Can Low-High-Density Lipoprotein Be a New Ri̇sk Factor for Multisystemic Inflammatory Syndrome in Children?

Can Low-High-Density Lipoprotein Be a New Ri̇sk Factor for Multisystemic Inflammatory Syndrome in Children? | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Can Low-High-Density Lipoprotein Be a New Ri̇sk Factor for Multisystemic Inflammatory Syndrome in Children? Muharrem Bostancı, Eren Cagan This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2436481/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objectives: Increasing acute phase reactants due to inflammation or infection cause some changes in lipid and lipoprotein metabolism. High-density lipoprotein(HDL) is part of the innate immune system that fights pathogens entering the body. Therefore, we think HDL has prognostic value in multisystemic inflammatory syndrome associated with Coronavirus (MIS-C) as in Kawasaki disease and other diseases. Study Design: We followed the 51 patients diagnosed with MİSS-C. We divided the patient into two groups according to cardiac involvement, and we compared the laboratory values of the patients. Results: Of these 51 patients, 65% (33) were male, and 35% (18) were female. We performed the echocardiographic examination on all patients, 69% (35) of the patients had cardiac pathology, and 31%(16) patients had no cardiac involvement. When comparing the patients' cholesterol levels according to cardiac involvement, the triglyceride value was higher in patients with the cardiac involvement group. The median triglyceride values of patients with cardiac participation were 192.6 mg/dl, and those without cardiac involvement were 134.2 mg/dl. (p=0.028) (IQR 119.4 – 122.9). And also, the HDL value was lower in patients with cardiac involvement. We found that the median HDL values of the patients with cardiac participation were 13.65mg/dl, and the median HDL values of the patients without cardiac involvement were 21.8mg/dl(p=0.003)(IQR 6 - 31) Conclusion: We found that not only high leukocyte and CRP values were associated with the severity of the disease, but also low HDL and high triglyceride values were associated with cardiac involvement. Coronavirus MİS-C serum cholesterols cardiac involvement HDL Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2436481","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":164504748,"identity":"6763a759-0205-4986-9ed2-16c8efc20f6a","order_by":0,"name":"Muharrem Bostancı","email":"data:image/png;base64,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","orcid":"","institution":"University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Muharrem","middleName":"","lastName":"Bostancı","suffix":""},{"id":164504750,"identity":"5e895a18-dd07-4f12-83f1-f8753c66ec93","order_by":1,"name":"Eren Cagan","email":"","orcid":"","institution":"University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Eren","middleName":"","lastName":"Cagan","suffix":""}],"badges":[],"createdAt":"2023-01-02 17:29:19","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-2436481/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-2436481/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":31199208,"identity":"3bd3b6ba-7a5c-48f3-bab2-0dc92f8ec750","added_by":"auto","created_at":"2023-01-06 06:03:41","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":296888,"visible":true,"origin":"","legend":"","description":"","filename":"mainmanuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-2436481/v1_covered.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eCan Low-High-Density Lipoprotein Be a New Ri̇sk Factor for Multisystemic Inflammatory Syndrome in Children?\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Coronavirus, MİS-C, serum cholesterols, cardiac involvement, HDL","lastPublishedDoi":"10.21203/rs.3.rs-2436481/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-2436481/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eObjectives: Increasing acute phase reactants due to inflammation or infection cause some changes in lipid and lipoprotein metabolism. High-density lipoprotein(HDL) is part of the innate immune system that fights pathogens entering the body. Therefore, we think HDL has prognostic value in multisystemic inflammatory syndrome associated with Coronavirus (MIS-C) as in Kawasaki disease and other diseases.\u003c/p\u003e\n\u003cp\u003eStudy Design: We followed the 51 patients diagnosed with MİSS-C. We divided the patient into two groups according to cardiac involvement, and we compared the laboratory values of the patients.\u003c/p\u003e\n\u003cp\u003eResults: Of these 51 patients, 65% (33) were male, and 35% (18) were female. We performed the echocardiographic examination on all patients, 69% (35) of the patients had cardiac pathology, and 31%(16) patients had no cardiac involvement. When comparing the patients' cholesterol levels according to cardiac involvement, the triglyceride value was higher in patients with the cardiac involvement group. The median triglyceride values of patients with cardiac participation were 192.6 mg/dl, and those without cardiac involvement were 134.2 mg/dl. (p=0.028) (IQR 119.4 – 122.9). And also, the HDL value was lower in patients with cardiac involvement. We found that the median HDL values of the patients with cardiac participation were 13.65mg/dl, and the median HDL values of the patients without cardiac involvement were 21.8mg/dl(p=0.003)(IQR 6 - 31)\u003c/p\u003e\n\u003cp\u003eConclusion: We found that not only high leukocyte and CRP values were associated with the severity of the disease, but also low HDL and high triglyceride values were associated with cardiac involvement.\u003c/p\u003e","manuscriptTitle":"Can Low-High-Density Lipoprotein Be a New Ri̇sk Factor for Multisystemic Inflammatory Syndrome in Children?","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2023-01-06 06:03:31","doi":"10.21203/rs.3.rs-2436481/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"13c5f689-053b-485e-8b76-e4748ba1fce7","owner":[],"postedDate":"January 6th, 2023","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-01-23T04:29:18+00:00","versionOfRecord":[],"versionCreatedAt":"2023-01-06 06:03:31","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-2436481","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-2436481","identity":"rs-2436481","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}