not-yet-known not-yet-known not-yet-known unknown Understanding Cueing Strategies for Gait Impairments in Parkinson’s Disease: study protocol of the international UNITE-PD study

not-yet-known not-yet-known not-yet-known unknown Understanding Cueing Strategies for Gait Impairments in Parkinson’s Disease: study protocol of the international UNITE-PD study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 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Data may be preliminary. 22 September 2025 V1 Latest version Share on not-yet-known not-yet-known not-yet-known unknown Understanding Cueing Strategies for Gait Impairments in Parkinson’s Disease: study protocol of the international UNITE-PD study Authors : Cindel Albers 0000-0003-0070-2785 [email protected] , Anat Mirelman , Laura Avanzino 0000-0001-6286-1509 , Bastiaan Bloem , Alessandro Botta , Joris van der Cruijsen , Elsa de Lange , … Show All … , Inbal Maidan , Alice Nieuwboer , Elisa Pelosin , Anouk Tosserams , Vivian Weerdesteyn , Moran Gilat , and Jorik Nonnekes Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.175857515.54538351/v1 308 views 238 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract not-yet-known not-yet-known not-yet-known unknown Background: Gait impairments impact independence and quality of life of persons with Parkinson’s disease(PD). The application of external and internal cueing strategies can improve gait but not every person benefits equally from the same strategy. It remains unclear i) which patient characteristics mediate cueing efficacy, ii) how cueing efficacy changes over time, iii) which patient characteristics are associated with long-term compliance and iv) what the neural correlates of cueing are. Methods: The UNITE-PD study is a collaboration between the Radboud University Medical Center(NLD), KU Leuven(BEL), Tel Aviv Sourasky Medical Center(ISR) and IRCCS Policlinico San Martino(ITA). The study consists of a joint prospective cohort project and four site-specific projects. We here describe the joint project, with the site-specific projects included as supplementary materials. All participants undergo a baseline assessment, consisting of extensive clinical testing and an objective gait assessment with and without external and internal cueing. Responders and non-responders to the strategy will be followed for six months. Responders will be instructed to apply the effective cueing strategies, as much as possible in daily life using a mobile cueing application which tracks compliance. At six months post-baseline, responders and non-responders return to the lab, during which the baseline protocol will be repeated to quantify the change in efficacy of the cueing strategies over time. Discussion: The UNITE-PD study will identify the relationship between patient characteristics, cueing efficacy, compliance and the underlying mechanisms of cueing. This knowledge will help refining personalized rehabilitation and identifies new avenues for neuroscientific inquiry in this domain. Supplementary Material File (protocolpaperunitepd.pdf) Download 651.52 KB Information & Authors Information Version history V1 Version 1 22 September 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection European Journal of Neuroscience Authors Affiliations Cindel Albers 0000-0003-0070-2785 [email protected] Radboudumc View all articles by this author Anat Mirelman Tel Aviv Sourasky Medical Center View all articles by this author Laura Avanzino 0000-0001-6286-1509 University of Genoa View all articles by this author Bastiaan Bloem Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre View all articles by this author Alessandro Botta IRCCS Ospedale Policlinico San Martino View all articles by this author Joris van der Cruijsen Radboudumc View all articles by this author Elsa de Lange KU Leuven View all articles by this author Inbal Maidan Tel Aviv Sourasky Medical Center View all articles by this author Alice Nieuwboer KU Leuven Biomedical Sciences Group View all articles by this author Elisa Pelosin IRCCS Ospedale Policlinico San Martino View all articles by this author Anouk Tosserams Radboudumc View all articles by this author Vivian Weerdesteyn Radboudumc View all articles by this author Moran Gilat KU Leuven View all articles by this author Jorik Nonnekes Radboudumc View all articles by this author Metrics & Citations Metrics Article Usage 308 views 238 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Cindel Albers, Anat Mirelman, Laura Avanzino, et al. not-yet-known not-yet-known not-yet-known unknown Understanding Cueing Strategies for Gait Impairments in Parkinson’s Disease: study protocol of the international UNITE-PD study. Authorea . 22 September 2025. DOI: https://doi.org/10.22541/au.175857515.54538351/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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