Long-term Cannabinoid Therapy can ameliorate Sleep Deprivation-Induced Behavioral and Neuroinflammatory Changes in Mice

Long-term Cannabinoid Therapy can ameliorate Sleep Deprivation-Induced Behavioral and Neuroinflammatory Changes in Mice | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 12 March 2025 V1 Latest version Share on Long-term Cannabinoid Therapy can ameliorate Sleep Deprivation-Induced Behavioral and Neuroinflammatory Changes in Mice Authors : Nasar Ullah Khan Niazi 0000-0003-3330-8581 [email protected] and Rabia Parveen Authors Info & Affiliations https://doi.org/10.22541/au.174178836.60427337/v1 Published Neuroscience Letters Version of record Peer review timeline 240 views 153 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Endocannabinoid system is an important contributor to body’s immune responses which are significantly impaired by sleep deprivation (SD). Although cannabinoids can modulate the endocannabinoid system, but most are understudied, especially regarding SD. To investigate the therapeutic potential of CBD, CBG, CBC and their combinations, current study analyzed SD-induced memory impairment, depression, glial responses, and cytokine expression and therapeutic effects of cannabinoid treatments. The results showed that memory impairment and depression were more evident in SD groups. Moreover, microglial activation and proinflammatory polarization was also more evident and was supported by increased proinflammatory cytokine concentrations in SD groups. These changes were significantly reversed the cannabinoid groups but the combination of CBD+CBC was more effective than other treatments in revering these SD-induced behavioral and neuro-inflammatory changes. Supplementary Material File (v1_short report-09-03-2025.docx) Download 1.34 MB Information & Authors Information Version history V1 Version 1 12 March 2025 Peer review timeline Published Neuroscience Letters Version of Record 1 Sep 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords cannabinoids depression microglia molecular docking sleep deprivation Authors Affiliations Nasar Ullah Khan Niazi 0000-0003-3330-8581 [email protected] Guangdong Ocean University Research Institute for Marine Drugs and Nutrition View all articles by this author Rabia Parveen Guangdong Medical University Shunde Women and Children's Hospital View all articles by this author Metrics & Citations Metrics Article Usage 240 views 153 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Nasar Ullah Khan Niazi, Rabia Parveen. Long-term Cannabinoid Therapy can ameliorate Sleep Deprivation-Induced Behavioral and Neuroinflammatory Changes in Mice. Authorea . 12 March 2025. DOI: https://doi.org/10.22541/au.174178836.60427337/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.174178836.60427337/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9fe6d7f9bcffdf88',t:'MTc3OTIzMjk0Ng=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();