [ 796 ], SRSF1 [ 797 ], YAP1 [ 798 ], ARID1A [ 799 ], ATM (ATM serine/threonine kinase) [ 800 ], HACD3 [ 801 ], LAMP2 [ 802 ], STAT2 [ 803 ], ANO6 [ 804 ], VCP (valosin containing protein) [ 805 ], HCFC2 [ 806 ], CUL1 [ 807 ], SLC39A9 [ 808 ], GOPC (golgi associated PDZ and coiled-coil motif containing) [ 809 ], MAP1LC3C [ 810 ], API5 [ 811 ], DDX24 [ 812 ], LARP4 [ 813 ], M6PR [ 814 ], ST3GAL2 [ 607 ], CAND1 [ 815 ], MAT2A [ 816 ], TRIM22 [ 817 ], TRIM5 [ 818 ], ARL5B [ 819 ], CAPN5 [ 820 ], ANG (angiogenin) [ 821 ], HPSE (heparanase) [ 822 ], TMPRSS13 [ 823 ], ARG2 [ 824 ], CLDN4 [ 825 ], IFI27 [ 826 ], ANXA1 [ 827 ], ISG15 [ 828 ], CDKN1A [ 829 ], TSPO (translocator protein) [ 830 ], MIF (macrophage migration inhibitory factor) [ 831 ], ACE (angiotensin I converting enzyme) [ 832 ], GPX1 [ 833 ], SPSB2 [ 834 ], PRSS8 [ 835 ,] KLF15 [ 836 ], RILP (Rab interacting lysosomal protein) [ 837 ], BNIP3 [ 838 ], CAMLG (calcium modulating ligand) [ 839 ], ABCA3 [ 840 ], MVP (major vault protein) [ 841 ], AGO4 [ 842 ], DAPK3 [ 843 ], HSPBP1 [ 844 ], HSF1 [ 845 ], ANG (angiogenin) [ 846 ], GDF15 [ 847 ], SOD3 [ 848 ], ZNF683 [ 849 ], RGS10 [ 850 ], IRF7 [ 338 ], CXCR3 [ 851 ], SLA2 [ 852 ], IRF5 [ 853 ], HMGB2 [ 854 ], RHEBL1 [ 855 ], MAF1 [ 856 ], AADAC (arylacetamidedeacetylase) [ 857 ], GPR18 [ 345 ] and HDAC11 [ 858 ] might serve as therapeutic targets for viral infections. F13A1 [ 859 ], CYP1B1 [ 860 ], CD4 [ 861 ], MMP2 [ 862 ], FURIN (furin, paired basic amino acid cleaving enzyme) [ 863 ], CAT (catalase) [ 864 ], ROBO1 [ 865 ], JAK1 [ 866 ], IGF1R [ 867 ], PTEN (phosphatase and tensin homolog)) [ 868 ], AGO1 [ 869 ], IGF2R [ 870 ], CPLANE1 [ 871 ], FBN2 [ 872 ], YAP1 [ 873 ], KIDINS220 [ 874 ], PEG10 [ 875 ], CUL1 [ 876 ], CDKN1A [ 877 ], MIF (macrophage migration inhibitory factor) [ 878 ], ACE (angiotensin I converting enzyme) [ 879 ], GPX1 [ 880 ], F2 [ 881 ], UCP2 [ 882 ], CDKN1C [ 883 ], BNIP3 [ 884 ], FN3KRP [ 885 ], GDF15 [ 886 ], ROMO1 [ 887 ], CXCR3 [ 888 ], IRF5 [ 889 ], SNHG7 [ 890 ] and TMUB1 [ 656 ] might have a significant role in the development of recurrent spontaneous abortion. Recent research indicated that HSD11B1 [ 891 ], CD4 [ 892 ], ITGA9 [ 893 ], MMP2 [ 894 ], SLC31A1 [ 895 ], GNA12 [ 896 ], HSF2 [ 897 ], TNFSF11 [ 898 ], HSP90AA1 [ 899 ], CORIN (corin, serine peptidase) [ 900 ], AGTR2 [ 901 ], USP22 [ 902 ], PRCP (prolylcarboxypeptidase) [ 903 ], ADAM9 [ 902 ], ABCA1 [ 904 ], ITGB1 [ 905 ], RBFOX2 [ 906 ], IGF1R [ 907 ], PTEN (phosphatase and tensin homolog) [ 908 ], SLC23A2 [ 909 ], MOV10 [ 910 ], APP (amyloid beta precursor protein) [ 911 ], MYLIP (myosin regulatory light chain interacting protein) [ 912 ], YAP1 [ 908 ], ARID1A [ 913 ], PEG10 [ 914 ], NFAT5 [ 915 ], VCP (valosin containing protein) [ 916 ], ANG (angiogenin) [ 917 ], HPSE (heparanase) [ 918 ], ARG2 [ 919 ], CLDN3 [ 920 ], ANXA1 [ 921 ], ISG15 [ 922 ], CDKN1A [ 923 ], MIF (macrophage migration inhibitory factor) [ 924 ], ACE (angiotensin I converting enzyme) [ 925 ], GPX1 [ 926 ], UCP2 [ 927 ], CDKN1C [ 928 ], BNIP3 [ 733 ], DDAH2 [ 929 ], RPL39 [ 930 ], CAPN10 [ 931 ], COPS9 [ 932 ], HSF1 [ 933 ], ANG (angiogenin) [ 934 ], GDF15 [ 935 ], SOD3 [ 936 ], PPP1R3G [ 937 ], TMBIM4 [ 938 ], SNHG7 [ 939 ] and ANKRD37 [ 940 ] might be considered as a pathogenic genetic factors for preeclampsia. The CCND1 [ 941 ], CD4 [ 942 ], USP22 [ 943 ], ADAM9 [ 944 ], CAT (catalase) [ 945 ], IGF1R [ 946 ], KDM4A [ 947 ], ATRX (ATRX chromatin remodeler) [ 271 ], DNAJC9 [ 948 ], CUL1 [ 949 ] and HPSE (heparanase) [ 950 ] plays a crucial role in establishing chromosomal abnormalities. CYP1B1 [ 951 ], CD4 [ 952 ], STRA6 [ 953 ], PLA2R1 [ 954 ], HSP90AA1 [ 955 ], DDX5 [ 956 ], CAT (catalase) [ 957 ], ZMPSTE24 [ 958 ], ITGB1 [ 959 ], IGF1R [ 960 ], PTEN (phosphatase and tensin homolog) [ 961 ], CHD4 [ 962 ], KDM4A [ 963 ], APP (amyloid beta precursor protein) [ 964 ], RBMX (RNA binding motif protein X-linked) [ 965 ], ATRX (ATRX chromatin remodeler) [ 966 ], MSI2 [ 967 ], SRSF1 [ 968 ], DHX36 [ 969 ], YAP1 [ 970 ], ARID1A [ 971 ], ATM (ATM serine/threonine kinase) [ 972 ], HSD17B6 [ 973 ], STAT2 [ 974 ], VCP (valosin containing protein) [ 975 ], UBA1 [ 976 ], TNKS (tankyrase) [ 977 ], MAT2A [ 978 ], CHD3 [ 979 ], HPSE (heparanase) [ 980 ], CLDN4 [ 981 ], ISG15 [ 982 ], CDKN1A [ 983 ], ALDH2 [ 984 ], KSR1 [ 985 ], MIF (macrophage migration inhibitory factor) [ 986 ], ACE (angiotensin I converting enzyme) [ 987 ], GPX1 [ 988 ], BNIP3 [ 989 ], MVP (major vault protein) [ 990 ], FLOT1 [ 991 ], NUDT1 [ 992 ], COPS9 [ 993 ], HSF1 [ 994 ], SIRT7 [ 995 ], MOB2 [ 996 ], TKT (transketolase) [ 997 ], ADH1B [ 998 ], CEBPD (CCAAT enhancer binding protein delta) [ 999 ], SOD3 [ 1000 ], IRF5 [ 1001 ] and PIERCE1 [ 1002 ] were recently found to be a promoter of DNA damage. CD4 [ 1003 ], TGFB3 [ 1004 ], STRA6 [ 548 ], CORIN (corin, serine peptidase) [ 900 ], CAT (catalase) [ 1005 ], ABCA1 [ 1006 ], IGF1R [ 1007 ], PTEN (phosphatase and tensin homolog) [ 1008 ], IGF2R [ 1009 ], SOS1 [ 1010 ], SLC26A6 [ 1011 ], M6PR [ 1012 ], ANG (angiogenin) [ 1013 ], CLDN4 [ 1014 ], ANXA1 [ 1015 ], MIF (macrophage migration inhibitory factor) [ 1016 ], ACE (angiotensin I converting enzyme) [ 1017 ], CAPN10 [ 1018 ], SIRT7 [ 1019 ], ANG (angiogenin) [ 1020 ] and GDF15 [ 1021 ] were found to be linked with gestational diabetes mellitus. TGFB3 [ 1022 ], HSF2 [ 1023 ], HSP90AA1 [ 1024 ], ITPR1 [ 1025 ], TAF7L [ 1026 ], CAT (catalase) [ 1027 ], ABCA1 [ 1028 ], PTEN (phosphatase and tensin homolog) [ 1029 ], IGF2R [ 1030 ], PRKAR1A [ 1031 ], DHX36 [ 1032 ], YAP1 [ 1033 ], HFE (homeostatic iron regulator) [ 1034 ], CHD7 [ 1035 ], CCDC188 [ 1036 ], DCAF17 [ 1037 ], ALDH2 [ 1038 ], ACE (angiotensin I converting enzyme) [ 1039 ], GPX1 [ 1027 ], ND3 [ 1040 ], TPST2 [ 1041 ], ATG4D [ 1042 ], UBE2B [ 1043 ], MT1A [ 753 ] and MTMR14 [ 1044 ] could potentially play a role in the onset of male infertility. CDKN2C [ 1045 ], SLC26A6 [ 1046 ] and ACE (angiotensin I converting enzyme) [ 1047 ] have been identified the involvement in hyperparathyroidism. Altered level of IGF1R [ 1048 ], PTEN (phosphatase and tensin homolog) [ 1049 ], AGO1 [ 1050 ], ND2 [ 1051 ], MAT2A [ 1052 ], HPSE (heparanase) [ 1053 ], CLDN4 [ 1054 ] and CLDN3[ 1054 ] can facilitate RIF. These research findings concur with those from this investigation, which suggest that enriched genes might have a role in the pathophysiology of RIF, and the enrichment analysis of GO terms and pathways also suggests that enriched genes might participate in the autoimmunity, endometrial cancer, psychosocial consequences, insulin resistance, obesity, endometriosis, polycystic ovary syndrome, inflammation, endometrial receptivity, immunomodulation, oxidative stress, viral infections, recurrent spontaneous abortion, preeclampsia, chromosomal abnormalities, DNA damage, gestational diabetes mellitus, male infertility and hyperparathyroidism. PPI networks of the DEGs in RIF were analyzed by using IMex interactome database. These analyses could help to find some key factors involved in the regulation of RIF and its associated complications. We identified hub genes from the PPI networks. Several hub genes have been reported to be related to RIF and its associated complications. APP (amyloid beta precursor protein) [ 124 ], CDKN1A [ 134 ] and ISG15 [ 133 ] might serve as genetic markers of autoimmunity. Expression of APP (amyloid beta precursor protein) [ 124 ], HSP90AA1 [ 557 ], CUL1 [ 603 ], HSP90AB1 [ 562 ], SIRT7 [ 638 ], CDKN1A [ 134 ], ISG15 [ 616 ], HSPA4 [ 301 ], CUL5 [ 1055 ] and VCP (valosin containing protein) [ 602 ] promotes the development of inflammation. APP (amyloid beta precursor protein) [ 268 ], HSP90AA1 [ 239 ], SIRT7 [ 329 ], HSPA4 [ 301 ] and VCP (valosin containing protein) [ 296 ] are associated to the risk of psychosocial consequences. APP (amyloid beta precursor protein) [ 363 ] is found to be associated with insulin resistance. Some studies have shown that APP (amyloid beta precursor protein) [ 418 ], SIRT7 [ 456 ] and UBB (ubiquitin B) [ 399 ] plays a key role in obesity. Altered expression of APP (amyloid beta precursor protein) [ 699 ], SIRT7 [ 743 ], ISG15 [ 725 ] and VCP (valosin containing protein) [ 718 ] promotes oxidative stress. A previous study reported that the APP (amyloid beta precursor protein) [ 792 ], HSP90AA1 [ 773 ], CAND1 [ 815 ], CUL1 [ 807 ], HSP90AB1 [ 562 ], CDKN1A [ 829 ], ISG15 [ 828 ], CUL5 [ 1056 ] and VCP (valosin containing protein) [ 805 ] genes were associated with viral infections. Altered expression of APP (amyloid beta precursor protein) [ 911 ], HSP90AA1 [ 899 ], CDKN1A [ 923 ], ISG15 [ 922 ], VCP (valosin containing protein) [ 916 ] and RBFOX2 [ 906 ] are associated with prognosis in patients with preeclampsia. APP (amyloid beta precursor protein) [ 964 ], HSP90AA1 [ 955 ], SIRT7 [ 995 ], CDKN1A [ 983 ], ISG15 [ 982 ] and VCP (valosin containing protein) [ 975 ] are involved in DNA damage progression. HSP90AA1 [ 1024 ] gene is a potential marker for the detection and prognosis of male infertility at an early age. A previous study reported that CUL1 [ 876 ] and CDKN1A [ 877 ] are altered expression in recurrent spontaneous abortion. Research has revealed that CUL1 [ 949 ] is expressed in chromosomal abnormalities. SIRT7 [ 204 ], CDKN1A [ 193 ], ISG15 [ 192 ], CUL5 [ 1057 ] and RBFOX2 [ 169 ] have been found to have a strong association with endometrial cancer. SIRT7 [ 1019 ] was an important target gene of gestational diabetes mellitus. CDKN1A [ 491 ] has been reported to be expressed in endometriosis. The expression pattern of CDKN1A [ 523 ] might offer useful information for treating polycystic ovary syndrome. ISG15 [ 672 ] gene is associated with immunomodulation. New biomarkers associated with diagnosis were identified in this investigation: SRC (SRC proto-oncogene, non-receptor tyrosine kinase). RPS16, POLR2B, YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta), YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta), RPL13, RPS27L, RPS7 and RPS21. These hub genes might contribute to a better understanding of the molecular mechanisms underlying the pathogenesis of RIF and its associated complications. We constructed a miRNA-hub gene regulatory network and TF-hub gene regulatory network for these hub genes and screened for a top-scoring miRNAs and TFs. Meanwhile, we found that miRNAs and TFs were involved in the whole process of RIF progression. CLTC (clathrin heavy chain) [ 263 ], HSP90AA1 [ 239 ], APP (amyloid beta precursor protein) [ 268 ], GABARAP (GABA type A receptor-associated protein) [ 1058 ], hsa-miR-574-3p [ 1059 ], hsa-mir-208a-3p [ 1060 ], hsa-miR-218-5p [ 1061 ], SREBF1 [ 1062 ], BRCA1 [ 1063 ], MAX (MYC associated factor X) [ 1064 ] and NR2E3 [ 1065 ] are known to be involved in the development of psychosocial consequences. Studies have indicated that CLTC (clathrin heavy chain) [ 579 ], HSP90AB1 [ 562 ], HSP90AA1 [ 557 ], APP (amyloid beta precursor protein) [ 124 ], CDKN1A [ 134 ], GABARAP (GABA type A receptor-associated protein) [ 1066 ], CUL5 [ 1055 ], DDX5 [ 568 ], ISG15 [ 616 ], SREBF1 [ 1067 ], IRF2 [ 1068 ], BRCA1 [ 1069 ], MAX (MYC associated factor X) [ 1070 ] and NR2E3 [ 1071 ] plays a substantial role in inflammation. CLTC (clathrin heavy chain) [ 789 ], CAND1 [ 815 ], HSP90AB1 [ 562 ], HSP90AA1 [ 773 ], APP (amyloid beta precursor protein) [ 792 ], CDKN1A [ 829 ], CUL5 [ 1056 ], DDX5 [ 782 ], ISG15 [ 828 ], GATA3 [ 1072 ], IRF2 [ 1073 ] and BRCA1 [ 1074 ] are associated with the progression of viral infections. HSP90AA1 [ 899 ], APP (amyloid beta precursor protein) [ 911 ], CDKN1A [ 923 ], ISG15 [ 922 ], hsa-mir-31-5p [ 1075 ], hsa-miR-218-5p [ 1076 ], hsa-mir-205-5p [ 1077 ] and GATA3 [ 1078 ] are a critical biomarkers and are widely involved in preeclampsia. HSP90AA1 [ 955 ], APP (amyloid beta precursor protein) [ 964 ], CDKN1A [ 983 ], DDX5 [ 956 ], ISG15 [ 982 ], SREBF1 [ 1079 ], ARID3A [ 1080 ] and GATA3 [ 1081 ] were identified to be closely associated with DNA damage, HSP90AA1 [ 1024 ] and BRCA1 [ 1082 ] can be used as an important therapeutic targets for male infertility. APP (amyloid beta precursor protein) [ 124 ], CDKN1A [ 134 ], ISG15 [ 133 ], hsa-mir-216b-5p [ 1083 ], ARID3A [ 1084 ], GATA3 [ 1085 ], IRF2 [ 1086 ] and BRCA1 [ 1087 ] were found to be altered expression in autoimmunity patients. APP (amyloid beta precursor protein) [ 363 ], SREBF1 [ 1088 ] and GATA3 [ 1089 ] were significantly associated with insulin resistance. APP (amyloid beta precursor protein) [ 418 ], HRAS (HRas proto-oncogene, GTPase) [ 451 ], EMD (emerin) [ 466 ], hsa-mir-205-5p [ 1090 ], SREBF1 [ 1091 ], GATA3 [ 1089 ] and BRCA1 [ 1092 ] are a therapeutic targets for obesity. The altered expression of APP (amyloid beta precursor protein) [ 699 ], EMD (emerin) [ 764 ], ISG15 [ 725 ], SREBF1 [ 1093 ], IRF2 [ 1094 ], BRCA1 [ 1092 ] and NR2E3 [ 1095 ] are associated with oxidative stress. CDKN1A [ 877 ], GATA3 [ 1096 ] and MAX (MYC associated factor X) [ 1097 ] have become a potential biomarker for recurrent spontaneous abortion. CDKN1A [ 193 ], CUL5 [ 1057 ], DDX5 [ 165 ], ISG15 [ 192 ], SREBF1 [ 1098 ], GATA3 [ 1099 ], BRCA1 [ 1100 ] and MAX (MYC associated factor X) [ 1101 ] promotes the initialization and development of endometrial cancer. CDKN1A [ 491 ], hsa-miR-574-3p [ 1102 ], GATA3 [ 1103 ] and BRCA1 [ 1104 ] are a potential targets for endometriosis therapy. CDKN1A [ 523 ], MAP1LC3A [ 534 ], hsa-mir-208a-3p [ 1105 ], SREBF1 [ 1106 ] and BRCA1 [ 1107 ] play important roles in polycystic ovary syndrome growth and progression. ISG15 [ 672 ], GATA3 [ 1089 ] and BRCA1 [ 1108 ] are expected to become a predictive biomarkers for a immunomodulation. hsa-miR-218-5p [ 1109 ] and SREBF1 [ 1110 ] were significantly associated with prognosis of gestational diabetes mellitus. hsa-mir-205-5p [ 1111 ] and SREBF1 [ 1112 ] makes a vital regulatory role in endometrial receptivity. Some studies have reported that upregulated GATA3 [ 1113 ] and MAX (MYC associated factor X) [ 1114 ] correlates with prognosis in hyperparathyroidism. BRCA1 [ 1115 ] vital for the development of chromosomal abnormalities. There were intersected to finally obtain novel biomarkers related to RIP and its associated complication, which included the following: RPS16, MAP1LC3B, SRC (SRC proto-oncogene, non-receptor tyrosine kinase), YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta), hsa-mir-382-5p, miR-218-1-3p, hsa-mir-548ad-5p, hsa-mir-6132, RELA (RELA proto-oncogene, NF-kB subunit), TFAP2C and SPIB (Spi-B transcription factor). In short, focusing on miRNAs and TFs regulations could provide potential approaches for the treatment of RIP and its associated complication. Conclusions In the current investigation, we identified 958 significant DEGs in RIF. Therefore, the results in this investigation provided reliable key genes and signaling pathways for RIP and its associated complication, which will be useful for RIF molecular mechanisms, diagnosis and candidate targeted treatment. However, further investigations are needed to investigate the potential impact of these genes and signaling pathways on RIP progression, in order to fully validate their role in RIP. Conflict of interest The authors declare that they have no conflict of interest. Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors. Informed consent No informed consent because this study does not contain human or animals participants. Availability of data and materials The datasets supporting the conclusions of this article are available in the GEO (Gene Expression Omnibus) ( https://www.ncbi.nlm.nih.gov/geo/ ) repository. [(GSE243550) https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE243550 ] Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Author Contributions B. V. - Writing original draft, and review and editing C. V. - Software and investigation Acknowledgement I thanks very much to Fan Y, Shi C, Huang N, Fang F, Tian L, Wang J, Peking University People’s Hospital, Beijing, China, the authors who deposited their NGS dataset GSE243550, into the public GEO database. References 1. ↵ Diedrich K , Fauser BC , Devroey P , Griesinger G; Evian Annual Reproduction (EVAR) Workshop Group. The role of the endometrium and embryo in human implantation . Hum Reprod Update . 2007 ; 13 ( 4 ): 365 – 377 . doi: 10.1093/humupd/dmm011 OpenUrl CrossRef PubMed Web of Science 2. ↵ Meldrum DR , Silverberg KM , Bustillo M , Stokes L . Success rate with repeated cycles of in vitro fertilization-embryo transfer . Fertil Steril . 1998 ; 69 ( 6 ): 1005 – 1009 . doi: 10.1016/s0015-0282(98)00083-1 OpenUrl CrossRef PubMed Web of Science 3. ↵ Coughlan C , Ledger W , Wang Q , Liu F , Demirol A , Gurgan T , Cutting R , Ong K , Sallam H , Li TC . Recurrent implantation failure: definition and management . Reprod Biomed Online . 2014 ; 28 ( 1 ): 14 – 38 . doi: 10.1016/j.rbmo.2013.08.011 OpenUrl CrossRef PubMed 4. ↵ Busnelli A , Reschini M , Cardellicchio L , Vegetti W , Somigliana E , Vercellini P . How common is real repeated implantation failure? An indirect estimate of the prevalence . Reprod Biomed Online . 2020 ; 40 ( 1 ): 91 – 97 . doi: 10.1016/j.rbmo.2019.10.014 OpenUrl CrossRef PubMed 5. ↵ Ma J , Gao W , Li D . Recurrent implantation failure: A comprehensive summary from etiology to treatment . Front Endocrinol (Lausanne ). 2023 ; 13 : 1061766 . doi: 10.3389/fendo.2022.1061766 OpenUrl CrossRef 6. ↵ DiMarco A , Christakis I , Constantinides V , Regan L , Palazzo FF . Undiagnosed Primary Hyperparathyroidism and Recurrent Miscarriage: The First Prospective Pilot Study . World J Surg . 2018 ; 42 ( 3 ): 639 – 645 . doi: 10.1007/s00268-017-4395-7 OpenUrl CrossRef PubMed 7. ↵ Wang Y , Zhao H , Li Y , Zhang J , Tan J , Liu Y . Relationship between recurrent miscarriage and insulin resistance . Gynecol Obstet Invest . 2011 ; 72 ( 4 ): 245 – 251 . doi: 10.1159/000325165 OpenUrl CrossRef PubMed 8. ↵ Cavalcante MB , Sarno M , Peixoto AB , Araujo Júnior E , Barini R . Obesity and recurrent miscarriage: A systematic review and meta-analysis . J Obstet Gynaecol Res . 2019 ; 45 ( 1 ): 30 – 38 . doi: 10.1111/jog.13799 OpenUrl CrossRef PubMed 9. ↵ Fukui A , Kamoi M , Funamizu A , Fuchinoue K , Chiba H , Yokota M , Fukuhara R , Mizunuma H . NK cell abnormality and its treatment in women with reproductive failures such as recurrent pregnancy loss, implantation failures, preeclampsia, and pelvic endometriosis . Reprod Med Biol . 2015 ; 14 ( 4 ): 151 – 157 . doi: 10.1007/s12522-015-0207-7 OpenUrl CrossRef PubMed 10. ↵ Puscheck EE , Jeyendran RS . The impact of male factor on recurrent pregnancy loss . Curr Opin Obstet Gynecol . 2007 ; 19 ( 3 ): 222 – 228 . doi: 10.1097/GCO.0b013e32813e3ff0 OpenUrl CrossRef PubMed 11. ↵ Zhong C , Gao L , Shu L , Hou Z , Cai L , Huang J , Liu J , Mao Y . Analysis of IVF/ICSI Outcomes in Endometriosis Patients With Recurrent Implantation Failure: Influence on Cumulative Live Birth Rate . Front Endocrinol (Lausanne ). 2021 ; 12 : 640288 . doi: 10.3389/fendo.2021.640288 OpenUrl CrossRef 12. ↵ Lee S , Arffman RK , Komsi EK , Lindgren O , Kemppainen JA , Metsola H , Rossi HR , Ahtikoski A , Kask K , Saare M , et al. AI-algorithm training and validation for identification of endometrial CD138+ cells in infertility-associated conditions; polycystic ovary syndrome (PCOS) and recurrent implantation failure (RIF) . J Pathol Inform . 2024 ; 15 : 100380 . doi: 10.1016/j.jpi.2024.100380 OpenUrl CrossRef 13. ↵ Wang Q , Sun Y , Fan R , Wang M , Ren C , Jiang A , Yang T . Role of inflammatory factors in the etiology and treatment of recurrent implantation failure . Reprod Biol . 2022 ; 22 ( 4 ): 100698 . doi: 10.1016/j.repbio.2022.100698 OpenUrl CrossRef PubMed 14. ↵ Kwak-Kim J , Skariah A , Wu L , Salazar D , Sung N , Ota K . Humoral and cellular autoimmunity in women with recurrent pregnancy losses and repeated implantation failures: A possible role of vitamin D . Autoimmun Rev . 2016 ; 15 ( 10 ): 943 – 947 . doi: 10.1016/j.autrev.2016.07.015 OpenUrl CrossRef PubMed 15. ↵ Gambadauro P , Gudmundsson J . Endometrial cancer in a woman undergoing hysteroscopy for recurrent IVF failure . Gynecol Surg . 2017 ; 14 ( 1 ): 4 . doi: 10.1186/s10397-017-1009-1 OpenUrl CrossRef PubMed 16. ↵ Ohara Y , Matsubayashi H , Suzuki Y , Takaya Y , Yamaguchi K , Doshida M , Takeuchi T , Ishikawa T , Handa M , Miyake T , et al. Clinical relevance of a newly developed endometrial receptivity test for patients with recurrent implantation failure in Japan . Reprod Med Biol. 2022 ; 21 ( 1 ): e12444 . doi: 10.1002/rmb2.12444 OpenUrl CrossRef PubMed 17. ↵ Newton CR , Hearn MT , Yuzpe AA . Psychological assessment and follow-up after in vitro fertilization: assessing the impact of failure . Fertil Steril . 1990 ; 54 ( 5 ): 879 – 886 . doi: 10.1016/s0015-0282(16)53950-8 OpenUrl CrossRef PubMed Web of Science 18. ↵ Safdarian L , Najmi Z , Aleyasin A , Aghahosseini M , Rashidi M , Asadollah S . Recurrent IVF failure and hereditary thrombophilia . Iran J Reprod Med . 2014 ; 12 ( 7 ): 467 – 470 . OpenUrl PubMed 19. ↵ Cernera G , Liguori R , Bruzzese D , Castaldo G , De Placido G , Conforti A , Amato F , Alviggi C , Comegna M . The relevance of prothrombotic genetic variants in women who experienced pregnancy loss or embryo implantation failure: A retrospective analysis of 1922 cases . Int J Gynaecol Obstet . 2024 ; 165 ( 1 ): 148 – 154 . doi: 10.1002/ijgo.15282 OpenUrl CrossRef PubMed 20. ↵ De Sutter P , Stadhouders R , Dutré M , Gerris J , Dhont M . Prevalence of chromosomal abnormalities and timing of karyotype analysis in patients with recurrent implantation failure (RIF) following assisted reproduction . Facts Views Vis Obgyn . 2012 ; 4 ( 1 ): 59 – 65 . OpenUrl PubMed 21. ↵ Rezaei M , Moghoofei M . The role of viral infection in implantation failure: direct and indirect effects . Reprod Biol Endocrinol . 2024 ; 22 ( 1 ): 142 . doi: 10.1186/s12958-024-01303-w OpenUrl CrossRef PubMed 22. ↵ Chen H , Fu J , Huang W . Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent miscarriage history . Cochrane Database Syst Rev . 2016 ; 7 ( 7 ):CD008883. doi: 10.1002/14651858.CD008883.pub2 OpenUrl CrossRef 23. ↵ Khairy M , Harb H , Eapen A , Melo P , Kazem R , Rajkhowa M , Ndukuwe G , Coomarasamy A . The use of immunomodulation therapy in women with recurrent implantation failure undergoing assisted conception: A multicentre cohort study . Am J Reprod Immunol . 2024 ; 91 ( 2 ): e13819 . doi: 10.1111/aji.13819 OpenUrl CrossRef PubMed 24. ↵ Ata B , Kalafat E , Somigliana E . A new definition of recurrent implantation failure on the basis of anticipated blastocyst aneuploidy rates across female age . Fertil Steril . 2021 ; 116 ( 5 ): 1320 – 1327 . doi: 10.1016/j.fertnstert.2021.06.045 OpenUrl CrossRef PubMed 25. ↵ Rokhsartalab Azar P , Karimi S , Haghtalab A , Taram S , Hejazi M , Sadeghpour S , Pashaei MR , Ghasemnejad-Berenji H , Taheri-Anganeh M. The role of the endometrial microbiome in embryo implantation and recurrent implantation failure . J Reprod Immunol . 2024 ; 162 : 104192 . doi: 10.1016/j.jri.2024.104192 OpenUrl CrossRef PubMed 26. ↵ Saravelos SH , Yan J , Rehmani H , Li TC . The prevalence and impact of fibroids and their treatment on the outcome of pregnancy in women with recurrent miscarriage . Hum Reprod . 2011 ; 26 ( 12 ): 3274 – 3279 . doi: 10.1093/humrep/der293 OpenUrl CrossRef PubMed Web of Science 27. ↵ Ping P , Liu Y , Zheng Z , Ma Y , Dong F , Chen X . Association of embryo aneuploidy and sperm DNA damage in unexplained recurrent implantation failure patients under NGS-based PGT-A cycles . Arch Gynecol Obstet . 2023 ; 308 ( 3 ): 997 – 1005 . doi: 10.1007/s00404-023-07098-2 OpenUrl CrossRef PubMed 28. ↵ Sheikhansari G , Soltani-Zangbar MS , Pourmoghadam Z , Kamrani A , Azizi R , Aghebati-Maleki L , Danaii S , Koushaeian L , Hojat-Farsangi M , Yousefi M . Oxidative stress, inflammatory settings, and microRNA regulation in the recurrent implantation failure patients with metabolic syndrome . Am J Reprod Immunol . 2019 ; 82 ( 4 ): e13170 . doi: 10.1111/aji.13170 OpenUrl CrossRef PubMed 29. ↵ Farhi J , Ben-Haroush A , Dresler H , Pinkas H , Sapir O , Fisch B . Male factor infertility, low fertilisation rate following ICSI and low number of high-quality embryos are associated with high order recurrent implantation failure in young IVF patients . Acta Obstet Gynecol Scand . 2008 ; 87 ( 1 ): 76 – 80 . doi: 10.1080/00016340701743074 OpenUrl CrossRef PubMed 30. ↵ Wang F , Liu Y . Identification of key genes, regulatory factors, and drug target genes of recurrent implantation failure (RIF) . Gynecol Endocrinol . 2020 ; 36 ( 5 ): 448 – 455 . doi: 10.1080/09513590.2019.1680622 OpenUrl CrossRef PubMed 31. ↵ Coulam CB , Jeyendran RS , Fishel LA , Roussev R . Multiple thrombophilic gene mutations are risk factors for implantation failure . Reprod Biomed Online . 2006 ; 12 ( 3 ): 322 – 327 . doi: 10.1016/s1472-6483(10)61004-8 OpenUrl CrossRef PubMed Web of Science 32. ↵ Arias-Sosa LA , Acosta ID , Lucena-Quevedo E , Moreno-Ortiz H , Esteban-Pérez C , Forero-Castro M . Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss . J Assist Reprod Genet . 2018 ; 35 ( 3 ): 355 – 366 . doi: 10.1007/s10815-017-1108-y OpenUrl CrossRef PubMed 33. ↵ Bastu E , Demiral I , Gunel T , Ulgen E , Gumusoglu E , Hosseini MK , Sezerman U , Buyru F , Yeh J. otential Marker Pathways in the Endometrium That May Cause Recurrent Implantation Failure . Reprod Sci . 2019 ; 26 ( 7 ): 879 – 890 . doi: 10.1177/1933719118792104 OpenUrl CrossRef PubMed 34. ↵ Nowak I , Wilczyńska K , Wilczyński JR , Malinowski A , Radwan P , Radwan M , Kuśnierczyk P. KIR , LILRB and their Ligands’ Genes as Potential Biomarkers in Recurrent Implantation Failure . Arch Immunol Ther Exp (Warsz ). 2017 ; 65 ( 5 ): 391 – 399 . doi: 10.1007/s00005-017-0474-6 OpenUrl CrossRef PubMed 35. ↵ Piekarska K , Radwan P , Tarnowska A , Radwan M , Wilczyński JR , Malinowski A , Nowak I . ERAP/HLA-C and KIR Genetic Profile in Couples with Recurrent Implantation Failure . Int J Mol Sci . 2022 ; 23 ( 20 ): 12518 . doi: 10.3390/ijms23201251 OpenUrl CrossRef PubMed 36. ↵ Zhang XX , Zhang ZC , Liu YS , Zhou L , Hu YQ , Zhang CH , Song WH , Wu XH . Bioinformatic Analysis of the Significance of the KIR2DL4 Gene in Recurrent Implantation Failure . Biochem Genet . 2024 . doi: 10.1007/s10528-024-10857-8 OpenUrl CrossRef 37. ↵ Kwon MJ , Kim JH , Kim KJ , Ko EJ , Lee JY , Ryu CS , Ha YH , Kim YR , Kim NK . Genetic Association between Inflammatory-Related Polymorphism in STAT3, IL-1β, IL-6, TNF-α and Idiopathic Recurrent Implantation Failure . Genes (Basel) . 2023 ; 14 ( 8 ): 1588 . doi: 10.3390/genes14081588 OpenUrl CrossRef PubMed 38. ↵ Choi Y , Kim JO , Shim SH , Lee Y , Kim JH , Jeon YJ , Ko JJ , Lee WS , Kim NK . Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure . PLoS One . 2016 ; 11 ( 8 ): e0160884 . doi: 10.1371/journal.pone.0160884 OpenUrl CrossRef PubMed 39. ↵ Zhou Q , Yan G , Ding L , Liu J , Yu X , Kong S , Zhang M , Wang Z , Liu Y , Jiang Y , et al. HD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure . EBioMedicine . 2019 ; 50 : 343 – 354 . doi: 10.1016/j.ebiom.2019.10.018 OpenUrl CrossRef PubMed 40. ↵ Fu H , Tan W , Chen Z , Ye Z , Duan Y , Huang J , Qi H , Liu X . TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway . Reprod Biol Endocrinol . 2022 ; 20 ( 1 ): 142 . doi: 10.1186/s12958-022-01013-1 OpenUrl CrossRef PubMed 41. ↵ Li H , Sun N , Zhu Y , Wang W , Cai M , Luo X , Xia W , Quan S . Growth hormone inhibits the JAK/STAT3 pathway by regulating SOCS1 in endometrial cells in vitro: a clue to enhance endometrial receptivity in recurrent implantation failure . Eur J Histochem . 2023 ; 67 ( 1 ): 3580 . doi: 10.4081/ejh.2023.3580 OpenUrl CrossRef PubMed 42. ↵ Chen X , Qi L , Zhao C , Xue J , Chen M , Diao L , He W , Lv B , Zeng Y , Xue Z . Decreased expression of SEMA4D in recurrent implantation failure induces reduction of trophoblast invasion and migration via the Met/PI3K/Akt pathway . J Reprod Immunol . 2022 ; 153 : 103657 . doi: 10.1016/j.jri.2022.103657 OpenUrl CrossRef 43. ↵ Zhang H , Wang Z , Zhou Q , Cao Z , Jiang Y , Xu M , Liu J , Zhou J , Yan G , Sun H . Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway . J Assist Reprod Genet . 2023 ; 40 ( 5 ): 1135 – 1146 . doi: 10.1007/s10815-023-02762-7 OpenUrl CrossRef PubMed 44. ↵ Pujar M , Vastrad B , Kavatagimath S , Vastrad C , Kotturshetti S . Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis . Sci Rep . 2022 ; 12 ( 1 ): 9157 . doi: 10.1038/s41598-022-13291-1 OpenUrl CrossRef PubMed 45. ↵ Ganekal P , Vastrad B , Vastrad C , Kotrashetti S . Identification of biomarkers, pathways, and potential therapeutic targets for heart failure using next-generation sequencing data and bioinformatics analysis . Ther Adv Cardiovasc Dis . 2023 ; 17 : 17539447231168471 . doi: 10.1177/17539447231168471 OpenUrl CrossRef PubMed 46. ↵ Clough E , Barrett T . The Gene Expression Omnibus Database . Methods Mol Biol . 2016 ; 1418 : 93 – 110 . doi: 10.1007/978-1-4939-3578-9_5 OpenUrl CrossRef PubMed 47. ↵ Ritchie ME , Phipson B , Wu D , Hu Y , Law CW , Shi W , Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies . Nucleic Acids Res . 2015 ; 43 ( 7 ): e47 . doi: 10.1093/nar/gkv007 OpenUrl CrossRef PubMed 48. ↵ Green GH , Diggle PJ . On the operational characteristics of the Benjamini and Hochberg False Discovery Rate procedure . Stat Appl Genet Mol Biol . 2007 ; 6 :Article27. doi: 10.2202/1544-6115.1302 OpenUrl CrossRef 49. ↵ Thomas PD . The Gene Ontology and the Meaning of Biological Function . Methods Mol Biol . 2017 ; 1446 : 15 24 . doi: 10.1007/978-1-4939-3743-1_2 OpenUrl CrossRef 50. ↵ Fabregat A , Jupe S , Matthews L , Sidiropoulos K , Gillespie M , Garapati P , Haw R , Jassal B , Korninger F , May B et al. The Reactome Pathway Knowledgebase. Nucleic Acids Res . 2018 ; 46 ( D1 ): D649 – D655 . doi: 10.1093/nar/gkx1132 OpenUrl CrossRef PubMed 51. ↵ Reimand J , Kull M , Peterson H , Hansen J , Vilo J. g:Profiler--a web-based toolset for functional profiling of gene lists from large-scale experiments . Nucleic Acids Res . 2007 ; 35 ( Web Server issue ): W193 - W200 . doi: 10.1093/nar/gkm226 OpenUrl CrossRef PubMed Web of Science 52. ↵ Porras P , Barrera E , Bridge A , Del-Toro N , Cesareni G , Duesbury M , Hermjakob H , Iannuccelli M , Jurisica I , Kotlyar M , et al. owards a unified open access dataset of molecular interactions . Nat Commun . 2020 ; 11 ( 1 ): 6144 . doi: 10.1038/s41467-020-19942-z OpenUrl CrossRef PubMed 53. ↵ Shannon P , Markiel A , Ozier O , Baliga NS , Wang JT , Ramage D , Amin N , Schwikowski B , Ideker T Cytoscape: a software environment for integrated models of biomolecular interaction networks . Genome Res 2003 ; 13 ( 11 ): 2498 – 2504 . doi: 10.1101/gr.1239303 OpenUrl Abstract / FREE Full Text 54. ↵ Luo X , Guo L , Dai XJ , Wang Q , Zhu W , Miao X , Gong H . Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis . Neuropsychiatr Dis Treat . 2017 ; 13 : 2011 – 2020 . doi: 10.2147/NDT.S142742 OpenUrl CrossRef PubMed 55. ↵ Li Y , Li W , Tan Y , Liu F , Cao Y , Lee KY . Hierarchical Decomposition for Betweenness Centrality Measure of Complex Networks . Sci Rep . 2017 ; 7 : 46491 . doi: 10.1038/srep46491 OpenUrl CrossRef PubMed 56. ↵ Gilbert M , Li Z , Wu XN , Rohr L , Gombos S , Harter K , Schulze WX . Comparison of path-based centrality measures in protein-protein interaction networks revealed proteins with phenotypic relevance during adaptation to changing nitrogen environments . J Proteomics . 2021 ; 235 : 104114 . doi: 10.1016/j.jprot.2021.104114 OpenUrl CrossRef PubMed 57. ↵ Li G , Li M , Wang J , Li Y , Pan Y . United Neighborhood Closeness Centrality and Orthology for Predicting Essential Proteins . IEEE/ACM Trans Comput Biol Bioinform . 2020 ; 17 ( 4 ): 1451 – 1458 . doi: 10.1109/TCBB.2018.2889978 OpenUrl CrossRef 58. ↵ Zaki N , Efimov D , Berengueres J . Protein complex detection using interaction reliability assessment and weighted clustering coefficient . BMC Bioinformatics . 2013 ; 14 : 163 . doi: 10.1186/1471-2105-14 OpenUrl CrossRef 59. ↵ Fan Y , Xia J ( 2018 ) miRNet-Functional Analysis and Visual Exploration of miRNA-Target Interactions in a Network Context . Methods Mol Biol 1819 : 215 – 233 . doi: 10.1007/978-1-4939-8618-7_10 OpenUrl CrossRef PubMed 60. ↵ Zhou G , Soufan O , Ewald J , Hancock REW , Basu N , Xia J ( 2019 ) NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis . Nucleic Acids Res 47 : W234 – W241 . doi: 10.1093/nar/gkz240 OpenUrl CrossRef PubMed 61. ↵ Robin X , Turck N , Hainard A , Tiberti N , Lisacek F , Sanchez JC , Müller M . pROC: an open-source package for R and S+ to analyze and compare ROC curves . BMC Bioinformatics 2011 ; 12 : 77 . doi: 10.1186/1471-2105-12-77 OpenUrl CrossRef PubMed 62. ↵ Shaulov T , Sierra S , Sylvestre C . Recurrent implantation failure in IVF: A Canadian Fertility and Andrology Society Clinical Practice Guideline . Reprod Biomed Online . 2020 ; 41 ( 5 ): 819 – 833 . doi: 10.1016/j.rbmo.2020.08.007 OpenUrl CrossRef PubMed 63. ↵ İnce B , Guloksuz S , Altınbaş K , Oral ET , Alpkan LR , Altinoz MA . Minor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes . J Affect Disord . 2013 ; 151 ( 1 ): 405 – 408 . doi: 10.1016/j.jad.2013.06.042 OpenUrl CrossRef PubMed 64. ↵ Yu L , Chibnik LB , Srivastava GP , Pochet N , Yang J , Xu J , Kozubek J , Obholzer N , Leurgans SE , Schneider JA , et al. Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease . JAMA Neurol . 2015 ; 72 ( 1 ): 15 - 24 . doi: 10.1001/jamaneurol.2014.3049 OpenUrl CrossRef PubMed 65. ↵ Hanif F , Amir Q , Washdev W . Effect of DIO2 Gene Polymorphism on Thyroid Hormone Levels and Its Correlation with the Severity of Schizophrenia in a Pakistani Population . Int J Mol Sci . 2024 ; 25 ( 3 ): 1915 . doi: 10.3390/ijms25031915 OpenUrl CrossRef PubMed 66. ↵ Peng R , Dai W , Li Y . High serum levels of tenascin-C are associated with suicide attempts in depressed patients . Psychiatry Res . 2018 ; 268 : 60 – 64 . doi: 10.1016/j.psychres.2018.06.069 OpenUrl CrossRef PubMed 67. ↵ Routy JP , Monte M , Beaulieu R , Toma E , St-Pierre L , Dumont M . Increase of hemoglobin A2 in human immunodeficiency virus-1-infected patients treated with zidovudine . Am J Hematol . 1993 ; 43 ( 2 ): 86 – 90 . doi: 10.1002/ajh.2830430203 OpenUrl CrossRef PubMed Web of Science 68. ↵ Wu J , Han Y , Lyu R , Zhang F , Jiang N , Tao H , You Q , Zhang R , Yuan M , Nawaz W , et al. OLR1-induced folate deficiency reduces viral replication via modulating APOBEC3 family expression . Virol Sin . 2023 ; 38 ( 3 ): 409 – 418 . doi: 10.1016/j.virs.2023.04.001 OpenUrl CrossRef PubMed 69. ↵ Ko H , Pasternak JA , Mulligan MK , Hamonic G , Ramesh N , MacPhee DJ , Plastow GS , Harding JCS . A DIO2 missense mutation and its impact on fetal response to PRRSV infection . BMC Vet Res . 2024 ; 20 ( 1 ): 255 . doi: 10.1186/s12917-024-04099-4 OpenUrl CrossRef PubMed 70. ↵ Mafuika SN , Naicker T . The role of Tenascin-C in HIV associated pre-eclampsia . Pregnancy Hypertens . 2021 ; 25 : 156 – 160 . doi: 10.1016/j.preghy.2021.06.001 OpenUrl CrossRef PubMed 71. ↵ Bourne CR , Finn MG , Zlotnick A . Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1 . J Virol . 2006 ; 80 ( 22 ): 11055 – 11061 . doi: 10.1128/JVI.00933-06 OpenUrl Abstract / FREE Full Text 72. ↵ Chakrabarti A , Bhattacharya D , Deb S , Chakraborty M . Differential thermal stability and oxidative vulnerability of the hemoglobin variants, HbA2 and HbE . PLoS One . 2013 ; 8 ( 11 ): e81820 . doi: 10.1371/journal.pone.0081820 OpenUrl CrossRef PubMed 73. ↵ Sagliocchi S , Cicatiello AG , Di Cicco E , Ambrosio R , Miro C , Di Girolamo D , Nappi A , Mancino G , De Stefano MA , Luongo C , et al. The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress . Redox Biol . 2019 ; 24 : 101228 . doi: 10.1016/j.redox.2019.101228 OpenUrl CrossRef 74. ↵ Hasanzadeh Z , Nourazarian A , Nikanfar M , Laghousi D , Vatankhah AM , Sadrirad S . Evaluation of the Serum Dkk-1, Tenascin-C, Oxidative Stress Markers Levels and Wnt Signaling Pathway Genes Expression in Patients with Alzheimer’s Disease . J Mol Neurosci . 2021 ; 71 ( 4 ): 879 – 887 . doi: 10.1007/s12031-020-01710-9 OpenUrl CrossRef PubMed 75. ↵ Hama Amin RR , Aziz TA . Gastroprotective Effect of Azilsartan Through Ameliorating Oxidative Stress, Inflammation, and Restoring Hydroxyproline, and Gastrin Levels in Ethanol-Induced Gastric Ulcer . J Inflamm Res . 2022 ; 15 : 2911 – 2923 . doi: 10.2147/JIR.S365090 OpenUrl CrossRef PubMed 76. ↵ Di Pietro P , Abate AC , Prete V , Damato A , Venturini E , Rusciano MR , Izzo C , Visco V , Ciccarelli M , Vecchione C , et al. C2CD4B Evokes Oxidative Stress and Vascular Dysfunction via a PI3K/Akt/PKCα-Signaling Pathway . Antioxidants (Basel ). 2024 ; 13 ( 1 ): 101 . doi: 10.3390/antiox13010101 OpenUrl CrossRef PubMed 77. ↵ Luo X , Lu F , Yin Z , Zhou Z , Wang Z , Zhang H . Hormetic effects of EGC and EGCG on CES1 activity and its rescue from oxidative stress in rat liver S9 . Chem Biol Interact . 2023 ; 382 : 110612 . doi: 10.1016/j.cbi.2023.110612 OpenUrl CrossRef 78. ↵ Cheng X , Lan Y , Zhang L , Cheng H . Combination therapy of Sanjie Zhentong capsules for endometriosis: Impact on hormone regulation and serum expression of FOLR1 and MSLN . Medicine (Baltimore ). 2024 ; 103 ( 41 ): e39953 . doi: 10.1097/MD.0000000000039953 OpenUrl CrossRef PubMed 79. ↵ Moriyama M , Nakamura K , Nagata H , Wada I , Nagira K , Azuma Y , Sato E , Harada T , Taniguchi F . Role of tenascin C in lesion formation in early peritoneal endometriosis . F S Sci . 2024 ; 5 ( 1 ): 69 – 79 . doi: 10.1016/j.xfss.2023.12.004 OpenUrl CrossRef PubMed 80. ↵ Maleitzke T , Hildebrandt A , Dietrich T , Appelt J , Jahn D , Otto E , Zocholl D , Baranowsky A , Duda GN , Tsitsilonis S , Keller J . The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis . iScience . 2021 ; 25 ( 1 ): 103689 . doi: 10.1016/j.isci.2021.103689 OpenUrl CrossRef PubMed 81. ↵ Cheng AWM , Bolognesi M , Kraus VB . DIO2 modifies inflammatory responses in chondrocytes . Osteoarthritis Cartilage . 2012 ; 20 ( 5 ): 440 – 445 . doi: 10.1016/j.joca.2012.02.006 OpenUrl CrossRef PubMed 82. ↵ Imanaka-Yoshida K . Tenascin-C in Heart Diseases-The Role of Inflammation . Int J Mol Sci . 2021 ; 22 ( 11 ): 5828 . doi: 10.3390/ijms22115828 OpenUrl CrossRef PubMed 83. ↵ Pan J , Zhao Y , Sang R , Yang R , Bao J , Wu Y , Fei Y , Wu J , Chen G . Huntington-associated protein 1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation . Pain . 2023 ; 164 ( 6 ): e286 – e302 . doi: 10.1097/j.pain.0000000000002837 OpenUrl CrossRef PubMed 84. ↵ Elfiky AMI , Canñizares JL , Li J , Li Yim AYF , Verhoeven AJ , Ghiboub M , de Jonge WJ . Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype . J Leukoc Biol . 2024 ; 116 ( 5 ): 1094 – 1108 . doi: 10.1093/jleuko/qiae137 OpenUrl CrossRef PubMed 85. ↵ Wang Z , Yan S , Liao S , Zhang Y , Wu S , Zhou M , Jin W , Zhang Y , Qi X , Yang C , et al. Dysregulated lncSNHG12 suppresses the invasion and migration of trophoblasts by regulating Dio2/Snail axis to involve in recurrent spontaneous abortion . Biochem Pharmacol . 2024 ; 229 : 116459 . doi: 10.1016/j.bcp.2024.116459 OpenUrl CrossRef 86. ↵ Tempest N , Batchelor E , Hill CJ , Al-Lamee H , Drury J , Drakeley AJ , Hapangama DK . Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure . Int J Mol Sci . 2021 ; 22 ( 8 ): 3835 . doi: 10.3390/ijms22083835 OpenUrl CrossRef PubMed 87. ↵ Leiria LB , Dora JM , Wajner SM , Estivalet AA , Crispim D , Maia AL . The rs225017 polymorphism in the 3’UTR of the human DIO2 gene is associated with increased insulin resistance . PLoS One . 2014 ; 9 ( 8 ): e103960 . doi: 10.1371/journal.pone.0103960 OpenUrl CrossRef PubMed 88. ↵ Ota T , Mori J , Kawabe Y , Morimoto H , Fukuhara S , Kodo K , Sugimoto S , Kosaka K , Nakajima H , Hosoi H . Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study . Children (Basel ). 2022 ; 9 ( 10 ): 1421 . doi: 10.3390/children9101421 OpenUrl CrossRef PubMed 89. ↵ Benbow JH , Thompson KJ , Cope HL , Brandon-Warner E , Culberson CR , Bossi KL , Li T , Russo MW , Gersin KS , McKillop IH , et al. Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling . Am J Pathol . 2016 ; 186 ( 1 ): 145 – 158 . doi: 10.1016/j.ajpath.2015.09.015 OpenUrl CrossRef PubMed 90. ↵ Wang H , Wu S , Weng Y , Yang X , Hou L , Liang Y , Wu W , Ying Y , Ye F , Luo X . Increased serum carboxylesterase-1 levels are associated with metabolic dysfunction associated steatotic liver disease and metabolic syndrome in children with obesity . Ital J Pediatr . 2024 ; 50 ( 1 ): 162 . doi: 10.1186/s13052-024-01733-7 OpenUrl CrossRef PubMed 91. ↵ Janowska M , Potocka N , Paszek S , Skrzypa M , Żulewicz K, Kluz M, Januszek S, Baszuk P, Gronwald J, Lubiński J , et al. An Assessment of GPX1 (rs1050450), DIO2 (rs225014) and SEPP1 (rs7579) Gene Polymorphisms in Women with Endometrial Cancer . Genes (Basel) . 2022 ; 13 ( 2 ): 188 . doi: 10.3390/genes13020188 OpenUrl CrossRef PubMed 92. ↵ Tahara S , Nojima S , Takashima T , Okuzaki D , Morii E . Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern . Pathol Res Pract . 2024 ; 262 : 155562 . doi: 10.1016/j.prp.2024.155562 OpenUrl CrossRef 93. ↵ Jiang H , Hu H , Lin F , Lim YP , Hua Y , Tong X , Zhang S . S100P is Overexpressed in Squamous Cell and Adenosquamous Carcinoma Subtypes of Endometrial Cancer and Promotes Cancer Cell Proliferation and Invasion . Cancer Invest . 2016 ; 34 ( 10 ): 477 – 488 . doi: 10.1080/07357907.2016.1212206 OpenUrl CrossRef PubMed 94. ↵ Guerra A , Sapio MR , Carrano M , Di Stasi V , Volpe A , Murino A , Izzo G , Vitale M . Prevalence of Dio2(T92A) polymorphism and its association with thyroid autoimmunity . J Endocrinol Invest . 2013 ; 36 ( 5 ): 303 – 306 . doi: 10.3275/8618 OpenUrl CrossRef PubMed 95. ↵ Machino-Ohtsuka T , Tajiri K , Kimura T , Sakai S , Sato A , Yoshida T , Hiroe M , Yasutomi Y , Aonuma K , Imanaka-Yoshida K. enascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation . J Am Heart Assoc . 2014 ; 3 ( 6 ): e001052 . doi: 10.1161/JAHA.114.001052 OpenUrl Abstract / FREE Full Text 96. ↵ Kishikawa H , Nakamura K , Ojiro K , Katayama T , Arahata K , Takarabe S , Sasaki A , Miura S , Hayashi Y , Hoshi H , et al. Relevance of pepsinogen, gastrin, and endoscopic atrophy in the diagnosis of autoimmune gastritis . Sci Rep . 2022 ; 12 ( 1 ): 4202 . doi: 10.1038/s41598-022-07947-1 OpenUrl CrossRef PubMed 97. ↵ Hedegaard Jensen G , Mortensen MB , Klöppel G , Nielsen MFB , Nielsen O , Detlefsen S . Utility of pVHL, maspin, IMP3, S100P and Ki67 in the distinction of autoimmune pancreatitis from pancreatic ductal adenocarcinoma . Pathol Res Pract . 2020 ; 216 ( 5 ): 152925 . doi: 10.1016/j.prp.2020.152925 OpenUrl CrossRef PubMed 98. ↵ Wu H , Yang M , Yan C , Liu M , Wang H , Zhang W . Tenascin C activates the toll like receptor 4/NF κB signaling pathway to promote the development of polycystic ovary syndrome . Mol Med Rep . 2024 ; 29 ( 6 ): 106 . doi: 10.3892/mmr.2024.13230 OpenUrl CrossRef PubMed 99. ↵ Yalcin F , Dzaye O , Xia S . Tenascin-C Function in Glioma: Immunomodulation and Beyond . Adv Exp Med Biol . 2020 ; 1272 : 149 – 172 . doi: 10.1007/978-3-030-48457-6_9 OpenUrl CrossRef PubMed 100. ↵ Calatayud S , Alvarez A , Víctor VM . Gastrin: an acid-releasing, proliferative and immunomodulatory peptide? . Mini Rev Med Chem . 2010 ; 10 ( 1 ): 8 – 19 . doi: 10.2174/138955710791112532 OpenUrl CrossRef PubMed 101. ↵ Jamaluddin MFB , Nagendra PB , Nahar P , Oldmeadow C , Tanwar PS . Proteomic Analysis Identifies Tenascin-C Expression Is Upregulated in Uterine Fibroids . Reprod Sci . 2019 ; 26 ( 4 ): 476 – 486 . doi: 10.1177/1933719118773420 OpenUrl CrossRef PubMed 102. ↵ Wesdorp RI , Wang CA , Hirsch H , Fischer JE . Plasma and parathyroid tumor tissue gastrin and hyperparathyroidism . Am J Surg . 1976 ; 131 ( 1 ): 60 – 63 . doi: 10.1016/0002-9610(76)90421-9 OpenUrl CrossRef PubMed Web of Science 103. ↵ Martínez M , Hernanz A , Grande C , Pallardo LF . Plasma molecular forms of gastrin, neurotensin and somatostatin in pregnancy and gestational diabetes after an oral glucose load or a mixed meal . Regul Pept . 1993 ; 47 ( 1 ): 73 – 80 . doi: 10.1016/0167-0115(93)90274-c OpenUrl CrossRef PubMed 104. ↵ Banerjee R , Sotero-Caio CG , Fu B , Yang F . Chromosomal instability (CIN) in HAP1 cell lines revealed by multiplex fluorescence in situ hybridisation (M-FISH) . Mol Cytogenet . 2022 ; 15 ( 1 ): 46 . doi: 10.1186/s13039-022-00625-x OpenUrl CrossRef PubMed 105. ↵ Barzilay G , Walker LJ , Rothwell DG , Hickson ID . Role of the HAP1 protein in repair of oxidative DNA damage and regulation of transcription factors . Br J Cancer Suppl . 1996 ; 27 : S145 – S150 . OpenUrl PubMed 106. ↵ Benkhalifa M , Zayani Y , Bach V , Copin H , Feki M , Benkhalifa M , Allal-Elasmi M . Does the dysregulation of matrix metalloproteinases contribute to recurrent implantation failure? . Expert Rev Proteomics . 2018 ; 15 ( 4 ): 311 – 323 . doi: 10.1080/14789450.2018.1464915 OpenUrl CrossRef PubMed 107. ↵ Yang Z , Li Q , Yuan F , Wang M , Zhang R , Chen Y , Fu W , Yang Q , Hu L . Decreased NOTCH1 signaling activated autophagy in the mid-secretory endometrium of patients with recurrent implantation failure† . Biol Reprod . 2023 ; 108 ( 6 ): 974 – 987 . doi: 10.1093/biolre/ioad034 OpenUrl CrossRef PubMed 108. ↵ Al-Moujahed A , Velez G , Vu JT , Lima de Carvalho JR , Levi SR , Bassuk AG , Sepah YJ , Tsang SH , Mahajan VB . Proteomic analysis of autoimmune retinopathy implicates NrCAM as a potential biomarker . Ophthalmol Sci . 2022 ; 2 ( 2 ): 100131 . doi: 10.1016/j.xops.2022.100131 OpenUrl CrossRef PubMed 109. ↵ Palacios R , Goni J , Martinez-Forero I , Iranzo J , Sepulcre J , Melero I , Villoslada P . A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases . PLoS One . 2007 ; 2 ( 11 ): e1222 . doi: 10.1371/journal.pone.0001222 OpenUrl CrossRef PubMed 110. ↵ Brandt D , Hedrich CM . TCRαβ+CD3+CD4-CD8-(double negative) T cells in autoimmunity . Autoimmun Rev . 2018 ; 17 ( 4 ): 422 – 430 . doi: 10.1016/j.autrev.2018.02.001 OpenUrl CrossRef PubMed 111. ↵ Esparza J , Kruse M , Lee J , Michaud M , Madri JA . MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity . FASEB J . 2004 ; 18 ( 14 ): 1682 – 1691 . doi: 10.1096/fj.04-2445com OpenUrl CrossRef PubMed Web of Science 112. ↵ Zhang C , Liu X , Gu C , Su Y , Lv J , Liu Y , Gao Y , Chen H , Xu N , Xiao J , et al. Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis . J Adv Res . 2024 . doi: 10.1016/j.jare.2024.07.029 OpenUrl CrossRef 113. ↵ Abe M , Yaguchi H , Kudo A , Nagai A , Shirai S , Takahashi-Iwata I , Matsushima M , Nakamura N , Isahaya K , Yamano Y , et al. Sez6l2 autoimmunity in a large cohort study . J Neurol Neurosurg Psychiatry . 2023 ; 94 ( 8 ): 667 – 668 . doi: 10.1136/jnnp-2022-330194 OpenUrl FREE Full Text 114. ↵ Cavalcanti CAJ , Germoglio V , de Azevêdo Silva J , Glesse N , Vianna P , Cechim G , Monticielo OA , Xavier RM , Brenol JCT , Brenol CV , et al. T-cell specific upregulation of Sema4A as risk factor for autoimmunity in systemic lupus erythematosus and rheumatoid arthritis . Autoimmunity . 2020 ; 53 ( 2 ): 65 – 70 . doi: 10.1080/08916934.2019.1704273 OpenUrl CrossRef PubMed 115. ↵ Potula HH , Xu Z , Zeumer L , Sang A , Croker BP , Morel L . Cyclin-dependent kinase inhibitor Cdkn2c deficiency promotes B1a cell expansion and autoimmunity in a mouse model of lupus . J Immunol . 2012 ; 189 ( 6 ): 2931 – 2940 . doi: 10.4049/jimmunol.1200556 OpenUrl Abstract / FREE Full Text 116. ↵ Munro KM , Dixon KJ , Gresle MM , Jonas A , Kemper D , Doherty W , Fabri LJ , Owczarek CM , Pearse M , Boyd AW , et al. EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE) . PLoS One . 2013 ; 8 ( 2 ): e55948 . doi: 10.1371/journal.pone.0055948 OpenUrl CrossRef PubMed 117. ↵ Umeda M , Yoshida N , Hisada R , Burbano C , Orite SYK , Kono M , Kyttaris VC , Krishfield S , Owen CA , Tsokos GC . ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-β1 . Proc Natl Acad Sci U S A . 2021 ; 118 ( 18 ): e2023230118 . doi: 10.1073/pnas.2023230118 OpenUrl Abstract / FREE Full Text 118. ↵ Jarius S , Bräuninger S , Chung HY , Geis C , Haas J , Komorowski L , Wildemann B , Roth C. Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature . J Neuroinflammation . 2022 ; 19 ( 1 ): 196 . doi: 10.1186/s12974-022-02545-4 OpenUrl CrossRef PubMed 119. ↵ Urusov AE , Tolmacheva AS , Aulova KS , Nevinsky GA . Autoantibody-Abzymes with Catalase Activity in Experimental Autoimmune Encephalomyelitis Mice . Molecules . 2023 ; 28 ( 3 ): 1330 . doi: 10.3390/molecules28031330 OpenUrl CrossRef PubMed 120. ↵ Vogel A , Martin K , Soukup K , Halfmann A , Kerndl M , Brunner JS , Hofmann M , Oberbichler L , Korosec A , Kuttke M , et al. JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction . Cell Rep . 2022 ; 38 ( 8 ): 110420 . doi: 10.1016/j.celrep.2022.110420 OpenUrl CrossRef PubMed 121. ↵ Tang W , Lv Q , Huang X , Li Y , Zou J , Zheng J , Sun L , Bao Y , Chen H , Li T , et al. MiR-143 Targets IGF-1R to Suppress Autoimmunity in Thyroid-Associated Ophthalmopathy . J Inflamm Res . 2022 ; 15 : 1543 – 1554 . doi: 10.2147/JIR.S339483 OpenUrl CrossRef PubMed 122. ↵ Blüml S , Sahin E , Saferding V , Goncalves-Alves E , Hainzl E , Niederreiter B , Hladik A , Lohmeyer T , Brunner JS , Bonelli M , et al. Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis . Arthritis Res Ther . 2015 ; 17 ( 1 ): 230 . doi: 10.1186/s13075-015-0742-y OpenUrl CrossRef PubMed 123. ↵ Jia M , Zou X , Yin S , Tian W , Zhao Y , Wang H , Xu G , Cai W , Shao Q . CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease . Immun Inflamm Dis . 2022 ; 10 ( 7 ): e644 . doi: 10.1002/iid3.644 OpenUrl CrossRef 124. ↵ Banati RB , Gehrmann J , Lannes-Vieira J , Wekerle H , Kreutzberg GW . Inflammatory reaction in experimental autoimmune encephalomyelitis (EAE) is accompanied by a microglial expression of the beta A4-amyloid precursor protein (APP) . Glia . 1995 ; 14 ( 3 ): 209 – 215 . doi: 10.1002/glia.440140306 OpenUrl CrossRef PubMed 125. ↵ Cassidy MF , Herbert ZT , Moulton VR . Splicing factor SRSF1 controls distinct molecular programs in regulatory and effector T cells implicated in systemic autoimmune disease . Mol Immunol . 2022 ; 141 : 94 – 103 . doi: 10.1016/j.molimm.2021.11.008 OpenUrl CrossRef PubMed 126. ↵ Perez-Gomez MV , Sanchez-Niño MD , Ortiz A . Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease . Clin Kidney J . 2020 ; 13 ( 3 ): 281 – 286 . doi: 10.1093/ckj/sfz171 OpenUrl CrossRef PubMed 127. ↵ Lee N , Kim D , Kim WU . Role of NFAT5 in the Immune System and Pathogenesis of Autoimmune Diseases . Front Immunol . 2019 ; 10 : 270 . doi: 10.3389/fimmu.2019.00270 OpenUrl CrossRef PubMed 128. ↵ Pandey R , Bakay M , Hakonarson H . CLEC16A-An Emerging Master Regulator of Autoimmunity and Neurodegeneration . Int J Mol Sci . 2023 ; 24 ( 9 ): 8224 . doi: 10.3390/ijms24098224 OpenUrl CrossRef 129. ↵ Mahajan VB , Skeie JM , Bassuk AG , Fingert JH , Braun TA , Daggett HT , Folk JC , Sheffield VC , Stone EM . Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration . PLoS Genet . 2012 ; 8 ( 10 ): e1003001 . doi: 10.1371/journal.pgen.1003001 OpenUrl CrossRef PubMed 130. ↵ Simeonovic CJ , Ziolkowski AF , Wu Z , Choong FJ , Freeman C , Parish CR. Heparanase and autoimmune diabetes . Front Immunol. 2013 ; 4 : 471 . doi: 10.3389/fimmu.2013.00471 OpenUrl CrossRef PubMed 131. ↵ Becanovic K , Jagodic M , Sheng JR , Dahlman I , Aboul-Enein F , Wallstrom E , Olofsson P , Holmdahl R , Lassmann H , Olsson T . Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis . J Immunol . 2006 ; 176 ( 10 ): 6055 – 6064 . doi: 10.4049/jimmunol.176.10.6055 OpenUrl Abstract / FREE Full Text 132. ↵ Piras G , Rattazzi L , Paschalidis N , Oggero S , Berti G , Ono M , Bellia F , D’Addario C, Dell’Osso B, Pariante CM , et al. Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells . Brain Behav Immun . 2020 ; 87 : 689 - 702 . doi: 10.1016/j.bbi.2020.02.015 OpenUrl CrossRef PubMed 133. ↵ Care MA , Stephenson SJ , Barnes NA , Fan I , Zougman A , El-Sherbiny YM , Vital EM , Westhead DR , Tooze RM , Doody GM . Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity . J Immunol . 2016 ; 197 ( 4 ): 1447 – 1459 . doi: 10.4049/jimmunol.1600624 OpenUrl Abstract / FREE Full Text 134. ↵ Seleznik GM , Reding T , Peter L , Gupta A , Steiner SG , Sonda S , Verbeke CS , Dejardin E , Khatkov I , Segerer S , et al. Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation . Gut . 2018 ; 67 ( 9 ): 1663 – 1673 . doi: 10.1136/gutjnl-2016-313458 OpenUrl Abstract / FREE Full Text 135. ↵ Assis DN , Leng L , Du X , Zhang CK , Grieb G , Merk M , Garcia AB , McCrann C , Chapiro J , Meinhardt A , et al. The role of macrophage migration inhibitory factor in autoimmune liver disease . Hepatology . 2014 ; 59 ( 2 ): 580 – 591 . doi: 10.1002/hep.26664 OpenUrl CrossRef 136. ↵ Efe C , Cengiz M , Kahramanoğlu-Aksoy E , Yilmaz B , Özşeker B , Beyazt Y , Tanoğlu A , Purnak T , Kav T , Turhan T , et al. Angiotensin-converting enzyme for noninvasive assessment of liver fibrosis in autoimmune hepatitis . Eur J Gastroenterol Hepatol . 2015 ; 27 ( 6 ): 649 – 654 . doi: 10.1097/MEG.0000000000000355 OpenUrl CrossRef PubMed 137. ↵ de Farias CR , Cardoso BR , de Oliveira GM , de Mello Guazzelli IC , Catarino RM , Chammas MC , Cozzolino SM , Knobel M . A randomized-controlled, double-blind study of the impact of selenium supplementation on thyroid autoimmunity and inflammation with focus on the GPx1 genotypes . J Endocrinol Invest . 2015 ; 38 ( 10 ): 1065 – 1074 . doi: 10.1007/s40618-015-0285-8 OpenUrl CrossRef PubMed 138. ↵ Habibullah MM , Hakamy A , Mansor AS , Atti IM , Alwadani AAJ , Kaabi YA . The Association of UCP2-866 G/A Genotype with Autoimmune Hypothyroidism in the Southwestern Saudi Arabia Population . Int J Gen Med . 2023 ; 16 : 875 – 879 . doi: 10.2147/IJGM.S400424 OpenUrl CrossRef PubMed 139. ↵ Didonna A , Cekanaviciute E , Oksenberg JR , Baranzini SE . Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis . Sci Rep . 2016 ; 6 : 31603 . doi: 10.1038/srep31603 OpenUrl CrossRef 140. ↵ Tu Y , Chen D , Pan T , Chen Z , Xu J , Jin L , Sheng L , Jin X , Wang X , et al. Inhibition of miR-431-5p attenuated liver apoptosis through KLF15/p53 signal pathway in S100 induced autoimmune hepatitis mice . Life Sci . 2021 ; 280 : 119698 . doi: 10.1016/j.lfs.2021.119698 OpenUrl CrossRef 141. ↵ Maalej A , Mbarki F , Rebai A , Karray F , Jouida J , Abid M , Ayadi H . Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family . Autoimmunity . 2004 ; 37 ( 3 ): 237 – 239 . doi: 10.1080/08916930410001702478 OpenUrl CrossRef PubMed 142. ↵ Arinaga-Hino T , Ide T , Akiba J , Suzuki H , Kuwahara R , Amano K , Kawaguchi T , Sano T , Inoue E , Koga H , et al. Growth differentiation factor 15 as a novel diagnostic and therapeutic marker for autoimmune hepatitis . Sci Rep . 2022 ; 12 ( 1 ): 8759 . doi: 10.1038/s41598-022-12762-9 OpenUrl CrossRef PubMed 143. ↵ Wang J , Wang X , Chen X , Lu S , Kuang Y , Fei J , Wang Z . Gpr97/Adgrg3 ameliorates experimental autoimmune encephalomyelitis by regulating cytokine expression . Acta Biochim Biophys Sin (Shanghai ). 2018 ; 50 ( 7 ): 666 – 675 . doi: 10.1093/abbs/gmy060 OpenUrl CrossRef PubMed 144. ↵ Ma W , Huang G , Wang Z , Wang L , Gao Q . IRF7: role and regulation in immunity and autoimmunity . Front Immunol . 2023 ; 14 : 1236923 .. doi: 10.3389/fimmu.2023.1236923 OpenUrl CrossRef PubMed 145. ↵ Keskitalo S , Haapaniemi EM , Glumoff V , Liu X , Lehtinen V , Fogarty C , Rajala H , Chiang SC , Mustjoki S , Kovanen P , et al. Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease . NPJ Genom Med . 2019 ; 4 : 14 . doi: 10.1038/s41525-019-0088-5 OpenUrl CrossRef 146. ↵ Rubinstein A , Kudryavtsev I , Arsentieva N , Korobova ZR , Isakov D , Totolian AA . CXCR3-Expressing T Cells in Infections and Autoimmunity . Front Biosci (Landmark Ed ). 2024 ; 29 ( 8 ): 301 . doi: 10.31083/j.fbl2908301 OpenUrl CrossRef PubMed 147. ↵ Manni M , Gupta S , Ricker E , Chinenov Y , Park SH , Shi M , Pannellini T , Jessberger R , Ivashkiv LB , Pernis AB. egulation of age-associated B cells by IRF5 in systemic autoimmunity . Nat Immunol . 2018 ; 19 ( 4 ): 407 – 419 . doi: 10.1038/s41590-018-0056-8 OpenUrl CrossRef PubMed 148. ↵ Ku D , Yang Y , Park Y , Jang D , Lee N , Lee YK , Lee K , Lee J , Han YB , Jang S , et al. SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulation . Preprint. bioRxiv . 2024 ; 2024.03.28.587146 . doi: 10.1101/2024.03.28.587146 OpenUrl Abstract / FREE Full Text 149. ↵ Xie W , Fang J , Shan Z , Guo J , Liao Y , Zou Z , Wang J , Wen S , Yang L , Zhang Y , et al. Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications . Sci Adv . 2022 ; 8 ( 39 ):eabo4250. doi: 10.1126/sciadv.abo4250 OpenUrl CrossRef 150. ↵ Cheng Y , Xie L , Xu Z , Hao M , Yang B , Shan W , Wang Y , Lv Q , Chen X . NrCAM secreted by endometrial stromal cells enhances the progestin sensitivity of endometrial cancer cells through epigenetic modulation of PRB . Cancer Gene Ther . 2022 ; 29 ( 10 ): 1452 – 1462 . doi: 10.1038/s41417-022-00467-0 OpenUrl CrossRef PubMed 151. ↵ Yang X , Xing G , Liu S , Li B , He Y , Wang F . LncRNA LOXL1-AS1 promotes endometrial cancer progression by sponging miR-28-5p to upregulate RAP1B expression . Biomed Pharmacother . 2020 ; 125 : 109839 . doi: 10.1016/j.biopha.2020.109839 OpenUrl CrossRef PubMed 152. ↵ Su Y , Zhou H , Ma Z , Liu J , Li C . CCND1-Induced Autophagy Contributes to Lymph Node Metastasis in Endometrial Cancer . Horm Metab Res . 2023 ; 55 ( 6 ): 413 – 419 . doi: 10.1055/a-2044-9227 OpenUrl CrossRef PubMed 153. ↵ Spyrou I , Sifakis S , Ploumidis A , Papalampros AE , Felekouras E , Tsatsakis AM , Spandidos DA , Androutsopoulos VP . Expression profile of CYP1A1 and CYP1B1 enzymes in endometrial tumors . Tumour Biol . 2014 ; 35 ( 10 ): 9549 – 9556 . doi: 10.1007/s13277-014-2240-2 OpenUrl CrossRef PubMed 154. ↵ Palomero J , Panisello C , Lozano-Rabella M , Tirtakasuma R , Díaz-Gómez J , Grases D , Pasamar H , Arregui L , Dorca Duch E , Guerra Fernández E , et al. Biomarkers of tumor-reactive CD4+ and CD8+ TILs associate with improved prognosis in endometrial cancer . J Immunother Cancer . 2022 ; 10 ( 12 ): e005443 . doi: 10.1136/jitc-2022-005443 OpenUrl CrossRef PubMed 155. ↵ Liu Y , Chang Y , Cai Y . circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis . Aging (Albany NY ). 2020 ; 12 ( 8 ): 6774 – 6792 . doi: 10.18632/aging.103037 OpenUrl CrossRef PubMed 156. ↵ Wang Z , Wang H , Wang Z , He S , Jiang Z , Yan C , Zhang S , Wang T . Associated analysis of PER1/TUBB2B with endometrial cancer development caused by circadian rhythm disorders . Med Oncol . 2020 ; 37 ( 10 ): 90 . doi: 10.1007/s12032-020-01415-4 OpenUrl CrossRef PubMed 157. ↵ Yang Y , Jiang Y , Jiang M , Zhang J , Yang B , She Y , Wang W , Deng Y , Ye Y . Protocadherin 10 inhibits cell proliferation and induces apoptosis via regulation of DEP domain containing 1 in endometrial endometrioid carcinoma . Exp Mol Pathol . 2016 ; 100 ( 2 ): 344 – 352 . doi: 10.1016/j.yexmp.2016.03.002 OpenUrl CrossRef PubMed 158. ↵ Ren F , Wang D , Wang Y , Chen P , Guo C . SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2 . Reprod Sci . 2020 ; 27 ( 7 ): 1391 – 1399 . doi: 10.1007/s43032-020-00197-4 OpenUrl CrossRef PubMed 159. ↵ Ikeda Y , Oda K , Ishihara H , Wada-Hiraike O , Miyasaka A , Kashiyama T , Inaba K , Fukuda T , Sone K , Matsumoto Y , et al. Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy . Br J Cancer . 2015 ; 113 ( 10 ): 1477 – 1483 . doi: 10.1038/bjc.2015.369 OpenUrl CrossRef PubMed 160. ↵ Yao H , Kong F , Zhou Y . MiR-182 promotes cell proliferation, migration and invasion by targeting FoxF2 in endometrial carcinoma cells . Int J Clin Exp Pathol . 2019 ; 12 ( 4 ): 1248 – 1259 . OpenUrl PubMed 161. ↵ Xiao Y , Huang W , Huang H , Wang L , Wang M , Zhang T , Fang X , Xia X . miR-182-5p and miR-96-5p Target PIAS1 and Mediate the Negative Feedback Regulatory Loop between PIAS1 and STAT3 in Endometrial Cancer . DNA Cell Biol . 2021 ; 40 ( 4 ): 618 – 628 . doi: 10.1089/dna.2020.6379 OpenUrl CrossRef PubMed 162. ↵ Al-Kuraishy HM , Al-Maiahy TJ , Al-Gareeb AI , Alexiou A , Papadakis M , Saad HM , Batiha GE . The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review . Cancer Rep (Hoboken ). 2024 ; 7 ( 1 ): e1920 . doi: 10.1002/cnr2.1920 OpenUrl CrossRef 163. ↵ Hao L , Wang J . miR-27a acts as an oncogene to regulate endometrial cancer progression by targeting USP46 . Int J Clin Exp Pathol . 2021 ; 14 ( 6 ): 720 – 725 . OpenUrl PubMed 164. ↵ Xing Y , Sun X , Li F , Jiang X , Jiang A , Li X , Lv R , Shao L . Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma . J Int Med Res . 2021 ; 49 ( 6 ): 3000605211013548 . doi: 10.1177/03000605211013548 OpenUrl CrossRef PubMed 165. ↵ Zhu X , Li Y , Shao Z , Lu X , Chen Y . NAP1L1 Promotes Endometrial Cancer Progression via EP300-Mediated DDX5 Promoter Acetylation . Mol Cancer Res . 2024 ; 22 ( 11 ): 1011 – 1021 . doi: 10.1158/1541-7786.MCR-23-0871 OpenUrl CrossRef PubMed 166. ↵ Wen Q , Xie X , Chen C , Wen B , Liu Y , Zhou J , Lin X , Jin H , Shi K . Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression . Aging (Albany NY ). 2023 ; 15 ( 21 ): 11860 – 11874 . doi: 10.18632/aging.205142 OpenUrl CrossRef PubMed 167. ↵ Michalczyk K , Kapczuk P , Witczak G , Bosiacki M , Kurzawski M , Chlubek D , Cymbaluk-Płoska A . The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer . Nutrients . 2022 ; 14 ( 15 ): 3079 . doi: 10.3390/nu14153079 OpenUrl CrossRef PubMed 168. ↵ Yu Z , Zhang Q , Wei S , Zhang Y , Zhou T , Zhang Q , Shi R , Zinovkin D , Pranjol ZI , Zhang J , et al. CD146+CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway . Cell Commun Signal . 2024 ; 22 ( 1 ): 170 . doi: 10.1186/s12964-024-01550-9 OpenUrl CrossRef PubMed 169. ↵ Zhang J , Chen S , Wei S , Cheng S , Shi R , Zhao R , Zhang W , Zhang Q , Hua T , Feng D , et al. CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer . Redox Biol . 2022 ; 57 : 102493 . doi: 10.1016/j.redox.2022.102493 OpenUrl CrossRef 170. ↵ Pu X , Gu Z , Gu Z . ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer . J Cancer . 2020 ; 11 ( 19 ): 5612 – 5622 . doi: 10.7150/jca.46097 OpenUrl CrossRef PubMed 171. ↵ Mondal SK , Sen MK . Loss of phosphatase activity in PTEN (phosphatase and tensin homolog deleted on chromosome ten) results in endometrial carcinoma in humans: An in-silico study . Heliyon . 2020 ; 6 ( 1 ): e03106 . doi: 10.1016/j.heliyon.2019.e03106 OpenUrl CrossRef 172. ↵ Zhang Q , Zhu F , Tong Y , Shi D , Zhang J . CHD4 R975H mutant activates tumorigenic pathways and promotes stemness and M2-like macrophage polarization in endometrial cancer . Sci Rep . 2024 ; 14 ( 1 ): 18617 . doi: 10.1038/s41598-024-69233-6 OpenUrl CrossRef PubMed 173. ↵ Swisher EM , Mutch DG , Herzog TJ , Rader JS , Kowalski LD , Elbendary A , Goodfellow PJ . Analysis of MSH3 in endometrial cancers with defective DNA mismatch repair . J Soc Gynecol Investig . 1998 ; 5 ( 4 ): 210 – 216 . doi: 10.1016/s1071-5576(98)00016-1 OpenUrl CrossRef PubMed 174. ↵ Yuan J , Mao Z , Lu Q , Xu P , Wang C , Xu X , Zhou Z , Zhang T , Yu W , Dong S , et al. Hypermethylated PCDHGB7 as a Biomarker for Early Detection of Endometrial Cancer in Endometrial Brush Samples and Cervical Scrapings . Front Mol Biosci . 2022 ; 8 : 774215 . doi: 10.3389/fmolb.2021.774215 OpenUrl CrossRef 175. ↵ Qiu MT , Fan Q , Zhu Z , Kwan SY , Chen L , Chen JH , Ying ZL , Zhou Y , Gu W , Wang LH , et al. KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1 . Oncotarget . 2015 ; 6 ( 31 ): 31702 – 31720 . doi: 10.18632/oncotarget.5165 OpenUrl CrossRef PubMed 176. ↵ Pavelić J , Radaković B , Pavelić K . Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6-phosphate) in endometrial adenocarcinoma . Gynecol Oncol . 2007 ; 105 ( 3 ): 727 – 735 . doi: 10.1016/j.ygyno.2007.02.012 OpenUrl CrossRef PubMed Web of Science 177. ↵ Tsigginou A , Bimpaki E , Nesterova M , Horvath A , Boikos S , Lyssikatos C , Papageorgiou C , Dimitrakakis C , Rodolakis A , Stratakis CA , et al. PRKAR1A gene analysis and protein kinase A activity in endometrial tumors . Endocr Relat Cancer . 2012 ; 19 ( 4 ): 457 – 462 . doi: 10.1530/ERC-11-0328 OpenUrl Abstract / FREE Full Text 178. ↵ Kong W , Huang Y , Jiang P , Tu Y , Li N , Wang J , Zhou Q , Zheng Y , Gou S , Tian C , et al. YAP1 affects the prognosis through the regulation of stemness in endometrial cancer . PeerJ . 2023 ; 11 : e15891 . doi: 10.7717/peerj.15891 OpenUrl CrossRef PubMed 179. ↵ Liu H , Wan J , Feng Q , Li J , Liu J , Cui S . Long non-coding RNA SOS1-IT1 promotes endometrial cancer progression by regulating hypoxia signaling pathway . J Cell Commun Signal . 2022 ; 16 ( 2 ): 253 – 270 . doi: 10.1007/s12079-021-00651-1 OpenUrl CrossRef PubMed 180. ↵ Yamashita H , Nakayama K , Kanno K , Ishibashi T , Ishikawa M , Iida K , Razia S , Kiyono T , Kyo S . Evaluation of ARID1A as a Potential Biomarker for Predicting Response to Immune Checkpoint Inhibitors in Patients with Endometrial Cancer . Cancers (Basel ). 2024 ; 16 ( 11 ): 1999 . doi: 10.3390/cancers16111999 OpenUrl CrossRef PubMed 181. ↵ Lu M , Ding N , Zhuang S , Li Y . LINC01410/miR-23c/CHD7 functions as a ceRNA network to affect the prognosis of patients with endometrial cancer and strengthen the malignant properties of endometrial cancer cells . Mol Cell Biochem . 2020 ; 469 ( 1-2 ): 9 – 19 . doi: 10.1007/s11010-020-03723-9 OpenUrl CrossRef PubMed 182. ↵ Meril S , Muhlbauer Avni M , Lior C , Bahlsen M , Olender T , Savidor A , Krausz J , Belhanes Peled H , Birisi H , David N , et al. Loss of EIF4G2 mediates aggressiveness in distinct human endometrial cancer subpopulations with poor survival outcome in patients . Oncogene . 2024 ; 43 ( 15 ): 1098 – 1112 . doi: 10.1038/s41388-024-02981-x OpenUrl CrossRef PubMed 183. ↵ Zhang A , Zhang L , Xie X , Liu D . Inhibition of ATM with KU-55933 Sensitizes Endometrial Cancer Cell Lines to Olaparib . Onco Targets Ther . 2023 ; 16 : 1061 – 1071 . doi: 10.2147/OTT.S426923 OpenUrl CrossRef PubMed 184. ↵ Zhang L , Wan Y , Zhang Z , Jiang Y , Gu Z , Ma X , Nie S , Yang J , Lang J , Cheng W , et al. IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression . Theranostics . 2021 ; 11 ( 3 ): 1100 – 1114 . doi: 10.7150/thno.49345 OpenUrl CrossRef PubMed 185. ↵ Xiong H , Wang N , Chen H , Zhang M , Lin Q . MicroRNA 199a/b 5p inhibits endometrial cancer cell metastasis and invasion by targeting FAM83B in the epithelial to mesenchymal transition signaling pathway . Mol Med Rep . 2021 ; 23 ( 5 ): 304 . doi: 10.3892/mmr.2021.11943 OpenUrl CrossRef PubMed 186. ↵ Sun D , Zhang A , Gao B , Zou L , Huang H , Zhao X , Xu D . Identification of Alternative Splicing-Related Genes CYB561 and FOLH1 in the Tumor-Immune Microenvironment for Endometrial Cancer Based on TCGA Data Analysis . Front Genet . 2022 ; 13 : 770569 . doi: 10.3389/fgene.2022.770569 OpenUrl CrossRef 187. ↵ Mrkonjic M , Turashvili G . EPM2AIP1 Immunohistochemistry Can Be Used as Surrogate Testing for MLH1 Promoter Methylation in Endometrial Cancer . Am J Surg Pathol . 2022 ; 46 ( 3 ): 376 – 382 . doi: 10.1097/PAS.0000000000001832 OpenUrl CrossRef PubMed 188. ↵ Zhang L , Zhang B , Wei M , Xu Z , Kong W , Deng K , Xu X , Zhang L , घhao X , Yan L. TRIM22 inhibits endometrial cancer progression through the NOD2/NF κB signaling pathway and confers a favorable prognosis . Int J Oncol . 2020 ; 56 ( 5 ): 1225 – 1239 . doi: 10.3892/ijo.2020.5004 OpenUrl CrossRef PubMed 189. ↵ Cao H , Yang S , Yu X , Xi M . Correlation between heparanase gene polymorphism and susceptibility to endometrial cancer . Mol Genet Genomic Med . 2020 ; 8 ( 10 ): e1257 . doi: 10.1002/mgg3.1257 OpenUrl CrossRef 190. ↵ Wang P , Liu T , Zhao Z , Wang Z , Liu S , Yang X . SPTBN2 regulated by miR-424-5p promotes endometrial cancer progression via CLDN4/PI3K/AKT axis . Cell Death Discov . 2021 ; 7 ( 1 ): 382 . doi: 10.1038/s41420-021-00776-7 OpenUrl CrossRef PubMed 191. ↵ Pedrola N , Devis L , Llauradó M , Campoy I , Martinez-Garcia E , Garcia M , Muinelo-Romay L , Alonso-Alconada L , Abal M , Alameda F , et al. Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion . Clin Exp Metastasis . 2015 ; 32 ( 5 ): 467 – 478 . doi: 10.1007/s10585-015-9720-7 OpenUrl CrossRef PubMed 192. ↵ Zhao X , Wang J , Wang Y , Zhang M , Zhao W , Zhang H , Zhao L . Interferon stimulated gene 15 promotes progression of endometrial carcinoma and weakens antitumor immune response . Oncol Rep . 2022 ; 47 ( 6 ): 110 . doi: 10.3892/or.2022.8321 OpenUrl CrossRef PubMed 193. ↵ Chen L , Zheng X , Liu W , Sun Y , Zhao S , Tian L , Tian W , Xue F , Kang C , et al. Compound AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR-EZH2 interaction and enhances the efficacy of tazemetostat in endometrial cancer . Cancer Lett . 2023 ; 578 : 216445 . doi: 10.1016/j.canlet.2023.21644 OpenUrl CrossRef 194. ↵ Cui YQ , Xiang Y , Meng F , Ji CH , Xiao R , Li JP , Dai ZT , Liao XH . ALDH2 promotes uterine corpus endometrial carcinoma proliferation and construction of clinical survival prognostic model . Aging (Albany NY ). 2021 ; 13 ( 20 ): 23588 – 23602 . doi: 10.18632/aging.203605 OpenUrl CrossRef PubMed 195. ↵ Llobet D , Eritja N , Domingo M , Bergada L , Mirantes C , Santacana M , Pallares J , Macià A , Yeramian A , Encinas M , et al. KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels . Am J Pathol . 2011 ; 178 ( 4 ): 1529 – 1543 . doi: 10.1016/j.ajpath.2010.12.041 OpenUrl CrossRef PubMed 196. ↵ Giannice R , Erreni M , Allavena P , Buscaglia M , Tozzi R . Chemokines mRNA expression in relation to the Macrophage Migration Inhibitory Factor (MIF) mRNA and Vascular Endothelial Growth Factor (VEGF) mRNA expression in the microenvironment of endometrial cancer tissue and normal endometrium: a pilot study . Cytokine . 2013 ; 64 ( 2 ): 509 – 515 . doi: 10.1016/j.cyto.2013.07.024 OpenUrl CrossRef PubMed 197. ↵ Freitas-Silva M , Pereira D , Coelho C , Bicho M , Lopes C , Medeiros R . Angiotensin I-converting enzyme gene insertion/deletion polymorphism and endometrial human cancer in normotensive and hypertensive women . Cancer Genet Cytogenet . 2004 ; 155 ( 1 ): 42 – 46 . doi: 10.1016/j.cancergencyto.2004.03.020 OpenUrl CrossRef PubMed Web of Science 198. ↵ Wang B , Ge S , Wang Z , Wang W , Wang Y , Leng H , Ma X . Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer . Aging (Albany NY ). 2023 ; 15 ( 19 ): 10322 – 10346 . doi: 10.18632/aging.205080 OpenUrl CrossRef PubMed 199. ↵ Cheng Y , Chen X , Hu D , Du J , Xing Y , Liang X , Yang Y . Downregulation of ATP5F1D inhibits mtROS/NLRP3/caspase-1/GSDMD axis to suppress pyroptosis-mediated malignant progression of endometrial cancer . Int Immunopharmacol . 2024 ; 139 : 112808 . doi: 10.1016/j.intimp.2024.112808 OpenUrl CrossRef 200. ↵ Szwarc MM , Kommagani R , Putluri V , Dubrulle J , Stossi F , Mancini MA , Coarfa C , Lanz RB , Putluri N , DeMayo FJ , et al. Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells . Sci Rep . 2018 ; 8 ( 1 ): 13134 . doi: 10.1038/s41598-018-31372-y OpenUrl CrossRef PubMed 201. ↵ Giatromanolaki A , Koukourakis MI , Gatter KC , Harris AL , Sivridis E . BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis . J Clin Pathol . 2008 ; 61 ( 2 ): 217 – 220 . doi: 10.1136/jcp.2007.046680 OpenUrl Abstract / FREE Full Text 202. ↵ Winship AL , Rainczuk K , Dimitriadis E . Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade . Cancer Invest . 2016 ; 34 ( 1 ): 26 – 31 . doi: 10.3109/07357907.2015.1084313 OpenUrl CrossRef PubMed 203. ↵ Engerud H , Tangen IL , Berg A , Kusonmano K , Halle MK , Oyan AM , Kalland KH , Stefansson I , Trovik J , Salvesen HB , et al. High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors . Br J Cancer . 2014 ; 111 ( 1 ): 78 – 84 . doi: 10.1038/bjc.2014.262 OpenUrl CrossRef PubMed 204. ↵ Mao S , Ma J , Yu H . Sirtuin-7 knockdown inhibits the growth of endometrial cancer cells by inducing apoptosis via the NF-κB signaling pathway . Oncol Lett . 2019 ; 17 ( 1 ): 937 – 943 . doi: 10.3892/ol.2018.9698 OpenUrl CrossRef PubMed 205. ↵ Engerud H , Hope K , Berg HF , Fasmer KE , Tangen IL , Haldorsen IS , Trovik J , Krakstad C . Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer . PLoS One . 2019 ; 14 ( 1 ): e0210585 . doi: 10.1371/journal.pone.0210585 OpenUrl CrossRef PubMed 206. ↵ Li Y , Zhang X , Xu S , Ge J , Liu J , Li L , Fang G , Meng Y , Zhang H , Sun X . Expression and clinical significance of FXYD3 in endometrial cancer . Oncol Lett . 2014 ; 8 ( 2 ): 517 – 522 . doi: 10.3892/ol.2014.2170 OpenUrl CrossRef PubMed 207. ↵ Yan J , Ye G , Shao Y . High expression of the ferroptosis-associated MGST1 gene in relation to poor outcome and maladjusted immune cell infiltration in uterine corpus endometrial carcinoma . J Clin Lab Anal . 2022 ; 36 ( 4 ): e24317 . doi: 10.1002/jcla.24317 OpenUrl CrossRef PubMed 208. ↵ Michalczyk K , Kapczuk P , Witczak G , Tousty P , Bosiacki M , Kurzawski M , Chlubek D , Cymbaluk-Płoska A. An Assessment of MT1A (rs11076161), MT2A (rs28366003) and MT1L (rs10636) Gene Polymorphisms and MT2 Concentration in Women with Endometrial Pathologies . Genes (Basel) . 2023 ; 14 ( 3 ): 773 . doi: 10.3390/genes14030773 OpenUrl CrossRef PubMed 209. ↵ Turan H , Vitale SG , Kahramanoglu I , Della Corte L , Giampaolino P , Azemi A , Durmus S , Sal V , Tokgozoglu N , Bese T , et al. Diagnostic and prognostic role of TFF3, Romo-1, NF-кB and SFRP4 as biomarkers for endometrial and ovarian cancers: a prospective observational translational study . Arch Gynecol Obstet . 2022 ; 306 ( 6 ): 2105 - 2114 . doi: 10.1007/s00404-022-06563-8 OpenUrl CrossRef PubMed 210. ↵ Xiao Y , Jin L , Deng C , Guan Y , Kalogera E , Ray U , Thirusangu P , Staub J , Sarkar Bhattacharya S , Xu H , et al. Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer . Oncogene . 2021 ; 40 ( 8 ): 1409 – 1424 . doi: 10.1038/s41388-020-01621-4 OpenUrl CrossRef PubMed 211. ↵ Sahoo SS , Ramanand SG , Gao Y , Abbas A , Kumar A , Cuevas IC , Li HD , Aguilar M , Xing C , Mani RS , et al. FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity . J Clin Invest . 2022 ; 132 ( 12 ): e157574 . doi: 10.1172/JCI157574 OpenUrl CrossRef PubMed 212. ↵ He Y , Xu S , Qi Y , Tian J , Xu F . Long noncoding RNA SNHG25 promotes the malignancy of endometrial cancer by sponging microRNA-497-5p and increasing FASN expression . J Ovarian Res . 2021 ; 14 ( 1 ): 163 . doi: 10.1186/s13048-021-00906-w OpenUrl CrossRef PubMed 213. ↵ Liu Y , Wang LL , Chen S , Zong ZH , Guan X , Zhao Y . LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1 . J Cell Mol Med . 2018 ; 22 ( 8 ): 3955 – 3964 . doi: 10.1111/jcmm.13675 OpenUrl CrossRef PubMed 214. ↵ Dong H , Sun M , Li H , Yue Y . CXCR3 predicts the prognosis of endometrial adenocarcinoma . BMC Med Genomics . 2023 ; 16 ( 1 ): 20 . doi: 10.1186/s12920-023-01451-9 OpenUrl CrossRef PubMed 215. ↵ Wang R , Yu X , Ye H , Ao M , Xi M , Hou M . LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial cancer by promoting DNMT1-mediated CDO1 promoter hypermethylation . J Biol Chem . 2024 ; 300 ( 9 ): 107680 . doi: 10.1016/j.jbc.2024.107680 OpenUrl CrossRef PubMed 216. ↵ Qiu H , Yan Q , Luo X , Zhang H , Bao W , Wan X . EMX2 is downregulated in endometrial cancer and correlated with tumor progression . Int J Gynecol Pathol . 2013 ; 32 ( 2 ): 193 – 198 . doi: 10.1097/PGP.0b013e31825d8049 OpenUrl CrossRef PubMed 217. ↵ Wang S , Huo X . Comprehensive Analysis of ESRRA in Endometrial Cancer . Technol Cancer Res Treat . 2021 ; 20 : 1533033821992083 . doi: 10.1177/1533033821992083 OpenUrl CrossRef 218. ↵ Arslan Ö , Soylu NK , Akillilar PT , Tazebay UH . Coiled-coil domain-containing protein-124 (Ccdc124) is a novel RNA binding factor up-regulated in endometrial, ovarian, and urinary bladder cancers . Cancer Biomark . 2021 ; 31 ( 2 ): 149 – 164 . doi: 10.3233/CBM-200802 OpenUrl CrossRef PubMed 219. ↵ Kim HJ , Kim HG , Kim MH , Kwack KB , Park JK , Kim T , Kim JW , Ban JY , Chung JH . Association between neuronal cell adhesion molecule (NRCAM) single nucleotide polymorphisms and schizophrenia in a Korean population . Psychiatry Clin Neurosci . 2009 ; 63 ( 1 ): 123 – 124 . doi: 10.1111/j.1440-1819.2008.01893.x OpenUrl CrossRef PubMed Web of Science 220. ↵ Esaki K , Kondo K , Hatano M , Saito T , Kishi T , Umene-Nakano W , Yoshimura R , Nakamura J , Ozaki N , Ikeda M , et al. Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder . J Hum Genet . 2013 ; 58 ( 8 ): 568 – 569 . doi: 10.1038/jhg.2013.52 OpenUrl CrossRef PubMed 221. ↵ Yu L , Chibnik LB , Srivastava GP , Pochet N , Yang J , Xu J , Kozubek J , Obholzer N , Leurgans SE , Schneider JA , et al. Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease . JAMA Neurol . 2015 ; 72 ( 1 ): 15 - 24 . doi: 10.1001/jamaneurol.2014.3049 OpenUrl CrossRef PubMed 222. ↵ Sargazi S , Heidari Nia M , Mirinejad S , Moudi M , Jafari Shahroudi M , Saravani R , Valian-Borojeni S . Association of a Novel KIF26B Gene Polymorphism with Susceptibility to Schizophrenia and Breast Cancer: A Case-Control Study . Iran J Public Health . 2021 ; 50 ( 2 ): 397 – 406 . doi: 10.18502/ijph.v50i2.5359 OpenUrl CrossRef PubMed 223. ↵ Kim JH , Afridi R , Cho E , Yoon JH , Lim YH , Lee HW , Ryu H , Suk K . Soluble ANPEP Released From Human Astrocytes as a Positive Regulator of Microglial Activation and Neuroinflammation: Brain Renin-Angiotensin System in Astrocyte-Microglia Crosstalk . Mol Cell Proteomics . 2022 ; 21 ( 11 ): 100424 . doi: 10.1016/j.mcpro.2022.100424 OpenUrl CrossRef PubMed 224. ↵ Dodd S , Skvarc DR , Dean OM , Anderson A , Kotowicz M , Berk M . Effect of Glucocorticoid and 11β-Hydroxysteroid-Dehydrogenase Type 1 (11β-HSD1) in Neurological and Psychiatric Disorders . Int J Neuropsychopharmacol . 2022 ; 25 ( 5 ): 387 – 398 . doi: 10.1093/ijnp/pyac014 OpenUrl CrossRef PubMed 225. ↵ Danzi BA , La Greca AM . Does age matter in genetics? The role of ADCYAP1R1 in sex-specific risk for posttraumatic stress disorder in trauma-exposed preadolescent children . J Psychiatr Res . 2023 ; 164 : 291 - 295 . doi: 10.1016/j.jpsychires.2023.06.024 OpenUrl CrossRef PubMed 226. ↵ de Vega L , Effendy E , Camellia V . Screening of Mental Disorders Related CD4 Count of People Living with HIV/AIDS with Anti-Retroviral Treatment in Medan, Indonesia . Open Access Maced J Med Sci . 2019 ; 7 ( 16 ): 2647 – 2651 . doi: 10.3889/oamjms.2019.818 OpenUrl CrossRef PubMed 227. ↵ Lombardi L , Blanchet C , Poirier K , Lebrun N , Ramoz N , Rose Moro M , Gorwood P , Bienvenu T . Anorexia nervosa is associated with Neuronatin variants . Psychiatr Genet . 2019 ; 29 ( 4 ): 103 – 110 . doi: 10.1097/YPG.0000000000000224 OpenUrl CrossRef PubMed 228. ↵ Cai S , Li J , Wu Y , Jiang Y . De novo mutations of TUBB2A cause infantile-onset epilepsy and developmental delay . J Hum Genet . 2020 ; 65 ( 7 ): 601 – 608 . doi: 10.1038/s10038-020-0739-5 OpenUrl CrossRef PubMed 229. ↵ Wang QW , Wang YH , Wang B , Chen Y , Lu SY , Yao J . Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants . PLoS Biol . 2021 ; 19 ( 7 ): e3001323 . doi: 10.1371/journal.pbio.3001323 OpenUrl CrossRef PubMed 230. ↵ Al-Mazidi SH , El-Ansary A , Abualnaja A , AlZarroug A , Alharbi T , Al-Ayadhi LY . Exploring the Potential Role of ADAM 17 and ADAM 22 in the Etiology of Autism Spectrum Disorders . Brain Sci . 2023 ; 13 ( 6 ): 972 . doi: 10.3390/brainsci13060972 OpenUrl CrossRef PubMed 231. ↵ Innos J , Koido K , Philips MA , Vasar E . Limbic system associated membrane protein as a potential target for neuropsychiatric disorders . Front Pharmacol . 2013 ; 4 : 32 . doi: 10.3389/fphar.2013.00032 OpenUrl CrossRef 232. ↵ Kong M , Kim Y , Lee C . A strong synergistic epistasis between FAM134B and TNFRSF19 on the susceptibility to vascular dementia . Psychiatr Genet . 2011 ; 21 ( 1 ): 37 – 41 . doi: 10.1097/YPG.0b013e3283413496 OpenUrl CrossRef PubMed 233. ↵ Zhang T , Yu J , Wang G , Zhang R . Amyloid precursor protein binds with TNFRSF21 to induce neural inflammation in Alzheimer’s Disease . Eur J Pharm Sci . 2021 ; 157 : 105598 . doi: 10.1016/j.ejps.2020.105598 OpenUrl CrossRef PubMed 234. ↵ Fu X , Zhang P , Song H , Wu C , Li S , Li S , Yan C . LTBP1 plays a potential bridge between depressive disorder and glioblastoma . J Transl Med . 2020 ; 18 ( 1 ): 391 . doi: 10.1186/s12967-020-02509-3 OpenUrl CrossRef 235. ↵ Ciccone L , Vandooren J , Nencetti S , Orlandini E . Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease . Pharmaceuticals (Basel ). 2021 ; 14 ( 2 ): 86 . doi: 10.3390/ph14020086 OpenUrl CrossRef PubMed 236. ↵ Konyukh M , Delorme R , Chaste P , Leblond C , Lemière N , Nygren G , Anckarsäter H , Rastam M , Ståhlberg O , Amsellem F , et al. Variations of the candidate SEZ6L2 gene on Chromosome 16p11.2 in patients with autism spectrum disorders and in human populations . PLoS One . 2011 ; 6 ( 3 ): e17289 . doi: 10.1371/journal.pone.0017289 OpenUrl CrossRef PubMed 237. ↵ Kouchaki E , Nikoueinejad H , Akbari H , Azimi S , Behnam M . The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis . J Immunoassay Immunochem . 2019 ; 40 ( 4 ): 396 – 406 . doi: 10.1080/15321819.2019.1613244 OpenUrl CrossRef PubMed 238. ↵ Lei W , Xiong Y , Shi Y , Song L , Xiang J , Yang F , Wu X , Wang H , Tian M . ADGRL1 variants: From developmental and epileptic encephalopathy to genetic epilepsy with febrile seizures plus . Dev Med Child Neurol . 2025 ; 67 ( 1 ): 119 – 125 . doi: 10.1111/dmcn.16005 OpenUrl CrossRef PubMed 239. ↵ Astillero-Lopez V , Villar-Conde S , Gonzalez-Rodriguez M , Flores-Cuadrado A , Ubeda-Banon I , Saiz-Sanchez D , Martinez-Marcos A . Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer’s disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells . Brain Pathol . 2024 ; 34 ( 4 ): e13235 . doi: 10.1111/bpa.13235 OpenUrl CrossRef PubMed 240. ↵ Clatot J , Currin CB , Liang Q , Pipatpolkai T , Massey SL , Helbig I , Delemotte L , Vogels TP , Covarrubias M , Goldberg EM . A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction . Proc Natl Acad Sci U S A . 2024 ; 121 ( 3 ): e2307776121 . doi: 10.1073/pnas.2307776121 OpenUrl CrossRef PubMed 241. ↵ Dibbens LM , Karakis I , Bayly MA , Costello DJ , Cole AJ , Berkovic SF . Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy . Arch Neurol . 2011 ; 68 ( 6 ): 812 – 813 . doi: 10.1001/archneurol.2011.120 OpenUrl CrossRef PubMed Web of Science 242. ↵ Zhang Y , Gao X , Bai X , Yao S , Chang YZ , Gao G . The emerging role of furin in neurodegenerative and neuropsychiatric diseases . Transl Neurodegener . 2022 ; 11 ( 1 ): 39 . doi: 10.1186/s40035-022-00313-1 OpenUrl CrossRef PubMed 243. ↵ Vervoort VS , Beachem MA , Edwards PS , Ladd S , Miller KE , de Mollerat X , Clarkson K , DuPont B , Schwartz CE , Stevenson RE , et al. AGTR2 mutations in X-linked mental retardation . Science . 2002 ; 296 ( 5577 ):2401-2403. doi: 10.1126/science.1072191 OpenUrl FREE Full Text 244. ↵ Rodek P , Kowalczyk M , Kowalski J , Owczarek A , Choręza P , Kucia K . Association Study of the SLC1A2 (rs4354668), SLC6A9 (rs2486001), and SLC6A5 (rs2000959) Polymorphisms in Major Depressive Disorder . J Clin Med . 2022 ; 11 ( 19 ): 5914 . doi: 10.3390/jcm11195914 OpenUrl CrossRef PubMed 245. ↵ Li Y , Su P , Chen Y , Nie J , Yuan TF , Wong AH , Liu F . The Eph receptor A4 plays a role in demyelination and depression-related behavior . J Clin Invest . 2022 ; 132 ( 8 ): e152187 . doi: 10.1172/JCI152187 OpenUrl CrossRef PubMed 246. ↵ Kuo MC , Chu YT , Su YA , Chen ML , Wu RM . Prosaposin variants in sporadic, familial, and early-onset Parkinson’s disease: a Taiwanese case-control study and meta-analysis . Sci Rep . 2024 ; 14 ( 1 ): 2225 . doi: 10.1038/s41598-024-51646-y OpenUrl CrossRef PubMed 247. ↵ Kushima I , Aleksic B , Ito Y , Nakamura Y , Nakamura K , Mori N , Kikuchi M , Inada T , Kunugi H , Nanko S , et al. Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population . J Hum Genet . 2010 ; 55 ( 3 ): 133 – 136 . doi: 10.1038/jhg.2009.139 OpenUrl CrossRef PubMed 248. ↵ Dumaine A , Maucuer A , Barbet A , Manceau V , Deshommes J , Méary A , Szöke A , Schürhoff F , Llorca PM , Lancon C , Leboyer M , et al. Genetic and molecular exploration of UHMK1 in schizophrenic patients . Psychiatr Genet . 2011 ; 21 ( 6 ): 315 – 318 . doi: 10.1097/YPG.0b013e3283458a37 OpenUrl CrossRef PubMed 249. ↵ Cong L , Jia J . Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer’s disease . Neurobiol Aging . 2011 ; 32 ( 1 ): 54 – 62 . doi: 10.1016/j.neurobiolaging.2009.01.001 OpenUrl CrossRef PubMed 250. ↵ Ghosh M , Ali A , Joshi S , Srivastava AS , Tapadia MG . SLC1A3 C3590T but not BDNF G196A is a predisposition factor for stress as well as depression, in an adolescent eastern Indian population . BMC Med Genet . 2020 ; 21 ( 1 ): 53 . doi: 10.1186/s12881-020-0993-6 OpenUrl CrossRef PubMed 251. ↵ Maussion G , Cruceanu C , Rosenfeld JA , Bell SC , Jollant F , Szatkiewicz J , Collins RL , Hanscom C , Kolobova I , de Champfleur NM , et al. Implication of LRRC4C and DPP6 in neurodevelopmental disorders . Am J Med Genet A . 2017 ; 173 ( 2 ): 395 – 406 . doi: 10.1002/ajmg.a.38021 OpenUrl CrossRef PubMed 252. ↵ Fındıklı E , Camkurt MA , İzci F, Karaaslan MF, Fındıklı HA, Sümer P, Kurutaş EB . The Diagnostic Value of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Drug Naïve, First Episode, Non-Smoker Generalized Anxiety Disorder Patients . Clin Psychopharmacol Neurosci . 2018 ; 16 ( 1 ): 88 – 94 . doi: 10.9758/cpn.2018.16.1.88 OpenUrl CrossRef PubMed 253. ↵ Green TE , Scheffer IE , Berkovic SF , Hildebrand MS . UNC13B and focal epilepsy . Brain . 2022 ; 145 ( 3 ): e10 – e12 . doi: 10.1093/brain/awab485 OpenUrl CrossRef PubMed 254. ↵ Albobali Y , Shahwan MY , Madi MY , Al-Nuaimi S . Two Sisters From Qatar With TUSC3 Genetic Mutation: Psychiatric Considerations . Cureus . 2021 ; 13 ( 8 ): e17616 . doi: 10.7759/cureus.17616 OpenUrl CrossRef 255. ↵ Paseban T , Alavi MS , Etemad L , Roohbakhsh A . The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review . Expert Opin Ther Targets . 2023 ; 27 ( 7 ): 531 – 552 . doi: 10.1080/14728222.2023.2235718 OpenUrl CrossRef PubMed 256. ↵ Singh NK , Banerjee BD , Bala K , Mitrabasu, Dung Dung AA, Chhillar N. APOE and LRPAP1 gene polymorphism and risk of Parkinson’s disease . Neurol Sci . 2014 ; 35 ( 7 ): 1075 – 1081 . doi: 10.1007/s10072-014-1651-6 OpenUrl CrossRef PubMed 257. ↵ Küry S , Zhang J , Besnard T , Caro-Llopis A , Zeng X , Robert SM , Josiah SS , Kiziltug E , Denommé-Pichon AS , Cogné B , et al. Rare pathogenic variants in WNK3 cause X-linked intellectual disability . Genet Med . 2022 ; 24 ( 9 ): 1941 – 1951 . doi: 10.1016/j.gim.2022.05.009 OpenUrl CrossRef PubMed 258. ↵ Scuderi C , Saccuzzo L , Vinci M , Castiglia L , Galesi O , Salemi M , Mattina T , Borgione E , Città S , Romano C , et al. Biallelic intragenic duplication in ADGRB3 (BAI3) gene associated with intellectual disability, cerebellar atrophy, and behavioral disorder . Eur J Hum Genet . 2019 ; 27 ( 4 ): 594 – 602 . doi: 10.1038/s41431-018-0321-1 OpenUrl CrossRef PubMed 259. ↵ Benkortbi Elouaer AAE , Ben Mohamed B , Zaafrane F , Gaha L , Bel Hadj Jrad Tensaout B. Case control study: G-allele of rs4244165 in JAK1 gene correlated with high-level brief psychiatric rating scale in bipolar patients . Medicine (Baltimore) . 2023 ; 102 ( 37 ): e34652 . doi: 10.1097/MD.0000000000034652 OpenUrl CrossRef PubMed 260. ↵ Shimizu H , Iwayama Y , Yamada K , Toyota T , Minabe Y , Nakamura K , Nakajima M , Hattori E , Mori N , Osumi N , et al. Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia . Schizophr Res . 2006 ; 84 ( 2-3 ): 244 – 252 . doi: 10.1016/j.schres.2006.03.017 OpenUrl CrossRef PubMed Web of Science 261. ↵ Yang K , Zhang T , Niu R , Zhao L , Cheng Z , Li J , Wang L . Unveiling the role of IGF1R in autism spectrum disorder: a multi-omics approach to decipher common pathogenic mechanisms in the IGF signaling pathway . Front Genet . 2024 ; 15 : 1483574 . doi: 10.3389/fgene.2024.1483574 OpenUrl CrossRef 262. ↵ Li N , Gao S , Wang S , He S , Wang J , He L , Jiang D , Shi YS , Zhang J , Gu Y , et al. Attractin Participates in Schizophrenia by Affecting Testosterone Levels . Front Cell Dev Biol . 2021 ; 9 : 755165 . doi: 10.3389/fcell.2021.755165 OpenUrl CrossRef 263. ↵ Manti F , Nardecchia F , Barresi S , Venditti M , Pizzi S , Hamdan FF , Blau N , Burlina A , Tartaglia M , Leuzzi V . Neurotransmitter trafficking defect in a patient with clathrin (CLTC) variation presenting with intellectual disability and early-onset parkinsonism . Parkinsonism Relat Disord . 2019 ; 61 : 207 – 210 . doi: 10.1016/j.parkreldis.2018.10.012 OpenUrl CrossRef PubMed 264. ↵ Pascolini G , Majore S , Valiante M , Bottillo I , Laino L , Agolini E , Novelli A , Grammatico B , Calvani M , Grammatico P . Autism spectrum disorder in a patient with a genomic rearrangement that only involves the EPHA5 gene . Psychiatr Genet . 2019 ; 29 ( 3 ): 86 – 90 . doi: 10.1097/YPG.0000000000000217 OpenUrl CrossRef PubMed 265. ↵ Tomé S , Manley K , Simard JP , Clark GW , Slean MM , Swami M , Shelbourne PF , Tillier ER , Monckton DG , Messer A , et al. MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington’s disease mice . PLoS Genet . 2013 ; 9 ( 2 ): e1003280 . doi: 10.1371/journal.pgen.1003280 OpenUrl CrossRef PubMed 266. ↵ Vincent B , Maitra S . BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer’s disease with psychosis? . Ageing Res Rev . 2023 ; 89 : 101988 . doi: 10.1016/j.arr.2023.101988 OpenUrl CrossRef 267. ↵ Schalk A , Cousin MA , Dsouza NR , Challman TD , Wain KE , Powis Z , Minks K , Trimouille A , Lasseaux E , Lacombe D , et al. De novo coding variants in the AGO1 gene cause a neurodevelopmental disorder with intellectual disability . J Med Genet . 2022 ; 59 ( 10 ): 965 – 975 . doi: 10.1136/jmedgenet-2021-107751 OpenUrl Abstract / FREE Full Text 268. ↵ Long JM , Maloney B , Rogers JT , Lahiri DK . Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5’-untranslated region: Implications in Alzheimer’s disease . Mol Psychiatry . 2019 ; 24 ( 3 ): 345 – 363 . doi: 10.1038/s41380-018-0266-3 OpenUrl CrossRef PubMed 269. ↵ Bonea M , Coroama CI , Popp RA , Miclutia IV . The association between the CCDC88A gene polymorphism at rs1437396 and alcohol use disorder, with or without major depression disorder . Arh Hig Rada Toksikol . 2023 ; 74 ( 2 ): 127 – 133 . doi: 10.2478/aiht-2023-74-3690 OpenUrl CrossRef PubMed 270. ↵ He D , He X , Shen D , Liu L , Yang X , Hao M , Wang Y , Li Y , Liu Q , Liu M , et al. Loss-of-function variants in RNA binding motif protein X-linked induce neuronal defects contributing to amyotrophic lateral sclerosis pathogenesis . MedComm (2020) . 2024 ; 5 ( 9 ): e712 . doi: 10.1002/mco2.712 OpenUrl CrossRef 271. ↵ Timpano S , Picketts DJ . Neurodevelopmental Disorders Caused by Defective Chromatin Remodeling: Phenotypic Complexity Is Highlighted by a Review of ATRX Function . Front Genet . 2020 ; 11 : 885 . doi: 10.3389/fgene.2020.00885 OpenUrl CrossRef PubMed 272. ↵ Myers CT , Stong N , Mountier EI , Helbig KL , Freytag S , Sullivan JE , Ben Zeev B , Nissenkorn A , Tzadok M , Heimer G , et al. De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures . Am J Hum Genet . 2017 ; 101 ( 4 ): 516 – 524 . doi: 10.1016/j.ajhg.2017.08.013 OpenUrl CrossRef PubMed 273. ↵ Fattahi M , Bushehri A , Alavi A , Asghariazar V , Nozari A , Ghasemi Firouzabadi S , Motamedian Dehkordi P , Javid M , Farajzadeh Valiliou S , Karimian J , et al. Bi-allelic Mutations in ALDH5A1 is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability . Gene . 2020 . doi: 10.1016/j.gene.2020.144918 OpenUrl CrossRef 274. ↵ Luan ZL , Cui XH , Xu H , Lu HY , Li YY , Lu TL , Zhang D . Association of MSI2 Gene Polymorphism with Age-at-Onset of Schizophrenia in a Chinese Population . Neurosci Bull . 2017 ; 33 ( 6 ): 731 – 733 . doi: 10.1007/s12264-017-0176-4 OpenUrl CrossRef PubMed 275. ↵ Bitar T , Hleihel W , Marouillat S , Vonwill S , Vuillaume ML , Soufia M , Vourc’h P , Laumonnier F , Andres CR . Identification of rare copy number variations reveals PJA2, APCS, SYNPO, and TAC1 as novel candidate genes in Autism Spectrum Disorders . Mol Genet Genomic Med. 2019 ; 7 ( 8 ): e786 . doi: 10.1002/mgg3.786 OpenUrl CrossRef 276. ↵ Ma F , Bian H , Jiao W , Zhang N . Single-cell RNA-seq reveals the role of YAP1 in prefrontal cortex microglia in depression . BMC Neurol . 2024 ; 24 ( 1 ): 191 . doi: 10.1186/s12883-024-03685-1 OpenUrl CrossRef PubMed 277. ↵ Kim Y , Connor JR . The roles of iron and HFE genotype in neurological diseases . Mol Aspects Med . 2020 ; 75 : 100867 . doi: 10.1016/j.mam.2020.100867 OpenUrl CrossRef 278. ↵ Qi H , Pan D , Zhang Y , Zhu Y , Zhang X , Fu T . NEXMIF Combined with KIDINS220 Gene Mutation Caused Neurodevelopmental Disorder and Epilepsy: One Case Report . Actas Esp Psiquiatr . 2024 ; 52 ( 4 ): 588 – 594 . doi: 10.62641/aep.v52i4.1625 OpenUrl CrossRef PubMed 279. ↵ Chelban V , Tucci A , Lynch DS , Polke JM , Santos L , Jonvik H , Groppa S , Wood NW , Houlden H . Truncating mutations in SPAST patients are associated with a high rate of psychiatric comorbidities in hereditary spastic paraplegia . J Neurol Neurosurg Psychiatry . 2017 ; 88 ( 8 ): 681 – 687 . doi: 10.1136/jnnp-2017-315796 OpenUrl Abstract / FREE Full Text 280. ↵ Palmer DS , Howrigan DP , Chapman SB , Adolfsson R , Bass N , Blackwood D , Boks MPM , Chen CY , Churchhouse C , Corvin AP , et al. Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia . Nat Genet . 2022 ; 54 ( 5 ): 541 – 547 . doi: 10.1038/s41588-022-01034-x OpenUrl CrossRef PubMed 281. ↵ Bidart M , El Atifi M , Miladi S , Rendu J , Satre V , Ray PF , Bosson C , Devillard F , Lehalle D , Malan V , et al. Microduplication of the ARID1A gene causes intellectual disability with recognizable syndromic features . Genet Med . 2017 ; 19 ( 6 ): 701 – 710 . doi: 10.1038/gim.2016.180 OpenUrl CrossRef PubMed 282. ↵ Davidkova G , McCullumsmith RE , Meador-Woodruff JH . Expression of ARHGEF11 mRNA in schizophrenic thalamus . Ann N Y Acad Sci . 2003 ; 1003 : 375 – 377 . doi: 10.1196/annals.1300.030 OpenUrl CrossRef PubMed Web of Science 283. ↵ Choy KR , Watters DJ . Neurodegeneration in ataxia-telangiectasia: Multiple roles of ATM kinase in cellular homeostasis . Dev Dyn . 2018 ; 247 ( 1 ): 33 – 46 . doi: 10.1002/dvdy.24522 OpenUrl CrossRef PubMed 284. ↵ Xing L , Zhang K , Dai L , Li F , Guo Y , Huang S , Zheng Z , Zhang F , Gao X . A family-based association study of PRSS12 and mental retardation in the Qinba mountain region of China . Psychiatr Genet . 2013 ; 23 ( 3 ): 137 . doi: 10.1097/YPG.0b013e32835d6fed OpenUrl CrossRef PubMed 285. ↵ Weiner S , Sauer M , Brinkmalm G , Constantinescu J , Constantinescu R , Gomes BF , Becker B , Nellgård B , Dalla K , Galasko D , et al. SCRN1: A cerebrospinal fluid biomarker correlating with tau in Alzheimer’s disease . Alzheimers Dement . 2023 ; 19 ( 10 ): 4609 – 4618 . doi: 10.1002/alz.13042 OpenUrl CrossRef PubMed 286. ↵ Kunde SA , Rademacher N , Tzschach A , Wiedersberg E , Ullmann R , Kalscheuer VM , Shoichet SA . Characterisation of de novo MAPK10/JNK3 truncation mutations associated with cognitive disorders in two unrelated patients . Hum Genet . 2013 ; 132 ( 4 ): 461 – 471 . doi: 10.1007/s00439-012-1260-5 OpenUrl CrossRef PubMed 287. ↵ Koh K , Ishiura H , Beppu M , Shimazaki H , Ichinose Y , Mitsui J , Kuwabara S , Tsuji S , Takiyama Y; Japan Spastic Paraplegia Research Consortium. Novel mutations in the ALDH18A1 gene in complicated hereditary spastic paraplegia with cerebellar ataxia and cognitive impairment . J Hum Genet . 2018 ; 63 ( 9 ): 1009 - 1013 . doi: 10.1038/s10038-018-0477-0 OpenUrl CrossRef PubMed 288. ↵ Bastos CR , Bevilacqua LM , Mendes LFB , Xavier J , Gruhn K , Kaster MP , Ghisleni G . Amygdala-specific changes in Cacna1c, Nfat5, and Bdnf expression are associated with stress responsivity in mice: A possible mechanism for psychiatric disorders . J Psychiatr Res . 2024 ; 175 : 259 - 270 . doi: 10.1016/j.jpsychires.2024.05.019 OpenUrl CrossRef PubMed 289. ↵ Zeng S , Liu K , Zhang J , Chen C , Xu Y , Wu Y , Deng Y , Sun X , Wen G , Jing L . In Vivo Structural and Functional Abnormalities of the Striatums Is Related to Decreased Astrocytic BDNF in Itpr2-/-Mice Exhibiting Depressive-Like Behavior . Neural Plast . 2020 ; 2020 : 8830670 . doi: 10.1155/2020/8830670 OpenUrl CrossRef PubMed 290. ↵ Liu FR , Zhou Y , Wang Y , Huang LL , Zhang X , Luo H , Wu SY , Lyu HY , Huang LH , Xu H , et al. Pedigree-based study to identify GOLGB1 as a risk gene for bipolar disorder . Transl Psychiatry . 2022 ; 12 ( 1 ): 390 . doi: 10.1038/s41398-022-02163-x OpenUrl CrossRef PubMed 291. ↵ Krishna G , Kn A , Kumar RS , Sagar BC , Philip M , Dahale AB , Issac TG , Mukku SSR , Sivakumar PT , Subramanian S . Higher levels of lysosomal associated membrane protein-2 (LAMP-2) in plasma exosomes from Alzheimer’s disease: An exploratory study from South India . Asian J Psychiatr . 2020 ; 48 : 101898 . doi: 10.1016/j.ajp.2019.101898 OpenUrl CrossRef 292. ↵ Gupta M , Neavin D , Liu D , Biernacka J , Hall-Flavin D , Bobo WV , Frye MA , Skime M , Jenkins GD , Batzler A , et al. TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics . Mol Psychiatry . 2016 ; 21 ( 12 ): 1717 - 1725 . doi: 10.1038/mp.2016.6 OpenUrl CrossRef PubMed 293. ↵ Endo R , Chen YK , Burke J , Takashima N , Suryawanshi N , Hui KK , Miyazaki T , Tanaka M . Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3 . Proc Natl Acad Sci U S A . 2023 ; 120 ( 12 ): e2211522120 . doi: 10.1073/pnas.2211522120 OpenUrl CrossRef PubMed 294. ↵ Kakiuchi C , Ishiwata M , Nanko S , Kunugi H , Minabe Y , Nakamura K , Mori N , Fujii K , Umekage T , Tochigi M , et al. Association analysis of HSP90B1 with bipolar disorder . J Hum Genet . 2007 ; 52 ( 10 ): 794 – 803 . doi: 10.1007/s10038-007-0188-4 OpenUrl CrossRef PubMed 295. ↵ Su Y , Yang L , Li Z , Wang W , Xing M , Fang Y , Cheng Y , Lin GN , Cui D . The interaction of ASAH1 and NGF gene involving in neurotrophin signaling pathway contributes to schizophrenia susceptibility and psychopathology . Prog Neuropsychopharmacol Biol Psychiatry . 2021 ; 104 : 110015 . doi: 10.1016/j.pnpbp.2020.110015 OpenUrl CrossRef 296. ↵ Kobayashi R , Naruse H , Kawakatsu S , Iseki C , Suzuki Y , Koyama S , Morioka D , Ishiura H , Mitsui J , Ohta Y , et al. Valosin-containing protein Asp395Gly mutation in a patient with frontotemporal dementia: a case report . BMC Neurol . 2022 ; 22 ( 1 ): 406 . doi: 10.1186/s12883-022-02951-4 OpenUrl CrossRef PubMed 297. ↵ Gidado KI , Adeshakin FO , Rabiu L , Zhang Z , Zhang G , Wan X . Multifaceted roles of DLG3/SAP102 in neurophysiology, neurological disorders and tumorigenesis . Neuroscience . 2024 . doi: 10.1016/j.neuroscience.2024.11.081 OpenUrl CrossRef 298. ↵ Maheshwari M , Christian SL , Liu C , Badner JA , Detera-Wadleigh S , Gershon ES , Gibbs RA . Mutation screening of two candidate genes from 13q32 in families affected with Bipolar disorder: human peptide transporter (SLC15A1) and human glypican5 (GPC5) . BMC Genomics . 2002 ; 3 ( 1 ): 30 . doi: 10.1186/1471-2164-3-30 OpenUrl CrossRef PubMed 299. ↵ Matrone C , Dzamko N , Madsen P , Nyegaard M , Pohlmann R , Søndergaard RV , Lassen LB , Andresen TL , Halliday GM , Jensen PH , et al. Mannose 6-Phosphate Receptor Is Reduced in-Synuclein Overexpressing Models of Parkinsons Disease . PLoS One . 2016 ; 11 ( 8 ): e0160501 . doi: 10.1371/journal.pone.0160501 OpenUrl CrossRef PubMed 300. ↵ Wigner P , Czarny P , Synowiec E , Bijak M , Talarowska M , Galecki P , Szemraj J , Sliwinski T . Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development . Eur Psychiatry . 2018 ; 52 : 95 - 103 . doi: 10.1016/j.eurpsy.2018.05.001 OpenUrl CrossRef PubMed 301. ↵ Yang Y , Zhang S , Guan J , Jiang Y , Zhang J , Luo L , Sun C . SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson’s disease . Biochim Biophys Acta Mol Basis Dis . 2022 ; 1868 ( 5 ): 166365 . doi: 10.1016/j.bbadis.2022.166365 OpenUrl CrossRef 302. ↵ You C , Xu N , Qiu S , Li Y , Xu L , Li X , Yang L . A novel composition of two heterozygous GFM1 mutations in a Chinese child with epilepsy and mental retardation . Brain Behav . 2020 ; 10 ( 10 ): e01791 . doi: 10.1002/brb3.1791 OpenUrl CrossRef PubMed 303. ↵ Wang Y , Zhang X , Song Z , Gu F . An anti-CAPN5 intracellular antibody acts as an inhibitor of CAPN5-mediated neuronal degeneration . Oncotarget . 2017 ; 8 ( 59 ): 100312 – 100325 . doi: 10.18632/oncotarget.22221 OpenUrl CrossRef PubMed 304. ↵ Gagliardi S , Davin A , Bini P , Sinforiani E , Poloni TE , Polito L , Rivoiro C , Binetti G , Paterlini A , Benussi L , et al. A Novel Nonsense Angiogenin Mutation is Associated With Alzheimer Disease . Alzheimer Dis Assoc Disord . 2019 ; 33 ( 2 ): 163 – 165 . doi: 10.1097/WAD.0000000000000272 OpenUrl CrossRef PubMed 305. ↵ Correia CT , Conceição IC , Oliveira B , Coelho J , Sousa I , Sequeira AF , Almeida J , Café C , Duque F , Mouga S , et al. Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders . Mol Autism . 2014 ; 5 ( 1 ): 28 . doi: 10.1186/2040-2392-5-28 OpenUrl CrossRef PubMed 306. ↵ Xu P , Tao Y , Zhang H , Jin M , Xu H , Zou S , Deng F , Huang L , Zhang H , Wang X , et al. RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients . BMC Psychiatry . 2022 ; 22 ( 1 ): 561 . doi: 10.1186/s12888-022-04196-4 OpenUrl CrossRef PubMed 307. ↵ Yoshimasu K , Mure K , Hashimoto M , Takemura S , Tsuno K , Hayashida M , Kinoshita K , Takeshita T , Miyashita K . Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms as indicator of mental disorders in Japanese employees . Alcohol Alcohol . 2015 ; 50 ( 1 ): 39 – 45 . doi: 10.1093/alcalc/agu080 OpenUrl CrossRef PubMed 308. ↵ Rupprecht R , Rupprecht C , Di Benedetto B , Rammes G . Neuroinflammation and psychiatric disorders: Relevance of C1q, translocator protein (18 kDa) (TSPO), and neurosteroids . World J Biol Psychiatry . 2022 ; 23 ( 4 ): 257 – 263 . doi: 10.1080/15622975.2021.1961503 OpenUrl CrossRef PubMed 309. ↵ Zeng L , Hu P , Zhang Y , Li M , Zhao Y , Li S , Luo A . Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders . Cytokine Growth Factor Rev . 2024 ; 77 : 67 – 75 . doi: 10.1016/j.cytogfr.2024.03.00 OpenUrl CrossRef PubMed 310. ↵ Santiago TC , Parra L , Nani JV , Fidalgo TM , Bradshaw NJ , Hayashi MAF . Angiotensin-converting enzymes as druggable features of psychiatric and neurodegenerative disorders . J Neurochem . 2023 ; 166 ( 2 ): 138 – 155 . doi: 10.1111/jnc.15806 OpenUrl CrossRef PubMed 311. ↵ Shao X , Yan C , Sun D , Fu C , Tian C , Duan L , Zhu G . Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population . Neuropsychiatr Dis Treat . 2020 ; 16 : 2297 – 2305 . doi: 10.2147/NDT.S272278 OpenUrl CrossRef PubMed 312. ↵ Qu L , Tang Y , Wu J , Yun X , Lo HH , Song L , Wang X , Wang H , Zhang R , Liu M , et al. FBXL16: a new regulator of neuroinflammation and cognition in Alzheimer’s disease through the ubiquitination-dependent degradation of amyloid precursor protein . Biomark Res . 2024 ; 12 ( 1 ): 144 . doi: 10.1186/s40364-024-00691-w OpenUrl CrossRef PubMed 313. ↵ Ji J , Li S , Jiang Z , Yu J , Sun Y , Cai Z , Dong Y , Sun X . Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model . Int J Mol Sci . 2022 ; 23 ( 18 ): 10822 . doi: 10.3390/ijms231810822 OpenUrl CrossRef PubMed 314. ↵ Sims NA . Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders . Cytokine Growth Factor Rev . 2015 ; 26 ( 5 ): 517 – 522 . doi: 10.1016/j.cytogfr.2015.07.014 OpenUrl CrossRef PubMed 315. ↵ Song Q , Zhao F , Yao J , Dai H , Hu L , Yu S . Protective effect of microRNA-134-3p on multiple sclerosis through inhibiting PRSS57 and promotion of CD34+ cell proliferation in rats . J Cell Biochem . 2020 ; 121 ( 11 ): 4347 – 4363 . doi: 10.1002/jcb.29643 OpenUrl CrossRef PubMed 316. ↵ Kozlova AA , Vaganova AN , Rodionov RN , Gainetdinov RR , Bernhardt N . Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods . Int J Mol Sci . 2022 ; 23 ( 19 ): 11902 . doi: 10.3390/ijms231911902 OpenUrl CrossRef PubMed 317. ↵ Lim JH , Kang HM , Kim DH , Jeong B , Lee DY , Lee JR , Baek JY , Cho HS , Son MY , Kim DS , et al. ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model . J Exp Med . 2024 ; 221 ( 1 ): e20230367 . doi: 10.1084/jem.20230367 OpenUrl CrossRef PubMed 318. ↵ Wu Y , Zhao K , Chen Y , Wu L , Qiu F , Yuan Y , Shen G , Wang K , Kang Y , Jiang Y , et al. The interaction between the major vault protein rs4788186 polymorphism, alcohol dependence, and depression among male Chinese problem drinkers . Front Psychiatry . 2023 ; 14 : 1111712 . doi: 10.3389/fpsyt.2023.1111712 OpenUrl CrossRef 319. ↵ Zhong J , Li S , Zeng W , Li X , Gu C , Liu J , Luo XJ . Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder . Neuropsychopharmacology . 2019 ; 44 ( 9 ): 1542 – 1551 . doi: 10.1038/s41386-019-0345-4 OpenUrl CrossRef PubMed 320. ↵ Isrie M , Zamani Esteki M , Peeters H , Voet T , Van Houdt J , Van Paesschen W , Van Esch H . Homozygous missense mutation in STYXL1 associated with moderate intellectual disability, epilepsy and behavioural complexities . Eur J Med Genet . 2015 ; 58 ( 4 ): 205 – 210 . doi: 10.1016/j.ejmg.2015.02.006 OpenUrl CrossRef PubMed 321. ↵ Morimoto M , Bhambhani V , Gazzaz N , Davids M , Sathiyaseelan P , Macnamara EF , Lange J , Lehman A , Zerfas PM , Murphy JL , et al. Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment . NPJ Genom Med . 2023 ; 8 ( 1 ): 4 . doi: 10.1038/s41525-022-00343-8 OpenUrl CrossRef PubMed 322. ↵ Zeman T , Balcar VJ , Cahová K , Janoutová J , Janout V , Lochman J , Šerý O . Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer’s Disease . Mol Neurobiol . 2021 ; 58 ( 3 ): 996 – 1005 . doi: 10.1007/s12035-020-02153-4 OpenUrl CrossRef PubMed 323. ↵ Shigemizu D , Asanomi Y , Akiyama S , Higaki S , Sakurai T , Ito K , Niida S , Ozaki K . Network-based meta-analysis and the candidate gene association studies reveal novel ethnicity-specific variants in MFSD3 and MRPL43 associated with dementia with Lewy bodies . Am J Med Genet B Neuropsychiatr Genet . 2022 ; 189 ( 5 ): 139 – 150 . doi: 10.1002/ajmg.b.32908 OpenUrl CrossRef PubMed 324. ↵ Wu K , Cai Y . The SNP43 (G/A) polymorphism in CAPN10 gene confers an increased risk of cognitive impairment in cerebral small vessel disease . J Clin Lab Anal . 2018 ; 32 ( 9 ): e22615 . doi: 10.1002/jcla.22615 OpenUrl CrossRef PubMed 325. ↵ Krishnan D , Menon RN , Gopala S . SHARPIN: Role in Finding NEMO and in Amyloid-Beta Clearance and Degradation (ABCD) Pathway in Alzheimer’s Disease? . Cell Mol Neurobiol . 2022 ; 42 ( 5 ): 1267 – 1281 . doi: 10.1007/s10571-020-01023-w OpenUrl CrossRef PubMed 326. ↵ Fleming J , Hernandez G , Hartman L , Maksimovic J , Nace S , Lawler B , Risa T , Cook T , Agni R , Reichelderfer M , et al. Safety and efficacy of helminth treatment in relapsing-remitting multiple sclerosis: Results of the HINT 2 clinical trial . Mult Scler . 2019 ; 25 ( 1 ): 81 – 91 . doi: 10.1177/1352458517736377 OpenUrl CrossRef PubMed 327. ↵ Zhang C , Zhan FX , Tian WT , Xu YQ , Zhu ZY , Wang Y , Song XW , Cao L . Ataxia with novel compound heterozygous PEX10 mutations and a literature review of PEX10-related peroxisome biogenesis disorders . Clin Neurol Neurosurg . 2019 ; 177 : 92 – 96 . doi: 10.1016/j.clineuro.2019.01.004 OpenUrl CrossRef PubMed 328. ↵ Hashimoto-Torii K , Torii M , Fujimoto M , Nakai A , El Fatimy R , Mezger V , Ju MJ , Ishii S , Chao SH , Brennand KJ , et al. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders . Neuron . 2014 ; 82 ( 3 ): 560 – 572 . doi: 10.1016/j.neuron.2014.03.002 OpenUrl CrossRef PubMed 329. ↵ Reddy BR , Maitra S , Jhelum P , Kumar KP , Bagul PK , Kaur G , Banerjee SK , Kumar A , Chakravarty S . Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats . J Biosci . 2016 ; 41 ( 3 ): 407 – 417 . doi: 10.1007/s12038-016-9627-8 OpenUrl CrossRef PubMed 330. ↵ Alavez-Rubio JS , Juarez-Cedillo T . ACAT1 as a Therapeutic Target and its Genetic Relationship with Alzheimer’s Disease . Curr Alzheimer Res . 2019 ; 16 ( 8 ): 699 – 709 . doi: 10.2174/1567205016666190823125245 OpenUrl CrossRef PubMed 331. ↵ Osier ND , Bales JW , Pugh B , Shin S , Wyrobek J , Puccio AM , Okonkwo DO , Ren D , Alexander S , Conley YP , et al. Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury . J Neurotrauma . 2017 ; 34 ( 1 ): 86 – 96 . doi: 10.1089/neu.2015.4343 OpenUrl CrossRef PubMed 332. ↵ Kim YN , Kim DH . Decreased serum angiogenin level in Alzheimer’s disease . Prog Neuropsychopharmacol Biol Psychiatry . 2012 ; 38 ( 2 ): 116 – 120 . doi: 10.1016/j.pnpbp.2012.02.010 OpenUrl CrossRef PubMed 333. ↵ Itoh M , Yonemoto T , Ueno F , Iwahara C , Yumoto Y , Nakayama H , Maesato H , Kimura M , Matsushita S . Influence of Comorbid Psychiatric Disorders on the Risk of Development of Alcohol Dependence by Genetic Variations of ALDH2 and ADH1B . Alcohol Clin Exp Res . 2020 ; 44 ( 11 ): 2275 – 2282 . doi: 10.1111/acer.14450 OpenUrl CrossRef PubMed 334. ↵ Høgh S , Borgsted C , Hegaard HK , Renault KM , Ekelund K , Bruzzone SE , Clemmensen C , Klein AB , Frokjaer VG . Growth Differentiation Factor 15 during pregnancy and postpartum as captured in blood, cerebrospinal fluid and placenta: A cohort study on associations with maternal mental health . Psychoneuroendocrinology . 2025 ; 171 : 107212 . doi: 10.1016/j.psyneuen.2024.107212 OpenUrl CrossRef 335. ↵ Lutzenberger M , Burwinkel M , Riemer C , Bode V , Baier M . Ablation of CCAAT/Enhancer-Binding Protein Delta (C/EBPD): Increased Plaque Burden in a Murine Alzheimer’s Disease Model . PLoS One . 2015 ; 10 ( 7 ): e0134228 . doi: 10.1371/journal.pone.0134228 OpenUrl CrossRef PubMed 336. ↵ Rivero G , Gabilondo AM , García-Sevilla JA , et al. Brain RGS4 and RGS10 protein expression in schizophrenia and depression . Effect of drug treatment. Psychopharmacology (Berl ). 2013 ; 226 ( 1 ): 177 – 188 . doi: 10.1007/s00213-012-2888-5 OpenUrl CrossRef 337. ↵ Yang H , Yuan Y , Yang K , Wang N , Li X . ELK4 ameliorates cognitive impairment and neuroinflammation induced by obstructive sleep apnea . Brain Res Bull . 2024 ; 216 : 111054 . doi: 10.1016/j.brainresbull.2024.111054 OpenUrl CrossRef 338. ↵ Costa AS , Agostini S , Guerini FR , Mancuso R , Zanzottera M , Ripamonti E , Racca V , Nemni R , Clerici M . Modulation of Immune Responses to Herpes Simplex Virus Type 1 by IFNL3 and IRF7 Polymorphisms: A Study in Alzheimer’s Disease . J Alzheimers Dis . 2017 ; 60 ( 3 ): 1055 – 1063 . doi: 10.3233/JAD-170520 OpenUrl CrossRef 339. ↵ Potash JB , Buervenich S , Cox NJ , Zandi PP , Akula N , Steele J , Rathe JA , Avramopoulos D , Detera-Wadleigh SD , Gershon ES , et al. Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1 . Am J Med Genet B Neuropsychiatr Genet . 2008 ; 147B ( 1 ): 59 - 67 . doi: 10.1002/ajmg.b.30574 OpenUrl CrossRef PubMed 340. ↵ Wang F , Guo B , Jia Z , Jing Z , Wang Q , Li M , Lu B , Liang W , Hu W , Fu X . The Role of CXCR3 in Nervous System-Related Diseases . Mediators Inflamm . 2024 ; 2024 : 8347647 . doi: 10.1155/2024/8347647 OpenUrl CrossRef PubMed 341. ↵ Zhang H , Wang Z , Hu K , Liu H . Downregulation of long noncoding RNA SNHG7 protects against inflammation and apoptosis in Parkinson’s disease model by targeting the miR-425-5p/TRAF5/NF-κB axis . J Biochem Mol Toxicol . 2021 ; 35 ( 10 ): e22867 . doi: 10.1002/jbt.22867 OpenUrl CrossRef PubMed 342. ↵ Zhang L , Zhu B , Zhou X , Ning H , Zhang F , Yan B , Chen J , Ma T . ZNF787 and HDAC1 Mediate Blood-Brain Barrier Permeability in an In Vitro Model of Alzheimer’s Disease Microenvironment . Neurotox Res . 2024 ; 42 ( 1 ): 12 . doi: 10.1007/s12640-024-00693-4 OpenUrl CrossRef PubMed 343. ↵ Zhang M , Xi Z , Ghani M , Jia P , Pal M , Werynska K , Moreno D , Sato C , Liang Y , Robertson J , et al. Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28 . J Neurol Neurosurg Psychiatry . 2016 ; 87 ( 11 ): 1268 – 1270 . doi: 10.1136/jnnp-2016-313592 OpenUrl FREE Full Text 344. ↵ Deng H , Le WD , Guo Y , Huang MS , Xie WJ , Jankovic J . Extended study of A265G variant of HS1BP3 in essential tremor and Parkinson disease . Neurology . 2005 ; 65 ( 4 ): 651 – 652 . doi: 10.1212/01.wnl.0000173033.32535.23 OpenUrl CrossRef PubMed 345. ↵ Hermes DJ , Yadav-Samudrala BJ , Xu C , Paniccia JE , Meeker RB , Armstrong ML , Reisdorph N , Cravatt BF , Mackie K , Lichtman AH , Ignatowska-Jankowska BM , et al. PR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration . Exp Neurol . 2021 ; 341 : 113699 . doi: 10.1016/j.expneurol.2021.113699 OpenUrl CrossRef PubMed 346. ↵ Han P , Mo S , Wang Z , Xu J , Fu X , Tian Y . UXT at the crossroads of cell death, immunity and neurodegenerative diseases . Front Oncol . 2023 ; 13 : 1179947 . doi: 10.3389/fonc.2023.1179947 OpenUrl CrossRef 347. ↵ Cheon J , Jung H , Kang BY , Kim M . Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson’s disease . Genes Genomics . 2025 ; 47 ( 1 ): 47 - 57 . doi: 10.1007/s13258-024-01591-x OpenUrl CrossRef PubMed 348. ↵ Gershlick DC , Ishida M , Jones JR , Bellomo A , Bonifacino JS , Everman DB . A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes . Hum Mol Genet . 2019 ; 28 ( 9 ): 1548 – 1560 . doi: 10.1093/hmg/ddy423 OpenUrl CrossRef PubMed 349. ↵ Paprocka J , Nowak M , Chuchra P , Śmigiel R. COQ8A-Ataxia as a Manifestation of Primary Coenzyme Q Deficiency . Metabolites . 2022 ; 12 ( 10 ): 955 . doi: 10.3390/metabo12100955 OpenUrl CrossRef PubMed 350. ↵ Sun L , Telles E , Karl M , Cheng F , Luetteke N , Sotomayor EM , Miller RH , Seto E . Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model . Life Sci Alliance . 2018 ; 1 ( 5 ): e201800039 . doi: 10.26508/lsa.201800039 OpenUrl Abstract / FREE Full Text 351. ↵ Li N , Du J , Yang Y , Zhao T , Wu D , Peng F , Wang D , Kong L , Zhou W , Hao A . Microglial PCGF1 alleviates neuroinflammation associated depressive behavior in adolescent mice . Mol Psychiatry . 2024 . doi: 10.1038/s41380-024-02714-2 OpenUrl CrossRef 352. ↵ Casana E , Jimenez V , Jambrina C , Sacristan V , Muñoz S , Rodo J , Grass I , Garcia M , Mallol C , León X , et al. AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity . Mol Ther Methods Clin Dev . 2022 ; 25 : 190 – 204 . doi: 10.1016/j.omtm.2022.03.007 OpenUrl CrossRef PubMed 353. ↵ Mori RC , Santos-Bezerra DP , Pelaes TS , Admoni SN , Perez RV , Monteiro MB , Machado CG , Queiroz MS , Machado UF , Correa-Giannella ML . Variants in HSD11B1 gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes . Diabetes Metab Res Rev . 2021 ; 37 ( 1 ): e3352 . doi: 10.1002/dmrr.3352 OpenUrl CrossRef PubMed 354. ↵ Fabbrini E , Cella M , McCartney SA , Fuchs A , Abumrad NA , Pietka TA , Chen Z , Finck BN , Han DH , Magkos F , et al. Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals . Gastroenterology . 2013 ; 145 ( 2 ): 366 – 74.e743 . doi: 10.1053/j.gastro.2013.04.010 OpenUrl CrossRef PubMed 355. ↵ Liu Y , Ge X , Dou X , Guo L , Liu Y , Zhou SR , Wei XB , Qian SW , Huang HY , Xu CJ , et al. Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue . Diabetes . 2015 ; 64 ( 12 ): 4061 – 4074 . doi: 10.2337/db15-0278 OpenUrl Abstract / FREE Full Text 356. ↵ Zhao A , Yang Y , Yang Y , Chi Z , Sun Y . Circ-ADAM9 Knockdown Reduces Insulin Resistance and Placental Injury in Diabetic Mice via MAPK Pathway Inactivation . Am J Reprod Immunol . 2024 ; 92 ( 5 ): e70017 . doi: 10.1111/aji.70017 OpenUrl CrossRef PubMed 357. ↵ González-Domínguez Á , Visiedo F , Domínguez-Riscart J , Durán-Ruiz MC , Saez-Benito A , Lechuga-Sancho AM , Mateos RM . Catalase post-translational modifications as key targets in the control of erythrocyte redox homeostasis in children with obesity and insulin resistance . Free Radic Biol Med . 2022 ; 191 : 40 – 47 . doi: 10.1016/j.freeradbiomed.2022.08.017 OpenUrl CrossRef PubMed 358. ↵ Vincent V , Thakkar H , Aggarwal S , Mridha AR , Ramakrishnan L , Singh A . ATP-binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity . Diabetes Metab Syndr Obes . 2019 ; 12 : 275 – 284 . doi: 10.2147/DMSO.S186565 OpenUrl CrossRef PubMed 359. ↵ Huang H , Chen H , Yao Y , Lou X . Branched-chain amino acids supplementation induces insulin resistance and pro-inflammatory macrophage polarization via INFGR1/JAK1/STAT1 signal pathway . Mol Med . 2024 ; 30 ( 1 ): 149 . doi: 10.1186/s10020-024-00894-9 OpenUrl CrossRef PubMed 360. ↵ Garg N , Thakur S , McMahan CA , Adamo ML . High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice . Biochem Biophys Res Commun . 2011 ; 413 ( 3 ): 476 – 480 . doi: 10.1016/j.bbrc.2011.08.123 OpenUrl CrossRef PubMed 361. ↵ Li A , Qiu M , Zhou H , Wang T , Guo W. PTEN, Insulin Resistance and Cancer . Curr Pharm Des . 2017 ; 23 ( 25 ): 3667 - 3676 . doi: 10.2174/1381612823666170704124611 OpenUrl CrossRef PubMed 362. ↵ Han Y , Quan Z , Tian M , Wang R , Guo D , Zhang D , Liu L . BACE1 inhibition via miR-6838-5p overexpression inhibits insulin resistance and the immune response in HFD-induced obesity in mice model . Immunopharmacol Immunotoxicol . 2024 . doi: 10.1080/08923973.2024.2430668 OpenUrl CrossRef 363. ↵ Mullins RJ , Diehl TC , Chia CW , Kapogiannis D . Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease . Front Aging Neurosci . 2017 ; 9 : 118 . doi: 10.3389/fnagi.2017.00118 OpenUrl CrossRef PubMed 364. ↵ Lin X , Du Y , Lu W , Gui W , Sun S , Zhu Y , Wang G , Eserberg DT , Zheng F , Zhou J , et al. CircRNF111 Protects Against Insulin Resistance and Lipid Deposition via Regulating miR-143-3p/IGF2R Axis in Metabolic Syndrome . Front Cell Dev Biol . 2021 ; 9 : 663148 . doi: 10.3389/fcell.2021.663148 OpenUrl CrossRef 365. ↵ Barton JC , Barton JC , Adams PC , Acton RT . Risk Factors for Insulin Resistance, Metabolic Syndrome, and Diabetes in 248 HFE C282Y Homozygotes Identified by Population Screening in the HEIRS Study . Metab Syndr Relat Disord . 2016 ; 14 ( 2 ): 94 - 101 . doi: 10.1089/met.2015.0123 OpenUrl CrossRef PubMed 366. ↵ Liu J , Chen X , Guo Q , Ma X , Zhang J , Huang X , Zhang X , Zhang S . Association of ARHGEF11 R1467H polymorphism with risk for type 2 diabetes mellitus and insulin resistance in Chinese population . Mol Biol Rep . 2011 ; 38 ( 4 ): 2499 – 2505 . doi: 10.1007/s11033-010-0387-5 OpenUrl CrossRef PubMed 367. ↵ Connelly PJ , Smith N , Chadwick R , Exley AR , Shneerson JM , Pearson ER . Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance . Diabet Med . 2016 ; 33 ( 3 ): 371 – 375 . doi: 10.1111/dme.13037 OpenUrl CrossRef PubMed 368. ↵ Dankel SN , Svärd J , Matthä S , Claussnitzer M , Klöting N , Glunk V , Fandalyuk Z , Grytten E , Solsvik MH , Nielsen HJ , et al. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size . Obesity (Silver Spring) . 2014 ; 22 ( 8 ): 1807 – 1813 . doi: 10.1002/oby.20758 OpenUrl CrossRef PubMed 369. ↵ Lee HH , An SM , Ye BJ , Lee JH , Yoo EJ , Jeong GW , Kang HJ , Alfadda AA , Lim SW , Park J , et al. TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging . Nat Commun . 2019 ; 10 ( 1 ): 3536 . doi: 10.1038/s41467-019-11302-w OpenUrl CrossRef PubMed 370. ↵ Turnbull J , Tiberia E , Pereira S , Zhao X , Pencea N , Wheeler AL , Yu WQ , Ivovic A , Naranian T , Israelian N , et al. Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance . J Biol Chem . 2013 ; 288 ( 48 ): 34627 - 34637 . doi: 10.1074/jbc.M113.483198 OpenUrl Abstract / FREE Full Text 371. ↵ Liu W , Gui R , Li Y , Li M , Lei Z , Jin Y , Yu Y , Li Y , Qian L , Xiong Y . Linarin Identified as a Bioactive Compound of Lycii Cortex Ameliorates Insulin Resistance and Inflammation Through the c-FOS/ARG2 Signaling Axis . Phytother Res . doi: 10.1002/ptr.8370 OpenUrl CrossRef 372. ↵ Okura T , Nakamura R , Anno M , Ito Y , Kitao S , Endo S , Taneda N , Matsumoto K , Shoji K , Okura H , et al. Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes . Metabol Open . 2023 ; 18 : 100242 . doi: 10.1016/j.metop.2023.100242 OpenUrl CrossRef 373. ↵ Ekblad LL , Tuisku J , Koivumäki M , Helin S , Rinne JO , Snellman A . Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly . J Cereb Blood Flow Metab . 2023 ; 43 ( 9 ): 1588 – 1600 . doi: 10.1177/0271678X231172519 OpenUrl CrossRef PubMed 374. ↵ Morrison MC , Kleemann R . Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies . Front Immunol . 2015 ; 6 : 308 . doi: 10.3389/fimmu.2015.00308 OpenUrl CrossRef PubMed 375. ↵ Li J , Lin Z , Wang S , Shi Q . Angiotensin Converting Enzyme (ACE) Gene I/D Polymorphism Is Significantly Associated with Insulin Resistance and Polycystic Ovary Syndrome: A Meta-Analysis . Gynecol Obstet Invest . 2023 ; 88 ( 3 ): 174 – 184 . doi: 10.1159/000530089 OpenUrl CrossRef PubMed 376. ↵ Andersen G , Dalgaard LT , Justesen JM , Anthonsen S , Nielsen T , Thørner LW , Witte D , Jørgensen T , Clausen JO , Lauritzen T , et al. The frequent UCP2-866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes . Int J Obes (Lond ). 2013 ; 37 ( 2 ): 175 – 181 . doi: 10.1038/ijo.2012.22 OpenUrl CrossRef PubMed 377. ↵ Jung DY , Chalasani U , Pan N , Friedline RH , Prosdocimo DA , Nam M , Azuma Y , Maganti R , Yu K , Velagapudi A , et al. KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance . PLoS One . 2013 ; 8 ( 10 ): e77851 . doi: 10.1371/journal.pone.0077851 OpenUrl CrossRef PubMed 378. ↵ Liu J , Quan L , Wang J , Zhang G , Cai L , Pan Z , Liu S , Zhu C , Wu R , Wang L , et al. Knockdown of VEGF-B improves HFD-induced insulin resistance by enhancing glucose uptake in vascular endothelial cells via the PI3K/Akt pathway . Int J Biol Macromol . 2025 ; 285 : 138279 . doi: 10.1016/j.ijbiomac.2024.138279 OpenUrl CrossRef 379. ↵ Heo JY , Cha HN , Kim KY , Lee E , Kim SJ , Kim YW , Kim JY , Lee IK , Gladyshev VN , Kim HY , et al. Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice . Free Radic Res . 2017 ; 51 ( 1 ): 24 – 37 . doi: 10.1080/10715762.2016.1261133 OpenUrl CrossRef PubMed 380. ↵ Sáez ME , González-Sánchez JL , Ramírez-Lorca R , Martínez-Larrad MT , Zabena C , González A , Morón FJ , Ruiz A , Serrano-Ríos M . The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population . PLoS One . 2008 ; 3 ( 8 ): e2953 . doi: 10.1371/journal.pone.0002953 OpenUrl CrossRef PubMed 381. ↵ Xiang W , Yang Y , Weng L , Ye Z , Ding P , Li H , Sun J , Zeng C . Hyperhomocysteinemia activates NLRP3 inflammasome to cause hepatic steatosis and insulin resistance via MDM2-mediated ubiquitination of HSF1 . Int Immunopharmacol . 2023 ; 118 : 110085 . doi: 10.1016/j.intimp.2023.110085 OpenUrl CrossRef 382. ↵ Winnier DA , Fourcaudot M , Norton L , Abdul-Ghani MA , Hu SL , Farook VS , Coletta DK , Kumar S , Puppala S , Chittoor G , Dyer TD , et al. Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES) . PLoS One . 2015 ; 10 ( 4 ): e0119941 . doi: 10.1371/journal.pone.0119941 OpenUrl CrossRef PubMed 383. ↵ Patel S , Haider A , Alvarez-Guaita A , Bidault G , El-Sayed Moustafa JS , Guiu-Jurado E , Tadross JA , Warner J , Harrison J , Virtue S , et al. Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice . Mol Metab . 2022 ; 65 : 101589 . doi: 10.1016/j.molmet.2022.101589 OpenUrl CrossRef 384. ↵ Gao D , Hu S , Zheng X , Lin W , Gao J , Chang K , Zhao D , Wang X , Zhou J , Lu S , et al. SOD3 Is Secreted by Adipocytes and Mitigates High-Fat Diet-Induced Obesity, Inflammation, and Insulin Resistance . Antioxid Redox Signal . 2020 ; 32 ( 3 ): 193 – 212 . doi: 10.1089/ars.2018.7628 OpenUrl CrossRef PubMed 385. ↵ Fang X , Chung J , Olsen E , Snider I , Earls RH , Jeon J , Park HJ , Lee JK . Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract . Nutr Res . 2019 ; 70 : 50 – 59 . doi: 10.1016/j.nutres.2018.06.004 OpenUrl CrossRef PubMed 386. ↵ Cortés VA , Cautivo KM , Rong S , Garg A , Horton JD , Agarwal AK . Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/-lipodystrophic mice independent of hepatocyte leptin receptors . J Lipid Res . 2014 ; 55 ( 2 ): 276 – 288 . doi: 10.1194/jlr.M045799 OpenUrl Abstract / FREE Full Text 387. ↵ Zhu B , Guo X , Xu H , Jiang B , Li H , Wang Y , Yin Q , Zhou T , Cai JJ , Glaser S , et al. Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells . Lab Invest . 2021 ; 101 ( 3 ): 328 – 340 . doi: 10.1038/s41374-020-00523-z OpenUrl CrossRef PubMed 388. ↵ Kumar A , Sundaram K , Teng Y , Mu J , Sriwastva MK , Zhang L , Hood JL , Yan J , Zhang X , Park JW , et al. Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance . Theranostics . 2022 ; 12 ( 3 ): 1388 – 1403 . doi: 10.7150/thno.62514 OpenUrl CrossRef PubMed 389. ↵ Wang XA , Zhang R , Zhang S , Deng S , Jiang D , Zhong J , Yang L , Wang T , Hong S , Guo S , et al. Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance . Am J Physiol Endocrinol Metab . 2013 ; 305 ( 4 ): E485 – E495 . doi: 10.1152/ajpendo.00505.2012 OpenUrl CrossRef PubMed Web of Science 390. ↵ Deiuliis JA , Oghumu S , Duggineni D , Zhong J , Rutsky J , Banerjee A , Needleman B , Mikami D , Narula V , Hazey J , et al. CXCR3 modulates obesity-induced visceral adipose inflammation and systemic insulin resistance . Obesity (Silver Spring) . 2014 ; 22 ( 5 ): 1264 – 1274 . doi: 10.1002/oby.20642 OpenUrl CrossRef PubMed 391. ↵ Kaartinen MT , Arora M , Heinonen S , Rissanen A , Kaprio J , Pietiläinen KH . Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response . Int J Mol Sci . 2020 ; 21 ( 21 ): 8289 . doi: 10.3390/ijms21218289 OpenUrl CrossRef PubMed 392. ↵ Dentillo DB , Meola J , Rosa e Silva JC , Giuliatti S , Silva Junior WA Jr . , Ferriani RA , Martelli L. Deregulation of LOXL1 and HTRA1 gene expression in endometriosis . Reprod Sci . 2010 ; 17 ( 11 ): 1016 - 1023 . doi: 10.1177/1933719110377662 OpenUrl CrossRef PubMed 393. ↵ Chedid MF , do Nascimento FV , de Oliveira FS , de Souza BM, Kruel CRP, Gurski RR, Canani LH, Crispim D, Gerchman F . Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study . Diabetol Metab Syndr . 2019 ; 11 : 78 . doi: 10.1186/s13098-019-0474-2 OpenUrl CrossRef PubMed 394. ↵ Thun GA , Imboden M , Berger W , Rochat T , Probst-Hensch NM . The association of a variant in the cell cycle control gene CCND1 and obesity on the development of asthma in the Swiss SAPALDIA study . J Asthma . 2013 ; 50 ( 2 ): 147 – 154 . doi: 10.3109/02770903.2012.757776 OpenUrl CrossRef PubMed 395. ↵ Zhu J , Qiu J , Magrane G , Abedalthagafi M , Zanko A , Golabi M , Chehab FF . Duplication of C7orf58, WNT16 and FAM3C in an obese female with a t(7;22)(q32.1;q11.2) chromosomal translocation and clinical features resembling Coffin-Siris Syndrome . PLoS One . 2012 ; 7 ( 12 ): e52353 . doi: 10.1371/journal.pone.0052353 OpenUrl CrossRef PubMed 396. ↵ Li F , Jiang C , Larsen MC , Bushkofsky J , Krausz KW , Wang T , Jefcoate CR , Gonzalez FJ . Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity . J Proteome Res . 2014 ; 13 ( 5 ): 2679 – 2687 . doi: 10.1021/pr500145n OpenUrl CrossRef PubMed 397. ↵ Suda N , Bartolomé A , Liang J , Son J , Yagishita Y , Siebel C , Accili D , Ding H , Pajvani UB . β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice . Mol Metab . 2024 ; 81 : 101894 . doi: 10.1016/j.molmet.2024.101894 OpenUrl CrossRef 398. ↵ Cimino I , Rimmington D , Tung YCL , Lawler K , Larraufie P , Kay RG , Virtue S , Lam BYH , Fagnocchi L , Ma MKL , et al. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity . Sci Rep . 2021 ; 11 ( 1 ): 17571 . doi: 10.1038/s41598-021-96278-8 OpenUrl CrossRef PubMed 399. ↵ Ryu KY , Garza JC , Lu XY , Barsh GS , Kopito RR . Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene . Proc Natl Acad Sci U S A . 2008 ; 105 ( 10 ): 4016 – 4021 . doi: 10.1073/pnas.0800096105 OpenUrl Abstract / FREE Full Text 400. ↵ Boaghi A , Pop RM , Vasilache SL , Banescu C , Hutanu A , Marginean OC , Pascanu IM . Plasma RBP4 Level in Association with Body Composition, Metabolic Profile, STRA6 and RBP4 Gene Polymorphisms in Obese Romanian Children . Diabetes Metab Syndr Obes . 2020 ; 13 : 4643 - 4650 . doi: 10.2147/DMSO.S273146 OpenUrl CrossRef PubMed 401. ↵ Errera FI , Canani LH , Yeh E , Kague E , Armelin-Corrêa LM , Suzuki OT , Tschiedel B , Silva ME , Sertié AL , Passos-Bueno MR . COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its “frizzled” motif is associated with obesity in diabetes type 2 patients . An Acad Bras Cienc . 2008 ; 80 ( 1 ): 167 - 177 . doi: 10.1590/s0001-37652008000100012 OpenUrl CrossRef PubMed 402. ↵ Belo VA , Luizon MR , Carneiro PC , Gomes VA , Lacchini R , Lanna CM , Souza-Costa DC , Tanus-Santos JE . Effect of metabolic syndrome risk factors and MMP-2 genetic variations on circulating MMP-2 levels in childhood obesity . Mol Biol Rep . 2013 ; 40 ( 3 ): 2697 – 2704 . doi: 10.1007/s11033-012-2356-7 OpenUrl CrossRef PubMed 403. ↵ Cheng S , Ni X , Yao Y , Sun Y , Yu X , Xia D , Yang Z , Hu MG , Hou X . Hyperoside prevents high-fat diet-induced obesity by increasing white fat browning and lipophagy via CDK6-TFEB pathway . J Ethnopharmacol . 2023 ; 307 : 116259 . doi: 10.1016/j.jep.2023.116259 OpenUrl CrossRef 404. ↵ Dietzsch AN , Al-Hasani H , Altschmied J , Bottermann K , Brendler J , Haendeler J , Horn S , Kaczmarek I , Körner A , et al. Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity . Signal Transduct Target Ther . 2024 ; 9 ( 1 ): 103 . doi: 10.1038/s41392-024-01810-7 OpenUrl CrossRef PubMed 405. ↵ Hwang JY , Lee HJ , Go MJ , Jang HB , Park SI , Kim BJ , Lee HJ . An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population . Sci Rep . 2016 ; 6 : 33043 . doi: 10.1038/srep33043 OpenUrl CrossRef PubMed 406. ↵ Zhao C , Zhang T , Xue ST , Zhang P , Wang F , Li Y , Liu Y , Zhao L , Wu J , Yan Y , et al. Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex . Cell Metab . 2024 . doi: 10.1016/j.cmet.2024.09.013 OpenUrl CrossRef 407. ↵ Pereira MJ , Vranic M , Kamble PG , Jernow H , Kristófi R , Holbikova E , Skrtic S , Kullberg J , Svensson MK , Hetty S , et al. CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage? . Transl Res . 2022 ; 242 : 105 – 121 . doi: 10.1016/j.trsl.2021.12.003 OpenUrl CrossRef PubMed 408. ↵ Yamaguchi M , Murata T . Involvement of regucalcin gene promoter region-related protein-p117, a transcription factor, in human obesity . Biomed Rep . 2017 ; 6 ( 4 ): 374 – 378 . doi: 10.3892/br.2017.874 OpenUrl CrossRef PubMed 409. ↵ Kim TH , Yang YM , Han CY , Koo JH , Oh H , Kim SS , You BH , Choi YH , Park TS , Lee CH , et al. Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration . J Clin Invest . 2018 ; 128 ( 12 ): 5587 – 5602 . doi: 10.1172/JCI97831 OpenUrl CrossRef PubMed 410. ↵ Perry JR , Voight BF , Yengo L , Amin N , Dupuis J , Ganser M , Grallert H , Navarro P , Li M , Qi L , et al. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases . PLoS Genet . 2012 ; 8 ( 5 ): e1002741 . doi: 10.1371/journal.pgen.1002741 OpenUrl CrossRef PubMed 411. ↵ De Hert E , Verboven K , Wouters K , Jocken JWE , De Meester I . Prolyl Carboxypeptidase Activity Is Present in Human Adipose Tissue and Is Elevated in Serum of Obese Men with Type 2 Diabetes . Int J Mol Sci . 2022 ; 23 ( 21 ): 13529 . doi: 10.3390/ijms232113529 OpenUrl CrossRef PubMed 412. ↵ Loyd C , Liu Y , Kim T , Holleman C , Galloway J , Bethea M , Ediger BN , Swain TA , Tang Y , Stoffers DA , et al. LDB1 Regulates Energy Homeostasis During Diet-Induced Obesity . Endocrinology . 2017 ; 158 ( 5 ): 1289 – 1297 . doi: 10.1210/en.2016-1791 OpenUrl CrossRef PubMed 413. ↵ Zhang J , Chen Y , Yan L , Zhang X , Zheng X , Qi J , Yang F , Li J . EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice . J Biomed Res . 2022 ; 37 ( 3 ): 179 – 193 . doi: 10.7555/JBR.36.20220168 OpenUrl CrossRef PubMed 414. ↵ Ricco RC , Ricco RG , Queluz MC , de Paula MTS , Atique PV , Custódio RJ , Tourinho Filho H , Del Roio Liberatori R Jr . , Martinelli CE Jr. IGF-1R mRNA expression is increased in obese children . Growth Horm IGF Res . 2018 ; 39 : 1 - 5 . doi: 10.1016/j.ghir.2017.11.001 OpenUrl CrossRef PubMed 415. ↵ Westin SN , Ju Z , Broaddus RR , Krakstad C , Li J , Pal N , Lu KH , Coleman RL , Hennessy BT , Klempner SJ , et al. PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients . Mol Oncol . 2015 ; 9 ( 8 ): 1694 – 1703 . doi: 10.1016/j.molonc.2015.04.014 OpenUrl CrossRef PubMed 416. ↵ He L , Gunn TM , Bouley DM , Lu XY , Watson SJ , Schlossman SF , Duke-Cohan JS , Barsh GS . A biochemical function for attractin in agouti-induced pigmentation and obesity . Nat Genet . 2001 ; 27 ( 1 ): 40 – 47 . doi: 10.1038/83741 OpenUrl CrossRef PubMed Web of Science 417. ↵ Wang F , Liu Y , Jiang J , Qin Y , Ge X , Li J , Qi X , Mao Y . High expression of AMPD2 and obesity are associated with poor prognosis in colorectal cancer . Int J Clin Exp Pathol . 2018 ; 11 ( 1 ): 216 – 223 . OpenUrl PubMed 418. ↵ Lee YH , Martin JM , Maple RL , Tharp WG , Pratley RE . Plasma amyloid-beta peptide levels correlate with adipocyte amyloid precursor protein gene expression in obese individuals . Neuroendocrinology . 2009 ; 90 ( 4 ): 383 – 390 . doi: 10.1159/000235555 OpenUrl CrossRef PubMed 419. ↵ Yang SA . Association between exonic polymorphism (rs629849, Gly1619Arg) of IGF2R gene and obesity in Korean population . J Exerc Rehabil . 2015 ; 11 ( 5 ): 282 - 286 . doi: 10.12965/jer.150239 OpenUrl CrossRef PubMed 420. ↵ Zhang D , Yao X , Teng Y , Zhao T , Lin L , Li Y , Shang H , Jin Y , Jin Q . Adipocytes-Derived Exosomal microRNA-1224 Inhibits M2 Macrophage Polarization in Obesity-Induced Adipose Tissue Inflammation via MSI2-Mediated Wnt/β-Catenin Axis . Mol Nutr Food Res . 2022 ; 66 ( 18 ): e2100889 . doi: 10.1002/mnfr.202100889 OpenUrl CrossRef PubMed 421. ↵ Loid P , Pekkinen M , Reyes M , Mustila T , Viljakainen H , Jüppner H , Mäkitie O. GNAS, PDE4D, and PRKAR1A Mutations and GNAS Methylation Changes Are Not a Common Cause of Isolated Early-Onset Severe Obesity Among Finnish Children . Front Pediatr . 2020 ; 8 : 145 . doi: 10.3389/fped.2020.00145 OpenUrl CrossRef PubMed 422. ↵ Santo J , Lopez-Herrera C , Apolit C , Bareche Y , Lapasset L , Chavey C , Capozi S , Mahuteau-Betzer F , Najman R , Fornarelli P , et al. Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice . Int J Obes (Lond) . 2017 ; 41 ( 3 ): 390 – 401 . doi: 10.1038/ijo.2016.220 OpenUrl CrossRef PubMed 423. ↵ Jiang Y , Liang M , Chen L , Wang J , Huang Y , Huo H , Xiao D , Hu Y , Wang Z , Ji Q , et al. Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation . Cell Mol Life Sci . 2023 ; 81 ( 1 ): 4 . doi: 10.1007/s00018-023-05050-w OpenUrl CrossRef PubMed 424. ↵ Xing F , Zhao D , Wu SY , Tyagi A , Wu K , Sharma S , Liu Y , Deshpande R , Wang Y , Cleary J , et al. Epigenetic and Posttranscriptional Modulation of SOS1 Can Promote Breast Cancer Metastasis through Obesity-Activated c-Met Signaling in African-American Women . Cancer Res . 2021 ; 81 ( 11 ): 3008 – 3021 . doi: 10.1158/0008-5472.CAN-19-4031 OpenUrl Abstract / FREE Full Text 425. ↵ Josifova DJ , Monroe GR , Tessadori F , de Graaff E , van der Zwaag B , Mehta SG ; DDD Study ; Harakalova M , Duran KJ , Savelberg SM , et al. Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity . Hum Mol Genet . 2016 ; 25 ( 11 ): 2158 - 2167 . doi: 10.1093/hmg/ddw082 OpenUrl CrossRef PubMed 426. ↵ Giri AK , Parekatt V , Dwivedi OP , Banerjee P , Bandesh K , Prasad G , Tandon N , Bharadwaj D . Common variants of ARID1A and KAT2B are associated with obesity in Indian adolescents . Sci Rep . 2018 ; 8 ( 1 ): 3964 . doi: 10.1038/s41598-018-22231-x OpenUrl CrossRef PubMed 427. ↵ Zhang W , Su R , Feng H , Lin L , Wang C , Yang H . Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia . J Diabetes Res . 2019 ; 2019 : 6320839 . doi: 10.1155/2019/6320839 OpenUrl CrossRef PubMed 428. ↵ Sandin ES , Folberth J , Müller-Fielitz H , Pietrzik CU , Herold E , Willnow TE , Pfluger PT , Nogueiras R , Prevot V , Krey T , et al. Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity? . Int J Mol Sci . 2021 ; 22 ( 9 ): 4998 . doi: 10.3390/ijms22094998 OpenUrl CrossRef PubMed 429. ↵ McCulloch LJ , Rawling TJ , Sjöholm K , Franck N , Dankel SN , Price EJ , Knight B , Liversedge NH , Mellgren G , Nystrom F , et al. COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity . Endocrinology . 2015 ; 156 ( 1 ): 134 – 146 . doi: 10.1210/en.2014-1042 OpenUrl CrossRef PubMed 430. ↵ Yasuda-Yamahara M , Kume S , Yamahara K , Nakazawa J , Chin-Kanasaki M , Araki H , Araki S , Koya D , Haneda M , Ugi S , Maegawa H , Uzu T. et al. Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure . Biochem Biophys Res Commun . 2015 ; 465 ( 2 ): 249 – 255 . doi: 10.1016/j.bbrc.2015.08.010 OpenUrl CrossRef PubMed 431. ↵ Zangerolamo L , Soares GM , Vettorazzi JF , do Amaral ME , Carneiro EM , Olalla-Saad ST , Boschero AC , Barbosa-Sampaio HC . ARHGAP21 deficiency impairs hepatic lipid metabolism and improves insulin signaling in lean and obese mice . Can J Physiol Pharmacol . 2019 ; 97 ( 11 ): 1018 - 1027 . doi: 10.1139/cjpp-2018-0691 OpenUrl CrossRef PubMed 432. ↵ Gavaldà-Navarro A , Mirra S , Manso Y , Sánchez-Infantes D , Giralt M , Soriano E , Villarroya F . The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity . Int J Obes (Lond) . 2022 ; 46 ( 9 ): 1652 - 1661 . doi: 10.1038/s41366-022-01169-1 OpenUrl CrossRef PubMed 433. ↵ Shi S , Wang J , Gong H , Huang X , Mu B , Cheng X , Feng B , Jia L , Luo Q , Liu W , et al. PGC-1α-Coordinated Hypothalamic Antioxidant Defense Is Linked to SP1-LanCL1 Axis during High-Fat-Diet-Induced Obesity in Male Mice . Antioxidants (Basel) . 2024 ; 13 ( 2 ): 252 . doi: 10.3390/antiox13020252 OpenUrl CrossRef PubMed 434. ↵ Yang HM , Kim J , Shin D , Kim JY , You J , Lee HC , Jang HD , Kim HS . Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases . Metabolism . 2023 ; 138 : 155343 . doi: 10.1016/j.metabol.2022.155343 OpenUrl CrossRef PubMed 435. ↵ Kokaze A , Ishikawa M , Matsunaga N , Yoshida M , Makita R , Satoh M , Teruya K , Sekiguchi K , Masuda Y , Harada M , et al. Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men . Mech Ageing Dev . 2005 ; 126 ( 6-7 ): 705 – 709 . doi: 10.1016/j.mad.2005.01.005 OpenUrl CrossRef PubMed 436. ↵ Jeyaratnaganthan N , Højlund K , Kroustrup JP , Larsen JF , Bjerre M , Levin K , Beck-Nielsen H , Frago S , Hassan AB , Flyvbjerg A , et al. Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes . Growth Horm IGF Res . 2010 ; 20 ( 3 ): 185 – 191 . doi: 10.1016/j.ghir.2009.12.005 OpenUrl CrossRef PubMed 437. ↵ Hu L , Yuan D , Zhu Q , Wu M , Tie M , Song S , Chen Y , Yang Y , He A . Evaluation of the role of hepatic Gstm4 in diet-induced obesity and dyslipidemia . Biochem Biophys Res Commun . 2024 ; 737 : 150920 . doi: 10.1016/j.bbrc.2024.150920 OpenUrl CrossRef 438. ↵ Sáez ME , Grilo A , Morón FJ , Manzano L , Martínez-Larrad MT , González-Pérez A , Serrano-Hernando J , Ruiz A , Ramírez-Lorca R , Serrano-Ríos M . Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity . Cardiovasc Diabetol . 2008 ; 7 : 23 . doi: 10.1186/1475-2840-7-23 OpenUrl CrossRef PubMed 439. ↵ Hermano E , Goldberg R , Rubinstein AM , Sonnenblick A , Maly B , Nahmias D , Li JP , Bakker MAH , van der Vlag J , Vlodavsky I , et al. Heparanase Accelerates Obesity-Associated Breast Cancer Progression . Cancer Res . 2019 ; 79 ( 20 ): 5342 – 5354 . doi: 10.1158/0008-5472.CAN-18-4058 OpenUrl Abstract / FREE Full Text 440. ↵ Zaytouni T , Tsai PY , Hitchcock DS , DuBois CD , Freinkman E , Lin L , Morales-Oyarvide V , Lenehan PJ , Wolpin BM , Mino-Kenudson M , et al. Critical role for arginase 2 in obesity-associated pancreatic cancer . Nat Commun . 2017 ; 8 ( 1 ): 242 . doi: 10.1038/s41467-017-00331-y OpenUrl CrossRef PubMed 441. ↵ Fang L , Liu C , Jiang ZZ , Wang M , Geng K , Xu Y , Zhu Y , Fu Y , Xue J , Shan W , et al. Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity . Signal Transduct Target Ther . 2024 ; 9 ( 1 ): 218 . doi: 10.1038/s41392-024-01930-0 OpenUrl CrossRef PubMed 442. ↵ Hsu LA , Yeh YH , Chang CJ , Chen WJ , Tsai HY , Chang GJ . Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection . Int J Mol Sci . 2024 ; 25 ( 4 ): 2186 . doi: 10.3390/ijms25042186 OpenUrl CrossRef PubMed 443. ↵ Lassance L , Haghiac M , Minium J , Catalano P , Hauguel-de Mouzon S . Obesity-induced down-regulation of the mitochondrial translocator protein (TSPO) impairs placental steroid production . J Clin Endocrinol Metab . 2015 ; 100 ( 1 ): E11 – E18 . doi: 10.1210/jc.2014-2792 OpenUrl CrossRef PubMed 444. ↵ Khamlaoui W , Mehri S , Hammami S , Elosua R , Hammami M . Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population . J Renin Angiotensin Aldosterone Syst . 2020 ; 21 ( 2 ): 1470320320907820 . doi: 10.1177/1470320320907820 OpenUrl CrossRef PubMed 445. ↵ Ahmad AA , Rahimi Z , Asadi S , Vaisi-Raygani A , Kohsari M . The GPx-1 Gene Variants (rs1050450) in Obesity: Association with the Risk of Obesity and the GPx Activity in Females . Rep Biochem Mol Biol . 2023 ; 12 ( 1 ): 185 – 194 . doi: 10.52547/rbmb.12.1.185 OpenUrl CrossRef PubMed 446. ↵ Katsouda A , Valakos D , Dionellis VS , Bibli SI , Akoumianakis I , Karaliota S , Zuhra K , Fleming I , Nagahara N , Havaki S , et al. MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity . J Exp Med . 2022 ; 219 ( 7 ): e20211894 . doi: 10.1084/jem.20211894 OpenUrl CrossRef PubMed 447. ↵ Hu Y , Xu J , Gao R , Xu Y , Huangfu B , Asakiya C , Huang X , Zhang F , Huang K , He X , et al. Diallyl Trisulfide Prevents Adipogenesis and Lipogenesis by Regulating the Transcriptional Activation Function of KLF15 on PPARγ to Ameliorate Obesity . Mol Nutr Food Res . 2022 ; 66 ( 22 ): e2200173 . doi: 10.1002/mnfr.202200173 OpenUrl CrossRef PubMed 448. ↵ Van de Pette M , Tunster SJ , John RM . Loss of Imprinting of Cdkn1c Protects against Age and Diet-Induced Obesity . Int J Mol Sci . 2018 ; 19 ( 9 ): 2734 . doi: 10.3390/ijms19092734 OpenUrl CrossRef PubMed 449. ↵ Canto P , Benítez Granados J , Martínez Ramírez MA , Reyes E , Feria-Bernal G , García-García E , Tejeda ME , Zavala E , Tapia A , Rojano-Mejía D , et al. Genetic variants in ATP6 and ND3 mitochondrial genes are not associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity . Aging Male . 2016 ; 19 ( 3 ): 187 – 191 . doi: 10.1080/13685538.2016.1185409 OpenUrl CrossRef PubMed 450. ↵ Andreasen CH , Mogensen MS , Borch-Johnsen K , Sandbaek A , Lauritzen T , Sørensen TI , Hansen L , Almind K , Jørgensen T , Pedersen O , et al. Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes . PLoS One . 2008 ; 3 ( 8 ): e2872 . doi: 10.1371/journal.pone.0002872 OpenUrl CrossRef PubMed 451. ↵ Oba D , Inoue SI , Miyagawa-Tomita S , Nakashima Y , Niihori T , Yamaguchi S , Matsubara Y , Aoki Y . Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis . EBioMedicine . 2018 ; 27 : 138 – 150 . doi: 10.1016/j.ebiom.2017.11.029 OpenUrl CrossRef PubMed 452. ↵ Tong Y , Zhang Y , Shan Z , Xu Y , Gao X , Yao W . Improving high-fat diet-induced obesity and fatty liver by adipose tissue targeted delivery of vascular endothelial growth factor-B . Life Sci . 2020 ; 253 : 117677 . doi: 10.1016/j.lfs.2020.117677 OpenUrl CrossRef 453. ↵ Lehuédé C , Li X , Dauvillier S , Vaysse C , Franchet C , Clement E , Esteve D , Longué M , Chaltiel L , Le Gonidec S , et al. Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP) . Breast Cancer Res . 2019 ; 21 ( 1 ): 7 . doi: 10.1186/s13058-018-1088-6 OpenUrl CrossRef 454. ↵ Cheverud JM , Fawcett GL , Jarvis JP , Norgard EA , Pavlicev M , Pletscher LS , Polonsky KS , Ye H , Bell GI , Semenkovich CF . Calpain-10 is a component of the obesity-related quantitative trait locus Adip1 . J Lipid Res . 2010 ; 51 ( 5 ): 907 – 913 . doi: 10.1194/jlr.M900128 OpenUrl Abstract / FREE Full Text 455. ↵ Rao Y , Su R , Wu C , Yang G , Fu R , Wu J , Liang J , Liu J , Jiang Z , Xu C , et al. Marine fungus Aspergillus c1. sp metabolite activates the HSF1/PGC-1α axis, inducing a thermogenic program for treating obesity . Front Pharmacol . 2024 ; 15 : 1320040 . doi: 10.3389/fphar.2024.1320040 OpenUrl CrossRef 456. ↵ Kurylowicz A , Owczarz M , Polosak J , Jonas MI , Lisik W , Jonas M , Chmura A , Puzianowska-Kuznicka M . SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status . Int J Obes (Lond) . 2016 ; 40 ( 11 ): 1635 – 1642 . doi: 10.1038/ijo.2016.131 OpenUrl CrossRef PubMed 457. ↵ Huang LH , Melton EM , Li H , Sohn P , Jung D , Tsai CY , Ma T , Sano H , Ha H , Friedline RH , et al. Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity . Am J Physiol Endocrinol Metab . 2018 ; 315 ( 3 ): E340 – E356 . doi: 10.1152/ajpendo.00174.2017 OpenUrl CrossRef PubMed 458. ↵ Tian N , Liu Q , Li Y , Tong L , Lu Y , Zhu Y , Zhang P , Chen H , Hu L , Meng J , et al. Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis . Diabetes . 2020 ; 69 ( 7 ): 1355 – 1367 . doi: 10.2337/db19-1087 OpenUrl Abstract / FREE Full Text 459. ↵ Zhang J , Sun J , Li J , Xia H . Targeting the GDF15 Signalling for Obesity Treatment: Recent Advances and Emerging Challenges . J Cell Mol Med . 2024 ; 28 ( 24 ): e70251 . doi: 10.1111/jcmm.70251 OpenUrl CrossRef PubMed 460. ↵ Bennett CE , Nsengimana J , Bostock JA , Cymbalista C , Futers TS , Knight BL , McCormack LJ , Prasad UK , Riches K , Rolton D , et al. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study . Diab Vasc Dis Res . 2010 ; 7 ( 3 ): 195 – 203 . doi: 10.1177/1479164110366274 OpenUrl CrossRef PubMed 461. ↵ Zhang C , Wang G , Yin X , Gou L , Guo M , Suo F , Zhuang T , Yuan Z , Liu Y , Gu M , et al. Hepatic protein phosphatase 1 regulatory subunit 3G alleviates obesity and liver steatosis by regulating the gut microbiota and bile acid metabolism . J Pharm Anal . 2024 ; 14 ( 8 ): 100976 . doi: 10.1016/j.jpha.2024.100976 OpenUrl CrossRef PubMed 462. ↵ Agarwal AK , Tunison K , Dalal JS , Yen CL , Farese RV Jr , Horton JD , Garg A . Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice . J Lipid Res . 2016 ; 57 ( 4 ): 616 – 630 . doi: 10.1194/jlr.M065896 OpenUrl Abstract / FREE Full Text 463. ↵ Bochkis IM , Shin S , Kaestner KH . Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity . Mol Metab . 2013 ; 2 ( 4 ): 447 – 456 . doi: 10.1016/j.molmet.2013.08.005 OpenUrl CrossRef PubMed 464. ↵ Orliaguet L , Ejlalmanesh T , Humbert A , Ballaire R , Diedisheim M , Julla JB , Chokr D , Cuenco J , Michieletto J , Charbit J , et al. Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling . Nat Commun . 2022 ; 13 ( 1 ): 5089 . doi: 10.1038/s41467-022-32813-z OpenUrl CrossRef PubMed 465. ↵ Cruz-Color L , Hernández-Nazará ZH , Maldonado-González M , Navarro-Muñíz E , Domínguez-Rosales JA , Torres-Baranda JR , Ruelas-Cinco EDC , Ramírez-Meza SM , Ruíz-Madrigal B . Association of the PNPLA2, SCD1 and Leptin Expression with Fat Distribution in Liver and Adipose Tissue From Obese Subjects . Exp Clin Endocrinol Diabetes . 2020 ; 128 ( 11 ): 715 - 722 . doi: 10.1055/a-0829-6324 OpenUrl CrossRef PubMed 466. ↵ Spanu F , Saba L . Obesity and pericallosal lipoma in X-linked emery-dreifuss muscular dystrophy: A case report - Does Emerin play a role in adipocyte differentiation? . World J Radiol . 2018 ; 10 ( 7 ): 78 – 82 . doi: 10.4329/wjr.v10.i7.78 OpenUrl CrossRef PubMed 467. ↵ Larsen LH , Rose CS , Sparsø T , Overgaard J , Torekov SS , Grarup N , Jensen DP , Albrechtsen A , Andersen G , Ek J , et al. Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes . Int J Obes (Lond) . 2007 ; 31 ( 2 ): 365 – 370 . doi: 10.1038/sj.ijo.0803408 OpenUrl CrossRef PubMed 468. ↵ Yang H , Chen L , Sun Q , Yao F , Muhammad S , Sun C . The role of HDAC11 in obesity-related metabolic disorders: A critical review . J Cell Physiol . 2021 ; 236 ( 8 ): 5582 – 5591 . doi: 10.1002/jcp.30286 OpenUrl CrossRef PubMed 469. ↵ Zubrzycka A , Migdalska-Sęk M , Jędrzejczyk S , Brzeziańska-Lasota E . Assessment of BMP7, SMAD4, and CDH1 Expression Profile and Regulatory miRNA-542-3p in Eutopic and Ectopic Endometrium of Women with Endometriosis . Int J Mol Sci . 2023 ; 24 ( 7 ): 6637 . doi: 10.3390/ijms24076637 OpenUrl CrossRef PubMed 470. ↵ Yang X , Jiang L , Xu Y . HSD11B1 overexpression in dendritic cells and stromal cells relates to endometriosis by inhibiting dendritic cell proliferation and maturation . Gynecol Endocrinol . 2024 ; 40 ( 1 ): 2411607 . doi: 10.1080/09513590.2024.2411607 OpenUrl CrossRef PubMed 471. ↵ Wei C , Mei J , Tang L , Liu Y , Li D , Li M , Zhu X . 1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis . Cell Death Dis . 2016 ; 7 ( 12 ): e2489 . doi: 10.1038/cddis.2016.375 OpenUrl CrossRef PubMed 472. ↵ Cho YJ , Hur SE , Lee JY , Song IO , Moon HS , Koong MK , Chung HW . Single nucleotide polymorphisms and haplotypes of the genes encoding the CYP1B1 in Korean women: no association with advanced endometriosis . J Assist Reprod Genet . 2007 ; 24 ( 7 ): 271 – 277 . doi: 10.1007/s10815-007-9122-0 OpenUrl CrossRef PubMed Web of Science 473. ↵ Yoo JY , Shin H , Kim TH , Choi WS , Ferguson SD , Fazleabas AT , Young SL , Lessey BA , Ha UH , Jeong JW . CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis . PLoS One . 2014 ; 9 ( 6 ): e100481 . doi: 10.1371/journal.pone.0100481 OpenUrl CrossRef PubMed 474. ↵ Podgaec S , Rizzo LV , Fernandes LF , Baracat EC , Abrao MS . CD4(+) CD25(high) Foxp3(+) cells increased in the peritoneal fluid of patients with endometriosis . Am J Reprod Immunol . 2012 ; 68 ( 4 ): 301 – 308 . doi: 10.1111/j.1600-0897.2012.01173.x OpenUrl CrossRef PubMed 475. ↵ Xiaolei T , Jiang M , Yang N , Jing Z . Effects of EZH2 on Invasion and Migration of Endometrial Stromal Cells in Endometriosis Patients by Regulating PCDH10 Gene H3K27 Methylation . Altern Ther Health Med . 2023 ; 29 ( 2 ): 42 – 49 . OpenUrl 476. ↵ Kodarahmian M , Amidi F , Moini A , Kashani L , Shabani Nashtaei M , Pazhohan A , Bahramrezai M , Berenjian S , Sobhani A . The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial . Gynecol Endocrinol . 2019 ; 35 ( 8 ): 719 – 726 . doi: 10.1080/09513590.2019.1576612 OpenUrl CrossRef PubMed 477. ↵ Liu J , Wang Y , Chen P , Ma Y , Wang S , Tian Y , Wang A , Wang D . AC002454.1 and CDK6 synergistically promote endometrial cell migration and invasion in endometriosis . Reproduction . 2019 ; 157 ( 6 ): 535 – 543 . doi: 10.1530/REP-19-0005 OpenUrl CrossRef PubMed 478. ↵ Zhang Z , Yuan Y , He L , Yao X , Chen J . Involvement of angiotensin II receptor type 1/NF-κB signaling in the development of endometriosis . Exp Ther Med . 2020 ; 20 ( 4 ): 3269 – 3277 . doi: 10.3892/etm.2020.9071 OpenUrl CrossRef PubMed 479. ↵ Zarafshan SS , Salehi Z , Salahi E , Sabet EE , Shabanipour S , Zahiri Z . Polymorphism of catalase gene (CAT C-262T) in women with endometriosis . J Obstet Gynaecol . 2015 ; 35 ( 3 ): 269 – 271 . doi: 10.3109/01443615.2014.948402 OpenUrl CrossRef PubMed 480. ↵ Xu H , Gao Y , Shu Y , Wang Y , Shi Q . EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis . Biosci Rep . 2019 ; 39 ( 7 ):BSR20182274. doi: 10.1042/BSR20182274 OpenUrl Abstract / FREE Full Text 481. ↵ Huang Y , Jiang Y , Ji H , Gao Y , Xiao L , Zha W , Zhou J , Huang H . CHS-a activates the IGF1R/PI3K signal pathway with inhibited pyroptosis of endometrial stromal cells and progress of endometriosis . Int Immunopharmacol . 2024 ; 143 ( Pt 3 ): 113527 . doi: 10.1016/j.intimp.2024.113527 OpenUrl CrossRef PubMed 482. ↵ Zhou A , Cai Q , Hong Y , Lv Y . Down-Regulation of Casein Kinase 1α Contributes to Endometriosis through Phosphatase and Tensin Homolog/Autophagy-Related 7-Mediated Autophagy . Am J Pathol . 2021 ; 191 ( 12 ): 2195 – 2202 . doi: 10.1016/j.ajpath.2021.08.015 OpenUrl CrossRef PubMed 483. ↵ Strauß T , Greve B , Gabriel M , Achmad N , Schwan D , Espinoza-Sanchez NA , Laganà AS , Kiesel L , Poutanen M , Götte M , et al. Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis . Int J Mol Sci . 2022 ; 23 ( 5 ): 2851 . doi: 10.3390/ijms23052851 OpenUrl CrossRef PubMed 484. ↵ Lin SC , Li WN , Lin SC , Hou HT , Tsai YC , Lin TC , Wu MH , Tsai SJ . Targeting YAP1 ameliorates progesterone resistance in endometriosis . Hum Reprod . 2023 ; 38 ( 6 ): 1124 – 1134 . doi: 10.1093/humrep/dead071 OpenUrl CrossRef PubMed 485. ↵ Mai H , Liao Y , Luo S , Wei K , Yang F , Shi H . Histone deacetylase HDAC2 silencing prevents endometriosis by activating the HNF4A/ARID1A axis . J Cell Mol Med . 2021 ; 25 ( 21 ): 9972 – 9982 . doi: 10.1111/jcmm.16835 OpenUrl CrossRef PubMed 486. ↵ Zhang S , Zhuang L , Liu Q , Yu X , Min Q , Chen M , Chen Q . PPARγ induces the paroxysm of endometriosis by regulating the transcription of MAT2A gene . Am J Transl Res . 2021 ; 13 ( 3 ): 1377 – 1388 . OpenUrl PubMed 487. ↵ Liu W , Cheng L , Du Y , Liu X , Ma J , Yan L . 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) Hexanol Inhibits Proliferation and Induces Apoptosis of Endometriosis by Regulating Glutathione S-Transferase Mu Class 4 . Reprod Sci. 2023 ; 30 ( 10 ): 2945 - 2961 . doi: 10.1007/s43032-023-01207-x OpenUrl CrossRef PubMed 488. ↵ Fu JL , Hsiao KY , Lee HC , Li WN , Chang N , Wu MH , Tsai SJ . Suppression of COUP-TFII upregulates angiogenin and promotes angiogenesis in endometriosis . Hum Reprod . 2018 ; 33 ( 8 ): 1517 – 1527 . doi: 10.1093/humrep/dey220 OpenUrl CrossRef PubMed 489. ↵ Mikołajczyk M , Wirstlein P , Skrzypczak J . Aberrant claudin-4 transcript levels in eutopic endometrium of women with idiopathic infertility and minimal endometriosis . Ginekol Pol . 2013 ; 84 ( 2 ): 90 – 94 . doi: 10.17772/gp/1546 OpenUrl CrossRef PubMed 490. ↵ Vieira RR , da Silva RA , Sasso GRS, Franco PC, Borges FT, Lima PDA, Sanches JM, Gil CD, Carbonel AAF . Lack of Annexin A1 Exacerbates Inflammatory Response in Acute Endometritis Model . Inflammation . 2024 ; 47 ( 3 ): 1041 - 1052 . doi: 10.1007/s10753-023-01959-3 OpenUrl CrossRef PubMed 491. ↵ Zhu TH , Zhang FB , Yan H , Yu WY , Chen M , Guan YT . A novel CDKN1A-JAZF1 gene fusion in low-grade endometrial stromal sarcoma arising from endometriosis in abdominal wall cesarean section scar: A case report and literature review . Taiwan J Obstet Gynecol . 2022 ; 61 ( 6 ): 1082 – 1085 . doi: 10.1016/j.tjog.2022.04.010 OpenUrl CrossRef PubMed 492. ↵ McAllister SL , Sinharoy P , Vasu M , Gross ER . Aberrant reactive aldehyde detoxification by aldehyde dehydrogenase-2 influences endometriosis development and pain-associated behaviors . Pain . 2021 ; 162 ( 1 ): 71 – 83 . doi: 10.1097/j.pain.0000000000001949 OpenUrl CrossRef PubMed 493. ↵ Casalechi M , Dela Cruz C , Assis WA , Vieira-Lopes M , Lopes FEF , Francisco AMC , Reis FM . Translocator protein expression and localization in human endometrium and endometriosis: A potential target for a noninvasive diagnosis? . Cell Biol Int . 2024 ; 48 ( 6 ): 898 – 906 . doi: 10.1002/cbin.12157 OpenUrl CrossRef PubMed 494. ↵ Elbaradie SMY , Bakry MS , Bosilah AH . Serum macrophage migration inhibition factor for diagnosing endometriosis and its severity: case-control study . BMC Womens Health . 2020 ; 20 ( 1 ): 189 . doi: 10.1186/s12905-020-01051-0 OpenUrl CrossRef PubMed 495. ↵ Kowalczyńska LJ , Ferenc T , Wojciechowski M , Mordalska A , Pogoda K , Malinowski A . Endometriosis and RAS system gene polymorphisms: the association of ACE A2350G polymorphism with endometriosis in Polish individuals . DNA Cell Biol . 2014 ; 33 ( 5 ): 328 – 335 . doi: 10.1089/dna.2013.2255 OpenUrl CrossRef PubMed 496. ↵ Felgueiras R , Neto AC , Rodrigues AR , Gouveia AM , Almeida H , Neves D . Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3-independent GPx1 expression in the heart of mice with endometriosis . Horm Mol Biol Clin Investig . 2022 ; 43 ( 4 ): 405 – 414 . doi: 10.1515/hmbci-2022-0039 OpenUrl CrossRef PubMed 497. ↵ Huang Y , Wang Z , Li B , Ke L , Xiong Y , Zhang Y . Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis . J Endocrinol . 2024 ; 261 ( 2 ): e230319 . doi: 10.1530/JOE-23-0319 OpenUrl CrossRef PubMed 498. ↵ Pan HY , Wan J . Serum HSF1 is upregulated in endometriosis patients and serves as a potential diagnostic biomarker . Kaohsiung J Med Sci . 2023 ; 39 ( 10 ): 1045 – 1051 . doi: 10.1002/kjm2.12723 OpenUrl CrossRef PubMed 499. ↵ Santoso B , Rahmawati NY , Sa’adi A , Dwiningsih SR , Annas JY , Tunjungseto A , Widyanugraha MYA , Mufid AF , Ahsan F . Elevated peritoneal soluble endoglin and GDF-15 in infertile women with severe endometriosis and pelvic adhesion . J Reprod Immunol . 2021 ; 146 : 103343 . doi: 10.1016/j.jri.2021.103343 OpenUrl CrossRef 500. ↵ Ling X , Liu L , Jiang A , Shi X , Liu L , Wang X , Lu C , Ren C , Yu Z . PFKFB3 promotes endometriosis cell proliferation via enhancing the protein stability of β-catenin . Mol Cell Endocrinol . 2024 ; 579 : 112083 . doi: 10.1016/j.mce.2023.112083 OpenUrl CrossRef 501. ↵ Feng Y , Tan B , Dong H , Zheng L . FoxA2 represses ERβ-mediated pyroptosis in endometriosis by transcriptionally inhibiting IGF2BP1 . Exp Cell Res . 2023 ; 426 ( 1 ): 113539 . doi: 10.1016/j.yexcr.2023.113539 OpenUrl CrossRef PubMed 502. ↵ Furuya M , Yoneyama T , Miyagi E , Tanaka R , Nagahama K , Miyagi Y , Nagashima Y , Hirahara F , Inayama Y , Aoki I . Differential expression patterns of CXCR3 variants and corresponding CXC chemokines in clear cell ovarian cancers and endometriosis . Gynecol Oncol . 2011 ; 122 ( 3 ): 648 – 655 . doi: 10.1016/j.ygyno.2011.05.034 OpenUrl CrossRef PubMed 503. ↵ Treloar SA , Zhao ZZ , Le L , Zondervan KT , Martin NG , Kennedy S , Nyholt DR , Montgomery GW . Variants in EMX2 and PTEN do not contribute to risk of endometriosis . Mol Hum Reprod . 2007 ; 13 ( 8 ): 587 – 594 . doi: 10.1093/molehr/gam023 OpenUrl CrossRef PubMed Web of Science 504. ↵ Khalaf M , Morera J , Bourret A , Reznik Y , Denoual C , Herlicoviez M , Mittre H , Benhaim A . BMP system expression in GCs from polycystic ovary syndrome women and the in vitro effects of BMP4, BMP6, and BMP7 on GC steroidogenesis . Eur J Endocrinol . 2013 ; 168 ( 3 ): 437 - 444 . doi: 10.1530/EJE-12-0891 OpenUrl Abstract / FREE Full Text 505. ↵ Schweighofer N , Lerchbaum E , Trummer O , Schwetz V , Pilz S , Pieber TR , Obermayer-Pietsch B . Androgen levels and metabolic parameters are associated with a genetic variant of F13A1 in women with polycystic ovary syndrome . Gene . 2012 ; 504 ( 1 ): 133 – 139 . doi: 10.1016/j.gene.2012.04.050 OpenUrl CrossRef PubMed Web of Science 506. ↵ Li X , Hu S , Zhu Q , Yao G , Yao J , Li J , Wang Y , Ding Y , Qi J , Xu R , et al. Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model . Metabolism . 2021 ; 119 : 154749 . doi: 10.1016/j.metabol.2021.154749 OpenUrl CrossRef 507. ↵ Zou S , Sang Q , Wang H , Feng R , Li Q , Zhao X , Xing Q , Jin L , He L , Wang L . Common genetic variation in CYP1B1 is associated with concentrations of T, FT and FT in the sera of polycystic ovary syndrome patients . Mol Biol Rep . 2013 ; 40 ( 4 ): 3315 – 3320 . doi: 10.1007/s11033-012-2406-1 OpenUrl CrossRef PubMed 508. ↵ Nasri F , Doroudchi M , Namavar Jahromi B , Gharesi-Fard B . T Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome . Iran J Immunol . 2018 ; 15 ( 3 ): 175 – 185 . doi: 10.22034/IJI.2018.39387 OpenUrl CrossRef PubMed 509. ↵ Li J , Huang C , Lin Z , Hu Y , Shi Q . Two MMP2 gene polymorphisms significantly associated with polycystic ovary syndrome: A case-control analysis . Eur J Obstet Gynecol Reprod Biol . 2022 ; 271 : 204 – 209 . doi: 10.1016/j.ejogrb.2022.02.019 OpenUrl CrossRef PubMed 510. ↵ Ibrahem MA , Saber Al-Karamany A , Esawy MM , Elasy AN . Plasma Corin: A New Biochemical Marker for Polycystic Ovary Syndrome . Reprod Sci . 2024 ; 31 ( 8 ): 2219 – 2227 . doi: 10.1007/s43032-024-01531-w OpenUrl CrossRef PubMed 511. ↵ Salahshoor MR , Sohrabi M , Jalili F , Jalili P , Rezavand N , Haghnazari L , Jalili C. o evidence for a major effect of three common polymorphisms of the GPx1, MnSOD, and CAT genes on PCOS susceptibility . J Cell Biochem . 2019 ; 120 ( 2 ): 2362 – 2369 . doi: 10.1002/jcb.27564 OpenUrl CrossRef PubMed 512. ↵ Babashamsi MM , Koukhaloo SZ , Halalkhor S , Salimi A , Babashamsi M . ABCA1 and metabolic syndrome; a review of the ABCA1 role in HDL-VLDL production, insulin-glucose homeostasis, inflammation and obesity . Diabetes Metab Syndr . 2019 ; 13 ( 2 ): 1529 – 1534 . doi: 10.1016/j.dsx.2019.03.004 OpenUrl CrossRef PubMed 513. ↵ Zhao X , Xiong Y , Shen Y . Leptin plays a role in the multiplication of and inflammation in ovarian granulosa cells in polycystic ovary syndrome through the JAK1/STAT3 pathway . Clinics (Sao Paulo) . 2023 ; 78 : 100265 . doi: 10.1016/j.clinsp.2023.100265 OpenUrl CrossRef 514. ↵ Powell MJ , Fuller S , Gunderson EP , Benz CC . Reduced cardiovascular risks in women with endometriosis or polycystic ovary syndrome carrying a common functional IGF1R variant . Hum Reprod . 2022 ; 37 ( 5 ): 1083 – 1094 . doi: 10.1093/humrep/deac059 OpenUrl CrossRef PubMed 515. ↵ Zhou Z , Zhang X , Yi G , Zhang Y , Zhang J , Tan C , Wan B , Li Y , Lu H , Lu W . LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A . Reprod Biol . 2023 ; 23 ( 2 ): 100764 . doi: 10.1016/j.repbio.2023.100764 OpenUrl CrossRef PubMed 516. ↵ Gong Z , Shi X , Xu W , Fang Y , Fang M , Yao M , Jiang Y , Sui H , Luo M . LncRNA PWRN2 promotes polycystic ovary syndrome progression via epigenetically reducing ATRX by recruiting LSD1 . Reprod Biol . 2023 ; 23 ( 3 ): 100782 . doi: 10.1016/j.repbio.2023.100782 OpenUrl CrossRef PubMed 517. ↵ Lidaka L , Bekere L , Lazdane G , Lazovska M , Dzivite-Krisane I , Gailite L . Role of Single Nucleotide Variants in the YAP1 Gene in Adolescents with Polycystic Ovary Syndrome . Biomedicines . 2022 ; 10 ( 7 ): 1688 . doi: 10.3390/biomedicines10071688 OpenUrl CrossRef PubMed 518. ↵ Ji XL , Liu X , Wang Z , Fang YC . Expression of ARID1A in polycystic ovary syndrome and its effect on the proliferation and apoptosis of ovarian granulosa cells . Ann Endocrinol (Paris) . 2020 ; 81 ( 6 ): 521 – 529 . doi: 10.1016/j.ando.2020.11.008 OpenUrl CrossRef PubMed 519. ↵ Ju R , Wu W , Fei J , Qin Y , Tang Q , Wu D , Xia Y , Wu J , Wang X . Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population . Eur J Endocrinol . 2015 ; 172 ( 3 ): 227 – 233 . doi: 10.1530/EJE-14-0615 OpenUrl Abstract / FREE Full Text 520. ↵ Javidan M , Changaei M , Ramezani Tehrani F , Mosaffa N , Noroozzadeh M , Hosseinzadeh R , Rajaei S . Altered expression of leukemia inhibitory factor (LIF), LIFR, gp130, and IL11 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome . Biochem Biophys Res Commun . 2022 ; 605 : 24 - 30 . doi: 10.1016/j.bbrc.2022.03.053 OpenUrl CrossRef PubMed 521. ↵ Xu X , Guan R , Gong K , Xie H , Shi L . Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome . Reprod Biol Endocrinol . 2022 ; 20 ( 1 ): 32 . doi: 10.1186/s12958-022-00891-9 OpenUrl CrossRef PubMed 522. ↵ González A , Sáez ME , Aragón MJ , Galán JJ , Vettori P , Molina L , Rubio C , Real LM , Ruiz A , Ramírez-Lorca R . Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome . Hum Reprod . 2006 ; 21 ( 4 ): 943 – 951 . doi: 10.1093/humrep/dei443 OpenUrl CrossRef PubMed Web of Science 523. ↵ Jiang L , Huang J , Li L , Chen Y , Chen X , Zhao X , Yang D . MicroRNA-93 promotes ovarian granulosa cells proliferation through targeting CDKN1A in polycystic ovarian syndrome . J Clin Endocrinol Metab . 2015 ; 100 ( 5 ): E729 – E738 . doi: 10.1210/jc.2014-3827 OpenUrl CrossRef PubMed 524. ↵ Mazloomi S , Sanoeei Farimani M , Tayebinia H , Karimi J , Amiri I , Abbasi E , Khodadadi I . The Association of Mitochondrial Translocator Protein and Voltage-Dependent Anion Channel-1 in Granulosa Cells with Estradiol Levels and Presence of Immature Follicles in Polycystic Ovary Syndrome . J Reprod Infertil . 2022 ; 23 ( 3 ): 148 – 159 . doi: 10.18502/jri.v23i3.10005 OpenUrl CrossRef PubMed 525. ↵ Calan M , Kume T , Yilmaz O , Arkan T , Kocabas GU , Dokuzlar O , Aygün K , Oktan MA , Danıs N , Temur M . A possible link between luteinizing hormone and macrophage migration inhibitory factor levels in polycystic ovary syndrome . Endocr Res . 2016 ; 41 ( 3 ): 261 – 269 . doi: 10.3109/07435800.2015.1135442 OpenUrl CrossRef PubMed 526. ↵ Sun Y , Li S , Liu H , Gong Y , Bai H , Huang W , Liu Q , Guan L , Fan P . Association of GPx1 P198L and CAT C-262T Genetic Variations With Polycystic Ovary Syndrome in Chinese Women . Front Endocrinol (Lausanne) . 2019 ; 10 : 771 . doi: 10.3389/fendo.2019.00771 OpenUrl CrossRef 527. ↵ Liu Y , Jiang H , Xing FQ , Huang WJ , Mao LH , He LY . Uncoupling protein 2 expression affects androgen synthesis in polycystic ovary syndrome . Endocrine . 2013 ; 43 ( 3 ): 714 – 723 . doi: 10.1007/s12020-012-9802-0 OpenUrl CrossRef PubMed 528. ↵ Dong S , Liu Y , Yang Z . Transcription factor YY1 adversely governs ovarian granulosa cell growth in PCOS by transcription activation-mediated CDKN1C upregulation . Funct Integr Genomics . 2024 ; 24 ( 5 ): 171 . doi: 10.1007/s10142-024-01448-2 OpenUrl CrossRef PubMed 529. ↵ Wang F , Han J , Wang X , Liu Y , Zhang Z . Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats . J Mol Histol . 2022 ; 53 ( 5 ): 833 – 842 . doi: 10.1007/s10735-022-10096-4 OpenUrl CrossRef PubMed 530. ↵ Cheng F , Zhao L , Wu Y , Huang T , Yang G , Zhang Z , Wu Y , Jia F , Wu J , Chen C , et al. Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment . Clin Endocrinol (Oxf) . 2016 ; 84 ( 3 ): 386 – 393 . doi: 10.1111/cen.12950 OpenUrl CrossRef PubMed 531. ↵ Li Y , Han T , Wang Y , Gao J , Zhang J , Wu Y , Luo J . Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysis . Front Genet . 2023 ; 14 : 1153960 . doi: 10.3389/fgene.2023.1153960 OpenUrl CrossRef 532. ↵ Li Q , Yan Z , Kuang Y , Zhou X , Jin L , He L , Sun X , Tao T , Wang L . Genetic variations in the 3’-untranslated region of SLC18A2 are associated with serum FSH concentration in polycystic ovary syndrome patients and regulate gene expression in vitro . Hum Reprod . 2016 ; 31 ( 9 ): 2150 – 2157 . doi: 10.1093/humrep/dew162 OpenUrl CrossRef PubMed 533. ↵ Magalhães FMV , Pestana RMC , Ferreira CN , Silva IFO , Candido AL , Oliveira FR , Reis FM , Gomes KB . GDF-15 levels in patients with polycystic ovary syndrome treated with metformin: a combined clinical and in silico pathway analysis . Arch Endocrinol Metab . 2024 ; 68 : e230416 . doi: 10.20945/2359-4292-2023-0416 OpenUrl CrossRef 534. ↵ Yang Y , Chen X , Liao X , Jiang W , Zhou Y , Sun Y , Zheng B . Identification of MAP1LC3A as a promising mitophagy-related gene in polycystic ovary syndrome . Sci Rep . 2024 ; 14 ( 1 ): 16982 . doi: 10.1038/s41598-024-67969-9 OpenUrl CrossRef PubMed 535. ↵ Hu M , Zhang Y , Li X , Cui P , Sferruzzi-Perri AN , Brännström M , Shao LR , Billig H . LR4-Associated IRF-7 and NFκB Signaling Act as a Molecular Link Between Androgen and Metformin Activities and Cytokine Synthesis in the PCOS Endometrium . J Clin Endocrinol Metab . 2021 ; 106 ( 4 ): 1022 – 1040 . doi: 10.1210/clinem/dgaa951 OpenUrl CrossRef PubMed 536. ↵ Aldakheel FM , Abuderman AA , Alduraywish SA , Xiao Y , Guo WW . MicroRNA-21 inhibits ovarian granulosa cell proliferation by targeting SNHG7 in premature ovarian failure with polycystic ovary syndrome . J Reprod Immunol . 2021 ; 146 : 103328 . doi: 10.1016/j.jri.2021.103328 OpenUrl CrossRef 537. ↵ Smoljan I , Detel D , Buljevic S , Erjavec I , Marić I . Therapeutic Potential of BMP7 in the Treatment of Osteoporosis Caused by the Interaction between Inflammation and Corticosteroids in Inflammatory Bowel Disease . Biomedicines . 2023 ; 11 ( 8 ): 2161 . doi: 10.3390/biomedicines11082161 OpenUrl CrossRef PubMed 538. ↵ Kaartinen MT , Arora M , Heinonen S , Hang A , Barry A , Lundbom J , Hakkarainen A , Lundholm N , Rissanen A , Kaprio J , et al. F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes . Int J Obes (Lond) . 2021 ; 45 ( 3 ): 577 – 587 . doi: 10.1038/s41366-020-00722-0 OpenUrl CrossRef PubMed 539. ↵ Yang A , Yan X , Fan X , Shi Y , Huang T , Li W , Chen W , Jia J , You H . Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice . Hepatol Int . 2021 ; 15 ( 5 ): 1122 – 1135 . doi: 10.1007/s12072-021-10210-w OpenUrl CrossRef PubMed 540. ↵ Chapman KE , Coutinho AE , Zhang Z , Kipari T , Savill JS , Seckl JR . Changing glucocorticoid action: 11β-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation . J Steroid Biochem Mol Biol . 2013 ; 137 : 82 – 92 . doi: 10.1016/j.jsbmb.2013.02.002 OpenUrl CrossRef PubMed 541. ↵ Liu X , Li X , Hua B , Yang X , Zheng J , Liu S . WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 cascade . Bone . 2021 ; 143 : 115793 . doi: 10.1016/j.bone.2020.115793 OpenUrl CrossRef PubMed 542. ↵ Falero-Perez J , Song YS , Zhao Y , Teixeira L , Sorenson CM , Sheibani N . Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells . PLoS One . 2018 ; 13 ( 10 ): e0206756 . doi: 10.1371/journal.pone.0206756 OpenUrl CrossRef PubMed 543. ↵ Zhang S , Pei L , Qu J , Sun L , Jiang W , Li W , Lin Z , Chen D . CRISPLD2 attenuates pro-inflammatory cytokines production in HMGB1-stimulated monocytes and septic mice . Am J Transl Res . 2021 ; 13 ( 5 ): 4080 – 4091 . OpenUrl PubMed 544. ↵ Nus M , Martínez-Poveda B , MacGrogan D , Chevre R , D’Amato G , Sbroggio M , Rodríguez C , Martínez-González J , Andrés V , Hidalgo A , et al. Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis . Cardiovasc Res . 2016 ; 112 ( 2 ): 568 – 580 . doi: 10.1093/cvr/cvw193 OpenUrl CrossRef PubMed 545. ↵ Wu Z , Zheng Y , Sheng J , Han Y , Yang Y , Pan H , Yao J . CD3+CD4-CD8-(Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer . Front Immunol . 2022 ; 13 : 816005 . doi: 10.3389/fimmu.2022.816005 OpenUrl CrossRef PubMed 546. ↵ Mzhavia N , Yu S , Ikeda S , Chu TT , Goldberg I , Dansky HM . Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice . Diabetes . 2008 ; 57 ( 10 ): 2774 – 2783 . doi: 10.2337/db07-1746 OpenUrl Abstract / FREE Full Text 547. ↵ Zhang H , Hao Y , Yang A , Xie L , Ding N , Xu L , Wang Y , Yang Y , Bai Y , Zhang H , et al. TGFB3-AS1 promotes Hcy-induced inflammationof macrophages via inhibiting the maturityof miR-144 and upregulating Rap1a . Mol Ther Nucleic Acids . 2021 ; 26 : 1318 – 1335 . doi: 10.1016/j.omtn.2021.10.031 OpenUrl CrossRef PubMed 548. ↵ Gokulakrishnan K , Pandey GK , Sathishkumar C , Sundararajan S , Durairaj P , Manickam N , Mohan V , Balasubramanyam M . Augmentation of RBP4/STRA6 signaling leads to insulin resistance and inflammation and the plausible therapeutic role of vildagliptin and metformin . Mol Biol Rep . 2021 ; 48 ( 5 ): 4093 – 4106 . doi: 10.1007/s11033-021-06420-y OpenUrl CrossRef PubMed 549. ↵ Aono Y , Suzuki Y , Horiguchi R , Inoue Y , Karayama M , Hozumi H , Furuhashi K , Enomoto N , Fujisawa T , Nakamura Y , et al. CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation . Am J Respir Cell Mol Biol . 2023 ; 68 ( 2 ): 201 – 212 . doi: 10.1165/rcmb.2022-0109OC OpenUrl CrossRef PubMed 550. ↵ Huang S , Zhen Y , Yin X , Yang Z , Li X , Wang R , Wen H , Zhong H , Yan J , Sun Q . KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3 . J Invest Dermatol . 2023 ; 143 ( 1 ): 37 – 47.e8 . doi: 10.1016/j.jid.2022.06.025 OpenUrl CrossRef PubMed 551. ↵ Palikhe S , Uuganbayar U , Trinh HKT , Ban GY , Yang EM , Park HS , Kim SH . A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics . Mediators Inflamm . 2017 ; 2017 : 3549375 . doi: 10.1155/2017/3549375 OpenUrl CrossRef PubMed 552. ↵ de Jager SCA , Hoefer IE . Beyond the matrix: MMP2 as critical regulator of inflammation-mediated vascular dysfunction . Cardiovasc Res . 2017 ; 113 ( 14 ): 1705 – 1707 . doi: 10.1093/cvr/cvx202 OpenUrl CrossRef PubMed 553. ↵ Sun Y , Liu T , Bai W . MAF bZIP Transcription Factor B (MAFB) Protected Against Ovalbumin-Induced Allergic Rhinitis via the Alleviation of Inflammation by Restoring the T Helper (Th) 1/Th2/Th17 Imbalance and Epithelial Barrier Dysfunction . J Asthma Allergy . 2022 ; 15 : 267 – 280 . doi: 10.2147/JAA.S335560 OpenUrl CrossRef PubMed 554. ↵ Zhang K , Li Z , Lu Y , Xiang L , Sun J , Zhang H . Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-κB pathway in chondrocytes . J Orthop Surg Res . 2021 ; 16 ( 1 ): 136 . doi: 10.1186/s13018-021-02268-x OpenUrl CrossRef PubMed 555. ↵ Iyer AS , Chapoval SP . Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor? . Int J Mol Sci . 2018 ; 20 ( 1 ): 124 . doi: 10.3390/ijms20010124 OpenUrl CrossRef 556. ↵ Onal M , St John HC , Danielson AL , Markert JW , Riley EM , Pike JW . Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-Induced Expression of RANKL . Endocrinology . 2016 ; 157 ( 2 ): 482 – 496 . doi: 10.1210/en.2015-1788 OpenUrl CrossRef PubMed 557. ↵ Zhang H , Huang J , Fan X , Miao R , Wang Y . HSP90AA1 promotes the inflammation in human gingival fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide via regulating of autophagy . BMC Oral Health . 2022 ; 22 ( 1 ): 366 . doi: 10.1186/s12903-022-02304-0 OpenUrl CrossRef PubMed 558. ↵ Murata T , Yamaguchi M , Kohno S , Takahashi C , Risa W , Hatori K , Hikita K , Kaneda N. egucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3-L1 cells . FEBS Open Bio . 2020 ; 10 ( 10 ): 1967 – 1984 . doi: 10.1002/2211-5463.12947 OpenUrl CrossRef PubMed 559. ↵ Gao W , Shen L , Long DD , Pan TT , Wang D , Chai XQ , Hu SS . Angiotensin II type 2 receptor pharmacological agonist, C21, reduces the inflammation and pain hypersensitivity in mice with joint inflammatory pain . Int Immunopharmacol . 2022 ; 110 : 108921 . doi: 10.1016/j.intimp.2022.108921 OpenUrl CrossRef PubMed 560. ↵ Xing X , Zhang G , Yi F , Xu X . Overexpression of USP22 ameliorates LPS-induced endometrial stromal cells inflammation and modulates cells decidualization by inhibiting ferroptosis . Reprod Biol . 2024 ; 24 ( 3 ): 100913 . doi: 10.1016/j.repbio.2024.100913 OpenUrl CrossRef PubMed 561. ↵ Kowalski EA , Chen J , Hazy A , Fritsch LE , Gudenschwager-Basso EK , Chen M , Wang X , Qian Y , Zhou M , Byerly M , et al. Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage . J Neuroinflammation . 2019 ; 16 ( 1 ): 210 . doi: 10.1186/s12974-019-1605-2 OpenUrl CrossRef PubMed 562. ↵ Zhao Y , Chen R , Xiao D , Zhang L , Song D , Wen Y , Wu R , Zhao Q , Du S , Wen X , et al. A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection . Int J Mol Sci . 2022 ; 23 ( 6 ): 3280 . doi: 10.3390/ijms23063280 OpenUrl CrossRef PubMed 563. ↵ van Leent MMT , Beldman TJ , Toner YC , Lameijer MA , Rother N , Bekkering S , Teunissen AJP , Zhou X , van der Meel R , Malkus J , et al. Prosaposin mediates inflammation in atherosclerosis . Sci Transl Med . 2021 ; 13 ( 584 ): eabe1433 . doi: 10.1126/scitranslmed.abe1433 OpenUrl Abstract / FREE Full Text 564. ↵ Ngo ML , Mahdi F , Kolte D , Shariat-Madar Z . Upregulation of prolylcarboxypeptidase (PRCP) in lipopolysaccharide (LPS) treated endothelium promotes inflammation . J Inflamm (Lond) . 2009 ; 6 : 3 . doi: 10.1186/1476-9255-6-3 OpenUrl CrossRef PubMed 565. ↵ Min Z , Wan J , Xin H , Liu X , Rao X , Fan Z , Yang L , Li D . R2C2 of macrophages promotes inflammation via NF-κB in LPS-induced orchitis in mice . Reproduction . 2023 ; 166 ( 3 ): 209 – 220 . doi: 10.1530/REP-23-0041 OpenUrl CrossRef PubMed 566. ↵ Cui L , Li H , Xie M , Xu X , Zhang Y , Wang W , Dou S , Xiao W . Relationship Between Proteinase with a Disintegrin and a Metalloproteinase Domain-9 (ADAM9), Inflammation, Airway Remodeling, and Emphysema in COPD Patients . Int J Chron Obstruct Pulmon Dis . 2020 ; 15 : 3335 – 3346 . doi: 10.2147/COPD.S276171 OpenUrl CrossRef PubMed 567. ↵ Zhuang GZ , Keeler B , Grant J , Bianchi L , Fu ES , Zhang YP , Erasso DM , Cui JG , Wiltshire T , Li Q , et al. Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway . PLoS One . 2015 ; 10 ( 3 ): e0118273 . doi: 10.1371/journal.pone.0118273 OpenUrl CrossRef PubMed 568. ↵ Xu J , Liu LY , Zhi FJ , Song YJ , Zhang ZH , Li B , Zheng FY , Gao PC , Zhang SZ , Zhang YY , et al. DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection . EMBO Rep . 2024 ; 25 ( 2 ): 770 – 795 . doi: 10.1038/s44319-023-00047-9 OpenUrl CrossRef PubMed 569. ↵ Shi X , Shi Z , Huang H , Zhu H , Zhou P , Zhu H , Ju D . Ability of recombinant human catalase to suppress inflammation of the murine lung induced by influenza A . Inflammation . 2014 ; 37 ( 3 ): 809 – 817 . doi: 10.1007/s10753-013-9800-2 OpenUrl CrossRef PubMed 570. ↵ Babashamsi MM , Koukhaloo SZ , Halalkhor S , Salimi A , Babashamsi M . ABCA1 and metabolic syndrome; a review of the ABCA1 role in HDL-VLDL production, insulin-glucose homeostasis, inflammation and obesity . Diabetes Metab Syndr . 2019 ; 13 ( 2 ): 1529 – 1534 . doi: 10.1016/j.dsx.2019.03.004 OpenUrl CrossRef PubMed 571. ↵ Messner M , Ghadge SK , Maurer T , Graber M , Staggl S , Christine Maier S , Pölzl G , Zaruba MM . ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA . Cells . 2020 ; 9 ( 9 ): 1981 . doi: 10.3390/cells9091981 OpenUrl CrossRef 572. ↵ Cho EC , Kuo ML , Cheng JH , Cheng YC , Hsieh YC , Liu YR , Hsieh RH , Yen Y . RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress . Mediators Inflamm . 2015 ; 2015 : 287345 . doi: 10.1155/2015/287345 OpenUrl CrossRef PubMed 573. ↵ Qi R , Wang Y , Yan F , Zhong J . Exosomes derived from ITGB1 modified Telocytes alleviates LPS-induced inflammation and oxidative stress through YAP1/ROS axis . Heliyon . 2024 ; 10 ( 5 ): e27086 . doi: 10.1016/j.heliyon.2024.e27086 OpenUrl CrossRef PubMed 574. ↵ Piñeiro-Hermida S , Alfaro-Arnedo E , Gregory JA , Torrens R , Ruíz-Martínez C , Adner M , López IP , Pichel JG . Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma . PLoS One . 2017 ; 12 ( 12 ): e0190159 . doi: 10.1371/journal.pone.0190159 OpenUrl CrossRef PubMed 575. ↵ Gao H , Zhao L , Wang H , Xie E , Wang X , Wu Q , Yu Y , He X , Ji H , et al. Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival . Proc Natl Acad Sci U S A . 2017 ; 114 ( 49 ): 12940 – 12945 . doi: 10.1073/pnas.1708018114 OpenUrl Abstract / FREE Full Text 576. ↵ Liu H , Wang W , Shen W , Wang L , Zuo Y . ARHGAP24 ameliorates inflammatory response through inactivating Rac1/Akt/NF-κB pathway in acute pneumonia model of rat . Ann Transl Med . 2020 ; 8 ( 20 ): 1289 . doi: 10.21037/atm-20-5000 OpenUrl CrossRef PubMed 577. ↵ Wang J , Li L , Su Q , Zhou Y , Chen H , Ma G , Liu T , Tang Z , Liu Y. Wang J , Li L , Su Q , Zhou Y , Chen H , Ma G , Liu T , Tang Z , Liu Y . The involvement of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in the regulation of inflammation following coronary microembolization . Cell Physiol Biochem . 2014 ; 33 ( 6 ): 1963 – 1974 . doi: 10.1159/000362973 OpenUrl CrossRef PubMed 578. ↵ Jiang Z , Zhao Q , Chen L , Luo Y , Shen L , Cao Z , Wang Q . UBR3 promotes inflammation and apoptosis via DUSP1/p38 pathway in the nucleus pulposus cells of patients with intervertebral disc degeneration . Hum Cell . 2022 ; 35 ( 3 ): 792 – 802 . doi: 10.1007/s13577-022-00693-6 OpenUrl CrossRef PubMed 579. ↵ Patel AS , Murphy KM , Hawkins AL , Cohen JS , Long PP , Perlman EJ , Griffin CA . RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors . Cancer Genet Cytogenet . 2007 ; 176 ( 2 ): 107 – 114 . doi: 10.1016/j.cancergencyto.2007.04.004 OpenUrl CrossRef PubMed Web of Science 580. ↵ Tseng-Rogenski SS , Munakata K , Choi DY , Martin PK , Mehta S , Koi M , Zheng W , Zhang Y , Carethers JM . The Human DNA Mismatch Repair Protein MSH3 Contains Nuclear Localization and Export Signals That Enable Nuclear-Cytosolic Shuttling in Response to Inflammation . Mol Cell Biol . 2020 ; 40 ( 13 ): e00029 – 20 . doi: 10.1128/MCB.00029-20 OpenUrl Abstract / FREE Full Text 581. ↵ Xu M , Gan D , Zhang XY , He XT , Wu RX , Yin Y , Jin R , Li L , Tan YJ , Chen FM , et al. SLC30A4-AS1 Mediates the Senescence of Periodontal Ligament Stem Cells in Inflammatory Environments via the Alternative Splicing of TP53BP1 . Cell Prolif . 2024 . doi: 10.1111/cpr.13778 OpenUrl CrossRef 582. ↵ Bruno A , Dolcetti E , Azzolini F , Buttari F , Gilio L , Iezzi E , Galifi G , Borrelli A , Furlan R , Finardi A , et al. BACE1 influences clinical manifestations and central inflammation in relapsing remitting multiple sclerosis . Mult Scler Relat Disord . 2023 ; 71 : 104528 . doi: 10.1016/j.msard.2023.104528 OpenUrl CrossRef 583. ↵ Zhang Y , Bai H , Zhang W , Gao J , Gao C , Deng T , Liu X , Sun X , Liu Y , Wang N , et al. miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1 . Exp Cell Res . 2023 ; 433 ( 2 ): 113828 . doi: 10.1016/j.yexcr.2023.113828 OpenUrl CrossRef PubMed 584. ↵ Li C , Li L , Chen K , Wang Y , Yang F , Wang G . UFL1 Alleviates Lipopolysaccharide-Induced Cell Damage and Inflammation via Regulation of the TLR4/NF-κB Pathway in Bovine Mammary Epithelial Cells . Oxid Med Cell Longev . 2019 ; 2019 : 6505373 . doi: 10.1155/2019/6505373 OpenUrl CrossRef PubMed 585. ↵ Means AL . ATRX Links Chromatin Remodeling to Inflammation and Tumorigenesis in the Pancreas . Cell Mol Gastroenterol Hepatol . 2019 ; 7 ( 1 ): 233 – 234 . doi: 10.1016/j.jcmgh.2018.10.001 OpenUrl CrossRef PubMed 586. ↵ Long P , Guo C , Wen T , Luo T , Yang L , Li Y , Wen A , Wang W , Wen X , He M . Therapeutic effects of Mudan granules on diabetic retinopathy: Mitigating fibrogenesis caused by FBN2 deficiency and inflammation associated with TNF-α elevation . J Ethnopharmacol . 2025 ; 337 (Pt 3 ): 118963 . doi: 10.1016/j.jep.2024.118963 OpenUrl CrossRef PubMed 587. ↵ Chakravarti D , Hu B , Mao X , Rashid A , Li J , Li J , Liao WT , Whitley EM , Dey P , Hou P , et al. Telomere dysfunction activates YAP1 to drive tissue inflammation . Nat Commun . 2020 ; 11 ( 1 ): 4766 . doi: 10.1038/s41467-020-18420-w OpenUrl CrossRef PubMed 588. ↵ Wallace DF , McDonald CJ , Ostini L , Subramaniam VN . Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2 . Blood . 2011 ; 117 ( 10 ): 2960 – 2966 . doi: 10.1182/blood-2010-08-303859 OpenUrl Abstract / FREE Full Text 589. ↵ Anbazhagan AN , Ge Y , Priyamvada S , Kumar A , Jayawardena D , Palani ARV , Husain N , Kulkarni N , Kapoor S , Kaur P , et al. Direct Link Implicating Loss of SLC26A6 to Gut Microbial Dysbiosis, Compromised Barrier Integrity, and Inflammation . Gastroenterology . 2024 ; 167 ( 4 ): 704 – 717.e3 . doi: 10.1053/j.gastro.2024.05.002 OpenUrl CrossRef PubMed 590. ↵ Ni X , Li X , Fang X , Li N , Cui W , Zhang B , Liu Y . Kidins220/ARMS contributes to airway inflammation and hyper-responsiveness in OVA-sensitized mice . Respir Physiol Neurobiol . 2011 ; 175 ( 1 ): 97 – 103 . doi: 10.1016/j.resp.2010.09.012 OpenUrl CrossRef PubMed 591. ↵ Batzorig U , Chen Y , Liu Y , Fernández-Méndez C , Mahapatra S , Lim SH , Hong SP , Sen GL . The Switch/Sucrose Nonfermentable Subunit ARID1A Mediates Neutrophil-Associated Skin Inflammatory Responses . J Invest Dermatol . 2024 ; 144 ( 10 ): 2324 – 2328.e4 . doi: 10.1016/j.jid.2024.03.015 OpenUrl CrossRef PubMed 592. ↵ Ullah MA , Vicente CT , Collinson N , Curren B , Sikder MAA , Sebina I , Simpson J , Varelias A , Lindquist JA , Ferreira MAR , et al. PAG1 limits allergen-induced type 2 inflammation in the murine lung . Allergy . 2020 ; 75 ( 2 ): 336 – 345 . doi: 10.1111/all.13991 OpenUrl CrossRef PubMed 593. ↵ Gao S , Liu L , Zhu S , Wang D , Wu Q , Ning G , Feng S . MicroRNA-197 regulates chondrocyte proliferation, migration, and inflammation in pathogenesis of osteoarthritis by targeting EIF4G2 . Biosci Rep . 2020 ; 40 ( 9 ):BSR20192095. doi: 10.1042/BSR20192095 OpenUrl CrossRef PubMed 594. ↵ Gesta S , Guntur K , Majumdar ID , Akella S , Vishnudas VK , Sarangarajan R , Narain NR . Reduced expression of collagen VI alpha 3 (COL6A3) confers resistance to inflammation-induced MCP1 expression in adipocytes . Obesity (Silver Spring) . 2016 ; 24 ( 8 ): 1695 – 1703 . doi: 10.1002/oby.21565 OpenUrl CrossRef PubMed 595. ↵ Zhao N , Yu H , Xi Y , Dong M , Wang Y , Sun C , Zhang J , Xu N , Liu W . MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5 . Toxicon . 2022 ; 212 : 11 – 18 . doi: 10.1016/j.toxicon.2022.03.010 OpenUrl CrossRef 596. ↵ Han EJ , Kim HY , Lee N , Kim NH , Yoo SA , Kwon HM , Jue DM , Park YJ , Cho CS , De TQ , et al. Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors . EBioMedicine . 2017 ; 18 : 261 – 273 . doi: 10.1016/j.ebiom.2017.03.039 OpenUrl CrossRef PubMed 597. ↵ Ma X , Zhu G , Jiao T , Shao F . Effects of circular RNA Ttc3/miR-148a/Rcan2 axis on inflammation and oxidative stress in rats with acute kidney injury induced by sepsis . Life Sci . 2021 ; 272 : 119233 . doi: 10.1016/j.lfs.2021.119233 OpenUrl CrossRef 598. ↵ Nadanaka S , Hashiguchi T , Kitagawa H . Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling . FASEB J . 2020 ; 34 ( 6 ): 8385 – 8401 . doi: 10.1096/fj.201902076R OpenUrl CrossRef PubMed 599. ↵ Zhou Q , Lei Y . ARMCX3 regulates ROS signaling, affects neural differentiation and inflammatory microenvironment in dental pulp stem cells . Heliyon . 2024 ; 10 ( 17 ): e37079 . doi: 10.1016/j.heliyon.2024.e37079 OpenUrl CrossRef PubMed 600. ↵ Duodu P , Sosa G , Canar J , Chhugani O , Gamero AM . Exposing the Two Contrasting Faces of STAT2 in Inflammation . J Interferon Cytokine Res . 2022 ; 42 ( 9 ): 467 – 481 . doi: 10.1089/jir.2022.0117 OpenUrl CrossRef PubMed 601. ↵ Keppner A , Malsure S , Nobile A , Auberson M , Bonny O , Hummler E . Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis . Inflamm Bowel Dis . 2016 ; 22 ( 12 ): 2824 – 2839 . doi: 10.1097/MIB.0000000000000940 OpenUrl CrossRef PubMed 602. ↵ Ghalandary M , Li Y , Fröhlich T , Magg T , Liu Y , Rohlfs M , Hollizeck S , Conca R , Schwerd T , Uhlig HH , et al. Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses . Sci Rep . 2022 ; 12 ( 1 ): 3906 . doi: 10.1038/s41598-022-07804-1 OpenUrl CrossRef PubMed 603. ↵ Singleton KD , Wischmeyer PE . Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation . Biochem Biophys Res Commun . 2008 ; 373 ( 3 ): 445 – 449 . doi: 10.1016/j.bbrc.2008.06.057 OpenUrl CrossRef PubMed 604. ↵ Wu Z , Gao S , Gao Q , Patel BA , Groarke EM , Feng X , Manley AL , Li H , Ospina Cardona D , Kajigaya S , et al. Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS . Cell Rep Med . 2023 ; 4 ( 8 ): 101160 . doi: 10.1016/j.xcrm.2023.101160 OpenUrl CrossRef PubMed 605. ↵ Matsumoto Y , Dimitriou ID , La Rose J , Lim M , Camilleri S , Law N , Adissu HA , Tong J , Moran MF , Chruscinski A , He F , et al. Tankyrase represses autoinflammation through the attenuation of TLR2 signaling . J Clin Invest . 2022 ; 132 ( 7 ): e140869 . doi: 10.1172/JCI140869 OpenUrl CrossRef PubMed 606. ↵ Shin JG , Kim HJ , Park BL , Bae JS , Kim LH , Cheong HS , Shin HD . Putative association of GPC5 polymorphism with the risk of inflammatory demyelinating diseases . J Neurol Sci . 2013 ; 335 ( 1-2 ): 82 – 88 . doi: 10.1016/j.jns.2013.08.031 OpenUrl CrossRef PubMed 607. ↵ Li X , Guo Y , Song Y , Sun R , Zhu M , Tan Z , Swaiba UE , Zhang L , Huang J . The glycosyltransferase ST3GAL2 modulates virus proliferation and the inflammation response in porcine reproductive and respiratory syndrome virus infection . Arch Virol . 2021 ; 166 ( 10 ): 2723 – 2732 . doi: 10.1007/s00705-021-05180-1 OpenUrl CrossRef PubMed 608. ↵ Jiang L , Li J , Ji K , Lei L , Li H . MAT2A inhibition suppresses inflammation in Porphyromonas gingivalis-infected human gingival fibroblasts . J Oral Microbiol . 2023 ; 16 ( 1 ): 2292375 . doi: 10.1080/20002297.2023.2292375 OpenUrl CrossRef PubMed 609. ↵ Wei Y , Huang X , Ma Y , Dai L . FOXC1 mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast like synoviocytes in rheumatoid arthritis via NF κB signaling pathway . Mol Med Rep . 2022 ; 26 ( 4 ): 304 . doi: 10.3892/mmr.2022.12820 OpenUrl CrossRef PubMed 610. ↵ Li H , Ma Y , Li T , Zeng Z , Luo L , Liu X , Li Y , Chen Y . CAPN5 attenuates cigarette smoke extract-induced apoptosis and inflammation in BEAS-2B cells . Tob Induc Dis . 2024 ; 22 : 10 . 18332 /tid/186183 . doi: 10.18332/tid/186183 OpenUrl CrossRef 611. ↵ Cai J , Li C , Liu S , Tan M , Sun Y , Sun X , Yang M , He B . Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome . Cell Death Differ . 2024 ; 31 ( 8 ): 1057 – 1069 . doi: 10.1038/s41418-024-01311-8 OpenUrl CrossRef PubMed 612. ↵ Secchi MF , Masola V , Zaza G , Lupo A , Gambaro G , Onisto M . Recent data concerning heparanase: focus on fibrosis, inflammation and cancer . Biomol Concepts . 2015 ; 6 ( 5-6 ): 415 – 421 . doi: 10.1515/bmc-2015-0021 OpenUrl CrossRef PubMed 613. ↵ Uchida Y , Torisu K , Aihara S , Imazu N , Ooboshi H , Kitazono T , Nakano T . Arginase 2 Promotes Cisplatin-Induced Acute Kidney Injury by the Inflammatory Response of Macrophages . Lab Invest . 2023 ; 103 ( 10 ): 100227 . doi: 10.1016/j.labinv.2023.100227 OpenUrl CrossRef PubMed 614. ↵ Päth G , Mehana AE , Pilz IH , Alt M , Baumann J , Sommerer I , Hoffmeister A , Seufert J . NUPR1 preserves insulin secretion of pancreatic β-cells during inflammatory stress by multiple low-dose streptozotocin and high-fat diet . Am J Physiol Endocrinol Metab . 2020 ; 319 ( 2 ): E338 – E344 . doi: 10.1152/ajpendo.00088.2020 OpenUrl CrossRef PubMed 615. ↵ Han PF , Che XD , Li HZ , Gao YY , Wei XC , Li PC . Annexin A1 involved in the regulation of inflammation and cell signaling pathways . Chin J Traumatol . 2020 ; 23 ( 2 ): 96 – 101 . doi: 10.1016/j.cjtee.2020.02.002 OpenUrl CrossRef PubMed 616. ↵ Zhang X , Bogunovic D , Payelle-Brogard B , Francois-Newton V , Speer SD , Yuan C , Volpi S , Li Z , Sanal O , Mansouri D , et al. Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation . Nature . 2015 ; 517 ( 7532 ):89-93. doi: 10.1038/nature13801 OpenUrl CrossRef PubMed 617. ↵ Liu H , Hu Q , Ren K , Wu P , Wang Y , Lv C . ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING pathway . Mol Med . 2023 ; 29 ( 1 ): 171 . doi: 10.1186/s10020-023-00769-5 OpenUrl CrossRef PubMed 618. ↵ Bai Y , Han G , Guo K , Yu L , Du X , Xu Y . Effect of lentiviral vector-mediated KSR1 gene silencing on the proliferation of renal tubular epithelial cells and expression of inflammatory factors in a rat model of ischemia/reperfusion injury . Acta Biochim Biophys Sin (Shanghai) . 2018 ; 50 ( 8 ): 807 – 816 . doi: 10.1093/abbs/gmy071 OpenUrl CrossRef PubMed 619. ↵ Sinitski D , Kontos C , Krammer C , Asare Y , Kapurniotu A , Bernhagen J . Macrophage Migration Inhibitory Factor (MIF)-Based Therapeutic Concepts in Atherosclerosis and Inflammation . Thromb Haemost . 2019 ; 119 ( 4 ): 553 – 566 . doi: 10.1055/s-0039-1677803 OpenUrl CrossRef PubMed 620. ↵ Gaddam RR , Chambers S , Bhatia M . ACE and ACE2 in inflammation: a tale of two enzymes . Inflamm Allergy Drug Targets . 2014 ; 13 ( 4 ): 224 – 234 . doi: 10.2174/1871528113666140713164506 OpenUrl CrossRef PubMed 621. ↵ Endler M , Saltvedt S , Eweida M , Åkerud H . Oxidative stress and inflammation in retained placenta: a pilot study of protein and gene expression of GPX1 and NFκB . BMC Pregnancy Childbirth . 2016 ; 16 ( 1 ): 384 . doi: 10.1186/s12884-016-1135-1 OpenUrl CrossRef PubMed 622. ↵ Zampas P , Li Z , Katsouda A , Varela A , Psarras S , Davos CH , Lefer DJ,Papapetropoulos A. Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation . Pharmacol Res . 2025 ; 211 : 107542 . doi: 10.1016/j.phrs.2024.107542 OpenUrl CrossRef 623. ↵ Kim JD , Yoon NA , Jin S , Diano S . Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding . Cell Metab . 2019 ; 30 ( 5 ): 952 – 962.e5 . doi: 10.1016/j.cmet.2019.08.010 OpenUrl CrossRef PubMed 624. ↵ Lin R , Ma C , Fang L , Xu C , Zhang C , Wu X , Wu W , Zhu R , Cong Y , Liu Z . TOB1 Blocks Intestinal Mucosal Inflammation Through Inducing ID2-Mediated Suppression of Th1/Th17 Cell Immune Responses in IBD . Cell Mol Gastroenterol Hepatol . 2022 ; 13 ( 4 ): 1201 – 1221 . doi: 10.1016/j.jcmgh.2021.12.007 OpenUrl CrossRef PubMed 625. ↵ Lu X , Yang B , Qi R , Xie Q , Li T , Yang J , Tong T , Niu K , Li M , Pan W , et al. Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation . Theranostics . 2023 ; 13 ( 1 ): 417 – 437 . doi: 10.7150/thno.77694 OpenUrl CrossRef PubMed 626. ↵ Audrito V , Messana VG , Deaglio S . NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation . Front Oncol . 2020 ; 10 : 358 . doi: 10.3389/fonc.2020.00358 OpenUrl CrossRef PubMed 627. ↵ Ma Z , Wang D , Weng J , Zhang S , Zhang Y . BNIP3 decreases the LPS-induced inflammation and apoptosis of chondrocytes by promoting the development of autophagy . J Orthop Surg Res . 2020 ; 15 ( 1 ): 284 . doi: 10.1186/s13018-020-01791-7 OpenUrl CrossRef PubMed 628. ↵ Zang L , Hong Q , Yang G , Gu W , Wang A , Dou J , Mu Y , Wu D , Lyu Z . MACROD1/LRP16 Enhances LPS-Stimulated Inflammatory Responses by Up-Regulating a Rac1-Dependent Pathway in Adipocytes . Cell Physiol Biochem . 2018 ; 51 ( 6 ): 2591 – 2603 . doi: 10.1159/000495931 OpenUrl CrossRef PubMed 629. ↵ Bry M , Kivelä R , Holopainen T , Anisimov A , Tammela T , Soronen J , Silvola J , Saraste A , Jeltsch M , Korpisalo P , et al. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation . Circulation . 2010 ; 122 ( 17 ): 1725 – 1733 . doi: 10.1161/CIRCULATIONAHA.110.957332 OpenUrl Abstract / FREE Full Text 630. ↵ Zhang S , Lu X , Fang X , Wang Z , Cheng S , Song J . Cigarette smoke extract combined with LPS reduces ABCA3 expression in chronic pulmonary inflammation may be related to PPARγ/ P38 MAPK signaling pathway . Ecotoxicol Environ Saf . 2022 ; 244 : 114086 . doi: 10.1016/j.ecoenv.2022.114086 OpenUrl CrossRef PubMed 631. ↵ Yoo HJ , Choi DW , Roh YJ , Lee YM , Lim JH , Eo S , Lee HJ , Kim NY , Kim S , Cho S , et al. MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation . Cell Rep . 2022 ; 41 ( 6 ): 111598 . doi: 10.1016/j.celrep.2022.111598 OpenUrl CrossRef PubMed 632. ↵ Routsias JG , Marinou D , Mavrouli M , Tsakris A , Pitiriga VC . Major Vault Protein/Lung Resistance-Related Protein: A Novel Biomarker for Inflammation and Acute Infections . Microorganisms . 2024 ; 12 ( 9 ): 1762 . doi: 10.3390/microorganisms12091762 OpenUrl CrossRef PubMed 633. ↵ Bao MH , Lv QL , Li HG , Zhang YW , Xu BF , He BS . A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway . Mediators Inflamm . 2020 ; 2020 : 6268514 . doi: 10.1155/2020/6268514 OpenUrl CrossRef PubMed 634. ↵ Shi L , Hu H , Sun P , Li Z , Ji L , Liu S , Zhang J . RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis . Inflamm Res . 2022 ; 71 ( 7-8 ): 977 – 989 . doi: 10.1007/s00011-022-01579-x OpenUrl CrossRef PubMed 635. ↵ Li X , Liu J , Lu L , Huang T , Hou W , Wang F , Yu L , Wu F , Qi J , Chen X , et al. Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation . Transl Res . 2022 ; 247 : 99 – 116 . doi: 10.1016/j.trsl.2022.04.005 OpenUrl CrossRef PubMed 636. ↵ Yao J , Jiang Y , Zhang P , Miao Y , Wu X , Lei H , Xie Z , Tian Y , Zhao X , Li J , et al. Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis . Pharmacol Res . 2025 . doi: 10.1016/j.phrs.2025.107620 OpenUrl CrossRef 637. ↵ Janus P , Kuś P , Vydra N , Toma-Jonik A , Stokowy T , Mrowiec K , Wojtaś B , Gielniewski B , Widłak W . HSF1 Can Prevent Inflammation following Heat Shock by Inhibiting the Excessive Activation of the ATF3 and JUN&FOS Genes . Cells . 2022 ; 11 ( 16 ): 2510 . doi: 10.3390/cells11162510 OpenUrl CrossRef 638. ↵ Sánchez-Navarro A , Martínez-Rojas MÁ , Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F, Bobadilla NA . Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury . Int J Mol Sci. 2022 ; 23 ( 5 ): 2573 . doi: 10.3390/ijms23052573 OpenUrl CrossRef PubMed 639. ↵ Jeong JH , Park SJ , Dickinson SI , Luo JL . A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance . Mol Cell . 2017 ; 65 ( 1 ): 154 - 167 . doi: 10.1016/j.molcel.2016.11.034 OpenUrl CrossRef PubMed 640. ↵ Mishra SK , Gao YG , Zou X , Stephenson DJ , Malinina L , Hinchcliffe EH , Chalfant CE , Brown RE . Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death . Prog Lipid Res . 2020 ; 78 : 101031 . doi: 10.1016/j.plipres.2020.101031 OpenUrl CrossRef 641. ↵ Cai J , Li C , Liu S , Tan M , Sun Y , Sun X , Yang M , He B . Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome . Cell Death Differ . 2024 ; 31 ( 8 ): 1057 – 1069 . doi: 10.1038/s41418-024-01311-8 OpenUrl CrossRef PubMed 642. ↵ Ko CY , Chang WC , Wang JM . Biological roles of CCAAT/Enhancer-binding protein delta during inflammation . J Biomed Sci . 2015 ; 22 ( 1 ): 6 . doi: 10.1186/s12929-014-0110-2 OpenUrl CrossRef PubMed 643. ↵ Deng M , Tan X , Peng X , Zheng W , Fu R , Tao S . HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis . Ren Fail . 2024 ; 46 ( 2 ): 2415517 . doi: 10.1080/0886022X.2024.2415517 OpenUrl CrossRef PubMed 644. ↵ Song F , Zhang Y , Pan Z , Hu X , Zhang Q , Huang F , Ye X , Huang P . The role of alcohol dehydrogenase 1C in regulating inflammatory responses in ulcerative colitis . Biochem Pharmacol . 2021 ; 192 : 114691 . doi: 10.1016/j.bcp.2021.114691 OpenUrl CrossRef PubMed 645. ↵ Giacconi R , Cipriano C , Muti E , Costarelli L , Maurizio C , Saba V , Gasparini N , Malavolta M , Mocchegiani E . Novel-209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc . Biogerontology . 2005 ; 6 ( 6 ): 407 – 413 . doi: 10.1007/s10522-005-4907-y OpenUrl CrossRef PubMed Web of Science 646. ↵ Zheng E , Cai Z , Li W , Ni C , Fang Q . Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma . World J Surg Oncol . 2022 ; 20 ( 1 ): 266 . doi: 10.1186/s12957-022-02722-y OpenUrl CrossRef PubMed 647. ↵ Ye L , Mao S , Fang S , Zhang J , Tan Y , Gu W . Increased Serum Romo1 Was Correlated with Lung Function, Inflammation, and Oxidative Stress in Chronic Obstructive Pulmonary Disease . Inflammation . 2019 ; 42 ( 5 ): 1555 – 1560 . doi: 10.1007/s10753-019-01017-x OpenUrl CrossRef PubMed 648. ↵ Yang Y , Shao Y , Gao X , Hu Z , Wang Y , Ma C , Jin G , Zhu F , Dong G , Zhou G . RGS10 Deficiency Alleviated Intestinal Mucosal Inflammation Through Suppression of Th1/Th17 Cell Immune Responses in Ulcerative Colitis . Immunology . 2025 ; 174 ( 1 ): 139 – 152 . doi: 10.1111/imm.13869 OpenUrl CrossRef 649. ↵ Hogea A , Shah S , Jones F , Carver CM , Hao H , Liang C , Huang D , Du X , Gamper N . Junctophilin-4 facilitates inflammatory signalling at plasma membrane-endoplasmic reticulum junctions in sensory neurons . J Physiol . 2021 ; 599 ( 7 ): 2103 – 2123 . doi: 10.1113/JP281331 OpenUrl CrossRef PubMed 650. ↵ Zhou Z , Plug LG , Patente TA , de Jonge-Muller ESM , Elmagd AA , van der Meulen-de Jong AE , Everts B , Barnhoorn MC , Hawinkels LJAC . Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation . Front Immunol . 2022 ; 13 : 966067 . doi: 10.3389/fimmu.2022.966067 OpenUrl CrossRef PubMed 651. ↵ Tao Y , Sun Y , Wu B , Xu D , Yang J , Gu L , Du C . Overexpression of FOXA2 attenuates cigarette smoke-induced cellular senescence and lung inflammation through inhibition of the p38 and Erk1/2 MAPK pathways . Int Immunopharmacol . 2021 ; 94 : 107427 . doi: 10.1016/j.intimp.2021.107427 OpenUrl CrossRef 652. ↵ Fan S , Popli S , Chakravarty S , Chakravarti R , Chattopadhyay S . Non-transcriptional IRF7 interacts with NF-κB to inhibit viral inflammation . J Biol Chem . 2024 ; 300 ( 4 ): 107200 . doi: 10.1016/j.jbc.2024.107200 OpenUrl CrossRef 653. ↵ Almuttaqi H , Udalova IA . Advances and challenges in targeting IRF5, a key regulator of inflammation . FEBS J . 2019 ; 286 ( 9 ): 1624 – 1637 . doi: 10.1111/febs.14654 OpenUrl CrossRef PubMed 654. ↵ Jha P , Claudel T , Baghdasaryan A , Mueller M , Halilbasic E , Das SK , Lass A , Zimmermann R , Zechner R , Hoefler G , et al. Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia . Hepatology . 2014 ; 59 ( 3 ): 858 – 869 . doi: 10.1002/hep.26732 OpenUrl CrossRef PubMed 655. ↵ Wu H , Chen L , Lu K , Liu Y , Lu W , Jiang J , Weng C . HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF-κβ Pathway . Mediators Inflamm . 2023 ; 2023 : 2157355 . doi: 10.1155/2023/2157355 OpenUrl CrossRef PubMed 656. ↵ Zhang X , Hu Y , Zhang Z , Zhang X , Liang L , Cui X , Wu Y , Hu F , Wu X . Inhibition of TMUB1 blocks apoptosis and NF-κB pathway-mediated inflammation in recurrent spontaneous abortion . Immun Inflamm Dis . 2023 ; 11 ( 5 ): e879 . doi: 10.1002/iid3.879 OpenUrl CrossRef PubMed 657. ↵ Xu Z , Song T , Yang X , Cong L , Yin L , Xu Y , Han X , Gao M , Xu L . TMT-based proteomics reveals methylprotodioscin alleviates oxidative stress and inflammation via COX6C in myocardial infraction . Biomed Pharmacother . 2024 ; 180 : 117489 . doi: 10.1016/j.biopha.2024.117489 OpenUrl CrossRef 658. ↵ Jiang X , Chen D . LncRNA FAM83H-AS1 maintains intervertebral disc tissue homeostasis and attenuates inflammation-related pain via promoting nucleus pulposus cell growth through miR-22-3p inhibition . Ann Transl Med . 2020 ; 8 ( 22 ): 1518 . doi: 10.21037/atm-20-7056 OpenUrl CrossRef PubMed 659. ↵ Zhang Z , Zhao C , Sun L , Cheng C , Tian Q , Wu C , Xu Y , Dong X , Zhang B , Zhang L , et al. Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice . Eur J Immunol . 2024 ; 54 ( 3 ): e2350836 . doi: 10.1002/eji.202350836 OpenUrl CrossRef PubMed 660. ↵ Honkisz-Orzechowska E , Łażewska D , Baran G , Kieć-Kononowicz K . Uncovering the Power of GPR18 Signalling: How RvD2 and Other Ligands Could Have the Potential to Modulate and Resolve Inflammation in Various Health Disorders . Molecules . 2024 ; 29 ( 6 ): 1258 . doi: 10.3390/molecules29061258 OpenUrl CrossRef PubMed 661. ↵ Sugawara S , Okada R , Loo TM , Tanaka H , Miyata K , Chiba M , Kawasaki H , Katoh K , Kaji S , Maezawa Y , et al. RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells . Commun Biol . 2022 ; 5 ( 1 ): 1420 . doi: 10.1038/s42003-022-04369-7 OpenUrl CrossRef PubMed 662. ↵ Fan XD , Wan LL , Duan M , Lu S . HDAC11 deletion reduces fructose-induced cardiac dyslipidemia, apoptosis and inflammation by attenuating oxidative stress injury . Biochem Biophys Res Commun . 2018 ; 503 ( 2 ): 444 – 451 . doi: 10.1016/j.bbrc.2018.04.090 OpenUrl CrossRef PubMed 663. ↵ Yuan C , Li X , Song H , Fan L , Su S , Dong B . BMP7 coordinates endometrial epithelial cell receptivity for blastocyst implantation through the endoglin pathway in cell lines and a mouse model . Exp Ther Med . 2019 ; 17 ( 4 ): 2547 – 2556 . doi: 10.3892/etm.2019.7265 OpenUrl CrossRef PubMed 664. ↵ Zhou W , Menkhorst E , Dimitriadis E . Jagged1 regulates endometrial receptivity in both humans and mice . FASEB J . 2021 ; 35 ( 8 ): e21784 . doi: 10.1096/fj.202100590R OpenUrl CrossRef PubMed 665. ↵ Hebeda CB , Sandri S , Benis CM , Paula-Silva M , Loiola RA , Reutelingsperger C , Perretti M , Farsky SHP . Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst . Cells . 2020 ; 9 ( 5 ): 1188 . doi: 10.3390/cells90511 OpenUrl CrossRef 666. ↵ Wiesli MG , Huber MW , Weisse B , Zboray R , Kiderlen S , González-Vázquez A , Maniura-Weber K , Rottmar M , Lackington WA . Immunomodulation Using BMP-7 and IL-10 to Enhance the Mineralization Capacity of Bone Progenitor Cells in a Fracture Hematoma-Like Environment . Adv Healthc Mater . 2024 . doi: 10.1002/adhm.202400077 OpenUrl CrossRef 667. ↵ Acebes-Huerta A , Huergo-Zapico L , Gonzalez-Rodriguez AP , Fernandez-Guizan A , Payer AR , López-Soto A , Gonzalez S . Lenalidomide induces immunomodulation in chronic lymphocytic leukemia and enhances antitumor immune responses mediated by NK and CD4 T cells . Biomed Res Int . 2014 ; 2014 : 265840 . doi: 10.1155/2014/265840 OpenUrl CrossRef PubMed 668. ↵ Karpouzas GA , Papotti B , Ormseth SR , Palumbo M , Hernandez E , Adorni MP , Zimetti F , Budoff MJ , Ronda N . Inflammation and immunomodulatory therapies influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis . J Transl Autoimmun . 2023 ; 7 : 100209 . doi: 10.1016/j.jtauto.2023.100209 OpenUrl CrossRef 669. ↵ Hu X , Zhang Y , Yu H , Zhao Y , Sun X , Li Q , Wang Y . The role of YAP1 in survival prediction, immune modulation, and drug response: A pan-cancer perspective . Front Immunol . 2022 ; 13 : 1012173 . doi: 10.3389/fimmu.2022.1012173 OpenUrl CrossRef 670. ↵ Song L , Wei X , Zhang X , Lu Y . Combining single-cell and transcriptomic analysis revealed the immunomodulatory effect of GOT2 on a glutamine-dependent manner in cutaneous melanoma . Front Pharmacol . 2023 ; 14 : 1241454 . doi: 10.3389/fphar.2023.1241454 OpenUrl CrossRef 671. ↵ De Luca F , Kha M , Swärd K , Johansson ME . Identification of ARMH4 and WIPF3 as human podocyte proteins with potential roles in immunomodulation and cytoskeletal dynamics . PLoS One . 2023 ; 18 ( 1 ): e0280270 . doi: 10.1371/journal.pone.0280270 OpenUrl CrossRef PubMed 672. ↵ Álvarez E , Falqui M , Sin L , McGrail JP , Perdiguero B , Coloma R , Marcos-Villar L , Tárrega C , Esteban M , Gómez CE , et al. Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers . Vaccines (Basel) . 2024 ; 12 ( 2 ): 153 . doi: 10.3390/vaccines12020153673 . OpenUrl CrossRef PubMed 673. ↵ Fairley LH , Lai KO , Grimm A , Eckert A , Barron AM. The mitochondrial translocator protein (TSPO) in Alzheimer’s disease: Therapeutic and immunomodulatory functions . Biochimie . 2024 ; 224 : 120 - 131 . doi: 10.1016/j.biochi.2024.07.003 OpenUrl CrossRef PubMed 674. ↵ Weiser JN , Roche AM , Hergott CB , LaRose MI , Connolly T , Jorgensen WL , Leng L , Bucala R , Das R . Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation . J Infect Dis . 2015 ; 212 ( 10 ): 1677 – 1682 . doi: 10.1093/infdis/jiv262 OpenUrl CrossRef PubMed 675. ↵ Gupta AK , Roy S , Das PK . Antileishmanial effect of the natural immunomodulator genipin through suppression of host negative regulatory protein UCP2 . J Antimicrob Chemother . 2021 ; 76 ( 1 ): 135 – 145 . doi: 10.1093/jac/dkaa406 OpenUrl CrossRef PubMed 676. ↵ Du YN , Zhao JW . GDF15: Immunomodulatory Role in Hepatocellular Carcinoma Pathogenesis and Therapeutic Implications . J Hepatocell Carcinoma . 2024 ; 11 : 1171 – 1183 . doi: 10.2147/JHC.S471239 OpenUrl CrossRef PubMed 677. ↵ Yang JW , Seo Y , Shin TH , Ahn JS , Oh SJ , Shin YY , Kang MJ , Lee BC , Lee S , Kang KS , et al. Extracellular Vesicles from SOD3-Transduced Stem Cells Exhibit Improved Immunomodulatory Abilities in the Murine Dermatitis Model . Antioxidants (Basel) . 2020 ; 9 ( 11 ): 1165 . doi: 10.3390/antiox9111165 OpenUrl CrossRef PubMed 678. ↵ Lammers KM , Khandelwal S , Chaudhry F , Kryszak D , Puppa EL , Casolaro V , Fasano A . Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease . Immunology . 2011 ; 132 ( 3 ): 432 – 440 . doi: 10.1111/j.1365-2567.2010.03378.x OpenUrl CrossRef PubMed 679. ↵ Yang J , Wang J , Ding B , Jiang Z , Yu F , Li D , Sun W , Wang L , Xu H , Hu S . Feedback delivery of BMP 7 on the pathological oxidative stress via smart hyaluronic acid hydrogel potentiated the repairing of the gut epithelial integrity . Int J Biol Macromol . 2024 ; 282 (Pt 1 ): 136794 . doi: 10.1016/j.ijbiomac.2024.136794 OpenUrl CrossRef PubMed 680. ↵ Tang Y , Scheef EA , Wang S , Sorenson CM , Marcus CB , Jefcoate CR , Sheibani N . CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression . Blood . 2009 ; 113 ( 3 ): 744 – 754 . doi: 10.1182/blood-2008-03-145219 OpenUrl Abstract / FREE Full Text 681. ↵ Solleiro-Villavicencio H , Rivas-Arancibia S . Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases . Front Cell Neurosci . 2018 ; 12 : 114 . doi: 10.3389/fncel.2018.00114 OpenUrl CrossRef PubMed 682. ↵ Plasterer C , Semenikhina M , Tsaih SW , Flister MJ , Palygin O . NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer . Mol Med . 2023 ; 29 ( 1 ): 87 . doi: 10.1186/s10020-023-00673-y OpenUrl CrossRef PubMed 683. ↵ Ma Y , Guo J , Rao H , Xin J , Song X , Liu R , Shao S , Hou J , Kong L , Hu Z , et al. The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress . J Extracell Vesicles . 2024 ; 13 ( 9 ): e12505 . doi: 10.1002/jev2.12505 OpenUrl CrossRef 684. ↵ Zheng J , Zhu S , Xu H , Li J , Tang H , Zhou Y , Huang Z , Liu G . miR-363-3p inhibits rat lung alveolar type II cell proliferation by downregulating STRA6 expression and induces cell apoptosis via cellular oxidative stress and G1-phase cell cycle arrest . Transl Pediatr . 2021 ; 10 ( 8 ): 2095 – 2105 . doi: 10.21037/tp-21-303 OpenUrl CrossRef PubMed 685. ↵ Oszajca K , Szemraj J . Assessment of the correlation between oxidative stress and expression of MMP-2, TIMP-1 and COX-2 in human aortic smooth muscle cells . Arch Med Sci Atheroscler Dis . 2021 ; 6 : e158 - e165 . doi: 10.5114/amsad.2021.109255 OpenUrl CrossRef 686. ↵ Tsuruma K , Nishimura Y , Kishi S , Shimazawa M , Tanaka T , Hara H . SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells . Invest Ophthalmol Vis Sci . 2012 ; 53 ( 10 ): 6729 – 6737 . doi: 10.1167/iovs.11-9378 OpenUrl Abstract / FREE Full Text 687. ↵ Wang W , Zhong GZ , Long KB , Liu Y , Liu YQ , Xu AL . Silencing miR-181b-5p upregulates PIAS1 to repress oxidative stress and inflammatory response in rats with alcoholic fatty liver disease through inhibiting PRMT1 . Int Immunopharmacol . 2021 ; 101 (Pt B ): 108151 . doi: 10.1016/j.intimp.2021.108151 OpenUrl CrossRef PubMed 688. ↵ Silva AMS , Socorro S , Hurtado de Llera A , Vaz CV , Correia S , Maia CJ . Overexpression of regucalcin mitigates the ageing-related changes in oxidative stress and sperm quality . Theriogenology . 2020 ; 157 : 472 – 482 . doi: 10.1016/j.theriogenology.2020.08.028 OpenUrl CrossRef PubMed 689. ↵ Han Z , Liu M , Xie Y , Zeng K , Zhan Z , Chen Y , Wang L , Chen X , Luo Y , Zeng Y , et al. Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis . Cell Death Discov . 2022 ; 8 ( 1 ): 445 . doi: 10.1038/s41420-022-01241-9 OpenUrl CrossRef PubMed 690. ↵ Mongaret C , Alexandre J , Thomas-Schoemann A , Bermudez E , Chéreau C , Nicco C , Goldwasser F , Weill B , Batteux F , Lemare F . Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form . Int J Cancer . 2011 ; 129 ( 4 ): 791 – 798 . doi: 10.1002/ijc.25746 OpenUrl CrossRef PubMed 691. ↵ Nandi A , Yan LJ , Jana CK , Das N . Role of Catalase in Oxidative Stress-and Age-Associated Degenerative Diseases . Oxid Med Cell Longev . 2019 ; 2019 : 9613090 . doi: 10.1155/2019/9613090 OpenUrl CrossRef 692. ↵ Luo Z , Yu X , Wang C , Zhao H , Wang X , Guan X . Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway . J Physiol Biochem . 2024 ; 80 ( 1 ): 67 – 79 . doi: 10.1007/s13105-023-00984-y OpenUrl CrossRef PubMed 693. ↵ Atwa AM , Abd El-Ghafar OAM , Hassanein EHM , Mahdi SE , Sayed GA , Alruhaimi RS , Alqhtani HA , Alotaibi MF , Mahmoud AM . Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling . Pharmaceuticals (Basel) . 2022 ; 15 ( 10 ): 1222 . doi: 10.3390/ph15101222 OpenUrl CrossRef PubMed 694. ↵ Olejnik A , Radajewska A , Krzywonos-Zawadzka A , Bil-Lula I . Klotho inhibits IGF1R/PI3K/AKT signalling pathway and protects the heart from oxidative stress during ischemia/reperfusion injury . Sci Rep . 2023 ; 13 ( 1 ): 20312 . doi: 10.1038/s41598-023-47686-5 OpenUrl CrossRef PubMed 695. ↵ Chang SJ , Bin PJ , Luo CW , Chai CY . CHD4 plays a critical role in arsenite-induced oxidative damage in human urothelial carcinoma . Pathol Res Pract . 2022 ; 240 : 154173 . doi: 10.1016/j.prp.2022.154173 OpenUrl CrossRef 696. ↵ Muto Y , Sato K . Pivotal role of attractin in cell survival under oxidative stress in the zitter rat brain with genetic spongiform encephalopathy . Brain Res Mol Brain Res . 2003 ; 111 ( 1-2 ): 111 – 122 . doi: 10.1016/s0169-328x(02)00696-4 OpenUrl CrossRef PubMed 697. ↵ Francelin C , Mitter SK , Qian Q , Barodia SK , Ip C , Qi X , Gu H , Quigley J , Goldberg MS , Grant MB , et al. BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage . Antioxidants (Basel) . 2021 ; 10 ( 10 ): 1539 . doi: 10.3390/antiox10101539 OpenUrl CrossRef PubMed 698. ↵ Zhang J , Xu H , He Y , Zheng X , Lin T , Yang L , Tan P , Wei Q . Inhibition of KDM4A restricts SQLE transcription and induces oxidative stress imbalance to suppress bladder cancer . Redox Biol . 2024 ; 77 : 103407 . doi: 10.1016/j.redox.2024.103407 OpenUrl CrossRef 699. ↵ Muche A , Arendt T , Schliebs R . Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells . PLoS One . 2017 ; 12 ( 6 ): e0178127 . doi: 10.1371/journal.pone.0178127 OpenUrl CrossRef PubMed 700. ↵ Qiao L , Farrell GC . Reciprocal control of apoptosis and proliferation in cultured rat hepatoma arl-6 cells: roles of nutrient supply, serum, and oxidative stress . In Vitro Cell Dev Biol Anim . 2000 ; 36 ( 7 ): 465 – 475 . doi: 10.1290/1071-2690(2000)0362.0.CO;2 OpenUrl CrossRef PubMed 701. ↵ Mulford KE , Fassler JS . Association of the Skn7 and Yap1 transcription factors in the Saccharomyces cerevisiae oxidative stress response . Eukaryot Cell . 2011 ; 10 ( 6 ): 761 – 769 . doi: 10.1128/EC.00328-10 OpenUrl Abstract / FREE Full Text 702. ↵ Feki K , Tounsi S , Masmoudi K , Brini F . The durum wheat plasma membrane Na+/H+ antiporter SOS1 is involved in oxidative stress response . Protoplasma . 2017 ; 254 ( 4 ): 1725 – 1734 . doi: 10.1007/s00709-016-1066-8 OpenUrl CrossRef PubMed 703. ↵ Nandar W , Neely EB , Unger E , Connor JR . A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice . Biochim Biophys Acta . 2013 ; 1832 ( 6 ): 729 – 741 . doi: 10.1016/j.bbadis.2013.02.009 OpenUrl CrossRef 704. ↵ Jiang H , Gao X , Gong J , Yang Q , Lan R , Wang T , Liu J , Yin C , Wang S , Liu Z . Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress . Oxid Med Cell Longev . 2018 ; 2018 : 1724648 . doi: 10.1155/2018/1724648 OpenUrl CrossRef PubMed 705. ↵ Wali G , Liyanage E , Blair NF , Sutharsan R , Park JS , Mackay-Sim A , Sue CM . Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons . Front Neurosci . 2020 ; 14 : 401 . doi: 10.3389/fnins.2020.00401 OpenUrl CrossRef 706. ↵ Winarto H , Tan MI , Sadikin M , Wanandi SI . ARID1A Expression is Down-Regulated by Oxidative Stress in Endometriosis and Endometriosis-Associated Ovarian Cancer . Transl Oncogenomics . 2017 ; 9 : 1177272716689818 . doi: 10.1177/1177272716689818 OpenUrl CrossRef 707. ↵ Xie D , Zhou Y , Luo X . Amorphous silica nanoparticles induce tumorigenesis via regulating ATP5H/SOD1-related oxidative stress, oxidative phosphorylation and EIF4G2/PABPC1-associated translational initiation . PeerJ . 2019 ; 7 : e6455 . doi: 10.7717/peerj.6455 OpenUrl CrossRef PubMed 708. ↵ Heinloth AN , Shackelford RE , Innes CL , Bennett L , Li L , Amin RP , Sieber SO , Flores KG , Bushel PR , Paules RS . ATM-dependent and - independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation . Radiat Res . 2003 ; 160 ( 3 ): 273 – 290 . doi: 10.1667/rr3047 OpenUrl CrossRef PubMed Web of Science 709. ↵ Chen X , Yuan L , Zhang L , Chen L , He Y , Wang C , Wu J , Chen S , Zhao W , Yu D . GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells . Epigenetics . 2023 ; 18 ( 1 ): 2208707 . doi: 10.1080/15592294.2023.2208707 OpenUrl CrossRef PubMed 710. ↵ Atilano SR , Lee DH , Fukuhara PS , Chwa M , Nesburn AB , Udar N , Kenney MC . Corneal Oxidative Damage in Keratoconus Cells due to Decreased Oxidant Elimination from Modified Expression Levels of SOD Enzymes, PRDX6, SCARA3, CPSF3, and FOXM1 . J Ophthalmic Vis Res. 2019 ; 14 ( 1 ): 62 - 70 . doi: 10.4103/jovr.jovr_80_18 OpenUrl CrossRef PubMed 711. ↵ Chiu CC , Chen YC , Bow YD , Chen JY , Liu W , Huang JL , Shu ED , Teng YN , Wu CY , Chang WT. diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C2-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation . Cancers (Basel) . 2022 ; 14 ( 10 ): 2528 . doi: 10.3390/cancers14102528 OpenUrl CrossRef PubMed 712. ↵ Lu MY , Hsieh PL , Chao SC , Fang CY , Ohiro Y , Liao YW , Yu CC , Chang MT . Targeting MetaLnc9/miR-143/FSCN1 axis inhibits oxidative stress and myofibroblast transdifferentiation in oral submucous fibrosis . J Dent Sci . 2024 ; 19 ( 3 ): 1416 – 1425 . doi: 10.1016/j.jds.2024.04.008 OpenUrl CrossRef PubMed 713. ↵ Nickel N , Cleven A , Enders V , Lisak D , Schneider L , Methner A . Androgen-inducible gene 1 increases the ER Ca(2+) content and cell death susceptibility against oxidative stress . Gene . 2016 ; 586 ( 1 ): 62 – 68 . doi: 10.1016/j.gene.2016.03.055 OpenUrl CrossRef PubMed 714. ↵ Huang H , Tsui YM , Ho DW , Chung CY , Sze KM , Lee E , Cheung GC , Zhang VX , Wang X , Lyu X , et al. LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress . Hepatology . 2024 ; 79 ( 2 ): 323 – 340 . doi: 10.1097/HEP.0000000000000523 OpenUrl CrossRef PubMed 715. ↵ Sugano E , Edwards G , Saha S , Wilmott LA , Grambergs RC , Mondal K , Qi H , Stiles M , Tomita H , Mandal N. verexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress . J Lipid Res . 2019 ; 60 ( 1 ): 30 – 43 . doi: 10.1194/jlr.M082198 OpenUrl Abstract / FREE Full Text 716. ↵ Kos I , Patterson MJ , Znaidi S , Kaloriti D, da Silva Dantas A, Herrero-de-Dios CM, d’Enfert C, Brown AJ, Quinn J . Mechanisms Underlying the Delayed Activation of the Cap1 Transcription Factor in Candida albicans following Combinatorial Oxidative and Cationic Stress Important for Phagocytic Potency . mBio . 2016 ; 7 ( 2 ): e00331 . doi: 10.1128/mBio.00331-16 OpenUrl CrossRef PubMed 717. ↵ Henry SA , Crivello S , Nguyen TM , Cybulska M , Hoang NS , Nguyen M , Badial T , Emami N , Awada N , Woodward JF , et al. G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress . Cell Stress Chaperones . 2021 ; 26 ( 1 ): 187 – 197 . doi: 10.1007/s12192-020-01168-z OpenUrl CrossRef PubMed 718. ↵ Rodriguez-Ortiz CJ , Flores JC , Valenzuela JA , Rodriguez GJ , Zumkehr J , Tran DN , Kimonis VE , Kitazawa M . The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress . Am J Pathol . 2016 ; 186 ( 6 ): 1623 – 1634 . doi: 10.1016/j.ajpath.2016.02.007 OpenUrl CrossRef PubMed 719. ↵ Chen PB , Shi GX , Liu T , Li B , Jiang SD , Zheng XF , Jiang LS . Oxidative Stress Aggravates Apoptosis of Nucleus Pulposus Cells through m6A Modification of MAT2A Pre-mRNA by METTL16 . Oxid Med Cell Longev . 2022 ; 2022 : 4036274 . doi: 10.1155/2022/4036274 OpenUrl CrossRef PubMed 720. ↵ Korytowski W , Rodriguez-Agudo D , Pilat A , Girotti AW . StarD4-mediated translocation of 7-hydroperoxycholesterol to isolated mitochondria: deleterious effects and implications for steroidogenesis under oxidative stress conditions . Biochem Biophys Res Commun . 2010 ; 392 ( 1 ): 58 – 62 . doi: 10.1016/j.bbrc.2009.12.165 OpenUrl CrossRef PubMed 721. ↵ Cho SH , Lee CH , Gi E , Yim Y , Koh HJ , Kang K , Paek NC . The Rice Rolled Fine Striped (RFS) CHD3/Mi-2 Chromatin Remodeling Factor Epigenetically Regulates Genes Involved in Oxidative Stress Responses During Leaf Development . Front Plant Sci . 2018 ; 9 : 364 . doi: 10.3389/fpls.2018.00364 OpenUrl CrossRef 722. ↵ Culurciello R , Bosso A , Troisi R , Barrella V , Di Nardo I , Borriello M , Gaglione R , Pistorio V , Aceto S , Cafaro V , et al. Protective Effects of Recombinant Human Angiogenin in Keratinocytes: New Insights on Oxidative Stress Response Mediated by RNases . Int J Mol Sci . 2022 ; 23 ( 15 ): 8781 . doi: 10.3390/ijms23158781 OpenUrl CrossRef PubMed 723. ↵ Wang Y , Li Y , Li Y , Cui Y , Zhang Y , Shi W , Wang J , Wu X , Liang R , Wang X , et al. The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging . Expert Opin Ther Targets . 2023 ; 27 ( 4-5 ): 393 – 407 . doi: 10.1080/14728222.2023.2216382 OpenUrl CrossRef PubMed 724. ↵ Yu C , Zhang L . Methylprednisolone up-regulates annexin A1 (ANXA1) to inhibit the inflammation, apoptosis and oxidative stress of cigarette smoke extract (CSE)-induced bronchial epithelial cells, a chronic obstructive pulmonary disease in vitro model, through the formyl peptide receptor 2 (FPR2) receptors and the adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) pathway . Bioengineered . 2022 ; 13 ( 2 ): 4028 – 4038 . doi: 10.1080/21655979.2022.2031769 OpenUrl CrossRef PubMed 725. ↵ Lee EJ , Kim JY , Yeo JH , Park S , Bae YJ , Kwon IJ , Seong SH , Lee J , Oh SH . ISG15-USP18 Dysregulation by Oxidative Stress Promotes IFN-γ Secretion from CD8+ T Cells in Vitiligo . J Invest Dermatol . 2024 ; 144 ( 2 ): 273 – 283.e11 . doi: 10.1016/j.jid.2023.08.006 OpenUrl CrossRef PubMed 726. ↵ Gao J , Hao Y , Piao X , Gu X . Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention . Int J Mol Sci . 2022 ; 23 ( 5 ): 2682 . doi: 10.3390/ijms23052682 OpenUrl CrossRef PubMed 727. ↵ Yang D , Shu T , Zhao H , Sun Y , Xu W , Tu G . Knockdown of macrophage migration inhibitory factor (MIF), a novel target to protect neurons from parthanatos induced by simulated post-spinal cord injury oxidative stress . Biochem Biophys Res Commun . 2020 ; 523 ( 3 ): 719 – 725 . doi: 10.1016/j.bbrc.2019.12.115 OpenUrl CrossRef PubMed 728. ↵ Napoli C , Sica V , de Nigris F , et al. Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension . Am Heart J . 2004 ; 148 ( 1 ): e5 . doi: 10.1016/j.ahj.2004.03.025 OpenUrl CrossRef PubMed 729. ↵ Luby A , Alves-Guerra MC . UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress Control . Int J Mol Sci . 2022 ; 23 ( 23 ): 15077 . doi: 10.3390/ijms232315077 OpenUrl CrossRef PubMed 730. ↵ Zheng H , Ye W , Huang K , Chen Q , Yang J , Luo L . KLF15 alleviates oxidative stress and apoptosis of H/R-induced trophoblast cells to improve invasion and migration capacity via the activation of IGF1R . Tissue Cell . 2024 ; 90 : 102485 . doi: 10.1016/j.tice.2024.102485 OpenUrl CrossRef 731. ↵ Yang C , Yan Z , Hu F , Wei W , Sun Z , Xu W . Silencing of microRNA-517a induces oxidative stress injury in melanoma cells via inactivation of the JNK signaling pathway by upregulating CDKN1C . Cancer Cell Int . 2020 ; 20 : 32 . doi: 10.1186/s12935-019-1064-y OpenUrl CrossRef 732. ↵ Lee HA , Chu KB , Moon EK , Quan FS . Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells via Forkhead Box M1 Suppression . J Cancer . 2021 ; 12 ( 17 ): 5086 – 5098 . doi: 10.7150/jca.60027 OpenUrl CrossRef PubMed 733. ↵ Zhou X , Zhao X , Zhou W , Qi H , Zhang H , Han TL , Baker P . Impaired placental mitophagy and oxidative stress are associated with dysregulated BNIP3 in preeclampsia . Sci Rep . 2021 ; 11 ( 1 ): 20469 . doi: 10.1038/s41598-021-99837-1 OpenUrl CrossRef PubMed 734. ↵ Cao G , Lee KP , van der Wijst J , de Graaf M , van der Kemp A , Bindels RJ , Hoenderop JG . Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress . J Biol Chem . 2010 ; 285 ( 34 ): 26081 – 26087 . doi: 10.1074/jbc.M110.103655 OpenUrl Abstract / FREE Full Text 735. ↵ Sohn EJ , Shin MJ , Eum WS , Kim DW , Yong JI , Ryu EJ , Park JH , Cho SB , Cha HJ , Kim SJ , et al. Tat-NOL3 protects against hippocampal neuronal cell death induced by oxidative stress through the regulation of apoptotic pathways . Int J Mol Med . 2016 ; 38 ( 1 ): 225 – 235 . doi: 10.3892/ijmm.2016.2596 OpenUrl CrossRef PubMed 736. ↵ Shi J , Xiong Z , Wang K , Yuan C , Huang Y , Xiao W , Meng X , Chen Z , Lv Q , Miao D , et al. HIF2α promotes tumour growth in clear cell renal cell carcinoma by increasing the expression of NUDT1 to reduce oxidative stress . Clin Transl Med . 2021 ; 11 ( 11 ): e592 . doi: 10.1002/ctm2.592 OpenUrl CrossRef 737. ↵ Xu QL , Wu J . Effects of Txk mediated activation of NF κB signaling pathway on neurological deficit and oxidative stress after ischemia reperfusion in rats . Mol Med Rep . 2021 ; 24 ( 1 ): 524 . doi: 10.3892/mmr.2021.12163 OpenUrl CrossRef PubMed 738. ↵ Huang K , Fu W , Wang A , Du G , Tang H , Yin L , Yin Z , Gao W . MSRB2 Ameliorates H2O2-induced Chondrocyte Oxidative Stress and Suppresses Apoptosis in Osteoarthritis . Immunol Invest . 2024 ; 53 ( 5 ): 813 – 829 . doi: 10.1080/08820139.2024.2343898 OpenUrl CrossRef PubMed 739. ↵ Betin VM , MacVicar TD , Parsons SF , Anstee DJ , Lane JD . A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress . Autophagy . 2012 ; 8 ( 4 ): 664 – 676 . doi: 10.4161/auto.19227 OpenUrl CrossRef PubMed 740. ↵ El-Mas MM , Abdel-Rahman AA . Estrogen modulation of the ethanol-evoked myocardial oxidative stress and dysfunction via DAPK3/Akt/ERK activation in male rats . Toxicol Appl Pharmacol . 2015 ; 287 ( 3 ): 284 – 292 . doi: 10.1016/j.taap.2015.06.015 OpenUrl CrossRef PubMed 741. ↵ Bai M , Lu W , Tan J , Mei X . HINT2 may be One Clinical Significance Target for Patient with Diabetes Mellitus and Reduced ROS-Induced Oxidative Stress and Ferroptosis by MCU . Horm Metab Res . 2024 ; 56 ( 9 ): 670 – 678 . doi: 10.1055/a-2238-2689 OpenUrl CrossRef 742. ↵ Cui T , Wang Y , Song P , Yi X , Chen J , Yang Y , Wang H , Kang P , Guo S , Liu L , et al. HSF1-Dependent Autophagy Activation Contributes to the Survival of Melanocytes Under Oxidative Stress in Vitiligo . J Invest Dermatol . 2022 ; 142 ( 6 ): 1659 – 1669.e4 . doi: 10.1016/j.jid.2021.11.007 OpenUrl CrossRef PubMed 743. ↵ Yu J , Yuan S , Song J , Yu S . USP39 interacts with SIRT7 to promote cervical squamous cell carcinoma by modulating autophagy and oxidative stress via FOXM1 . J Transl Med . 2023 ; 21 ( 1 ): 807 . doi: 10.1186/s12967-023-04623-4 OpenUrl CrossRef PubMed 744. ↵ Xu IM , Lai RK , Lin SH , Tse AP , Chiu DK , Koh HY , Law CT , Wong CM , Cai Z , Wong CC , et al. Transketolase counteracts oxidative stress to drive cancer development . Proc Natl Acad Sci U S A . 2016 ; 113 ( 6 ): E725 – E734 . doi: 10.1073/pnas.1508779113 OpenUrl Abstract / FREE Full Text 745. ↵ Culurciello R , Bosso A , Troisi R , Barrella V , Di Nardo I , Borriello M , Gaglione R , Pistorio V , Aceto S , Cafaro V , et al. Protective Effects of Recombinant Human Angiogenin in Keratinocytes: New Insights on Oxidative Stress Response Mediated by RNases . Int J Mol Sci . 2022 ; 23 ( 15 ): 8781 . doi: 10.3390/ijms23158781 OpenUrl CrossRef PubMed 746. ↵ Jiang Y , Zheng Z , Zhu J , Zhang P , Li S , Fu Y , Wang F , Zhang Z , Chang T , Zhang M , et al. The role of GDF15 in attenuating noise-induced hidden hearing loss by alleviating oxidative stress . Cell Biol Toxicol . 2024 ; 40 ( 1 ): 79 . doi: 10.1007/s10565-024-09912-2 OpenUrl CrossRef PubMed 747. ↵ Zhao J , Hu J , Zhang R , Deng J . CEBPD regulates oxidative stress and inflammatory responses in hypertensive cardiac remodeling . Shock . 2023 ; 60 ( 5 ): 713 – 723 . doi: 10.1097/SHK.0000000000002228 OpenUrl CrossRef PubMed 748. ↵ Li Y , Liu J , Liu D , Wang Z , Zhou Y , Yang S , Guo F , Yang L , Zhang X . The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the Development of Benign Prostatic Hyperplasia under Oxidative Stress . Oxid Med Cell Longev . 2022 ; 2022 : 7041739 . doi: 10.1155/2022/7041739 OpenUrl CrossRef PubMed 749. ↵ Wang X , Zhang Y , Wan X , Guo C , Cui J , Sun J , Li L . Responsive Expression of MafF to β-Amyloid-Induced Oxidative Stress . Dis Markers . 2020 ; 2020 : 8861358 . doi: 10.1155/2020/8861358 OpenUrl CrossRef PubMed 750. ↵ Ling XB , Wei HW , Wang J , Kong YQ , Wu YY , Guo JL , Li TF , Li JK . Mammalian Metallothionein-2A and Oxidative Stress . Int J Mol Sci . 2016 ; 17 ( 9 ): 1483 . doi: 10.3390/ijms17091483 OpenUrl CrossRef PubMed 751. ↵ Siritantikorn A , Johansson K , Ahlen K , Rinaldi R , Suthiphongchai T , Wilairat P , Morgenstern R . Protection of cells from oxidative stress by microsomal glutathione transferase 1 . Biochem Biophys Res Commun . 2007 ; 355 ( 2 ): 592 – 596 . doi: 10.1016/j.bbrc.2007.02.018 OpenUrl CrossRef PubMed Web of Science 752. ↵ Wert KJ , Velez G , Cross MR , Wagner BA , Teoh-Fitzgerald ML , Buettner GR , McAnany JJ , Olivier A , Tsang SH , Harper MM , et al. Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface . Free Radic Biol Med . 2018 ; 124 : 408 – 419 . doi: 10.1016/j.freeradbiomed.2018.06.024 OpenUrl CrossRef PubMed 753. ↵ Hassan J , Elmetwalli A , Helal M , Al Munajer EA , Hussien TM , Azem Saad AA , El-Sikaily A. admium exposure and its association with oxidative stress, MT1A methylation, and idiopathic male infertility in Egypt: A case-control study . Food Chem Toxicol . 2024 ; 192 : 114925 . doi: 10.1016/j.fct.2024.114925 OpenUrl CrossRef PubMed 754. ↵ Chung J , Jernigan J , Menees KB , Lee JK . RGS10 mitigates high glucose-induced microglial inflammation via the reactive oxidative stress pathway and enhances synuclein clearance in microglia . Front Cell Neurosci . 2024 ; 18 : 1374298 . doi: 10.3389/fncel.2024.1374298 OpenUrl CrossRef PubMed 755. ↵ Feng T , Tao Y , Yan Y , Lu S , Li Y , Zhang X , Qiang J . Transcriptional Inhibition of AGPAT2 Induces Abnormal Lipid Metabolism and Oxidative Stress in the Liver of Nile Tilapia Oreochromis niloticus . Antioxidants (Basel) . 2023 ; 12 ( 3 ): 700 . doi: 10.3390/antiox12030700 OpenUrl CrossRef PubMed 756. ↵ Attri P , Park JH , De Backer J , Kim M , Yun JH , Heo Y , Dewilde S , Shiratani M , Choi EH , Lee W , ET AL . Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study . Int J Biol Macromol . 2020 ; 163 : 2405 – 2414 . doi: 10.1016/j.ijbiomac.2020.09.120 OpenUrl CrossRef PubMed 757. ↵ Sun D , Chen S , Li S , Wang N , Zhang S , Xu L , Zhu S , Li H , Gu Q , Xu X , et al. Enhancement of glycolysis-dependent DNA repair regulated by FOXO1 knockdown via PFKFB3 attenuates hyperglycemia-induced endothelial oxidative stress injury . Redox Biol . 2023 ; 59 : 102589 . doi: 10.1016/j.redox.2022.102589 OpenUrl CrossRef 758. ↵ Li W , Yin X , Zhang L . FOXA2 regulates endoplasmic reticulum stress, oxidative stress, and apoptosis in spermatogonial cells by the Nrf2 pathway under hypoxic conditions . Exp Cell Res . 2025 ; 444 ( 2 ): 114388 . doi: 10.1016/j.yexcr.2024.114388 OpenUrl CrossRef PubMed 759. ↵ Xing X , Xu F , Wang Y , Liu H . Role of the OTUB1/IRF7/NOX4 axis in oxidative stress injury and inflammatory responses in mice with Parkinson’s disease . Psychogeriatrics . 2023 ; 23 ( 1 ): 32 – 44 . doi: 10.1111/psyg.12900 OpenUrl CrossRef PubMed 760. ↵ Zhu L , Gao H , Huang S , Cao T , Zhai X , Hu J , Wang T , Dong J , Liu Z , Chen J , et al. Combination of STING agonist and CXCR3 antagonist disrupts immune tolerance to overcome anti-PD-L1 resistance in lung adenocarcinoma under oxidative stress . Gene . 2023 ; 851 : 146962 . doi: 10.1016/j.gene.2022.146962 OpenUrl CrossRef 761. ↵ Subramanian P , Becerra SP . Role of the PNPLA2 Gene in the Regulation of Oxidative Stress Damage of RPE . Adv Exp Med Biol . 2019 ; 1185 : 377 – 382 . doi: 10.1007/978-3-030-27378-1_62 OpenUrl CrossRef PubMed 762. ↵ Tan HY , Qing B , Luo XM , Liang HX . Correction to: Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury . J Inflamm (Lond) . 2021 ; 18 ( 1 ): 30 . doi: 10.1186/s12950-021-00297-1 OpenUrl CrossRef PubMed 763. ↵ Sohn EJ , Shin MJ , Eum WS , Kim DW , Yong JI , Ryu EJ , Park JH , Cho SB , Cha HJ , Kim SJ , et al. Tat-NOL3 protects against hippocampal neuronal cell death induced by oxidative stress through the regulation of apoptotic pathways . Int J Mol Med . 2016 ; 38 ( 1 ): 225 – 235 . doi: 10.3892/ijmm.2016.2596 OpenUrl CrossRef PubMed 764. ↵ Cenni V , Squarzoni S , Loi M , Mattioli E , Lattanzi G , Capanni C . Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization . Cells . 2020 ; 9 ( 6 ): 1415 . doi: 10.3390/cells9061415 OpenUrl CrossRef 765. ↵ Hoffman NE , Chandramoorthy HC , Shanmughapriya S , Zhang XQ , Vallem S , Doonan PJ , Malliankaraman K , Guo S , Rajan S , Elrod JW , et al. LC25A23 augments mitochondrial Ca² uptake, interacts with MCU, and induces oxidative stress-mediated cell death . Mol Biol Cell . 2014 ; 25 ( 6 ): 936 – 947 . doi: 10.1091/mbc.E13-08-0502 OpenUrl Abstract / FREE Full Text 766. ↵ Ercan H , Schrottmaier WC , Pirabe A , Schmuckenschlager A , Pereyra D , Santol J , Pawelka E , Traugott MT , Schörgenhofer C , Seitz T , et al. Platelet Phenotype Analysis of COVID-19 Patients Reveals Progressive Changes in the Activation of Integrin αIIbβ3, F13A1, the SARS-CoV-2 Target EIF4A1 and Annexin A5 . Front Cardiovasc Med . 2021 ; 8 : 779073 . doi: 10.3389/fcvm.2021.779073 OpenUrl CrossRef PubMed 767. ↵ Huang J , Zheng S , Li Q , Zhao H , Zhou X , Yang Y , Zhang W , Cao Y . Facilitates Replication of Infectious Hematopoietic Necrosis Virus by Targeting WNT3a and CCND1 . Vet Sci . 2024 ; 11 ( 5 ): 204 . doi: 10.3390/vetsci11050204 OpenUrl CrossRef PubMed 768. ↵ Li XJ , Liu XJ , Yang B , Fu YR , Zhao F , Shen ZZ , Miao LF , Rayner S , Chavanas S , Zhu H , et al. Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells . J Virol . 2015 ; 89 ( 13 ): 6792 – 6804 . doi: 10.1128/JVI.00351-15 OpenUrl Abstract / FREE Full Text 769. ↵ Li Y , Zhang Q , Liu Y , Luo Z , Kang L , Qu J , Liu W , Xia X , Liu Y , Wu K , et al. Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways . J Virol . 2012 ; 86 ( 23 ): 12531 – 12543 . doi: 10.1128/JVI.01136-12 OpenUrl Abstract / FREE Full Text 770. ↵ Sarek G , Järviluoma A , Moore HM , Tojkander S , Vartia S , Biberfeld P , Laiho M , Ojala PM . Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency . PLoS Pathog . 2010 ; 6 ( 3 ): e1000818 . doi: 10.1371/journal.ppat.1000818 OpenUrl CrossRef PubMed 771. ↵ Wang X , Zhang Q , Zhou Z , Liu M , Chen Y , Li J , Xu L , Guo J , Li Q , Yang J , et al. Retinoic acid receptor β, a potential therapeutic target in the inhibition of adenovirus replication . Antiviral Res . 2018 ; 152 : 84 – 93 . doi: 10.1016/j.antiviral.2018.01.014 OpenUrl CrossRef PubMed 772. ↵ Ciesla J , Huang KL , Wagner EJ , Munger J . A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection . PLoS Pathog . 2024 ; 20 ( 5 ): e1012058 . doi: 10.1371/journal.ppat.1012058 OpenUrl CrossRef PubMed 773. ↵ Liu C , Zhao W , Su J , Chen X , Zhao F , Fan J , Li X , Liu X , Zou L , Zhang M , et al. HSP90AA1 interacts with CSFV NS5A protein and regulates CSFV replication via the JAK/STAT and NF-κB signaling pathway . Front Immunol . 2022 ; 13 : 1031868 . doi: 10.3389/fimmu.2022.1031868 OpenUrl CrossRef 774. ↵ Nishimura Y , Sato K , Koyanagi Y , Wakita T , Muramatsu M , Shimizu H , Bergelson JM , Arita M . Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface . PLoS Pathog . 2024 ; 20 ( 2 ): e1012022 . doi: 10.1371/journal.ppat.1012022 OpenUrl CrossRef PubMed 775. ↵ Essalmani R , Jain J , Susan-Resiga D , Andréo U , Evagelidis A , Derbali RM , Huynh DN , Dallaire F , Laporte M , Delpal A , et al. Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity . J Virol . 2022 ; 96 ( 8 ): e0012822 . doi: 10.1128/jvi.00128-22 OpenUrl CrossRef PubMed 776. ↵ Cui C , Huang C , Zhou W , Ji X , Zhang F , Wang L , Zhou Y , Cui Q . AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells . IEEE/ACM Trans Comput Biol Bioinform . 2021 ; 18 ( 4 ): 1230 - 1233 . doi: 10.1109/TCBB.2020.3009099 OpenUrl CrossRef 777. ↵ Karlowitz R , Stanifer ML , Roedig J , Andrieux G , Bojkova D , Bechtel M , Smith S , Kowald L , Schubert R , Boerries M , et al. USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING . Cell Death Dis . 2022 ; 13 ( 8 ): 684 . doi: 10.1038/s41419-022-05124-w OpenUrl CrossRef PubMed 778. ↵ Pfaller CK , George CX , Samuel CE . Adenosine Deaminases Acting on RNA (ADARs) and Viral Infections . Annu Rev Virol . 2021 ; 8 ( 1 ): 239 – 264 . doi: 10.1146/annurev-virology-091919-065320 OpenUrl CrossRef PubMed 779. ↵ Bracke A , De Hert E , De Bruyn M , Claesen K , Vliegen G , Vujkovic A , van Petersen L , De Winter FHR , Hotterbeekx A , Brosius I , et al. Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients . Clin Chim Acta . 2022 ; 531 : 4 - 11 . doi: 10.1016/j.cca.2022.03.005 OpenUrl CrossRef 780. ↵ Bazzone LE , Zhu J , King M , Liu G , Guo Z , MacKay CR , Kyawe PP , Qaisar N , Rojas-Quintero J , Owen CA , et al. ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection . Nat Commun . 2024 ; 15 ( 1 ): 4153 . doi: 10.1038/s41467-024-48524-6 OpenUrl CrossRef PubMed 781. ↵ Liu P , Tang N , Meng C , Yin Y , Qiu X , Tan L , Sun Y , Song C , Liu W , Liao Y , et al. SLC1A3 facilitates Newcastle disease virus replication by regulating glutamine catabolism . Virulence . 2022 ; 13 ( 1 ): 1407 - 1422 . doi: 10.1080/21505594.2022.2112821 OpenUrl CrossRef PubMed 782. ↵ Li F , Ling X , Chakraborty S , Fountzilas C , Wang J , Jamroze A , Liu X , Kalinski P , Tang DG . Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence . J Exp Clin Cancer Res . 2023 ; 42 ( 1 ): 213 . doi: 10.1186/s13046-023-02787-x OpenUrl CrossRef PubMed 783. ↵ Adzhubei AA , Kulkarni A , Tolstova AP , Anashkina AA , Sviridov D , Makarov AA , Bukrinsky MI . Direct interaction between ABCA1 and HIV-1 Nef: Molecular modeling and virtual screening for inhibitors . Comput Struct Biotechnol J . 2021 ; 19 : 3876 – 3884 . doi: 10.1016/j.csbj.2021.06.050 OpenUrl CrossRef PubMed 784. ↵ Liu YY , Bai JS , Liu CC , Zhou JF , Chen J , Cheng Y , Zhou B . The Small GTPase Rab14 Regulates the Trafficking of Ceramide from Endoplasmic Reticulum to Golgi Apparatus and Facilitates Classical Swine Fever Virus Assembly . J Virol . 2023 ; 97 ( 5 ): e0036423 . doi: 10.1128/jvi.00364-23 OpenUrl CrossRef PubMed 785. ↵ Shilagardi K , Spear ED , Abraham R , Griffin DE , Michaelis S . The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation . mBio . 2022 ; 13 ( 5 ): e0254322 . doi: 10.1128/mbio.02543-22 OpenUrl CrossRef PubMed 786. ↵ Heuschkel MJ , Bach C , Meiss-Heydmann L , Gerges E , Felli E , Giannone F , Pessaux P , Schuster C , Lucifora J , Baumert TF , et al. JAK1 promotes HDV replication and is a potential target for antiviral therapy . J Hepatol . 2024 ; 80 ( 2 ): 220 – 231 . doi: 10.1016/j.jhep.2023.10.030 OpenUrl CrossRef PubMed 787. ↵ Ruan P , Dai P , Mao Y , Tang Z , He H , Wu G , Qin L , Tan Y . The in vitro and in vivo antiviral effects of IGF1R inhibitors against respiratory syncytial virus infection . J Biomol Struct Dyn . 2024 . doi: 10.1080/07391102.2024.2309643 OpenUrl CrossRef 788. ↵ Chi PI , Huang WR , Lai IH , Cheng CY , Liu HJ . The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10 (PTEN) and AMP-activated protein kinase (AMPK), as well as dsRNA-dependent protein kinase (PKR)/eIF2α signaling pathways . J Biol Chem . 2013 ; 288 ( 5 ): 3571 – 3584 . doi: 10.1074/jbc.M112.390245 OpenUrl Abstract / FREE Full Text 789. ↵ Liu T , Li J , Wang X , Huang T , Wu W , Li A , Li C , Huang X , Wang Q , Li D , et al. Knockout of CLTC gene reduces but not completely block SFTSV infection . PLoS One . 2023 ; 18 ( 8 ): e0285673 . doi: 10.1371/journal.pone.0285673 OpenUrl CrossRef PubMed 790. ↵ Ambati BK , Varshney A , Lundstrom K , Palú G , Uhal BD , Uversky VN , Brufsky AM . MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site . Front Virol . 2022 ; 2 : 834808 . doi: 10.3389/fviro.2022.834808 OpenUrl CrossRef 791. ↵ Yang X , Xiang Z , Sun Z , Ji F , Ren K , Pan D . Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response . PLoS Pathog . 2022 ; 18 ( 2 ): e1010301 . doi: 10.1371/journal.ppat.1010301 OpenUrl CrossRef PubMed 792. ↵ Chen J , Chen J , Lei Z , Zhang F , Zeng LH , Wu X , Li S , Tan J . Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of Alzheimer’s disease . Transl Psychiatry . 2023 ; 13 ( 1 ): 396 . doi: 10.1038/s41398-023-02692-z OpenUrl CrossRef PubMed 793. ↵ Wang X , Wei Z , Lan T , He Y , Cheng B , Li R , Chen H , Li F , Liu G , Jiang B , et al. CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation . Autophagy . 2022 ; 18 ( 2 ): 357 – 374 . doi: 10.1080/15548627.2021.1934271 OpenUrl CrossRef PubMed 794. ↵ Hirai Y , Honda T , Makino A , Watanabe Y , Tomonaga K . X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories . J Gen Virol . 2015 ; 96 ( 11 ): 3198 – 3203 . doi: 10.1099/jgv.0.000273 OpenUrl CrossRef PubMed 795. ↵ Li W , Lin Y , Wang X , Yang H , Ding Y , Chen Z , He Z , Zhang J , Zhao L , Jiao P . Chicken UFL1 Restricts Avian Influenza Virus Replication by Disrupting the Viral Polymerase Complex and Facilitating Type I IFN Production . J Immunol . 2024 ; 212 ( 9 ): 1479 – 1492 . doi: 10.4049/jimmunol.2300613 OpenUrl CrossRef PubMed 796. ↵ Walter RM , Majumder K , Kalejta RF . ATRX restricts Human Cytomegalovirus (HCMV) viral DNA replication through heterochromatinization and minimizes unpackaged viral genomes . PLoS Pathog . 2024 ; 20 ( 9 ): e1012516 . doi: 10.1371/journal.ppat.1012516 OpenUrl CrossRef PubMed 797. ↵ Sertznig H , Roesmann F , Wilhelm A , Heininger D , Bleekmann B , Elsner C , Santiago M , Schuhenn J , Karakoese Z , Benatzy Y , et al. SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps . Front Immunol . 2022 ; 13 : 935800 . doi: 10.3389/fimmu.2022.935800 OpenUrl CrossRef 798. ↵ Huang Z , Su B , Liu F , Zhang N , Ye Y , Zhang Y , Zhen Z , Liang S , Liang S , Chen L , et al. YAP1 Promotes Tumor Invasion and Metastasis in Nasopharyngeal Carcinoma with Hepatitis B Virus Infection . Onco Targets Ther . 2020 ; 13 : 5629 – 5642 . doi: 10.2147/OTT.S247699 OpenUrl CrossRef PubMed 799. ↵ Xing T , Li L , Rao X , Zhao J , Chen Y , Ju G , Xu Y , Gao X , Dong G , Xia X , Guan Y , et al. ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus-related hepatocellular carcinoma . BMC Gastroenterol . 2024 ; 24 ( 1 ): 11 . doi: 10.1186/s12876-023-03059-w OpenUrl CrossRef PubMed 800. ↵ Patra T , Meyer K , Ray RB , Ray R . Hepatitis C Virus Mediated Inhibition of miR-181c Activates ATM Signaling and Promotes Hepatocyte Growth . Hepatology . 2020 ; 71 ( 3 ): 780 – 793 . doi: 10.1002/hep.30893 OpenUrl CrossRef PubMed 801. ↵ Li Q , Jiang L , Wang Y , Liu X , Wang B , Shan Z , Wang YH , Wang Y , Chen H , Li C . HACD3 Prevents PB1 from Autophagic Degradation to Facilitate the Replication of Influenza A Virus . Viruses . 2024 ; 16 ( 5 ): 702 . doi: 10.3390/v16050702 OpenUrl CrossRef PubMed 802. ↵ Yin L , Wang Q , Liu S , Chen J , Zhang Y , Lu L , Lu H , Song Z , Zhang L . iTRAQ-based proteomic study on monocyte cell model discovered an association of LAMP2 downregulation with HIV-1 latency . Proteome Sci . 2024 ; 22 ( 1 ): 6 . doi: 10.1186/s12953-024-00230-3 OpenUrl CrossRef PubMed 803. ↵ Bucciol G , Moens L , Ogishi M , Rinchai D , Matuozzo D , Momenilandi M , Kerrouche N , Cale CM , Treffeisen ER , Al Salamah M , et al. Human inherited complete STAT2 deficiency underlies inflammatory viral diseases . J Clin Invest . 2023 ; 133 ( 12 ): e168321 . doi: 10.1172/JCI168321 OpenUrl CrossRef PubMed 804. ↵ Sim JR , Shin DH , Park PG , Park SH , Bae JY , Lee Y , Kang DY , Kim YJ , Aum S , Noh SH , et al. Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition . Cell Rep . 2022 ; 40 ( 3 ): 111117 . doi: 10.1016/j.celrep.2022.111117 OpenUrl CrossRef PubMed 805. ↵ Bartak M , Krahel WD , Chodkowski M , Grel H , Walczak J , Pallepati A , Komorowski M , Cymerys J . ATPase Valosin-Containing Protein (VCP) Is Involved During the Replication and Egress of Sialodacryoadenitis Virus (SDAV) in Neurons . Int J Mol Sci . 2024 ; 25 ( 21 ): 11633 . doi: 10.3390/ijms252111633 OpenUrl CrossRef PubMed 806. ↵ Sun L , Jiang Z , Acosta-Rodriguez VA , Berger M , Du X , Choi JH , Wang J , Wang KW , Kilaru GK , Mohawk JA , et al. HCFC2 is needed for IRF1-and IRF2-dependent Tlr3 transcription and for survival during viral infections . J Exp Med . 2017 ; 214 ( 11 ): 3263 – 3277 . doi: 10.1084/jem.20161630 OpenUrl Abstract / FREE Full Text 807. ↵ Mudhasani R , Tran JP , Retterer C, Kota KP, Whitehouse CA, Bavari S . Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase . PLoS Pathog . 2016 ; 12 ( 2 ): e1005437 . doi: 10.1371/journal.ppat.1005437 OpenUrl CrossRef PubMed 808. ↵ Gong M , Peng C , Yang C , Wang Z , Qian H , Hu X , Zhou P , Shan C , Ding Q . Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection . PLoS Pathog . 2024 ; 20 ( 8 ): e1012444 . doi: 10.1371/journal.ppat.1012444 OpenUrl CrossRef PubMed 809. ↵ Soh TK , Davies CTR , Muenzner J , Hunter LM , Barrow HG , Connor V , Bouton CR , Smith C , Emmott E , Antrobus R , et al. emporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation . Cell Rep . 2020 ; 33 ( 1 ): 108235 . doi: 10.1016/j.celrep.2020.108235 OpenUrl CrossRef PubMed 810. ↵ Sarkar R , Sharma KB , Kumari A , Asthana S , Kalia M . Japanese encephalitis virus capsid protein interacts with non-lipidated MAP1LC3 on replication membranes and lipid droplets . J Gen Virol . 2021 ; 102 ( 1 ): 10 . 1099 /jgv.0.001508. doi: 10.1099/jgv.0.001508 OpenUrl CrossRef 811. ↵ Deng T , Hu B , Wang X , Yan Y , Zhou J , Lin L , Xu Y , Zheng X , Zhou J . DeSUMOylation of Apoptosis Inhibitor 5 by Avibirnavirus VP3 Supports Virus Replication . mBio . 2021 ; 12 ( 4 ): e0198521 . doi: 10.1128/mBio.01985-21 OpenUrl CrossRef PubMed 812. ↵ Ma J , Rong L , Zhou Y , Roy BB , Lu J , Abrahamyan L , Mouland AJ , Pan Q , Liang C . The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA . Virology . 2008 ; 375 ( 1 ): 253 – 264 . doi: 10.1016/j.virol.2008.01.025 OpenUrl CrossRef PubMed Web of Science 813. ↵ Wang J , Zhang XZ , Sun XY , Tian WJ , Wang XJ . Cellular RNA-binding proteins LARP4 and PABPC1 synergistically facilitate viral translation of coronavirus PEDV . Vet Microbiol . 2024 ; 298 : 110219 . doi: 10.1016/j.vetmic.2024.110219 OpenUrl CrossRef 814. ↵ Liu Q , Wang W , Xu L , Zhang Q , Wang H . The host mannose-6-phosphate pathway and viral infection . Front Cell Infect Microbiol . 2024 ; 14 : 1349221 . doi: 10.3389/fcimb.2024.1349221 OpenUrl CrossRef 815. ↵ Tikhmyanova N , Tutton S , Martin KA , Lu F , Kossenkov AV , Paparoidamis N , Kenney S , Salvino JM , Lieberman PM . Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation . PLoS Pathog . 2017 ; 13 ( 7 ): e1006517 . doi: 10.1371/journal.ppat.1006517 OpenUrl CrossRef PubMed 816. ↵ Yang X , Huang T , Wang T , Gao H , Zhang H , Peng W , Zhao J , Hu S , Lu P , Hong Z , et al. MAT2A-Mediated S-Adenosylmethionine Level in CD4+ T Cells Regulates HIV-1 Latent Infection . Front Immunol . 2021 ; 12 : 745784 . doi: 10.3389/fimmu.2021.745784 OpenUrl CrossRef 817. ↵ Di Pietro A , Kajaste-Rudnitski A , Oteiza A , Nicora L , Towers GJ , Mechti N , Vicenzi E . TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation . J Virol . 2013 ; 87 ( 8 ): 4523 – 4533 . doi: 10.1128/JVI.02548-12 OpenUrl Abstract / FREE Full Text 818. ↵ Medrano LM , Rallón N , Berenguer J , Jiménez-Sousa MA , Soriano V , Aldámiz-Echevarria T , Fernández-Rodríguez A , García M , Tejerina F , Martínez I , et al. Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients . J Transl Med . 2016 ; 14 ( 1 ): 257 . doi: 10.1186/s12967-016-1005-7 OpenUrl CrossRef PubMed 819. ↵ Faure-Dupuy S , Jubrail J , Depierre M , Africano-Gomez K , Öberg L , Israelsson E , Thörn K , Delevoye C , Castellano F , Herit F , et al. ARL5b inhibits human rhinovirus 16 propagation and impairs macrophage-mediated bacterial clearance . EMBO Rep . 2024 ; 25 ( 3 ): 1156 – 1175 . doi: 10.1038/s44319-024-00069-x OpenUrl CrossRef PubMed 820. ↵ Bruening J , Lasswitz L , Banse P , Kahl S , Marinach C , Vondran FW , Kaderali L , Silvie O , Pietschmann T , Meissner F , et al. Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB . PLoS Pathog . 2018 ; 14 ( 7 ): e1007111 . doi: 10.1371/journal.ppat.1007111 OpenUrl CrossRef PubMed 821. ↵ Madhry D , Malvankar S , Phadnis S , Srivastava RK , Bhattacharyya S , Verma B . Synergistic correlation between host angiogenin and dengue virus replication . RNA Biol . 2023 ; 20 ( 1 ): 805 – 816 . doi: 10.1080/15476286.2023.2264003 OpenUrl CrossRef PubMed 822. ↵ Xiang J , Lu M , Shi M , Cheng X , Kwakwa KA , Davis JL , Su X , Bakewell SJ , Zhang Y , Fontana F , et al. Heparanase Blockade as a Novel Dual-Targeting Therapy for COVID-19 . J Virol . 2022 ; 96 ( 7 ): e0005722 . doi: 10.1128/jvi.00057-22 OpenUrl CrossRef PubMed 823. ↵ Han Y , Ma Y , Wang Z , Feng F , Zhou L , Feng H , Ma J , Ye R , Zhang R . TMPRSS13 promotes the cell entry of swine acute diarrhea syndrome coronavirus . J Med Virol . 2024 ; 96 ( 6 ): e29712 . doi: 10.1002/jmv.29712 OpenUrl CrossRef PubMed 824. ↵ Costa H , Xu X , Overbeek G , Vasaikar S , Patro CP , Kostopoulou ON , Jung M , Shafi G , Ananthaseshan S , Tsipras G , et al. Human cytomegalovirus may promote tumour progression by upregulating arginase-2 . Oncotarget . 2016 ; 7 ( 30 ): 47221 – 47231 . doi: 10.18632/oncotarget.9722 OpenUrl CrossRef PubMed 825. ↵ Wang X , Bi J , Yang C , Li Y , Yang Y , Deng J , Wang L , Gao X , Lin Y , Liu J , Yin G . Long non-coding RNA LOC103222771 promotes infection of porcine reproductive and respiratory syndrome virus in Marc-145 cells by downregulating Claudin-4 . Vet Microbiol . 2023 ; 286 : 109890 . doi: 10.1016/j.vetmic.2023.109890 OpenUrl CrossRef 826. ↵ Villamayor L , López-García D , Rivero V , Martínez-Sobrido L , Nogales A , DeDiego ML . The IFN-stimulated gene IFI27 counteracts innate immune responses after viral infections by interfering with RIG-I signaling . Front Microbiol . 2023 ; 14 : 1176177 . doi: 10.3389/fmicb.2023.1176177 OpenUrl CrossRef PubMed 827. ↵ Resende F , Araújo S , Tavares LP , Teixeira MM , Costa VV . The Multifaceted Role of Annexin A1 in Viral Infections . Cells . 2023 ; 12 ( 8 ): 1131 . doi: 10.3390/cells12081131 OpenUrl CrossRef 828. ↵ Sarkar L , Liu G , Gack MU . ISG15: its roles in SARS-CoV-2 and other viral infections . Trends Microbiol . 2023 ; 31 ( 12 ): 1262 – 1275 . doi: 10.1016/j.tim.2023.07.006 OpenUrl CrossRef PubMed 829. ↵ Hu K , Li J , Wu G , Zhou L , Wang X , Yan Y , Xu Z . The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma . Aging (Albany NY) . 2021 ; 13 ( 5 ): 6662 – 6680 . doi: 10.18632/aging.202519 OpenUrl CrossRef PubMed 830. ↵ Victorio CBL , Ganasarajah A , Novera W , Ong J , Msallam R , Chacko AM . Translocator protein (TSPO) is a biomarker of Zika virus (ZIKV) infection-associated neuroinflammation . Emerg Microbes Infect . 2024 ; 13 ( 1 ): 2348528 . doi: 10.1080/22221751.2024.2348528 OpenUrl CrossRef PubMed 831. ↵ de Souza GF , Muraro SP , Santos LD , Monteiro APT, da Silva AG, de Souza APD, Stein RT, Bozza PT, Porto BN . Macrophage migration inhibitory factor (MIF) controls cytokine release during respiratory syncytial virus infection in macrophages . Inflamm Res . 2019 ; 68 ( 6 ): 481 – 491 . doi: 10.1007/s00011-019-01233-z OpenUrl CrossRef PubMed 832. ↵ Schieffer E , Schieffer B . The Race for ACE: Targeting Angiotensin-Converting Enzymes (ACE) in SARS-CoV-2 Infection . J Renin Angiotensin Aldosterone Syst . 2022 ; 2022 : 2549063 . doi: 10.1155/2022/2549063 OpenUrl CrossRef PubMed 833. ↵ Li Y , Liu T , Zheng R , Lai J , Su J , Li J , Zhu B , Chen T . Translational selenium nanoparticles boost GPx1 activation to reverse HAdV-14 virus-induced oxidative damage . Bioact Mater . 2024 ; 38 : 276 – 291 . doi: 10.1016/j.bioactmat.2024.04.034 OpenUrl CrossRef PubMed 834. ↵ Wang M , Wang Y , Liu Y , Wang H , Xin X , Li J , Hao Y , Han L , Yu F , Zheng C , et al. SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation . PLoS One . 2019 ; 14 ( 7 ): e0219989 . doi: 10.1371/journal.pone.0219989 OpenUrl CrossRef PubMed 835. ↵ McLarnon T , McDaid D , Lynch SM , Cooper E , McLaughlin J , McGilligan VE , Watterson S , Shukla P , Zhang SD , Bucholc M , et al. Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients . Biomolecules . 2024 ; 14 ( 9 ): 1163 . doi: 10.3390/biom14091163 OpenUrl CrossRef PubMed 836. ↵ El-Mayet FS , Harrison KS , Jones C . Regulation of Krüppel-Like Factor 15 Expression by Herpes Simplex Virus Type 1 or Bovine Herpesvirus 1 Productive Infection . Viruses . 2021 ; 13 ( 6 ): 1148 . doi: 10.3390/v13061148 OpenUrl CrossRef PubMed 837. ↵ Wozniak AL , Long A , Jones-Jamtgaard KN , Weinman SA . Hepatitis C virus promotes virion secretion through cleavage of the Rab7 adaptor protein RILP . Proc Natl Acad Sci U S A . 2016 ; 113 ( 44 ): 12484 – 12489 . doi: 10.1073/pnas.1607277113 OpenUrl Abstract / FREE Full Text 838. ↵ Echavarria-Consuegra L , Dinesh Kumar N , van der Laan M , Mauthe M , Van de Pol D , Reggiori F , Smit JM . Mitochondrial protein BNIP3 regulates Chikungunya virus replication in the early stages of infection . PLoS Negl Trop Dis . 2023 ; 17 ( 11 ): e0010751 . doi: 10.1371/journal.pntd.0010751 OpenUrl CrossRef PubMed 839. ↵ Gladue DP , Largo E , Holinka LG , Ramirez-Medina E , Vuono EA , Berggren KA , Risatti GR , Nieva JL , Borca MV . Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum . Viruses . 2018 ; 10 ( 9 ): 460 . doi: 10.3390/v10090460 OpenUrl CrossRef PubMed 840. ↵ Kaltenborn E , Kern S , Frixel S , Fragnet L , Conzelmann KK , Zarbock R , Griese M . Respiratory syncytial virus potentiates ABCA3 mutation-induced loss of lung epithelial cell differentiation . Hum Mol Genet . 2012 ; 21 ( 12 ): 2793 – 2806 . doi: 10.1093/hmg/dds107 OpenUrl CrossRef PubMed 841. ↵ Wang W , Xiong L , Wang P , Wang F , Ma Q . Major vault protein plays important roles in viral infection . IUBMB Life . 2020 ; 72 ( 4 ): 624 – 631 . doi: 10.1002/iub.2200 OpenUrl CrossRef PubMed 842. ↵ Choi EJ , Ren J , Zhang K , Wu W , Lee YS , Lee I , Bao X . The Importance of AGO 1 and 4 in Post-Transcriptional Gene Regulatory Function of tRF5-GluCTC, an Respiratory Syncytial Virus-Induced tRNA-Derived RNA Fragment . Int J Mol Sci . 2020 ; 21 ( 22 ): 8766 . doi: 10.3390/ijms21228766 OpenUrl CrossRef PubMed 843. ↵ Sun J , Yu H , Wang Y , Li L , Zhu J , Ma P , Feng Z , Tu C . Classical swine fever virus NS5A protein activates autophagy via the PP2A-DAPK3-Beclin 1 axis . J Virol . 2023 ; 97 ( 12 ): e0098823 . doi: 10.1128/jvi.00988-23 OpenUrl CrossRef PubMed 844. ↵ Iyer K , Mitra A , Mitra D . Identification of 5’ upstream sequence involved in HSPBP1 gene transcription and its downregulation during HIV-1 infection . Virus Res . 2023 ; 324 : 199034 . doi: 10.1016/j.virusres.2022.199034 OpenUrl CrossRef 845. ↵ Pauciullo S , Riccio A , Santopolo S , Albecka A , Papa G , James LC , Piacentini S , Lanzilli G , Rossi A , Santoro MG . Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication . Cell Mol Life Sci . 2024 ; 81 ( 1 ): 386 . doi: 10.1007/s00018-024-05370-5 OpenUrl CrossRef 846. ↵ Madhry D , Malvankar S , Phadnis S , Srivastava RK , Bhattacharyya S , Verma B . Synergistic correlation between host angiogenin and dengue virus replication . RNA Biol . 2023 ; 20 ( 1 ): 805 – 816 . doi: 10.1080/15476286.2023.2264003 OpenUrl CrossRef PubMed 847. ↵ Rochette L , Zeller M , Cottin Y , Vergely C . GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism . Trends Endocrinol Metab . 2021 ; 32 ( 11 ): 875 – 889 . doi: 10.1016/j.tem.2021.08.011 OpenUrl CrossRef PubMed 848. ↵ Chen F , Chen L , Liang J , Chen Z , Zhang C , Zhang Z , Yang J . Potential Role of Superoxide Dismutase 3 (SOD3) in Resistance to Influenza A Virus Infection . Antioxidants (Basel) . 2023 ; 12 ( 2 ): 354 . doi: 10.3390/antiox12020354 OpenUrl CrossRef PubMed 849. ↵ Lu Y , Zhang MX , Pang W , Song TZ , Zheng HY , Tian RR , Zheng YT . Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFNγ Secretion of CD8+ T Cells . Viruses . 2022 ; 14 ( 4 ): 719 . doi: 10.3390/v14040719 OpenUrl CrossRef PubMed 850. ↵ Almutairi F , Sarr D , Tucker SL , Fantone K , Lee JK , Rada B . RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice . Front Immunol . 2021 ; 12 : 772288 . doi: 10.3389/fimmu.2021.772288 OpenUrl CrossRef 851. ↵ Kohlmeier JE , Cookenham T , Miller SC , Roberts AD , Christensen JP , Thomsen AR , Woodland DL . CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection . J Immunol . 2009 ; 183 ( 7 ): 4378 – 4384 . doi: 10.4049/jimmunol.0902022 OpenUrl Abstract / FREE Full Text 852. ↵ Pedersen LE , Harndahl M , Nielsen M , Patch JR , Jungersen G , Buus S , Golde WT . Identification of peptides from foot-and-mouth disease virus structural proteins bound by class I swine leukocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401 . Anim Genet . 2013 ; 44 ( 3 ): 251 - 258 . doi: 10.1111/j.1365-2052.2012.02400.x OpenUrl CrossRef PubMed 853. ↵ Vandenbroeck K , Alloza I , Swaminathan B , Antigüedad A , Otaegui D , Olascoaga J , Barcina MG , de las Heras V, Bartolomé M, Fernández-Arquero M , et al. Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection . Genes Immun . 2011 ; 12 ( 1 ): 40 – 45 . doi: 10.1038/gene.2010.46 OpenUrl CrossRef PubMed Web of Science 854. ↵ Neubert EN , DeRogatis JM , Lewis SA , Viramontes KM , Ortega P , Henriquez ML , Buisson R , Messaoudi I , Tinoco R . HMGB2 regulates the differentiation and stemness of exhausted CD8+ T cells during chronic viral infection and cancer . Nat Commun . 2023 ; 14 ( 1 ): 5631 . doi: 10.1038/s41467-023-41352-0 OpenUrl CrossRef PubMed 855. ↵ Buttrini M , De Conto F . Host Cell-dependent Modulatory Role of Ras Homolog Enriched in Brain-Like-1 (RhebL1) Protein in Influenza A/NWS/33 Virus-infected Mammalian Cells . Front Biosci (Landmark Ed) . 2024 ; 29 ( 3 ): 116 . doi: 10.31083/j.fbl2903116 OpenUrl CrossRef PubMed 856. ↵ Liu B , Gao TT , Fu XY , Xu ZH , Ren H , Zhao P , Qi ZT , Qin ZL . PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling . Virol Sin . 2021 ; 36 ( 3 ): 412 – 423 . doi: 10.1007/s12250-020-00291-6 OpenUrl CrossRef PubMed 857. ↵ Francis J , Zvada SP , Denti P , Hatherill M , Charalambous S , Mungofa S , Dawson R , Dorman S , Gupte N , Wiesner L , et al. A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine . Antimicrob Agents Chemother . 2019 ; 63 ( 4 ): e01964 – 18 . doi: 10.1128/AAC.01964-18 OpenUrl Abstract / FREE Full Text 858. ↵ Yuan Y , Zhao K , Yao Y , Liu C , Chen Y , Li J , Wang Y , Pei R , Chen J , Hu X , et al. HDAC11 restricts HBV replication through epigenetic repression of cccDNA transcription . Antiviral Res . 2019 ; 172 : 104619 . doi: 10.1016/j.antiviral.2019.104619 OpenUrl CrossRef 859. ↵ Xu Z , Zhang Y , Liu W , Liu Y , Su Y , Xing Q , He X , Wei Z , Cao Y , Xiang H. et al. Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women . Clin Appl Thromb Hemost . 2018 ; 24 ( 6 ): 894 - 900 . doi: 10.1177/1076029617750487 OpenUrl CrossRef PubMed 860. ↵ Karypidis AH , Söderström T , Nordmark A , Granath F , Cnattingius S , Rane A . Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage . Fertil Steril . 2006 ; 86 ( 5 ): 1498 – 1503 . doi: 10.1016/j.fertnstert.2006.03.059 OpenUrl CrossRef PubMed 861. ↵ Yang H , Qiu L , Di W , Zhao A , Chen G , Hu K , Lin Q . Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients . Fertil Steril . 2009 ; 92 ( 1 ): 301 – 305 . doi: 10.1016/j.fertnstert.2008.04.068 OpenUrl CrossRef PubMed 862. ↵ Goto S , Ozaki Y , Mori R , Ozawa F , Obayashi Y , Kitaori T , Sugiura-Ogasawara M . MMP2 and MMP9 are associated with the pathogenesis of recurrent pregnancy loss through protein expression rather than genetic polymorphism . J Reprod Immunol . 2024 ; 164 : 104270 . doi: 10.1016/j.jri.2024.104270 OpenUrl CrossRef 863. ↵ Ozbilgin K , Turan A , Kahraman B , Atay C , Vatansever S , Uluer ET , Ozçakir T. Distribution of furin, TNF-α , and TGF-β2 in the endometrium of missed abortion and voluntary first trimester termination cases . Anal Quant Cytopathol Histpathol . 2015 ; 37 ( 2 ): 123 – 133 . OpenUrl PubMed 864. ↵ Sabet EE , Salehi Z , Khodayari S , Zarafshan SS , Zahiri Z . Polymorphisms of glutathione peroxidase 1 (GPX1 Pro198Leu) and catalase (CAT C-262T) in women with spontaneous abortion . Syst Biol Reprod Med . 2014 ; 60 ( 5 ): 304 – 307 . doi: 10.3109/19396368.2014.892651 OpenUrl CrossRef PubMed 865. ↵ Li P , Shi Y , Shuai H , Cai Y , Lu W , Wang G , Gao L , Wang L , Fan X , Yang X . Alterted SLIT2/ROBO1 signalling is linked to impaired placentation of missed and threatened miscarriage in early pregnancy . Histopathology . 2017 ; 71 ( 4 ): 543 – 552 . doi: 10.1111/his.13250 OpenUrl CrossRef PubMed 866. ↵ Mu Z , Shen S , Tang L , Liu Y , Zhou Z , Lei L . Hyperin promotes proliferation, migration, and invasion of HTR-8/SVneo trophoblast cells via activation of JAK1/STAT3 pathway in recurrent spontaneous abortions . Heliyon . 2023 ; 9 ( 1 ): e12958 . doi: 10.1016/j.heliyon.2023.e12958 OpenUrl CrossRef PubMed 867. ↵ Wu PL , Zhu JW , Zeng C , Li X , Xue Q , Yang HX . IGFBP7 enhances trophoblast invasion via IGF-1R/c-Jun signaling in unexplained recurrent spontaneous abortion . Reproduction . 2022 ; 164 ( 5 ): 231 – 241 . doi: 10.1530/REP-21-0501 OpenUrl CrossRef PubMed 868. ↵ Liu X , Wei X , Wu J , Xu Y , Hu J , Qin C , Chen C , Lin Y . CBLL1 promotes endometrial stromal cell senescence via inhibiting PTEN in recurrent spontaneous abortion . FASEB J . 2024 ; 38 ( 14 ): e23833 . doi: 10.1096/fj.202400972R OpenUrl CrossRef PubMed 869. ↵ Kim YR , Ryu CS , Kim JO , An HJ , Cho SH , Ahn EH , Kim JH , Lee WS , Kim NK . Association study of AGO1 and AGO2 genes polymorphisms with recurrent pregnancy loss . Sci Rep . 2019 ; 9 ( 1 ): 15591 . doi: 10.1038/s41598-019-52073-0 OpenUrl CrossRef PubMed 870. ↵ Pereza N , Ostojić S , Volk M , Maver A , Kapović M , Peterlin B . The insulin-like growth factor 2 receptor gene Gly1619Arg polymorphism and idiopathic recurrent spontaneous abortion . J Matern Fetal Neonatal Med . 2012 ; 25 ( 4 ): 429 – 431 . doi: 10.3109/14767058.2011.581713 OpenUrl CrossRef PubMed 871. ↵ Bozhinovski G , Terzikj M , Kubelka-Sabit K , Plaseska-Karanfilska D . High Incidence of CPLANE1-Related Joubert Syndrome in the Products of Conceptions from Early Pregnancy Losses . Balkan Med J . 2024 ; 41 ( 2 ): 97 – 104 . doi: 10.4274/balkanmedj.galenos.2024.2023-10-72 OpenUrl CrossRef PubMed 872. ↵ Long N , Sun RL , Lai QH , Lu MY , Li XH , Chen YN , Zhu DY. HOTAIR/miR- 1277 -5p/FBN2 signaling axis is involved in recurrent spontaneous abortion by regulating the growth, migration, and invasion of HTR-8/SVneo cells† . Biol Reprod . 2024 ; 111 ( 1 ):135-147. doi: 10.1093/biolre/ioae030 OpenUrl CrossRef 873. ↵ Chen L , Dai F , Huang Y , Chen J , Li Z , Liu H , Cheng Y . Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss . J Assist Reprod Genet . 2024 ; 41 ( 6 ): 1669 – 1685 . doi: 10.1007/s10815-024-03096-8 OpenUrl CrossRef PubMed 874. ↵ El-Dessouky SH , Issa MY , Aboulghar MM , Gaafar HM , Elarab AE , Ateya MI , Omar HH , Beetz C , Zaki MS . Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant . Am J Med Genet A . 2020 ; 182 ( 12 ): 2867 – 2876 . doi: 10.1002/ajmg.a.61858 OpenUrl CrossRef PubMed 875. ↵ Dória S , Sousa M , Fernandes S , Ramalho C , Brandão O , Matias A , Barros A , Carvalho F . Gene expression pattern of IGF2, PHLDA2, PEG10 and CDKN1C imprinted genes in spontaneous miscarriages or fetal deaths . Epigenetics . 2010 ; 5 ( 5 ): 444 - 450 . doi: 10.4161/epi.5.5.12118 OpenUrl CrossRef PubMed Web of Science 876. ↵ Sun X , Tong X , Hao Y , Li C , Zhang Y , Pan Y , Dai Y , Liu L , Zhang T , Zhang S . Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation . Mol Hum Reprod . 2020 ; 26 ( 5 ): 327 – 339 . doi: 10.1093/molehr/gaaa021 OpenUrl CrossRef PubMed 877. ↵ Lv X , Cai Z , Li S . Increased apoptosis rate of human decidual cells and cytotrophoblasts in patients with recurrent spontaneous abortion as a result of abnormal expression of CDKN1A and Bax . Exp Ther Med . 2016 ; 12 ( 5 ): 2865 – 2868 . doi: 10.3892/etm.2016.3692 OpenUrl CrossRef PubMed 878. ↵ Yamada H , Kato EH , Morikawa M , Shimada S , Saito H , Watari M , Minakami H , Nishihira J . Decreased serum levels of macrophage migration inhibition factor in miscarriages with normal chromosome karyotype . Hum Reprod . 2003 ; 18 ( 3 ): 616 – 620 . doi: 10.1093/humrep/deg147 OpenUrl CrossRef PubMed Web of Science 879. ↵ Aslbahar F , Neamatzadeh H , Tabatabaiee RS , Karimi-Zarchi M , Javaheri A , Mazaheri M , Foroughi E , Nasiri R . Association of Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism with Recurrent Pregnancy Loss: a Meta-Analysis of 26 Case-Control Studies . Rev Bras Ginecol Obstet . 2018 ; 40 ( 10 ): 631 – 641 . doi: 10.1055/s-0038-1672137 OpenUrl CrossRef PubMed 880. ↵ Sabet EE , Salehi Z , Khodayari S , Zarafshan SS , Zahiri Z . Polymorphisms of glutathione peroxidase 1 (GPX1 Pro198Leu) and catalase (CAT C-262T) in women with spontaneous abortion . Syst Biol Reprod Med . 2014 ; 60 ( 5 ): 304 – 307 . doi: 10.3109/19396368.2014.892651 OpenUrl CrossRef PubMed 881. ↵ Xu Z , Zhang Y , Liu W , Liu Y , Su Y , Xing Q , He X , Wei Z , Cao Y , Xiang H . Polymorphisms of F2, PROC, PROZ, and F13A 1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women . Clin Appl Thromb Hemost . 2018 ; 24 ( 6 ): 894 - 900 . doi: 10.1177/1076029617750487 OpenUrl CrossRef PubMed 882. ↵ Verma PK , Prakash S , Parveen F , Faridi RM , Agrawal S . Genetic association of adipokine and UCP2 polymorphism with recurrent miscarriage among non-obese women . Reprod Biomed Online . 2012 ; 25 ( 5 ): 527 – 535 . doi: 10.1016/j.rbmo.2012.07.006 OpenUrl CrossRef PubMed 883. ↵ Suntharalingham JP , Ishida M , Buonocore F , Del Valle I , Solanky N , Demetriou C , Regan L , Moore GE , Achermann JC . Analysis of CDKN1C in fetal growth restriction and pregnancy loss . F1000Res . 2019 ; 8 : 90 . doi: 10.12688/f1000research.15016.2 OpenUrl CrossRef 884. ↵ Kou J , Yuan E , Yan G . Association between HIF-1α, BNIP3, and autophagy in the chorionic villi of missed abortion . J Obstet Gynaecol Res. 2023 ; 49 ( 7 ): 1710 - 1716 . doi: 10.1111/jog.15667 OpenUrl CrossRef PubMed 885. ↵ Kwon MJ , Kim JH , Lee JY , Ko EJ , Park HW , Shin JE , Ahn EH . Genetic Polymorphisms in the 3’-Untranslated Regions of SMAD5, FN3KRP, and RUNX-1 Are Associated with Recurrent Pregnancy Loss . Biomedicines . 2022 ; 10 ( 7 ): 1481 . doi: 10.3390/biomedicines10071481 OpenUrl CrossRef PubMed 886. ↵ Lyu C , Ni T , Guo Y , Zhou T , Chen ZJ , Yan J , Li Y . Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasion . Cell Prolif . 2023 ; 56 ( 12 ): e13514 . doi: 10.1111/cpr.13514 OpenUrl CrossRef PubMed 887. ↵ Amini MA , Karimi M , Talebi SS , Piri H , Karimi J . The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review . Chonnam Med J . 2022 ; 58 ( 3 ): 91 – 95 . doi: 10.4068/cmj.2022.58.3.91 OpenUrl CrossRef PubMed 888. ↵ Jiang PJ , Lin QD , Bao SM , Zhao AM , Zhang Y , Xiao SJ . Relationship between expression of chemokine receptors CCR3, CCR5 and CXCR3 on CD4(+) T cells and spontaneous abortion in mice . Chin Med J (Engl) . 2009 ; 122 ( 4 ): 390 - 395 . OpenUrl CrossRef PubMed 889. ↵ Amiri Jahromi R , Nasiri M , Jahromi AR . Interferon Regulatory Factor 5 Gene Polymorphisms in Iranian Women with Unexplained Recurrent Pregnancy Loss . Immunol Invest . 2017 ; 46 ( 1 ): 97 – 107 . doi: 10.1080/08820139.2016.1225759 OpenUrl CrossRef PubMed 890. ↵ Xiang H , Yan H , Sun B , Feng F , Chen P . Decreased expression of long non-coding RNA SNHG7 cause recurrent spontaneous abortion through suppression proliferation and invasion of trophoblast cells via miR-34a . Am J Transl Res . 2019 ; 11 ( 1 ): 463 – 472 . OpenUrl PubMed 891. ↵ Shimodaira M , Nakayama T , Sato I , Sato N , Izawa N , Mizutani Y , Furuya K , Yamamoto T . Glucocorticoid synthesis-related genes: HSD11B1 and HSD11B2 in hypertensive disorders in pregnancy . Gynecol Endocrinol . 2013 ; 29 ( 7 ): 657 – 661 . doi: 10.3109/09513590.2013.788623 OpenUrl CrossRef PubMed 892. ↵ Murray EJ , Gumusoglu SB , Santillan DA , Santillan MK . Manipulating CD4+ T Cell Pathways to Prevent Preeclampsia . Front Bioeng Biotechnol . 2022 ; 9 : 811417 . doi: 10.3389/fbioe.2021.811417 OpenUrl CrossRef 893. ↵ Xin Q , Xin G , Li L , Sun W , Jiang W , Wang J , Luan Y , Zhang Y , Cheng L , Duan S , et al. Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population . J Matern Fetal Neonatal Med. 2022 ; 35 ( 25 ): 5227 - 5235 . doi: 10.1080/14767058.2021.1876022 OpenUrl CrossRef 894. ↵ Nikolov A , Popovski N . Role of Gelatinases MMP-2 and MMP-9 in Healthy and Complicated Pregnancy and Their Future Potential as Preeclampsia Biomarkers . Diagnostics (Basel) . 2021 ; 11 ( 3 ): 480 . doi: 10.3390/diagnostics11030480 OpenUrl CrossRef PubMed 895. ↵ Shen XY , Huang J , Chen LL , Sha MT , Gao J , Xin H . Blocking lactate regulation of the Grhl2/SLC31A1 axis inhibits trophoblast cuproptosis and preeclampsia development . J Assist Reprod Genet . 2024 ; 41 ( 11 ): 3201 – 3212 . doi: 10.1007/s10815-024-03256-w OpenUrl CrossRef PubMed 896. ↵ Ye W , Shen L , Xiong Y , Zhou Y , Gu H , Yang Z . Preeclampsia is Associated with Decreased Methylation of the GNA12 Promoter . Ann Hum Genet . 2016 ; 80 ( 1 ): 7 – 10 . doi: 10.1111/ahg.12136 OpenUrl CrossRef PubMed 897. ↵ Cao Z , Ma L , Cai W , Niu X , Yang N , Ni J , Wang X , Wei M , Chen S , Li Y . Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China . Hypertens Pregnancy . 2023 ; 42 ( 1 ): 2256863 . doi: 10.1080/10641955.2023.2256863 OpenUrl CrossRef PubMed 898. ↵ Sivaraj N , Kusuma BP , Kutikuppala LVS , Rachel KV , Balaga VS , Gundakaram S . Association of TNFSF11 rs2200287 and TNFSF11 rs2148072 gene polymorphisms in preeclampsia . Am J Reprod Immunol . 2022 ; 88 ( 4 ): e13604 . doi: 10.1111/aji.13604 OpenUrl CrossRef PubMed 899. ↵ Torres-Salazar Q , Martínez-López Y , Reyes-Romero M , Pérez-Morales R , Sifuentes-Álvarez A , Salvador-Moysén J . Differential Methylation in Promoter Regions of the Genes NR3C1 and HSP90AA1 , Involved in the Regulation, and Bioavailability of Cortisol in Leukocytes of Women With Preeclampsia. Front Med (Lausanne) . 2020 ; 7 : 206 . doi: 10.3389/fmed.2020.00206 OpenUrl CrossRef 900. ↵ Boroń D , Kornacki J , Gutaj P , Mantaj U , Wirstlein P , Wender-Ozegowska E . Corin-The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus . J Clin Med . 2022 ; 12 ( 1 ): 61 . doi: 10.3390/jcm12010061 OpenUrl CrossRef PubMed 901. ↵ Zhou A , Dekker GA , Lumbers ER , Lee SY , Thompson SD , McCowan LM , Roberts CT; SCOPE consortium. The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI . Placenta . 2013 ; 34 ( 1 ): 75 - 81 . doi: 10.1016/j.placenta.2012.10.007 OpenUrl CrossRef PubMed 902. ↵ Liu J , Wang Y , Zhang S , Sun L , Shi Y . ADAM9 deubiquitination induced by USP22 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells in preeclampsia . Placenta . 2024 ; 146 : 50 – 57 . doi: 10.1016/j.placenta.2023.12.008 OpenUrl CrossRef PubMed 903. ↵ Wang L , Feng Y , Zhang Y , Zhou H , Jiang S , Niu T , Wei LJ , Xu X , Xu X , Wang X . Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia . Am J Obstet Gynecol . 2006 ; 195 ( 1 ): 162 – 171 . doi: 10.1016/j.ajog.2006.01.079 OpenUrl CrossRef PubMed 904. ↵ Wang H , Ma L , Pan X , Du Z , Chen Y . Novel associations of SNPs MYLIP rs3757354 and ABCA1 2230806 gene with early-onset-preeclampsia: A case-control candidate genetic study . Pregnancy Hypertens . 2021 ; 23 : 185 – 190 . doi: 10.1016/j.preghy.2020.12.005 OpenUrl CrossRef PubMed 905. ↵ Zou AX , Chen B , Li QX , Liang YC . MiR-134 inhibits infiltration of trophoblast cells in placenta of patients with preeclampsia by decreasing ITGB1 expression . Eur Rev Med Pharmacol Sci . 2018 ; 22 ( 8 ): 2199 – 2206 . doi: 10.26355/eurrev_201804_14804 OpenUrl CrossRef PubMed 906. ↵ Freitag N , Xie Y , Adam LM , Borowski S , Blois SM , Barrientos G . Expression of the alternative splicing regulator Rbfox2 during placental development is differentially regulated in preeclampsia mouse models . Am J Reprod Immunol . 2021 ; 86 ( 6 ): e13491 . doi: 10.1111/aji.13491 OpenUrl CrossRef PubMed 907. ↵ Powell M , Fuller S , Gunderson E , Benz C . A common IGF1R gene variant predicts later life breast cancer risk in women with preeclampsia . Breast Cancer Res Treat . 2023 ; 197 ( 1 ): 149 – 159 . doi: 10.1007/s10549-022-06789-9 OpenUrl CrossRef PubMed 908. ↵ Atigan A , Karakaya YA , Kiliç D , Guler OT . Microarray expression results of VEGF, YAP1 and PTEN immunostains in preeclampsia cases . J Immunoassay Immunochem . 2023 ; 44 ( 2 ): 204 - 212 . doi: 10.1080/15321819.2023.2182219 OpenUrl CrossRef PubMed 909. ↵ Hou H , Zhang Y , Wu H , Huang Z , Liu S , Liang H , Xu Y . Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk for Preeclampsia in a Chinese Han Population . J Nutr Sci Vitaminol (Tokyo) . 2022 ; 68 ( 5 ): 368 – 374 . doi: 10.3177/jnsv.68.368 OpenUrl CrossRef PubMed 910. ↵ Xin Q , Xin G , Li L , Sun W , Jiang W , Wang J , Luan Y , Zhang Y , Cheng L , Duan S , et al. Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population . J Matern Fetal Neonatal Med. 2022 ; 35 ( 25 ): 5227 - 5235 . doi: 10.1080/14767058.2021.1876022 OpenUrl CrossRef 911. ↵ Lederer W , Schaffenrath H , Alomar-Dominguez C , Thaler J , Fantin R , Dostal L , Putz G , Humpel C . Cerebrospinal beta-amyloid peptides(1-40) and (1-42) in severe preeclampsia and HELLP syndrome - a pilot study . Sci Rep . 2020 ; 10 ( 1 ): 5783 . doi: 10.1038/s41598-020-62805-2 OpenUrl CrossRef PubMed 912. ↵ Wang H , Ma L , Pan X , Du Z , Chen Y . Novel associations of SNPs MYLIP rs3757354 and ABCA1 2230806 gene with early-onset-preeclampsia: A case-control candidate genetic study . Pregnancy Hypertens . 2021 ; 23 : 185 – 190 . doi: 10.1016/j.preghy.2020.12.005 OpenUrl CrossRef PubMed 913. ↵ Fantone S , Mazzucchelli R , Giannubilo SR , Ciavattini A , Marzioni D , Tossetta G . AT-rich interactive domain 1A protein expression in normal and pathological pregnancies complicated by preeclampsia . Histochem Cell Biol . 2020 ; 154 ( 3 ): 339 – 346 . doi: 10.1007/s00418-020-01892-8 OpenUrl CrossRef PubMed 914. ↵ Baird L , Cannon P , Kandel M , Nguyen TV , Nguyen A , Wong G , Murphy C , Brownfoot FC , Kadife E , Hannan NJ , et al. Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia . Reprod Biol Endocrinol . 2023 ; 21 ( 1 ): 65 . doi: 10.1186/s12958-023-01116-3 OpenUrl CrossRef PubMed 915. ↵ Raja Xavier JP , Okumura T , Apweiler M , Chacko NA , Singh Y , Brucker SY , Takeda S , Lang F , Salker MS . Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development . Biol Res . 2024 ; 57 ( 1 ): 55 . doi: 10.1186/s40659-024-00526-w OpenUrl CrossRef PubMed 916. ↵ Ozsoy AZ , Cayli S , Sahin C , Ocakli S , Sanci TO , Ilhan DB . Altered expression of p97/Valosin containing protein and impaired autophagy in preeclamptic human placenta . Placenta . 2018 ; 67 : 45 – 53 . doi: 10.1016/j.placenta.2018.05.013 OpenUrl CrossRef PubMed 917. ↵ Shaarawy M , Al-Sokkary F , Sheba M , Wahba O , Kandil HO , Abdel-Mohsen I . Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia . Int J Gynaecol Obstet . 2005 ; 88 ( 2 ): 112 – 117 . doi: 10.1016/j.ijgo.2004.10.005 OpenUrl CrossRef PubMed 918. ↵ Famá EA , Souza RS , Melo CM , Melo Pompei L , Pinhal MA . Evaluation of glycosaminoglycans and heparanase in placentas of women with preeclampsia . Clin Chim Acta . 2014 ; 437 : 155 – 160 . doi: 10.1016/j.cca.2014.07.023 OpenUrl CrossRef 919. ↵ Luizon MR , Pinto-Souza CC , Coeli-Lacchini F , Lacchini R , Cavalli RC , Sandrim VC . ARG2 single-nucleotide polymorphism rs3742879 affects plasma arginase 2 levels, nitric oxide formation and antihypertensive therapy response in preeclampsia . Pharmacogenomics . 2022 ; 23 ( 13 ): 713 – 722 . doi: 10.2217/pgs-2022-0079 OpenUrl CrossRef PubMed 920. ↵ Zhao A , Qi Y , Liu K . CLDN3 expression and function in pregnancy-induced hypertension . Exp Ther Med . 2020 ; 20 ( 4 ): 3798 – 3806 . doi: 10.3892/etm.2020.9084 OpenUrl CrossRef PubMed 921. ↵ Ruikar K , Aithal M , Shetty P , Dinesh US , Bargale A , Sadashiv R , Sarathkumar E , Khode V , Desai R , Patil P . Placental Expression and Relative Role of Anti-inflammatory Annexin A1 and Animal Lectin Galectin-3 in the Pathogenesis of Preeclampsia . Indian J Clin Biochem . 2022 ; 37 ( 1 ): 60 – 68 . doi: 10.1007/s12291-020-00952-z OpenUrl CrossRef PubMed 922. ↵ Ozmen A , Guzeloglu-Kayisli O , Tabak S , Guo X , Semerci N , Nwabuobi C , Larsen K , Wells A , Uyar A , Arlier S , et al. Preeclampsia is Associated With Reduced ISG15 Levels Impairing Extravillous Trophoblast Invasion . Front Cell Dev Biol . 2022 ; 10 : 898088 . doi: 10.3389/fcell.2022.898088 OpenUrl CrossRef 923. ↵ Kreis NN , Friemel A , Jennewein L , Hoock SC , Hentrich AE , Nowak T , Louwen F , Yuan J . Functional Analysis of p21Cip1/CDKN1A and Its Family Members in Trophoblastic Cells of the Placenta and Its Roles in Preeclampsia . Cells . 2021 ; 10 ( 9 ): 2214 . doi: 10.3390/cells10092214 OpenUrl CrossRef 924. ↵ Todros T , Paulesu L , Cardaropoli S , Rolfo A , Masturzo B , Ermini L , Romagnoli R , Ietta F . Role of the Macrophage Migration Inhibitory Factor in the Pathophysiology of Pre-Eclampsia . Int J Mol Sci . 2021 ; 22 ( 4 ): 1823 . doi: 10.3390/ijms22041823 OpenUrl CrossRef PubMed 925. ↵ González-Garrido JA , García-Sánchez JR , Tovar-Rodríguez JM , Olivares-Corichi IM . Preeclampsia is associated with ACE I/D polymorphism, obesity and oxidative damage in Mexican women . Pregnancy Hypertens . 2017 ; 10 : 22 – 27 . doi: 10.1016/j.preghy.2017.04.001 OpenUrl CrossRef PubMed 926. ↵ Gao H , Liu C , Lin P , Xu L , Li X , Chen Y , Cheng B , Li A , Liu S . Effects of GSTP1 and GPX1 Polymorphisms on the Risk of Preeclampsia in Chinese Han Women . Cell Physiol Biochem . 2016 ; 39 ( 5 ): 2025 – 2032 . doi: 10.1159/000447898 OpenUrl CrossRef PubMed 927. ↵ Huang L , Ma Y , Chen L , Chang J , Zhong M , Wang Z , Sun Y , Chen X , Sun F , Xiao L , et al. Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARγ-UCP2 cascade . FASEB J . 2021 ; 35 ( 6 ): e21555 . doi: 10.1096/fj.202002639RRR OpenUrl CrossRef 928. ↵ Staniczek J , Manasar-Dyrbuś M , Drosdzol-Cop A , Stojko R . Beckwith-Wiedemann Syndrome in Newborn of Mother with HELLP Syndrome/Preeclampsia: An Analysis of Literature and Case Report with Fetal Growth Restriction and Absence of CDKN1C Typical Pathogenic Genetic Variation . Int J Mol Sci . 2023 ; 24 ( 17 ): 13360 . doi: 10.3390/ijms241713360 OpenUrl CrossRef PubMed 929. ↵ Mendes FS , Luizon MR , Lopes ACDS , Pereira DA , Evangelista FCG , Godoi LC , Dusse LM , Alpoim PN . Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes . Rev Bras Ginecol Obstet . 2024 ; 46 : e-rbgo19 . doi: 10.61622/rbgo/2024AO19 OpenUrl CrossRef PubMed 930. ↵ Jie Q , Sun F , Li Q , Zhu J , Wei Y , Yang H , Long P , Wang Z , Yang X , Li D , et al. Downregulated ribosomal protein L39 inhibits trophoblast cell migration and invasion by targeting E-cadherin in the placenta of patients with preeclampsia . FASEB J . 2021 ; 35 ( 4 ): e21322 . doi: 10.1096/fj.202002061R OpenUrl CrossRef PubMed 931. ↵ Saarela T , Hiltunen M , Helisalmi S , Heinonen S , Laakso M . Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia . Eur J Obstet Gynecol Reprod Biol . 2006 ; 128 ( 1-2 ): 175 – 179 . doi: 10.1016/j.ejogrb.2005.12.015 OpenUrl CrossRef PubMed 932. ↵ Cayli S , Demirturk F , Ocakli S , Aytan H , Caliskan AC , Cimsir H . Altered expression of COP9 signalosome proteins in preeclampsia . Gynecol Endocrinol . 2012 ; 28 ( 6 ): 488 – 491 . doi: 10.3109/09513590.2011.633664 OpenUrl CrossRef PubMed 933. ↵ Padmini E , Lavanya S . Over expression of HSP70 and HSF1 in endothelial cells during pre-eclamptic placental stress . Aust N Z J Obstet Gynaecol . 2011 ; 51 ( 1 ): 47 – 52 . doi: 10.1111/j.1479-828X.2010.01246.x OpenUrl CrossRef PubMed 934. ↵ Shaarawy M , Al-Sokkary F , Sheba M , Wahba O , Kandil HO , Abdel-Mohsen I . Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia . Int J Gynaecol Obstet . 2005 ; 88 ( 2 ): 112 – 117 . doi: 10.1016/j.ijgo.2004.10.005 OpenUrl CrossRef PubMed 935. ↵ Zhang K , Zhang H , Wang B , Gao S , Sun C , Jia C , Cui J . NR2F1 overexpression alleviates trophoblast cell dysfunction by inhibiting GDF15/MAPK axis in preeclampsia . Hum Cell . 2024 ; 37 ( 5 ): 1405 – 1420 . doi: 10.1007/s13577-024-01095-6 OpenUrl CrossRef PubMed 936. ↵ Rosta K , Molvarec A , Enzsöly A , Nagy B , Rónai Z , Fekete A , Sasvári-Székely M , Rigó J Jr , Vér A . Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction . Eur J Obstet Gynecol Reprod Biol . 2009 ; 142 ( 2 ): 134 – 138 . doi: 10.1016/j.ejogrb.2008.10.014 OpenUrl CrossRef PubMed 937. ↵ Shi H , Kong R , Miao X , Gou L , Yin X , Ding Y , Cao X , Meng Q , Gu M , Suo F . Decreased PPP1R3G in pre-eclampsia impairs human trophoblast invasion and migration via Akt/MMP-9 signaling pathway . Exp Biol Med (Maywood) . 2023 ; 248 ( 16 ): 1373 – 1382 . doi: 10.1177/15353702231182214 OpenUrl CrossRef PubMed 938. ↵ Chen Y , Xiao L , Sun G , Li M , Yang H , Ming Z , Zhao K , Shang X , Zhang H , Liu C . TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia . Biology (Basel) . 2023 ; 12 ( 2 ): 208 . doi: 10.3390/biology12020208 OpenUrl CrossRef PubMed 939. ↵ Wang Y , Zhang Z . Increased expression of lncRNA SNHG7 promotes the cell viability, migration, and invasion in pre-eclampsia via modulating the miR-214-5p/TWIST1 axis . Hypertens Pregnancy . 2021 ; 40 ( 3 ): 261 – 270 . doi: 10.1080/10641955.2021.1981372 OpenUrl CrossRef PubMed 940. ↵ Tan W , Fu H , Zhou X , Duan Y , Yin N , Huang J , Liu X . ANKRD37 inhibits trophoblast migration and invasion by regulating the NF-κB pathway in preeclampsia . J Gene Med . 2022 ; 24 ( 5 ): e3416 . doi: 10.1002/jgm.3416 OpenUrl CrossRef PubMed 941. ↵ Jin Y , Jin C , Law S , Chu KM , Zhang H , Strombeck B , Yuen AP , Kwong YL . Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas . Cancer Genet Cytogenet . 2004 ; 148 ( 1 ): 21 – 28 . doi: 10.1016/s0165-4608(03)00213-9 OpenUrl CrossRef PubMed 942. ↵ Ravoet M , Sibille C , Roufosse F , Duvillier H , Sotiriou C , Schandené L , Martiat P , Goldman M , Willard-Gallo KE . 6q-is an early and persistent chromosomal aberration in CD3-CD4+ T-cell clones associated with the lymphocytic variant of hypereosinophilic syndrome . Haematologica . 2005 ; 90 ( 6 ): 753 – 765 . OpenUrl Abstract / FREE Full Text 943. ↵ Jeusset LM , Guppy BJ , Lichtensztejn Z , McDonald D , McManus KJ . Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination , Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis. Cancers (Basel) . 2021 ; 13 ( 5 ): 1043 . doi: 10.3390/cancers13051043 OpenUrl CrossRef PubMed 944. ↵ Vincent-Chong VK , Anwar A , Karen-Ng LP , Cheong SC , Yang YH , Pradeep PJ , Rahman ZA , Ismail SM , Zaini ZM , Prepageran N , et al. Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9 . PLoS One . 2013 ; 8 ( 2 ): e54705 . doi: 10.1371/journal.pone.0054705 OpenUrl CrossRef PubMed 945. ↵ Niikawa N , Fukushima Y , Taniguchi N , Iizuka S , Kajii T . Chromosome abnormalities involving 11p13 and low erythrocyte catalase activity . Hum Genet . 1982 ; 60 ( 4 ): 373 – 375 . doi: 10.1007/BF00569223 OpenUrl CrossRef PubMed 946. ↵ Cannarella R , Mattina T , Condorelli RA , Mongioì LM , Pandini G , La Vignera S , Calogero AE . Chromosome 15 structural abnormalities: effect on IGF1R gene expression and function . Endocr Connect . 2017 ; 6 ( 7 ): 528 – 539 . doi: 10.1530/EC-17-0158 OpenUrl Abstract / FREE Full Text 947. ↵ Young NL , Dere R . Mechanistic insights into KDM4A driven genomic instability . Biochem Soc Trans . 2021 ; 49 ( 1 ): 93 – 105 . doi: 10.1042/BST20191219 OpenUrl CrossRef PubMed 948. ↵ Balachandra V , Shrestha RL , Hammond CM , Lin S , Hendriks IA , Sethi SC , Chen L , Sevilla S , Caplen NJ , Chari R , et al. DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains . EMBO J. 2024 ; 43 ( 11 ): 2166 - 2197 . doi: 10.1038/s44318-024-00093-6 OpenUrl CrossRef PubMed 949. ↵ Lepage CC , Palmer MCL , Farrell AC , Neudorf NM , Lichtensztejn Z , Nachtigal MW , McManus KJ . Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer . Br J Cancer . 2021 ; 124 ( 10 ): 1699 – 1710 . doi: 10.1038/s41416-021-01317-w OpenUrl CrossRef PubMed 950. ↵ Yang S , Liao Y , Zhao Q , Xie Y , Zheng A , Wan H . Heparanase Is a Critical Regulator of Mitotic Spindles Required for Maintaining Chromosome Stability . DNA Cell Biol . 2018 ; 37 ( 4 ): 291 – 297 . doi: 10.1089/dna.2017.3990 OpenUrl CrossRef PubMed 951. ↵ Chen ZH , Hurh YJ , Na HK , Kim JH , Chun YJ , Kim DH , Kang KS , Cho MH , Surh YJ . Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells . Carcinogenesis . 2004 ; 25 ( 10 ): 2005 – 2013 . doi: 10.1093/carcin/bgh183 OpenUrl CrossRef PubMed Web of Science 952. ↵ Lavitrano M , Maione B , Forte E , Francolini M , Sperandio S , Testi R , Spadafora C . The interaction of sperm cells with exogenous DNA: a role of CD4 and major histocompatibility complex class II molecules . Exp Cell Res . 1997 ; 233 ( 1 ): 56 – 62 . doi: 10.1006/excr.1997.3534 OpenUrl CrossRef PubMed Web of Science 953. ↵ Carrera S , Cuadrado-Castano S , Samuel J , et al. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage . Cell Death Differ . 2013 ; 20 ( 7 ): 910 – 919 . doi: 10.1038/cdd.2013.14 OpenUrl CrossRef PubMed 954. ↵ Huna A , Griveau A , Vindrieux D , Jaber S , Flaman JM , Goehrig D , Azzi L , Médard JJ , Djebali S , Hernandez-Vargas H , et al. PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging . Cell Death Dis . 2021 ; 12 ( 2 ): 190 . doi: 10.1038/s41419-021-03468-3 OpenUrl CrossRef PubMed 955. ↵ Salces-Ortiz J , Ramón M , González C , Pérez-Guzmán MD , Garde JJ , García-Álvarez O , Maroto-Morales A , Calvo JH , Serrano MM . Differences in the ovine HSP90AA1 gene expression rates caused by two linked polymorphisms at its promoter affect rams sperm DNA fragmentation under environmental heat stress conditions . PLoS One . 2015 ; 10 ( 2 ): e0116360 . doi: 10.1371/journal.pone.0116360 OpenUrl CrossRef PubMed 956. ↵ McCann JJ , Fleenor DE , Chen J , Lai CH , Bass TE , Kastan MB. Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway . Radiat Res . 2023 ; 199 ( 4 ): 406 – 421 . doi: 10.1667/RADE-22-00219.1 OpenUrl CrossRef PubMed 957. ↵ Ivanović-Matić S , Bogojević D , Martinović V , Petrović A , Jovanović-Stojanov S , Poznanović G , Grigorov I . Catalase inhibition in diabetic rats potentiates DNA damage and apoptotic cell death setting the stage for cardiomyopathy . J Physiol Biochem . 2014 ; 70 ( 4 ): 947 – 959 . doi: 10.1007/s13105-014-0363-y OpenUrl CrossRef PubMed 958. ↵ Lee JH , Yoo NJ , Kim MS , An CH , Lee SH . Mutational and expressional alterations of ZMPSTE24, DNA damage response-related gene, in gastric and colorectal cancers . Pathol Res Pract . 2016 ; 212 ( 12 ): 1113 – 1118 . doi: 10.1016/j.prp.2016.10.001 OpenUrl CrossRef PubMed 959. ↵ Li Y , Sun C , Tan Y , Zhang H , Li Y , Zou H . ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition . Int J Biol Sci . 2021 ; 17 ( 2 ): 635 – 650 . doi: 10.7150/ijbs.52319 OpenUrl CrossRef PubMed 960. ↵ Yang C , Zhang Y , Chen Y , Ragaller F , Liu M , Corvigno S , Dahlstrand H , Carlson J , Chen Z , Näsman A , et al. Nuclear IGF1R interact with PCNA to preserve DNA replication after DNA-damage in a variety of human cancers . PLoS One . 2020 ; 15 ( 7 ): e0236291 . doi: 10.1371/journal.pone.0236291 OpenUrl CrossRef PubMed 961. ↵ Sharma A , Almasan A . Autophagy and PTEN in DNA damage-induced senescence . Adv Cancer Res . 2021 ; 150 : 249 – 284 . doi: 10.1016/bs.acr.2021.01.006 OpenUrl CrossRef PubMed 962. ↵ McKenzie LD , LeClair JW , Miller KN , Strong AD , Chan HL , Oates EL , Ligon KL , Brennan CW , Chheda MG . CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma . Sci Rep . 2019 ; 9 ( 1 ): 4444 . doi: 10.1038/s41598-019-40327-w OpenUrl CrossRef PubMed 963. ↵ Ding G , Xu X , Li D , Chen Y , Wang W , Ping D , Jia S , Cao L . Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation . Cell Death Dis . 2020 ; 11 ( 10 ): 893 . doi: 10.1038/s41419-020-03019-2 OpenUrl CrossRef PubMed 964. ↵ Lahiri DK , Xu Y , Klaunig J , Baiyewu O , Ogunniyi A , Hall K , Hendrie H , Sahota A . Effect of oxidative stress on DNA damage and beta-amyloid precursor proteins in lymphoblastoid cell lines from a Nigerian population . Ann N Y Acad Sci . 1999 ; 893 : 331 – 336 . doi: 10.1111/j.1749-6632.1999.tb07848.x OpenUrl CrossRef PubMed Web of Science 965. ↵ Adamson B , Smogorzewska A , Sigoillot FD , King RW , Elledge SJ . A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response . Nat Cell Biol . 2012 ; 14 ( 3 ): 318 – 328 . doi: 10.1038/ncb2426 OpenUrl CrossRef PubMed Web of Science 966. ↵ Lovejoy CA , Li W , Reisenweber S , Thongthip S , Bruno J , de Lange T , De S , Petrini JH , Sung PA , Jasin M , Rosenbluh J , et al. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway . PLoS Genet . 2012 ; 8 ( 7 ): e1002772 . doi: 10.1371/journal.pgen.1002772 OpenUrl CrossRef PubMed 967. ↵ Bychkov I , Deneka A , Topchu I , Pangeni RP , Lengner C , Karanicolas J , Golemis EA , Makhov P , Boumber Y . Musashi-2 (MSI2) regulation of DNA damage response in lung cancer . Preprint. bioRxiv . 2023 ; 2023.06.13.544756 . doi: 10.1101/2023.06.13.544756 OpenUrl Abstract / FREE Full Text 968. ↵ Arif W , Mathur B , Saikali MF , Chembazhi UV , Toohill K , Song YJ , Hao Q , Karimi S , Blue SM , Yee BA , et al. Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death . Nat Commun . 2023 ; 14 ( 1 ): 551 . doi: 10.1038/s41467-023-35932-3 OpenUrl CrossRef 969. ↵ Newman M , Sfaxi R , Saha A , Monchaud D , Teulade-Fichou MP , Vagner S . The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3’-End Processing Following UV-Induced DNA Damage . J Mol Biol . 2017 ; 429 ( 21 ): 3121 – 3131 . doi: 10.1016/j.jmb.2016.11.033 OpenUrl CrossRef PubMed 970. ↵ Calses PC , Pham VC , Guarnaccia AD , Choi M , Verschueren E , Bakker ST , Pham TH , Hinkle T , Liu C , Chang MT , et al. TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage . Mol Cell Proteomics . 2023 ; 22 ( 2 ): 100496 . doi: 10.1016/j.mcpro.2023.100496 OpenUrl CrossRef PubMed 971. ↵ Bakr A , Della Corte G , Veselinov O , Kelekçi S , Chen MM , Lin YY , Sigismondo G , Iacovone M , Cross A , et al. ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response . Nucleic Acids Res . 2024 ; 52 ( 10 ): 5698 – 5719 . doi: 10.1093/nar/gkae23 OpenUrl CrossRef PubMed 972. ↵ Li C , Park S , Zhang X , Eisenberg LM , Zhao H , Darzynkiewicz Z , Xu D . Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism . J Biol Chem . 2017 ; 292 ( 40 ): 16746 – 16759 . doi: 10.1074/jbc.M117.803338 OpenUrl Abstract / FREE Full Text 973. ↵ Shao X , Hou H , Chen H , Xia W , Geng X , Wang J . GATA1 activates HSD17B6 to improve efficiency of cisplatin in lung adenocarcinoma via DNA damage . Genes Environ . 2024 ; 46 ( 1 ): 27 . doi: 10.1186/s41021-024-00321-9 OpenUrl CrossRef PubMed 974. ↵ Wang C , Nan J , Holvey-Bates E , Chen X , Wightman S , Latif MB , Zhao J , Li X , Sen GC , Stark GR , et al. STAT2 hinders STING intracellular trafficking and reshapes its activation in response to DNA damage . Proc Natl Acad Sci U S A . 2023 ; 120 ( 16 ): e2216953120 . doi: 10.1073/pnas.2216953120 OpenUrl CrossRef PubMed 975. ↵ Livingstone M , Ruan H , Weiner J , Clauser KR , Strack P , Jin S , Williams A , Greulich H , Gardner J , Venere M , et al. Valosin-containing protein phosphorylation at Ser784 in response to DNA damage . Cancer Res . 2005 ; 65 ( 17 ): 7533 – 7540 . doi: 10.1158/0008-5472.CAN-04-3729 OpenUrl Abstract / FREE Full Text 976. ↵ Moudry P , Lukas C , Macurek L , Hanzlikova H , Hodny Z , Lukas J , Bartek J . Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage . Cell Cycle . 2012 ; 11 ( 8 ): 1573 – 1582 . doi: 10.4161/cc.19978 OpenUrl CrossRef PubMed Web of Science 977. ↵ White C , Gagnon SN , St-Laurent JF , Gravel C , Proulx LI , Desnoyers S . The DNA damage-inducible C. elegans tankyrase is a nuclear protein closely linked to chromosomes . Mol Cell Biochem . 2009 ; 324 ( 1-2 ): 73 – 83 . doi: 10.1007/s11010-008-9986-z OpenUrl CrossRef PubMed 978. ↵ Kalev P , Hyer ML , Gross S , Konteatis Z , Chen CC , Fletcher M , Lein M , Aguado-Fraile E , Frank V , Barnett A , et al. MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage . Cancer Cell . 2021 ; 39 ( 2 ): 209 – 224.e11 . doi: 10.1016/j.ccell.2020.12.010 OpenUrl CrossRef PubMed 979. ↵ Smith R , Sellou H , Chapuis C , Huet S , Timinszky G . CHD3 and CHD4 recruitment and chromatin remodeling activity at DNA breaks is promoted by early poly(ADP-ribose)-dependent chromatin relaxation . Nucleic Acids Res . 2018 ; 46 ( 12 ): 6087 – 6098 . doi: 10.1093/nar/gky334 OpenUrl CrossRef PubMed 980. ↵ Agelidis A , Suryawanshi RK , Patil CD , Campeau A , Gonzalez DJ , Shukla D . Dissociation of DNA damage sensing by endoglycosidase HPSE . iScience . 2021 ; 24 ( 3 ): 102242 . doi: 10.1016/j.isci.2021.102242 OpenUrl CrossRef PubMed 981. ↵ Yamamoto TM , Webb PG , Davis DM , Baumgartner HK , Woodruff ER , Guntupalli SR , Neville M , Behbakht K , Bitler BG . Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors . Mol Cancer Ther . 2022 ; 21 ( 4 ): 647 – 657 . doi: 10.1158/1535-7163.MCT-21-0827 OpenUrl CrossRef PubMed 982. ↵ Sandy Z , da Costa IC , Schmidt CK . More than Meets the ISG15: Emerging Roles in the DNA Damage Response and Beyond . Biomolecules . 2020 ; 10 ( 11 ): 1557 . doi: 10.3390/biom10111557 OpenUrl CrossRef PubMed 983. ↵ Sakai R , Kondo C , Oka H , Miyajima H , Kubo K , Uehara T . Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity . Toxicology . 2014 ; 315 : 8 – 16 . doi: 10.1016/j.tox.2013.10.009 OpenUrl CrossRef PubMed 984. ↵ Li K , Guo W , Li Z , Wang Y , Sun B , Xu D , Ling J , Song H , Liao Y , Wang T , et al. ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage . Neoplasia . 2019 ; 21 ( 6 ): 602 – 614 . doi: 10.1016/j.neo.2019.03.008 OpenUrl CrossRef PubMed 985. ↵ Razidlo GL , Johnson HJ , Stoeger SM , Cowan KH , Bessho T , Lewis RE . KSR1 is required for cell cycle reinitiation following DNA damage . J Biol Chem . 2009 ; 284 ( 11 ): 6705 – 6715 . doi: 10.1074/jbc.M806457200 OpenUrl Abstract / FREE Full Text 986. ↵ Nemajerova A , Moll UM , Petrenko O , Fingerle-Rowson G . Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle . Cell Cycle . 2007 ; 6 ( 9 ): 1030 – 1034 . doi: 10.4161/cc.6.9.4163 OpenUrl CrossRef PubMed 987. ↵ Pavlyushchik OO , Afonin VY , Sarokina VN , Chak TA , Khapaliuk AV , Anisovich MV . Association of the ace I/D gene polymorphism with DNA damage in hypertensive men . Tsitol Genet . 2016 ; 50 ( 5 ): 48 – 58 . OpenUrl PubMed 988. ↵ Gan F , Zhou Y , Hu Z , Hou L , Chen X , Xu S , Huang K . GPx1-mediated DNMT1 expression is involved in the blocking effects of selenium on OTA-induced cytotoxicity and DNA damage . Int J Biol Macromol . 2020 ; 146 : 18 – 24 . doi: 10.1016/j.ijbiomac.2019.11.221 OpenUrl CrossRef PubMed 989. ↵ Zhao Q , Liu K , Zhang L , Li Z , Wang L , Cao J , Xu Y , Zheng A , Chen Q , Zhao T . BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination . Cell Death Dis . 2022 ; 13 ( 11 ): 976 . doi: 10.1038/s41419-022-05413-4 OpenUrl CrossRef PubMed 990. ↵ Shimamoto Y , Sumizawa T , Haraguchi M , Gotanda T , Jueng HC , Furukawa T , Sakata R , Akiyama S . Direct activation of the human major vault protein gene by DNA-damaging agents . Oncol Rep . 2006 ; 15 ( 3 ): 645 – 652 . OpenUrl PubMed 991. ↵ Wang Y , Meng L , Meng S , Huang L , Luo S , Wu X , Gong X . Flotillin-1 enhances radioresistance through reducing radiation-induced DNA damage and promoting immune escape via STING signaling pathway in non-small cell lung cancer . Cancer Biol Ther . 2023 ; 24 ( 1 ): 2203332 . doi: 10.1080/15384047.2023.2203332 OpenUrl CrossRef PubMed 992. ↵ Agarwal S , de Jesus Perez VA . In Defense of the Nucleus: NUDT1 and Oxidative DNA Damage in Pulmonary Arterial Hypertension . Am J Respir Crit Care Med . 2021 ; 203 ( 5 ): 541 – 542 . doi: 10.1164/rccm.202009-3706ED OpenUrl CrossRef PubMed 993. ↵ Chung D , Dellaire G . The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair . Biomolecules . 2015 ; 5 ( 4 ): 2388 – 2416 . doi: 10.3390/biom5042388 OpenUrl CrossRef PubMed 994. ↵ Kim G , Meriin AB , Gabai VL , Christians E , Benjamin I , Wilson A , Wolozin B , Sherman MY . The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype . Aging Cell . 2012 ; 11 ( 4 ): 617 – 627 . doi: 10.1111/j.1474-9726.2012.00827.x OpenUrl CrossRef PubMed 995. ↵ Su Y , Wu C , Chang Y , Li L , Chen Y , Jia X , Wang X , Lv Y , Yu B , Yuan J . USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells . Breast Cancer Res Treat . 2022 ; 196 ( 1 ): 31 – 44 . doi: 10.1007/s10549-022-06711-3 OpenUrl CrossRef PubMed 996. ↵ Gundogdu R , Hergovich A . The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling . J Cell Signal (Los Angel) . 2016 ; 1 : 125 . 997. ↵ Li M , Lu Y , Li Y , Tong L , Gu XC , Meng J , Zhu Y , Wu L , Feng M , Tian N , et al. Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides . Cancer Res . 2019 ; 79 ( 14 ): 3689 – 3701 . doi: 10.1158/0008-5472.CAN-18-3776 OpenUrl Abstract / FREE Full Text 998. ↵ Weng H , Weng Z , Lu Y , Nakayama K , Morimoto K . Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay . Mutat Res . 2010 ; 701 ( 2 ): 132 – 136 . doi: 10.1016/j.mrgentox.2010.05.013 OpenUrl CrossRef PubMed Web of Science 999. ↵ Wang J , Sarkar TR , Zhou M , Sharan S , Ritt DA , Veenstra TD , Morrison DK , Huang AM , Sterneck E . CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage . Proc Natl Acad Sci U S A. 2010 ; 107 ( 37 ): 16131 - 16136 . doi: 10.1073/pnas.1002603107 OpenUrl Abstract / FREE Full Text 1000. ↵ Singh B , Bhat HK . Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer . Carcinogenesis . 2012 ; 33 ( 12 ): 2601 – 2610 . doi: 10.1093/carcin/bgs300 OpenUrl CrossRef PubMed Web of Science 1001. ↵ Bi X , Feng D , Korczeniewska J , Alper N , Hu G , Barnes BJ . Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis . Oncogene . 2014 ; 33 ( 25 ): 3288 – 3297 . doi: 10.1038/onc.2013.295 OpenUrl CrossRef PubMed 1002. ↵ Sung YH , Kim HJ , Devkota S , Roh J , Lee J , Rhee K , Bahk YY , Lee HW . Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response . Cancer Res . 2010 ; 70 ( 24 ): 10454 – 10463 . doi: 10.1158/0008-5472.CAN-10-0031 OpenUrl Abstract / FREE Full Text 1003. ↵ Sheu A , Chan Y , Ferguson A , Bakhtyari MB , Hawke W , White C , Chan YF , Bertolino PJ , Woon HG , Palendira U , et al. A proinflammatory CD4+ T cell phenotype in gestational diabetes mellitus . Diabetologia . 2018 ; 61 ( 7 ): 1633 – 1643 . doi: 10.1007/s00125-018-4615-1 OpenUrl CrossRef 1004. ↵ Xu Y , Wei C , Wu C , Han M , Wang J , Hou H , Zhang L , Liu S , Chen Y . Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with gestational diabetes mellitus . BMC Pregnancy Childbirth . 2020 ; 20 ( 1 ): 759 . doi: 10.1186/s12884-020-03459-w OpenUrl CrossRef PubMed 1005. ↵ Chang SY , Chen YW , Zhao XP , Chenier I , Tran S , Sauvé A , Ingelfinger JR , Zhang SL . Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system . Diabetes . 2012 ; 61 ( 10 ): 2565 – 2574 . doi: 10.2337/db12-0248 OpenUrl Abstract / FREE Full Text 1006. ↵ Tang F , Guan L , Liu X , Fan P , Zhou M , Wu Y , Liu R , Liu Y , Liu S , Li D , et al. A Common R219K Variant of ATP-Binding Cassette Transporter A1 Gene Alters Atherometabolic Traits in Pregnant Women With Gestational Diabetes Mellitus . Front Endocrinol (Lausanne) . 2021 ; 12 : 782453 . doi: 10.3389/fendo.2021.782453 OpenUrl CrossRef 1007. ↵ Liu Q , Han Y , Zhang M , Yang P , Xiang Y , Chen M , Xu F , Zhou X , Zheng D , Qin J . IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7 . Reprod Biol . 2024 ; 24 ( 1 ): 100850 . doi: 10.1016/j.repbio.2023.100850 OpenUrl CrossRef PubMed 1008. ↵ He Y , Bai J , Liu P , Dong J , Tang Y , Zhou J , Han P , Xing J , Chen Y , Yu X . miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus . EXCLI J . 2017 ; 16 : 1297 – 1307 . doi: 10.17179/excli2017-491 OpenUrl CrossRef PubMed 1009. ↵ Li W , She L , Zhang M , Yang M , Zheng W , He H , Wang P , Dai Q , Gong Z . The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study . PLoS One . 2024 ; 19 ( 5 ): e0298063 . doi: 10.1371/journal.pone.0298063 OpenUrl CrossRef PubMed 1010. ↵ Chen Q , Yang H , Feng Y , Zhang P , Wu W , Li S , Thompson B , Wang X , Peng T , Wang F , et al. SOS1 gene polymorphisms are associated with gestational diabetes mellitus in a Chinese population: Results from a nested case-control study in Taiyuan, China . Diab Vasc Dis Res . 2018 ; 15 ( 2 ): 158 – 161 . doi: 10.1177/1479164117745260 OpenUrl CrossRef PubMed 1011. ↵ Zhang FM , Tian SX , Geng Y , Wei CL , Li N , Zhang XG , Xie JP . Novel SLC26A6 gene polymorphism rs184187143 is associated with diabetic ketoacidosis of gestational diabetes . Eur Rev Med Pharmacol Sci . 2019 ; 23 ( 17 ): 7526 – 7531 . doi: 10.26355/eurrev_201909_18868 OpenUrl CrossRef PubMed 1012. ↵ Gelato MC , Rutherford C , San-Roman G , Shmoys S , Monheit A . The serum insulin-like growth factor-II/mannose-6-phosphate receptor in normal and diabetic pregnancy . Metabolism . 1993 ; 42 ( 8 ): 1031 – 1038 . doi: 10.1016/0026-0495(93)90019-k OpenUrl CrossRef PubMed 1013. ↵ Lassus P , Teramo K , Nupponen I , Markkanen H , Cederqvist K , Andersson S . Vascular endothelial growth factor and angiogenin levels during fetal development and in maternal diabetes . Biol Neonate . 2003 ; 84 ( 4 ): 287 – 292 . doi: 10.1159/000073636 OpenUrl CrossRef PubMed 1014. ↵ Fang J , Wu X , He J , Zhang H , Chen X , Zhang H , Novakovic B , Qi H , Yu X . RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4 . Mol Med . 2023 ; 29 ( 1 ): 23 . doi: 10.1186/s10020-023-00615-8 OpenUrl CrossRef PubMed 1015. ↵ Moreli JB , Santos MRD , Calderon IMP , Hebeda CB , Farsky SHP , Bevilacqua E , Oliani SM . The Role of Annexin A1 in DNA Damage Response in Placental Cells: Impact on Gestational Diabetes Mellitus . Int J Mol Sci . 2023 ; 24 ( 12 ): 10155 . doi: 10.3390/ijms241210155 OpenUrl CrossRef PubMed 1016. ↵ Chen Z , Jiang G , Jiang G , Ma S , Zhu Y , Zhao M . Circulating inflammatory cytokines and gestational diabetes mellitus: Unraveling the role of macrophage migration inhibitory factor (MIF) through a bidirectional mendelian randomization study . Cytokine . 2024 ; 182 : 156734 . doi: 10.1016/j.cyto.2024.156734 OpenUrl CrossRef 1017. ↵ Dmitrenko OP , Karpova NS , Nurbekov MK , Papysheva OV . I/D Polymorphism Gene ACE and Risk of Preeclampsia in Women with Gestational Diabetes Mellitus . Dis Markers . 2020 ; 2020 : 8875230 . doi: 10.1155/2020/8875230 OpenUrl CrossRef PubMed 1018. ↵ Yang R , Wang X , Zhang Y , Jin L , Zhao K , Chen J , Shang X , Zhou Y , Yu H . Genetic variations in IGF2BP2 and CAPN10 and their interaction with environmental factors increase gestational diabetes mellitus risk in Chinese women . Gene . 2025 ; 941 : 149226 . doi: 10.1016/j.gene.2025.149226 OpenUrl CrossRef 1019. ↵ Milan KL , Anuradha M , Ramkumar KM . Role of miR-125b-5p in modulating placental SIRT7 expression and its implications for lipid metabolism in gestational diabetes . J Reprod Immunol . 2025 ; 167 : 104422 . doi: 10.1016/j.jri.2024.104422 OpenUrl CrossRef 1020. ↵ Lassus P , Teramo K , Nupponen I , Markkanen H , Cederqvist K , Andersson S . Vascular endothelial growth factor and angiogenin levels during fetal development and in maternal diabetes . Biol Neonate . 2003 ; 84 ( 4 ): 287 – 292 . doi: 10.1159/000073636 OpenUrl CrossRef PubMed 1021. ↵ Lu YC , Liu SL , Zhang YS , Liang F , Zhu XY , Xiao Y , Wang J , Ding C , Banerjee S , Yin JY , et al. Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis . Front Endocrinol (Lausanne) . 2023 ; 14 : 1084896 . doi: 10.3389/fendo.2023.1084896 OpenUrl CrossRef 1022. ↵ Droździk M , Kaczmarek M , Malinowski D , Broś U , Kazienko A , Kurzawa R , Kurzawski M . TGFβ3 (TGFB3) polymorphism is associated with male infertility . Sci Rep . 2015 ; 5 : 17151 . doi: 10.1038/srep17151 OpenUrl CrossRef 1023. ↵ Tokunaga Y , Otsuyama KI , Kakuta S , Hayashida N . Heat Shock Transcription Factor 2 Is Significantly Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel Mechanisms of Several Severe Diseases . Int J Mol Sci . 2022 ; 23 ( 22 ): 13763 . doi: 10.3390/ijms232213763 OpenUrl CrossRef PubMed 1024. ↵ Xue Y , Jin J , Sun P , Li K . The association of rs11457523 in HSP90AA1 with idiopathic male infertility in the Chinese population . Andrologia . 2021 ; 53 ( 1 ): e13888 . doi: 10.1111/and.13888 OpenUrl CrossRef PubMed 1025. ↵ Sun B , Ni M , Tian S , Guo W , Cai S , Sondergaard MT , Chen Y , Mu Y , Estillore JP , Wang R , et al. A gain-of-function mutation in the ITPR1 gating domain causes male infertility in mice . J Cell Physiol . 2022 ; 237 ( 8 ): 3305 – 3316 . doi: 10.1002/jcp.30783 OpenUrl CrossRef PubMed 1026. ↵ Stouffs K , Willems A , Lissens W , Tournaye H , Van Steirteghem A , Liebaers I . The role of the testis-specific gene hTAF7L in the aetiology of male infertility . Mol Hum Reprod . 2006 ; 12 ( 4 ): 263 – 267 . doi: 10.1093/molehr/gal020 OpenUrl CrossRef PubMed Web of Science 1027. ↵ Fallah F , Colagar AH , Saleh HA , Ranjbar M . Variation of the genes encoding antioxidant enzymes SOD2 (rs4880), GPX1 (rs1050450), and CAT (rs1001179) and susceptibility to male infertility: a genetic association study and in silico analysis . Environ Sci Pollut Res Int. 2023 ; 30 ( 36 ): 86412 - 86424 . doi: 10.1007/s11356-023-28474-0 OpenUrl CrossRef 1028. ↵ Selva DM , Hirsch-Reinshagen V , Burgess B , Zhou S , Chan J , McIsaac S , Hayden MR , Hammond GL , Vogl AW , Wellington CL . The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility . J Lipid Res . 2004 ; 45 ( 6 ): 1040 – 1050 . doi: 10.1194/jlr.M400007-JLR200 OpenUrl Abstract / FREE Full Text 1029. ↵ Dorostghoal M , Galehdari H , Moramezi F , Danyari R . Sperm miR-26a-5p and its target PTEN transcripts content in men with unexplained infertility . Andrology . 2020 ; 8 ( 5 ): 1167 – 1173 . doi: 10.1111/andr.12801 OpenUrl CrossRef PubMed 1030. ↵ Pereza N , Ostojić S , Kapović M , Buretić-Tomljanović A . Insulin-like growth factor 2 and insulin-like growth factor 2 receptor gene polymorphisms in idiopathic male infertility . J Reprod Med . 2013 ; 58 ( 3-4 ): 132 – 136 . OpenUrl PubMed 1031. ↵ Dimitrovska M , Plaseska-Karanfilska D , Gogusev JK , Milenkovic T , Bozhinovski G , Dimitrovski C . Male Infertility associated with a Novel PRKAR1A Mutation in Carney Complex . Clin Med Insights Endocrinol Diabetes . 2024 ; 17 : 11795514241293073 . doi: 10.1177/11795514241293073 OpenUrl CrossRef 1032. ↵ Fu L , Wu Q , Fu J . Exploring the biological roles of DHX36, a DNA/RNA G-quadruplex helicase, highlights functions in male infertility: A comprehensive review . Int J Biol Macromol . 2024 ; 268 (Pt 2 ): 131811 . doi: 10.1016/j.ijbiomac.2024.131811 OpenUrl CrossRef PubMed 1033. ↵ Li C , Chen W , Cui Y , Zhang D , Yuan Q , Yu X , He Z . Essential Regulation of YAP1 in Fate Determinations of Spermatogonial Stem Cells and Male Fertility by Interacting with RAD21 and Targeting NEDD4 in Humans and Mice . Research (Wash D C) . 2024 ; 7 : 0544 . doi: 10.34133/research.0544 OpenUrl CrossRef PubMed 1034. ↵ Yu XY , Wang BB , Xin ZC , Liu T , Ma K , Jiang J , Fang X , Yu LH , Peng YF , Ma X . An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population . Asian J Androl . 2012 ; 14 ( 4 ): 599 – 603 . doi: 10.1038/aja.2012.1 OpenUrl CrossRef PubMed 1035. ↵ Li L , Wang R , Yu Y , Zhang H , Jiang Y , Yang X , Liu R . CHD7 missense variants and clinical characteristics of Chinese males with infertility . Mol Genet Genomic Med . 2020 ; 8 ( 9 ): e1372 . doi: 10.1002/mgg3.1372 OpenUrl CrossRef PubMed 1036. ↵ Qiu Y , Shimada K , Yamamoto K , Ikawa M . Loss of CCDC188 causes male infertility with defects in the sperm head-neck connection in mice . Biol Reprod . 2024 . doi: 10.1093/biolre/ioae137 OpenUrl CrossRef 1037. ↵ Ali A , Mistry BV , Ahmed HA , Abdulla R , Amer HA , Prince A , Alazami AM , Alkuraya FS , Assiri A . Deletion of DDB1-and CUL4-associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice . Sci Rep . 2018 ; 8 ( 1 ): 9202 . doi: 10.1038/s41598-018-27379-0 OpenUrl CrossRef PubMed 1038. ↵ Lv Y , Yang X , Sun X , Lv L , Zhang Z , Li C , Gao J , Li H , Wen Z , Zhu H . ALDH2 plays a role in spermatogenesis and male fertility by regulating oxidative stress in mice . Exp Cell Res . 2024 . doi: 10.1016/j.yexcr.2024.114397 OpenUrl CrossRef 1039. ↵ Zalata AA , Morsy HK , Badawy Ael-N , Elhanbly S , Mostafa T . ACE gene insertion/deletion polymorphism seminal associations in infertile men . J Urol . 2012 ; 187 ( 5 ): 1776 – 1780 . doi: 10.1016/j.juro.2011.12.076 OpenUrl CrossRef PubMed 1040. ↵ Dahadhah FW , Saleh Jaweesh M , Al Zoubi MS , Issam Abu Alarjah M, Hammadeh ME, Amor H . Lack of association between single polymorphic variants of the mitochondrial nicotinamide adenine dinucleotide dehydrogenase 3, and 4L (MT-ND3 and MT-ND4L) and male infertility . Andrologia . 2021 ; 53 ( 8 ): e14139 . doi: 10.1111/and.14139 OpenUrl CrossRef PubMed 1041. ↵ Borghei A , Ouyang YB , Westmuckett AD , Marcello MR , Landel CP , Evans JP , Moore KL . Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility . J Biol Chem . 2006 ; 281 ( 14 ): 9423 – 9431 . doi: 10.1074/jbc.M513768200 OpenUrl Abstract / FREE Full Text 1042. ↵ Sha Y , Liu W , Wei X , Zhu X , Tang B , Zhang X , Yang X , Wang Y , Wang X . Pathogenic variants of ATG4D in infertile men with non-obstructive azoospermia identified using whole-exome sequencing . Clin Genet . 2021 ; 100 ( 3 ): 280 – 291 . doi: 10.1111/cge.13995 OpenUrl CrossRef PubMed 1043. ↵ Yatsenko AN , Georgiadis AP , Murthy LJ , Lamb DJ , Matzuk MM . UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men . Mol Hum Reprod . 2013 ; 19 ( 6 ): 388 – 394 . doi: 10.1093/molehr/gat008 OpenUrl CrossRef PubMed 1044. ↵ Wen N , Yu MF , Liu J , Cai C , Liu QH , Shen J . Deficiency of MTMR14 impairs male fertility in Mus musculus . PLoS One . 2018 ; 13 ( 11 ): e0206224 . doi: 10.1371/journal.pone.0206224 OpenUrl CrossRef PubMed 1045. ↵ Mazarico-Altisent I , Capel I , Baena N , Bella-Cueto MR , Barcons S , Guirao X , Albert L , Cano A , Pareja R , Caixàs A , et al. Novel germline variants of CDKN1B and CDKN2C identified during screening for familial primary hyperparathyroidism . J Endocrinol Invest . 2023 ; 46 ( 4 ): 829 – 840 . doi: 10.1007/s40618-022-01948-7 OpenUrl CrossRef PubMed 1046. ↵ Corbetta S , Eller-Vainicher C , Frigerio M , Valaperta R , Costa E , Vicentini L , Baccarelli A , Beck-Peccoz P , Spada A . Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl-oxalate transporter in patients with primary hyperparathyroidism . Eur J Endocrinol . 2009 ; 160 ( 2 ): 283 – 288 . doi: 10.1530/EJE-08-0623 OpenUrl Abstract / FREE Full Text 1047. ↵ Lim V , Clarke BL . Coexisting primary hyperparathyroidism and sarcoidosis cause increased angiotensin-converting enzyme and decreased parathyroid hormone and phosphate levels . J Clin Endocrinol Metab . 2013 ; 98 ( 5 ): 1939 – 1945 . doi: 10.1210/jc.2012-4197 OpenUrl CrossRef PubMed 1048. ↵ Zhou C , Lv M , Wang P , Guo C , Ni Z , Bao H , Tang Y , Cai H , Lu J , Deng W , et al. Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation . J Mol Cell Biol . 2021 ; 13 ( 9 ): 646 – 661 . doi: 10.1093/jmcb/mjab034 OpenUrl CrossRef PubMed 1049. ↵ Shen LJ , He JL , Yang DH , Ding YB , Chen XM , Geng YQ , Liu SJ , Liu XQ , Wang YX . Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus . Reprod Sci . 2013 ; 20 ( 12 ): 1518 – 1528 . doi: 10.1177/1933719113488453 OpenUrl CrossRef PubMed 1050. ↵ Ryu CS , Kim YR , Kim JO , An HJ , Cho SH , Ahn EH , Kim JH , Lee WS , Kim NK . The association of AGO1 (rs595961G>A, rs636832A>G) and AGO2 (rs11996715C>A, rs2292779C>G, rs4961280C>A) polymorphisms and risk of recurrent implantation failure . Biosci Rep. 2019 ; 39 ( 11 ): BSR20190342 . doi: 10.1042/BSR20190342 OpenUrl CrossRef PubMed 1051. ↵ Zhang JL , Mao GH , Huang XH , Chang HY , Zheng Y , Cao X . Association between sperm mitochondrial ND2 gene variants and total fertilization failure . Syst Biol Reprod Med . 2018 ; 64 ( 4 ): 266 – 273 . doi: 10.1080/19396368.2018.1447616 OpenUrl CrossRef PubMed 1052. ↵ Cai S , Ye Q , Zeng X , Yang G , Ye C , Chen M , Yu H , Wang Y , Wang G , Huang S , et al. CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation . Cell Prolif . 2021 ; 54 ( 1 ): e12950 . doi: 10.1111/cpr.12950 OpenUrl CrossRef PubMed 1053. ↵ Wirstlein PK , Mikołajczyk M , Skrzypczak J . Correlation of the expression of heparanase and heparin-binding EGF-like growth factor in the implantation window of nonconceptual cycle endometrium . Folia Histochem Cytobiol . 2013 ; 51 ( 2 ): 127 – 134 . doi: 10.5603/FHC.2013.0020 OpenUrl CrossRef 1054. ↵ Zhang Y , Zhang Y , Xia X , Gao L , Gao C , Zhou J , Yan Z , Cui Y , Ma X , Kwak-Kim JYH , et al. Hyperlipidemia negatively impacts implantation by dysregulating tight junction and Claudin-3 and Claudin-4 expression in the endometrium . J Reprod Immunol . 2024 ; 166 : 104326 . doi: 10.1016/j.jri.2024.104326 OpenUrl CrossRef 1055. ↵ Kumar B , Field NS , Kim DD , Dar AA , Chen Y , Suresh A , Pastore CF , Hung LY , Porter N , Sawada K , et al. The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation . Nat Commun . 2022 ; 13 ( 1 ): 2786 . doi: 10.1038/s41467-022-30437-x OpenUrl CrossRef PubMed 1056. ↵ An P , Duggal P , Wang LH , O’Brien SJ , Donfield S , Goedert JJ , Phair J , Buchbinder S , Kirk GD , Winkler CA. olymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals . PLoS Genet . 2007 ; 3 ( 1 ): e19 . doi: 10.1371/journal.pgen.0030019 OpenUrl CrossRef PubMed 1057. ↵ Devor EJ , Schickling BM , Reyes HD , Warrier A , Lindsay B , Goodheart MJ , Santillan DA , Leslie KK . Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182 . Oncol Rep . 2016 ; 35 ( 4 ): 2461 – 2465 . doi: 10.3892/or.2016.4605 OpenUrl CrossRef PubMed 1058. ↵ Charych EI , Liu F , Moss SJ , Brandon NJ . GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders . Neuropharmacology . 2009 ; 57 ( 5-6 ): 481 – 495 . doi: 10.1016/j.neuropharm.2009.07.027 OpenUrl CrossRef PubMed Web of Science 1059. ↵ Prodan-Bărbulescu C , Alin CD , Faur IF , Bujor GC , Şeclăman EP, Enătescu V, Dănilă AI, Dăescu E, Hajjar R, Ghenciu LA , et al. Identification of Specific Plasma miRNAs as Potential Biomarkers for Major Depressive Disorder . Biomedicines . 2024 ; 12 ( 10 ): 2165 . doi: 10.3390/biomedicines12102165 OpenUrl CrossRef PubMed 1060. ↵ Cao H , Baranova A , Yue W , Yu H , Zhu Z , Zhang F , Liu D . miRNA-Coordinated Schizophrenia Risk Network Cross-Talk With Cardiovascular Repair and Opposed Gliomagenesis . Front Genet . 2020 ; 11 : 149 . doi: 10.3389/fgene.2020.00149 OpenUrl CrossRef 1061. ↵ You X , Zhang Y , Long Q , Liu Z , Ma X , Lu Z , Yang W , Feng Z , Zhang W , Teng Z , et al. Investigating aberrantly expressed microRNAs in peripheral blood mononuclear cells from patients with treatment resistant schizophrenia using miRNA sequencing and integrated bioinformatics . Mol Med Rep . 2020 ; 22 ( 5 ): 4340 – 4350 . doi: 10.3892/mmr.2020.11513 OpenUrl CrossRef PubMed 1062. ↵ Yang L , Chen J , Li Y , Wang Y , Liang S , Shi Y , Shi S , Xu Y . Association between SCAP and SREBF1 gene polymorphisms and metabolic syndrome in schizophrenia patients treated with atypical antipsychotics . World J Biol Psychiatry . 2016 ; 17 ( 6 ): 467 – 474 . doi: 10.3109/15622975.2016.116586 OpenUrl CrossRef PubMed 1063. ↵ Dibble KE , Donorfio LKM , Britner PA , Bellizzi KM . Stress, anxiety, and health-related quality of life in BRCA1/2-positive women with and without cancer: A comparison of four US female samples . Gynecol Oncol Rep . 2022 ; 42 : 101033 . doi: 10.1016/j.gore.2022.101033 OpenUrl CrossRef PubMed 1064. ↵ Resende LS , Amaral CE , Soares RB , Alves AS , Alves-Dos-Santos L , Britto LR , Chiavegatto S . Social stress in adolescents induces depression and brain-region-specific modulation of the transcription factor MAX . Transl Psychiatry . 2016 ; 6 ( 10 ): e914 . doi: 10.1038/tp.2016.202 OpenUrl CrossRef PubMed 1065. ↵ Ma X , Xu S , Zhou Y , Zhang Q , Yang H , Wan B , Yang Y , Miao Z , Xu X . Targeting Nr2e3 to Modulate Tet2 Expression: Therapeutic Potential for Depression Treatment . Adv Sci (Weinh) . 2024 ; 11 ( 31 ): e2400726 . doi: 10.1002/advs.202400726 OpenUrl CrossRef 1066. ↵ Gu D , Cao T , Yi S , Li X , Liu Y . Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis . Immunobiology . 2024 ; 229 ( 3 ): 152796 . doi: 10.1016/j.imbio.2024.152796 OpenUrl CrossRef PubMed 1067. ↵ Meng J , Li N , Liu X , Qiao S , Zhou Q , Tan J , Zhang T , Dong Z , Qi X , Kijlstra A , et al. NLRP3 Attenuates Intraocular Inflammation by Inhibiting AIM2-Mediated Pyroptosis Through the Phosphorylated Salt-Inducible Kinase 1/Sterol Regulatory Element Binding Transcription Factor 1 Pathway . Arthritis Rheumatol . 2023 ; 75 ( 5 ): 842 – 855 . doi: 10.1002/art.42420 OpenUrl CrossRef PubMed 1068. ↵ Qin RX , Ma XY , Han ZY , Ma SY , Shen ZJ , Lu ZH , Sun Y , Yu WL . IRF2 Affects LPS-and IFN-γ-Induced Pro-Inflammatory Responses, Cell Viability, Migration and Apoptosis of Macrophages by Regulating IRG1 . J Inflamm Res. 2024 ; 17 : 9651 - 9664 . doi: 10.2147/JIR.S490655 OpenUrl CrossRef PubMed 1069. ↵ Bruand M , Barras D , Mina M , Ghisoni E , Morotti M , Lanitis E , Fahr N , Desbuisson M , Grimm A , Zhang H , et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING . Cell Rep . 2021 ; 36 ( 3 ): 109412 . doi: 10.1016/j.celrep.2021.109412 OpenUrl CrossRef PubMed 1070. ↵ Li C , Qian YH . Inflammation-dependent activation of NCOA2 associates with p300 and c-MYC/Max heterodimer to transactivate RUNX2-AS1 and mediate RUNX2 downstream bone differentiation genes in the pathology of septic nonunion . Cytokine . 2022 ; 158 : 155992 . doi: 10.1016/j.cyto.2022.155992 OpenUrl CrossRef 1071. ↵ Ding Y , Chen L , Xu J , Liu Q . NR2E3 inhibits the inflammation and apoptosis in diabetic retinopathy by regulating the AHR/IL-17A signaling pathway . Naunyn Schmiedebergs Arch Pharmacol . 2024 ; 397 ( 11 ): 9081 – 9094 . doi: 10.1007/s00210-024-03213-5 OpenUrl CrossRef PubMed 1072. ↵ Li J , Haiyilati A , Zhou L , Chen J , Wang Y , Gao L , Cao H , Li X , Zheng SJ . GATA3 Inhibits Viral Infection by Promoting MicroRNA-155 Expression . J Virol . 2022 ; 96 ( 7 ): e0188821 . doi: 10.1128/jvi.01888-21 OpenUrl CrossRef PubMed 1073. ↵ Oh S , Santiago G , Manjunath L , Li J , Bouin A , Semler BL , Buisson R . A CRISPR-Cas9 knockout screening identifies IRF2 as a key driver of OAS3/RNase L-mediated RNA decay during viral infection . Proc Natl Acad Sci U S A . 2024 ; 121 ( 45 ): e2412725121 . doi: 10.1073/pnas.2412725121 OpenUrl CrossRef PubMed 1074. ↵ Guendel I , Meltzer BW , Baer A , Dever SM , Valerie K , Guo J , Wu Y , Kehn-Hall K . BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection . Virol J . 2015 ; 12 : 40 . doi: 10.1186/s12985-015-0266-8 OpenUrl CrossRef 1075. ↵ Mirzakhani H , Handy DE , Lu Z , Oppenheimer B , Litonjua AA , Loscalzo J , Weiss ST . Integration of circulating microRNAs and transcriptome signatures identifies early-pregnancy biomarkers of preeclampsia . Clin Transl Med . 2023 ; 13 ( 11 ): e1446 . doi: 10.1002/ctm2.1446 OpenUrl CrossRef PubMed 1076. ↵ Hayder H , Shan Y , Chen Y , O’Brien JA , Peng C . Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia . Front Cell Dev Biol . 2022 ; 10 : 995462 . doi: 10.3389/fcell.2022.995462 OpenUrl CrossRef PubMed 1077. ↵ Illarionov RA , Maltseva AR , Pachuliia OV , Postnikova TB , Vashukova ES , Popova AK , Nasykhova YA , Bespalova ON , Glotov AS . Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy . Noncoding RNA . 2024 ; 10 ( 6 ): 61 . doi: 10.3390/ncrna10060061 OpenUrl CrossRef PubMed 1078. ↵ Perna A , Hay E , Lucariello A , Scala B , De Blasiis P , Komici K , Sgambati E , Guerra G , Baldi A , De Luca A . GATA3 and TGF-β in normal placenta and pre-eclampsia . Tissue Cell . 2024 ; 88 : 102402 . doi: 10.1016/j.tice.2024.102402 OpenUrl CrossRef 1079. ↵ Ghanim BY , Ahmad M , Abdallah Q , Khaleel A , Qinna NA . Transcriptional profiling of drug-induced liver injury biomarkers: association of hepatic Srebf1/Pparα signaling and crosstalk of thrombin, alcohol dehydrogenase, MDR and DNA damage regulators . Mol Cell Biochem . 2023 ; 478 ( 9 ): 1949 – 1960 . doi: 10.1007/s11010-022-04648-1 OpenUrl CrossRef PubMed 1080. ↵ Lestari W , Ichwan SJ , Otsu M , Yamada S , Iseki S , Shimizu S , Ikeda MA . Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage . Biochem Biophys Res Commun . 2012 ; 417 ( 2 ): 710 – 716 . doi: 10.1016/j.bbrc.2011.12.003 OpenUrl CrossRef PubMed 1081. ↵ Wang X , Bai F , Liu X , Peng B , Xu X , Zhang H , Fu L , Zhu WG , Wang B , Pei XH . GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer . BMC Biol . 2024 ; 22 ( 1 ): 85 . doi: 10.1186/s12915-024-01881-6 . OpenUrl CrossRef PubMed 1082. ↵ Kabartan E , Gunes S , Arslan MA , Asci R . Investigating the relationship between BRCA1 and BRCA2 genes methylation profile and sperm DNA fragmentation in infertile men . Andrologia . 2019 ; 51 ( 7 ): e13308 . doi: 10.1111/and.13308 OpenUrl CrossRef PubMed 1083. ↵ Al-Nakhle H , Mohsen I , Elnaem B , Alharbi A , Alnakhli I , Almoarfi S , Fallatah J . Altered Expression of Vitamin D Metabolism Genes and Circulating MicroRNAs in PBMCs of Patients with Type 1 Diabetes: Their Association with Vitamin D Status and Ongoing Islet Autoimmunity . Noncoding RNA . 2023 ; 9 ( 5 ): 60 . doi: 10.3390/ncrna9050060 OpenUrl CrossRef PubMed 1084. ↵ Guo CC , Xu HE , Ma X . ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery . Acta Pharmacol Sin . 2023 ; 44 ( 11 ): 2139 – 2150 . doi: 10.1038/s41401-023-01134-2 OpenUrl CrossRef PubMed 1085. ↵ Kiaf B , Bode K , Schuster C , Kissler S. Gata3 is detrimental to regulatory T cell function in autoimmune diabetes. Preprint . bioRxiv . 2023 ; 2023.03.18.533297 . doi: 10.1101/2023.03.18.533297 OpenUrl Abstract / FREE Full Text 1086. ↵ Taki S . Type I interferons and autoimmunity: lessons from the clinic and from IRF-2-deficient mice . Cytokine Growth Factor Rev . 2002 ; 13 ( 4-5 ): 379 – 391 . doi: 10.1016/s1359-6101(02)00023-0 OpenUrl CrossRef PubMed 1087. ↵ Zhu Q , Han SX , Zhou CY , Cai MJ , Dai LP , Zhang JY . Autoimmune response to PARP and BRCA1/BRCA2 in cancer . Oncotarget . 2015 ; 6 ( 13 ): 11575 – 11584 . doi: 10.18632/oncotarget.3428 OpenUrl CrossRef PubMed 1088. ↵ Grarup N , Stender-Petersen KL , Andersson EA , Jørgensen T , Borch-Johnsen K , Sandbaek A , Lauritzen T , Schmitz O , Hansen T , Pedersen O . Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects . Diabetes . 2008 ; 57 ( 4 ): 1136 – 1142 . doi: 10.2337/db07-1534 OpenUrl Abstract / FREE Full Text 1089. ↵ El-Arabey AA , Abdalla M . GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes . Chem Biol Interact . 2022 ; 366 : 110141 . doi: 10.1016/j.cbi.2022.110141 OpenUrl CrossRef PubMed 1090. ↵ Kuryłowicz A , Wicik Z , Owczarz M , Jonas MI , Kotlarek M , Świerniak M, Lisik W, Jonas M, Noszczyk B, Puzianowska-Kuźnicka M . NGS Reveals Molecular Pathways Affected by Obesity and Weight Loss-Related Changes in miRNA Levels in Adipose Tissue . Int J Mol Sci . 2017 ; 19 ( 1 ): 66 . doi: 10.3390/ijms19010066 OpenUrl CrossRef PubMed 1091. ↵ Huang XY , Chen JX , Ren Y , Fan LC , Xiang W , He XJ . Exosomal miR-122 promotes adipogenesis and aggravates obesity through the VDR/SREBF1 axis . Obesity (Silver Spring) . 2022 ; 30 ( 3 ): 666 – 679 . doi: 10.1002/oby.23365 OpenUrl CrossRef PubMed 1092. ↵ Bhardwaj P , Iyengar NM , Zahid H , Carter KM , Byun DJ , Choi MH , Sun Q , Savenkov O , Louka C , Liu C , et al. Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2 . Sci Transl Med . 2023 ; 15 ( 684 ): eade1857 . doi: 10.1126/scitranslmed.ade1857 OpenUrl CrossRef PubMed 1093. ↵ Okuno Y , Fukuhara A , Hashimoto E , Kobayashi H , Kobayashi S , Otsuki M , Shimomura I . Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway . Diabetes . 2018 ; 67 ( 6 ): 1113 – 1127 . doi: 10.2337/db17-1032 OpenUrl Abstract / FREE Full Text 1094. ↵ He T , Yang L , Wu D . Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury . Drug Dev Res . 2022 ; 83 ( 4 ): 940 – 951 . doi: 10.1002/ddr.21919 OpenUrl CrossRef PubMed 1095. ↵ Khanal T , Kim D , Johnson A , Choubey D , Kim K . Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter . Toxicol Lett . 2015 ; 237 ( 3 ): 228 – 236 . doi: 10.1016/j.toxlet.2015.06.1708 OpenUrl CrossRef PubMed 1096. ↵ Yu S , Diao L , Lian R , Chen C , Huang C , Li X , Li Y , Zeng Y . Comparing the peri-implantation endometrial T-bet/GATA3 ratio between control fertile women and patients with recurrent miscarriage: establishment and application of a reference range . Hum Reprod . 2023 ; 38 ( 9 ): 1680 – 1689 . doi: 10.1093/humrep/dead132 OpenUrl CrossRef PubMed 1097. ↵ Ma W , Cao M , Bi S , Du L , Chen J , Wang H , Jiang Y , Wu Y , Liao Y , Kong S , et al. MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion . Cell Tissue Res . 2022 ; 388 ( 2 ): 453 – 469 . doi: 10.1007/s00441-022-03579-z OpenUrl CrossRef PubMed 1098. ↵ Qiu CP , Lv QT , Dongol S , Wang C , Jiang J . Single nucleotide polymorphism of SREBF-1 gene associated with an increased risk of endometrial cancer in Chinese women . PLoS One . 2014 ; 9 ( 3 ): e90491 . doi: 10.1371/journal.pone.0090491 OpenUrl CrossRef PubMed 1099. ↵ Liu YX , Yuan S , Liu XJ , Huang YX , Qiu P , Gao J , Deng GP . Correction to: LncRNA GATA3 AS1 promoted invasion and migration in human endometrial carcinoma by regulating the miR 361/ARRB2 axis . J Mol Med (Berl) . 2022 ; 100 ( 11 ): 1671 . doi: 10.1007/s00109-022-02259-3 OpenUrl CrossRef PubMed 1100. ↵ Sorouri K , Lynce F , Feltmate CM , Davis MR , Muto MG , Konstantinopoulos PA , Stover EH , Kurian AW , Hill SJ , Partridge AH , et al. Endometrial Cancer Risk Among Germline BRCA1/2 Pathogenic Variant Carriers: Review of Our Current Understanding and Next Steps . JCO Precis Oncol . 2023 ; 7 : e2300290 . doi: 10.1200/PO.23.00290 OpenUrl CrossRef 1101. ↵ Walker CJ , Rush CM , Dama P , O’Hern MJ , Cosgrove CM , Gillespie JL , Zingarelli RA , Smith B , Stein ME , Mutch DG , et al. MAX Mutations in Endometrial Cancer: Clinicopathologic Associations and Recurrent MAX p.His28Arg Functional Characterization . J Natl Cancer Inst . 2018 ; 110 ( 5 ): 517 - 526 . doi: 10.1093/jnci/djx238 OpenUrl CrossRef PubMed 1102. ↵ Zhao X , Wang J , Wang Y , Zhang M , Zhao W , Zhang H , Zhao L . Interferon stimulated gene 15 promotes progression of endometrial carcinoma and weakens antitumor immune response . Oncol Rep . 2022 ; 47 ( 6 ): 110 . doi: 10.3892/or.2022.8321 OpenUrl CrossRef PubMed 1103. ↵ Chen P , Wang DB , Liang YM . Evaluation of estrogen in endometriosis patients: Regulation of GATA-3 in endometrial cells and effects on Th2 cytokines . J Obstet Gynaecol Res . 2016 ; 42 ( 6 ): 669 – 677 . doi: 10.1111/jog.12957 OpenUrl CrossRef PubMed 1104. ↵ Govatati S , Challa K , Reddy SB , Pramod K , Deenadayal M , Chakravarty B , Shivaji S , Bhanoori M . BRCA1 alterations are associated with endometriosis, but BRCA2 alterations show no detectable endometriosis risk: a study in Indian population . J Assist Reprod Genet . 2015 ; 32 ( 2 ): 277 – 285 . doi: 10.1007/s10815-014-0379-9 OpenUrl CrossRef PubMed 1105. ↵ Brennan E , Butler AE , Drage DS , Sathyapalan T , Atkin SL . Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome . Front Endocrinol (Lausanne) . 2023 ; 14 : 1233484 . doi: 10.3389/fendo.2023.1233484 OpenUrl CrossRef PubMed 1106. ↵ Kong Y , Yang G , Feng X , Ji Z , Wang X , Shao Y , Meng J , Yao G , Ren C , Yang G . CTBP1 links metabolic syndrome to polycystic ovary syndrome through interruption of aromatase and SREBP1 . Commun Biol . 2024 ; 7 ( 1 ): 1174 . doi: 10.1038/s42003-024-06857-4 OpenUrl CrossRef PubMed 1107. ↵ Siddamalla S , Reddy TV , Govatati S , Guruvaiah P , Deenadayal M , Shivaji S , Bhanoori M . Influence of tumour suppressor gene (TP53, BRCA1 and BRCA2) polymorphisms on polycystic ovary syndrome in South Indian women . Eur J Obstet Gynecol Reprod Biol. 2018 ; 227 : 13 - 18 . doi: 10.1016/j.ejogrb.2018.05.027 OpenUrl CrossRef PubMed 1108. ↵ Petta TB , Carlson J . Exploring Molecular Drivers of PARPi Resistance in BRCA1-Deficient Ovarian Cancer: The Role of LY6E and Immunomodulation . Int J Mol Sci . 2024 ; 25 ( 19 ): 10427 . doi: 10.3390/ijms251910427 OpenUrl CrossRef PubMed 1109. ↵ Légaré C , Desgagné V , Thibeault K , White F , Clément AA , Poirier C , Luo ZC , Scott MS , Jacques PÉ , Perron P , et al. First Trimester Plasma MicroRNA Levels Predict Risk of Developing Gestational Diabetes Mellitus . Front Endocrinol (Lausanne) . 2022 ; 13 : 928508 . doi: 10.3389/fendo.2022.928508 OpenUrl CrossRef 1110. ↵ Han N , Chang XY , Yuan ZL , Wang YZ . Expression and correlation analysis of silent information regulator 1 (SIRT1), sterol regulatory element-binding protein-1 (SREBP1), and pyroptosis factor in gestational diabetes mellitus . J Matern Fetal Neonatal Med . 2024 ; 37 ( 1 ): 2311809 . doi: 10.1080/14767058.2024.2311809 OpenUrl CrossRef PubMed 1111. ↵ Yu SL , Jeong DU , Noh EJ , Jeon HJ , Lee DC , Kang M , Kim TH , Lee SK , Han AR , Kang J , et al. Exosomal miR-205-5p Improves Endometrial Receptivity by Upregulating E-Cadherin Expression through ZEB1 Inhibition . Int J Mol Sci . 2023 ; 24 ( 20 ): 15149 . doi: 10.3390/ijms242015149 OpenUrl CrossRef PubMed 1112. ↵ Tapia A , Vilos C , Marín JC , Croxatto HB , Devoto L . Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity . Reprod Biol Endocrinol . 2011 ; 9 : 14 . doi: 10.1186/1477-7827-9-14 OpenUrl CrossRef PubMed 1113. ↵ Pan S , Long S , Cai L , Wen J , Lin W , Chen G . Identification and in vivo functional analysis of a novel missense mutation in GATA3 causing hypoparathyroidism, sensorineural deafness and renal dysplasia syndrome in a Chinese family . Endocrine . 2024 . doi: 10.1007/s12020-024-04087-6 OpenUrl CrossRef 1114. ↵ Charoenngam N , Mannstadt M . Primary Hyperparathyroidism in a Patient With Bilateral Pheochromocytoma and a Mutation in the Tumor Suppressor MAX . JCEM Case Rep . 2023 ; 1 ( 1 ): luad006 . doi: 10.1210/jcemcr/luad006 OpenUrl CrossRef 1115. ↵ Grigorova M , Staines JM , Ozdag H , Caldas C , Edwards PA . Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1 . Cytogenet Genome Res . 2004 ; 104 ( 1-4 ): 333 - 340 . doi: 10.1159/000077512 OpenUrl CrossRef PubMed View the discussion thread. Back to top Previous Next Posted February 17, 2025. Download PDF Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Bioinformatics analysis of next generation sequencing data reveals novel biomarkers and signaling pathways associated with recurrent implantation failure Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Share Bioinformatics analysis of next generation sequencing data reveals novel biomarkers and signaling pathways associated with recurrent implantation failure Basavaraj Vastrad , Chanabasayya Vastrad bioRxiv 2025.02.13.638207; doi: https://doi.org/10.1101/2025.02.13.638207 Share This Article: Copy Citation Tools Bioinformatics analysis of next generation sequencing data reveals novel biomarkers and signaling pathways associated with recurrent implantation failure Basavaraj Vastrad , Chanabasayya Vastrad bioRxiv 2025.02.13.638207; doi: https://doi.org/10.1101/2025.02.13.638207 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Bioinformatics Subject Areas All Articles Animal Behavior and Cognition (7624) Biochemistry (17651) Bioengineering (13873) Bioinformatics (41887) Biophysics (21424) Cancer Biology (18566) Cell Biology (25465) Clinical Trials (138) Developmental Biology (13365) Ecology (19871) Epidemiology (2067) Evolutionary Biology (24293) Genetics (15591) Genomics (22478) Immunology (17715) Microbiology (40331) Molecular Biology (17150) Neuroscience (88492) Paleontology (666) Pathology (2828) Pharmacology and Toxicology (4817) Physiology (7635) Plant Biology (15114) Scientific Communication and Education (2044) Synthetic Biology (4286) Systems Biology (9817) Zoology (2268)