Estimation of TLR-4 and Cytokines Levels (Interleukin-1 Beta, Interleukin-8, and Tumor Necrosis Factor) in Serum and Peritoneal Fluid of Endometriosis Women

Jinan Abdul-abbas Shamkhi, Ahmed Abbas, Thuraya Hussam Al-Deen
In: Indian Journal of Public Health Research & Development · 2019 · vol. 10(4) , pp. 1666 · doi:10.5958/0976-5506.2019.00954.9 · W2943565585
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study found significantly higher serum and peritoneal fluid concentrations of TLR-4, IL-1β, IL-8, and TNF-α in women with endometriosis compared to controls.

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This 2019 study evaluated serum and peritoneal fluid levels of TLR-4 and the cytokines IL-1β, IL-8, and TNF-α in women with newly diagnosed endometriosis versus controls, using ELISA. The case group included 30 women with endometriosis and the control group included 30 women, recruited from gynecology departments over November 2016 to November 2017. Endometriosis patients had significantly higher concentrations of all four biomarkers in both serum and peritoneal fluid compared with controls. The authors’ main caveat is that the study is cross-sectional and focused on measuring biomarker differences rather than validating a diagnostic method. This paper is centrally about endometriosis — it specifically measures TLR-4 and cytokine levels in serum and peritoneal fluid to evaluate their diagnostic potential.

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Abstract

Many women have a delay in diagnosis of endometriosis; an important factor that contributes to the diagnostic delay is the lack of noninvasive methods for detecting the disease. The aim of this study was to evaluate the levels of IL-1β, IL-8, TNF-α, and TLR-4 in serum and peritoneal fluid (PF) of women with endometriosis. The case group comprised of 30 women with endometriosis who newly diagnosed (admitted to the Gynecology Department of Al-Emamain Al-Kademian Medical City, Al-Zahraa teaching hospital and Al-kut hospital of pediatric and obstetric) and 30 control group during the period from November 2016 to November 2017. The four biomarkers were measured by using ELISA. Endometriosis patients had significantly higher serum and PF concentrations of the four biomarkers compared to controls. These results may indicate the potential role of these biomarkers in non-invasive diagnosis of endometriosis.
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- Year: 2019 - Volume: 10 - Issue: 4 - Author: - Jinan Abdul-abbas Shamkhi1, Ahmed Abdul-hassan Abbas2,, Thuraya Hussam Al-Deen3 - Total Page Count: 7 - Page Number: 1666 to 1672 1 2 3 *Corresponding author: Ahmed Abdul-hassan Abbas, E-mail: [email protected] Many women have a delay in diagnosis of endometriosis; an important factor that contributes to the diagnostic delay is the lack of noninvasive methods for detecting the disease. The aim of this study was to evaluate the levels of IL-1β, IL-8, TNF-α, and TLR-4 in serum and peritoneal fluid (PF) of women with endometriosis. The case group comprised of 30 women with endometriosis who newly diagnosed (admitted to the Gynecology Department of Al-Emamain Al-Kademian Medical City, Al-Zahraa teaching hospital and Al-kut hospital of pediatric and obstetric) and 30 control group during the period from November 2016 to November 2017. The four biomarkers were measured by using ELISA. Endometriosis patients had significantly higher serum and PF concentrations of the four biomarkers compared to controls. These results may indicate the potential role of these biomarkers in non-invasive diagnosis of endometriosis. Endometriosis, Interleukin-1 beta, Tumor necrosis factor, TLR-4

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