An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: protocol

An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: protocol | medRxiv /* */ /* */ <!-- <!-- /*! * yepnope1.5.4 * (c) WTFPL, GPLv2 */ (function(a,b,c){function d(a){return"[object Function]"==o.call(a)}function e(a){return"string"==typeof a}function f(){}function g(a){return!a||"loaded"==a||"complete"==a||"uninitialized"==a}function h(){var a=p.shift();q=1,a?a.t?m(function(){("c"==a.t?B.injectCss:B.injectJs)(a.s,0,a.a,a.x,a.e,1)},0):(a(),h()):q=0}function i(a,c,d,e,f,i,j){function k(b){if(!o&&g(l.readyState)&&(u.r=o=1,!q&&h(),l.onload=l.onreadystatechange=null,b)){"img"!=a&&m(function(){t.removeChild(l)},50);for(var d in y[c])y[c].hasOwnProperty(d)&&y[c][d].onload()}}var j=j||B.errorTimeout,l=b.createElement(a),o=0,r=0,u={t:d,s:c,e:f,a:i,x:j};1===y[c]&&(r=1,y[c]=[]),"object"==a?l.data=c:(l.src=c,l.type=a),l.width=l.height="0",l.onerror=l.onload=l.onreadystatechange=function(){k.call(this,r)},p.splice(e,0,u),"img"!=a&&(r||2===y[c]?(t.insertBefore(l,s?null:n),m(k,j)):y[c].push(l))}function j(a,b,c,d,f){return q=0,b=b||"j",e(a)?i("c"==b?v:u,a,b,this.i++,c,d,f):(p.splice(this.i++,0,a),1==p.length&&h()),this}function k(){var a=B;return a.loader={load:j,i:0},a}var l=b.documentElement,m=a.setTimeout,n=b.getElementsByTagName("script")[0],o={}.toString,p=[],q=0,r="MozAppearance"in l.style,s=r&&!!b.createRange().compareNode,t=s?l:n.parentNode,l=a.opera&&"[object Opera]"==o.call(a.opera),l=!!b.attachEvent&&!l,u=r?"object":l?"script":"img",v=l?"script":u,w=Array.isArray||function(a){return"[object Array]"==o.call(a)},x=[],y={},z={timeout:function(a,b){return b.length&&(a.timeout=b[0]),a}},A,B;B=function(a){function b(a){var a=a.split("!"),b=x.length,c=a.pop(),d=a.length,c={url:c,origUrl:c,prefixes:a},e,f,g;for(f=0;f<d;f++)g=a[f].split("="),(e=z[g.shift()])&&(c=e(c,g));for(f=0;f<b;f++)c=x[f](c);return c}function g(a,e,f,g,h){var i=b(a),j=i.autoCallback;i.url.split(".").pop().split("?").shift(),i.bypass||(e&&(e=d(e)?e:e[a]||e[g]||e[a.split("/").pop().split("?")[0]]),i.instead?i.instead(a,e,f,g,h):(y[i.url]?i.noexec=!0:y[i.url]=1,f.load(i.url,i.forceCSS||!i.forceJS&&"css"==i.url.split(".").pop().split("?").shift()?"c":c,i.noexec,i.attrs,i.timeout),(d(e)||d(j))&&f.load(function(){k(),e&&e(i.origUrl,h,g),j&&j(i.origUrl,h,g),y[i.url]=2})))}function h(a,b){function c(a,c){if(a){if(e(a))c||(j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}),g(a,j,b,0,h);else if(Object(a)===a)for(n in m=function(){var b=0,c;for(c in a)a.hasOwnProperty(c)&&b++;return b}(),a)a.hasOwnProperty(n)&&(!c&&!--m&&(d(j)?j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}:j[n]=function(a){return function(){var b=[].slice.call(arguments);a&&a.apply(this,b),l()}}(k[n])),g(a[n],j,b,n,h))}else!c&&l()}var h=!!a.test,i=a.load||a.both,j=a.callback||f,k=j,l=a.complete||f,m,n;c(h?a.yep:a.nope,!!i),i&&c(i)}var i,j,l=this.yepnope.loader;if(e(a))g(a,0,l,0);else if(w(a))for(i=0;i (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0];var j=d.createElement(s);var dl=l!='dataLayer'?'&l='+l:'';j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;j.type='text/javascript';j.async=true;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-P4HH5NV'); Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: protocol View ORCID Profile Gashirai K. Mbizvo , Glen P. Martin , Matthew Sperrin , Laura J. Bonnett , Pieta Schofield , View ORCID Profile Iain Buchan , View ORCID Profile Gregory Y.H. Lip , Anthony G. Marson doi: https://doi.org/10.1101/2024.06.16.24308993 Gashirai K. Mbizvo 1 Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital , Liverpool, United Kingdom 2 Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool, United Kingdom 3 The Walton Centre NHS Foundation Trust , Liverpool, United Kingdom Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Gashirai K. Mbizvo For correspondence: Gashirai.Mbizvo{at}liverpool.ac.uk Glen P. Martin 4 Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester, United Kingdom Find this author on Google Scholar Find this author on PubMed Search for this author on this site Matthew Sperrin 4 Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester, United Kingdom Find this author on Google Scholar Find this author on PubMed Search for this author on this site Laura J. Bonnett 5 University of Liverpool Department of Biostatistics , Liverpool, United Kingdom Find this author on Google Scholar Find this author on PubMed Search for this author on this site Pieta Schofield 6 Department of Public Health, Policy and Systems, Institute of Population Health, University of Liverpool , Liverpool, United Kingdom Find this author on Google Scholar Find this author on PubMed Search for this author on this site Iain Buchan 6 Department of Public Health, Policy and Systems, Institute of Population Health, University of Liverpool , Liverpool, United Kingdom Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Iain Buchan Gregory Y.H. Lip 1 Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital , Liverpool, United Kingdom 7 Danish Centre for Health Services Research, Department of Clinical Medicine, Aalborg University , Aalborg, Denmark Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Gregory Y.H. Lip Anthony G. Marson 2 Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool, United Kingdom 3 The Walton Centre NHS Foundation Trust , Liverpool, United Kingdom Find this author on Google Scholar Find this author on PubMed Search for this author on this site Abstract Full Text Info/History Metrics Data/Code Preview PDF Abstract Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence extended this risk to men’s offspring, prompting recommendations to restrict use in everybody aged <55 years. This study will evaluate mortality and morbidity risks associated with valproate withdrawal by emulating a hypothetical randomised-controlled trial (called a “target trial”) using retrospective observational data. The data will be drawn from ∼250m mainly US patients in the TriNetX repository and ∼60m UK patients in Clinical Practice Research Datalink (CPRD). These will be scanned for individuals aged 16–54 years with epilepsy and on valproate who either continued, switched to lamotrigine or levetiracetam, or discontinued valproate between 2015–2018, creating four groups. Randomisation to these groups will be emulated by baseline confounder adjustment using g-methods. Mortality and morbidity outcomes will be assessed and compared between groups over five years, employing time-to-first-event and recurrent events analyses. A causal prediction model will be developed from these data to aid in predicting the safest alternative antiseizure medications. Together, these findings will optimise informed decision-making about valproate withdrawal and alternative treatment selection, providing immediate and vital information for patients, clinicians and regulators. Background Epilepsy impacts 70 million people worldwide. 1 Valproate is one of the most effective drugs for treating epilepsy, outperforming any other in idiopathic generalised epilepsy, which affects a third of people with epilepsy (PWE). 2 , 3 It was the most prescribed antiseizure medication (ASM) globally in the early 2000s. 4 However, widespread evidence demonstrating foetal congenital malformations (11%) and neurodevelopmental disorders (30–40%) associated with prenatal valproate exposure led to guidance changes between 2015–2018. 5 These prohibited valproate prescribing in women of childbearing potential unless other ASMs had failed, subsequently halving prescriptions in women. 4 , 5 Valproate remains the first-line ASM for men with newly diagnosed generalised epilepsy in most countries. 2 , 3 In the UK, regulators recently considered valproate’s known risks of impaired male fertility, emerging pre-clinical evidence of transgenerational risks with prenatal exposure, and animal studies suggesting adverse effects on testes. 5 , 6 In response, they announced a phased implementation (from January 2024) of recommendations restricting valproate prescribing for both men and women aged <55 years unless other ASMs have failed. 5 , 6 Similar restrictions are being considered in other countries. 7 - 9 Together, they are likely to result in withdrawal of valproate from a substantial number of men already taking it, as has been the case for women. 4 , 5 To support informed and safe decision-making, 10 it is vital to provide these young men and women and their clinicians with comprehensive information on the safety of valproate withdrawal. Whether there are any potential risks of personal harm or morbidity (including hospital admissions, injuries, or death) associated with valproate withdrawal has not yet been quantified for either men or women on valproate. 10 - 17 Existing studies have focused on the group of PWE in remission from seizures for ≥2 years, usually showing seizure relapse in generalised epilepsy. They have tended to be single-centre or small, looking at seizures alone or assessing women alone. 11 - 17 A valproate decision support tool is available from NHS England for patients and clinicians ( www.t.ly/NFi5m ), designed by our centre. 10 Figures for the risks of teratogenicity on valproate are provided on page 4 of the tool as 8–37 per 100 babies. 10 However, on the same page, the “risks to you” section from withdrawing from valproate and switching to another ASM remains devoid of any figures, 10 illustrating the insufficiency of current evidence to address this question. The rise of digital care records has transformed treatment evidence generation by enabling both immediate and extensive analysis of national and international cohorts. 18 This approach overcomes limitations in sample size, cost, and time associated with completing prospective studies while also facilitating exploration of previously unexamined patient outcomes. TriNetX, 19 the world’s largest real-world electronic health data platform, harbours 70 billion date- and patient-indexed electronic clinical observations from ∼250m patients across 19 countries, predominantly in America but also Europe, Middle East, Africa, and Asia. 18 , 19 We recently published a study of 8,991 men and 5,243 women aged 16–54 with epilepsy taking valproate in TriNetX. This was a survival analysis assessing 5-year mortality and morbidity in those withdrawn from valproate between 01/06/2015–01/06/2018 (regardless of whether switched to another ASM), with propensity-matched comparisons to those who remained on valproate. Results suggested substantially increased risks of emergency department (ED) attendances, hospital admissions, falls, injuries, burns and new-onset depression in both men and women withdrawn from valproate. 20 However, these were aggregate data designed to scope potential trends and generate hypotheses, not to probe causal links. To progress the field, we propose a comprehensive study examining mortality and morbidity outcomes in individuals who either continued valproate, switched to lamotrigine or levetiracetam, or discontinued valproate. Employing a novel approach known as target trial emulation, 21 , 22 this study will replicate a hypothetical randomised-controlled trial (RCT) using person-level retrospective observational data from both TriNetX and Clinical Practice Research Datalink (CPRD, which encompasses 60m UK patients). 23 Target trial emulation minimises confounder and selection biases in observational studies by statistically emulating randomisation at baseline (time 0). 21 Individuals are then analysed based on the treatment strategy aligned with their data. Results are available quickly and shown to mirror those of an RCT. 21 This offers a cost-effective and immediate alternative to conducting an RCT; 21 crucial given the urgency for information on valproate withdrawal safety amidst ongoing regulatory changes. 24 , 25 Additionally, the emulation facilitates creation of causal prediction models. 26 These are developed using observed data alongside causal theory and assumptions to calculate predicted risk under different hypothetical treatment conditions, allowing “what if” questions to be addressed for each potential (counterfactual) outcome. 26 This facilitates actionable prevention. 26 Aims Identify whether there are any differences in mortality or morbidity outcomes between remaining on valproate compared with valproate withdrawal and switch to lamotrigine, levetiracetam, or no new ASM. Develop and validate a causal prediction model that clinicians and patients could use when planning to withdraw from valproate to predict which of these alternative ASMs would have the lowest mortality and morbidity, taking baseline clinical and demographic characteristics into account. Hypotheses Some morbidity or mortality outcomes will be increased when valproate is withdrawn, regardless of whether switched to lamotrigine, levetiracetam, or no new ASM; The causal prediction model developed will be able to predict which alternative ASMs are safest. Benefits to PWE This study will benefit PWE as substantial numbers of young men and women may soon be invited by their clinicians to come off valproate owing to both current and new regulatory changes. 5 , 6 Whilst this is justified in terms of preventing teratogenic harm, the patients will wish to know what the risks of withdrawing from valproate are for their own health. 24 , 25 This study will provide immediate evidence to help doctors answer that question. 10 It will also help patients make safer decisions over switching to alternative ASMs by generating the first ever causal prediction tool for this purpose. 26 This will be the largest study of valproate withdrawal to date, the first to assess risks in men and first to assess multiple outcomes beyond seizures alone for both men and women. 11 - 17 These outcomes will be collaboratively chosen with PWE through public engagement strategies, ensuring their relevance and impact on those most affected. Finally, mortality prediction is highlighted as a key recommendation for epilepsy research by NICE, 27 meaning the causal prediction model generated by this study also addresses an established research need for PWE. Methods Public involvement This study protocol (including outcome selection) was co-developed with a members of the public with lived experience of epilepsy, caring for a person with epilepsy, or taking valproate. Addressing Aim 1: target trial emulation Target trial design A hypothetical target trial will be emulated in which young men and women taking valproate would be randomised to either continue valproate, switch to lamotrigine or levetiracetam, or discontinue valproate. 21 The following mortality and morbidity outcomes would be assessed over the subsequent five years: – Deaths (all-cause/epilepsy-related); – ED/hospital admissions (all-cause/epilepsy-related); – Seizures (symptom codes); – Falls; – Injuries; – Burns; – Aspiration pneumonia; – Manic/bipolar episodes; – New-onset depression; – Self-harm/suicide; – A composite morbidity index incorporating seizures, injuries, admissions, depression. Intention-to-treat (ITT) and per-protocol effects would be assessed between groups. 21 Analysis would take a time-to-first-event approach (Cox-proportional hazards model) for deaths, new-onset depression and composite morbidity. A recurrent events approach (e.g., Prentice-Williams-Peterson Total Time Model) would be taken for the remaining outcomes. Target trial emulation using observational data from TriNetX and CPRD Eligibility criteria Anonymised, person-level, electronic health data will be extracted from TriNetX and CPRD, linked across primary care, ED, inpatients, outpatients, and mortality subsets. Included will be men and women aged 16–54 years with ≥1 epilepsy disease or symptom code between 01/06/2015–01/06/2018 and ≥1 valproate prescription instance within the preceding 6 months and 6–12 months before the first epilepsy disease or symptom code to appear between 01/06/2015–01/06/2018. TriNetX and CPRD use ICD-10-CM and SNOMED codes, respectively. The coding strategy combining disease and symptom codes with valproate, as used our published study successfully, 20 was shown to accurately identify epilepsy cases in our prior work. 28 , 29 Treatment armsxs Withdrawn valproate and commenced lamotrigine Withdrawn valproate and commenced levetiracetam Withdrawn valproate and no new ASM commenced Continues valproate Treatment assignment Baseline (time 0) will be defined as when valproate dose reduction commences (treatment arms 1–3) or prescription of valproate at a matched time (arm 4). Eligible individuals are assigned at baseline to the treatment strategy that their data are consistent with. 21 To emulate randomisation, adjustment is made for baseline confounders using Robins’ generalised methods (g-methods, e.g., inverse probability weighting), 21 considering age, sex, ethnicity, deprivation, type of epilepsy (using G40 codes), baseline seizure frequency (symptom codes recorded over preceding 12 months), alcohol excess, developmental delay, Cambridge Multimorbidity Score, length of valproate treatment, valproate dose, and ASMs used other than valproate. The final set of covariates required to adjust for confounding will be chosen using a causal directed acyclic graph. 21 Outcomes These are listed in the target trial design section and derived from our prior work, 1 , 20 , 30 , 31 and public consultation. All coded events will be recorded for flexible categorical or continuous analyses, as needed. Causal estimand Assesses impact of treatment arms 1–3 vs. 4 on outcome (per-protocol assumption as observational data limits ITT assessment). 21 Start and end of follow-up Beginning at baseline (time 0), as defined above, and followed-up till outcome, censoring (including deviation from assigned treatment), or five years. Statistical analysis mirrors target trial section. Addressing Aim 2: causal prediction modelling A causal prediction model will be created using Cox-proportional hazards of time-to-first-event in a causal framework. 26 The predicted outcome will be a composite personal harms risk combining epilepsy-related deaths, seizures, injuries, admissions, and depression. Predictors for definite inclusion in the final model will be treatment arms 1–4. Candidate predictors considered in addition will be taken from the list of baseline confounders adjusted in the target trial emulation, alongside any additional variables considered to influence outcome but not treatment assignment. A priori clinical expertise and data-driven variable selection will refine the predictor variable list for modelling. 30 Penalisation methods (e.g., lasso ), will be used to combine variable selection with shrinkage (reducing overfitting risks). The model will be developed in TriNetX to help ensure it is internationally generalisable. 32 External validation will be undertaken in CPRD, facilitating subsequent clinical implementation. 32 Internal validation within TriNetX will involve 1,000 bootstrap analysis samples. Nagelkerke’s R 2 and Brier Scores will estimate overall model performance. Calibration will be estimated with calibration-in-the-large, calibration slope, and flexible calibration plots, and discrimination with C-index. Calibration and discrimination will be reassessed within CRPD to externally validate model performance. 32 Counterfactual prediction will be embedded into the model development, 26 allowing patients and clinicians to answer clinically meaningful questions such as “at the point of proposed valproate withdrawal, accounting for baseline characteristics, what is the risk of epilepsy-related death or composite morbidity for levetiracetam? And what is it for lamotrigine?” Sample size calculation See table 1 . View this table: View inline View popup Download powerpoint Table 1: Sample size calculation Contingency planning Studying both TriNetX and CPRD allows external cross-validation of findings between the two databases, enhancing generalisability whilst providing a contingency study cohort should one dataset encounter limitations. Pathways to impact The study will be published open-access in peer-reviewed journals and shared with regulators, charities, and PWE. Following our guide, 34 we will explore various presentation formats for the externally validated prediction model including points-based systems, graphical score charts, and nomograms, as informed by PWE at public engagement workshops and clinicians at scientific conferences. An interactive version of the final causal prediction model will be deposited online in a public repository (as was did for the mortality prediction tool we developed previously: https://seds-tool.github.io/seds ), making it globally accessible. We did similar with the CHA2DS2-VASc score we created and deposited on MDCalc.com ( www.t.ly/poRmb ): now the most widely incorporated prediction tool for stroke prevention in atrial fibrillation globally, embedded in NICE guidelines ( www.t.ly/d0d3W ). We will also add the model to the Civic Data Cooperative ( https://civicdatacooperative.com/about ) Digital Commons ( https://github.com/civicdatacoop ) to facilitate integration into health system core infrastructure. Colleagues at our centre who created NHS England’s valproate decision support tool ( www.t.ly/NFi5m ) are in support of figures generated in addressing Aim 1 being added to the medication change “risks to you” section on page 4, alongside including a link to the online version of the causal prediction model generated in addressing Aim 2. 10 Ethics and dissemination The University of Liverpool Research Ethics Committee has provided formal ethics review exemption for this study as it does not involve human participants, human tissue or personal data (REC Ref. 14455). Dissemination is outlined in the pathways to impact section. Data management plan Data will be curated through University of Liverpool’s (UoL) Active Data Storage -a centralised, secure, supported data storage facility with multiple layers of protection. Data are replicated between two secure physical locations and backed up regularly. A regular tape backup is made to a third physical location, and segregated from the public network both physically and logically. Data are encrypted in transit using SSL. We will use a public repository ( www.github.com ) to make all diagnostic and outcome coding algorithms, metadata, and R analysis scripts used publicly available, facilitating external replication and adaptation. All data storage and use will comply with legal obligations (including GDPR) and UoL’s Research Data Management Policy. Study status and timeline Funding has been received from the Epilepsy Research Institute and the Academy of Medical Sciences to proceed with this study. Permissions to access study data are being sought and PhD students to help complete the study are being recruited. We plan to complete the study within 36 months of protocol submission/publication.. Data Availability No datasets were generated or analysed during the current study. All relevant data from this study will be made available upon study completion. Funding statement This study is funded by an Academy of Medical Sciences (AMS) Starter Grant for Clinical Lecturers (REF: SGL030\1029), and an Epilepsy Research Institute Emerging Leader Fellowship (F2401) awarded to G.KM. G.K.M. is also supported by a National Institute for Health and Care Research (NIHR) Clinical Lectureship (CL-2022-07-002). AGM is supported by the NIHR Applied Research Collaboration North West Coast (ARC NWC). The funders had no role in the study design, data collection, analysis and interpretation, or writing of this manuscript. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR, AMS, the Epilepsy Research Institute, or the Department of Health and Social Care. Competing interests statement A.G.M. declares i) a UCB Pharma grant paid to University of Liverpool for the National Audit of Seizure Management in Hospitals (NASH) study, which is unrelated to the submitted work; ii) an Angelini grant to be paid to University of Liverpool as co-applicant for A multi-method PRoject to maximise efficient and equitable pathways tO suPport from a rEgional epiLepsy centre (PROPEL), which is unrelated to the submitted work; iii) Honoraria paid to University of Liverpool for lectures unrelated to the submitted work given at educational events sponsored by Sanofi, Eiasi, and GSK; iii) Support from Angelini for attendance unrelated to the submitted work at the 2024 International League Against Epilepsy (ILAE) congress. G.K.M declares an Angelini grant to be paid to University of Liverpool as co-applicant on the PROPEL study, which is unrelated to the submitted work; ii) Honoraria to be paid to University of Liverpool for delivering a lecture at an educational event sponsored by Angelini which was unrelated to the submitted work. The remaining authors declare no competing interests. Acknowledgements We thank our Public Advisors (including Sean Barnes and Steph Tomlinson) for support with this study, and NIHR Applied Research Collaboration North West Coast for providing access to Public Advisors. Footnotes ↵ ¶ Joint senior authors References 1. ↵ Mbizvo GK , Bennett K , Simpson CR , Duncan SE , Chin RFM . Epilepsy-related and other causes of mortality in people with epilepsy: A systematic review of systematic reviews . Epilepsy Res . Aug 27 2019 ; 157 : 106192 . doi: 10.1016/j.eplepsyres.2019.106192 OpenUrl CrossRef PubMed 2. ↵ Marson A , Burnside G , Appleton R , et al. The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial . Lancet . Apr 10 2021 ; 397 ( 10282 ): 1375 – 1386 . doi: 10.1016/S0140-6736(21)00246-4 OpenUrl CrossRef PubMed 3. ↵ Marson AG , Al-Kharusi AM , Alwaidh M , et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial . Lancet . Mar 24 2007 ; 369 ( 9566 ): 1016 – 26 . doi: 10.1016/S0140-6736(07)60461-9 OpenUrl CrossRef PubMed Web of Science 4. ↵ Thomas RH . Valproate: life-saving, life-changing . Clin Med (Lond) . Apr 1 2018 ; 18 ( Suppl 2 ): s1 – s8 . doi: 10.7861/clinmedicine.18-2-s1 OpenUrl Abstract / FREE Full Text 5. ↵ Medicines and Healthcare products Regulatory Agency . Valproate: reminder of current Pregnancy Prevention Programme requirements; information on new safety measures to be introduced in the coming months 2022 . Accessed 17/06/2023 . https://tinyurl.com/z8v8bb8e 6. ↵ Medicines and Healthcare products Regulatory Agency . National Patient Safety Alert: Valproate: organisations to prepare for new regulatory measures for oversight of prescribing to new patients and existing female patients (NatPSA/2023/013/MHRA) . 2023 . Accessed 07/12/2023 . https://tinyurl.com/55j6cu8b 7. ↵ Health Sciences Authority . Epilim® (Valproate) - Risk of neurodevelopmental disorders including autism spectrum disorders in children after paternal exposure . 2023 . Accessed 08/08/2023 . https://tinyurl.com/4xyp2hdd 8. New Zealand Medicines and Medical Devices Authority . Sodium valproate (Epilim) use in people who can father children: important new safety information . 2023 . Accessed 08/08/2023 . https://www.medsafe.govt.nz/safety/Alerts/Sodium_valproate_Epilim_use_in_people_who_can_father_children.asp 9. ↵ Swanborough N. Sanofi reports issues around safety study into valproate . 2023 . Accessed 08/08/2023 . https://epilepsysociety.org.uk/news/valproate-safety-study-concerns 10. ↵ The Walton Centre . Decision support tool: is valproate the right epilepsy treatment for me? 2023 . Accessed 07/12/2023 . https://www.england.nhs.uk/wp-content/uploads/2023/05/decision-support-tool-valproate-epilepsy-v1.1.pdf 11. ↵ Atalar AC , Sirin NG , Bebek N , Baykan B. Predictors of successful valproate withdrawal in women with epilepsy . Epilepsy Behav . Jun 2021 ; 119 : 107980 . doi: 10.1016/j.yebeh.2021.107980 OpenUrl CrossRef 12. Angus-Leppan H , Moghim MM , Cock H , Kinton L , Synnott Wells M , Shankar R. Valproate risk form-Surveying 215 clinicians involving 4775 encounters . Acta Neurol Scand . 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