Clinical application of polar-body based preimplantation genetic testing for maternal mutations in females with a limited number of oocytes

Clinical application of polar-body based preimplantation genetic testing for maternal mutations in females with a limited number of oocytes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Clinical application of polar-body based preimplantation genetic testing for maternal mutations in females with a limited number of oocytes Jia Chen, Xingwu Wu, Qiang Xu, Tao Ding, Ge Chen, Houyang Chen, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4286089/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 01 Apr, 2025 Read the published version in Orphanet Journal of Rare Diseases → Version 1 posted 5 You are reading this latest preprint version Abstract Background Trophectoderm (TE) cell biopsy at the blastocyst stage is currently the predominant method used in preimplantation genetic testing for monogenic disorders (PGT-M). However, this approach may result in the discarding of genetically unaffected embryos due to the fact that not all embryos progress to the blastocyst stage. This study aimed to investigate the advantages of utilizing polar body (PB) biopsy in females with disease-causing mutations and a limited number of oocytes undergoing PGT-M. Methods Three couples with females carrying autosomal dominant or X-linked mutations in IRF6, FMR1, and EDA were recruited. The number of retrieved oocytes was no more than six per cycle. The first and second PBs (PB1 and PB2) of each oocyte were individually biopsied and subjected to multiple displacement amplification (MDA). The genotype of each embryo was deduced by analyzing the MDA products of corresponding PB1 and PB2 using a novel strategy that combined direct mutation testing and single nucleotide polymorphism linkage analysis. Mutation-free embryos cryopreserved before the blastocyst stage were selected to transfer. Results In total, four cycles were conducted resulting in the retrieval of 15 oocytes for the three couples. The genotype of each embryo was successfully determined. Seven mutation-free embryos were identified. Three of them were transferred and resulted in two clinical pregnancies, culminating in the birth of two healthy babies. The accuracy of the embryo genotypes was validated through genetic testing of the fetuses in the second trimester or at birth. Conclusions The PB-based strategy is feasible and effective to detect the mutation carrier statuses of embryos in PGT-M for maternal mutations. Compared with blastocyst stage detection, this method may preserve a higher number of genetically unaffected embryos for the patients. Further clinic trials are warranted to verify whether PB biopsy offers greater benefits than TE cell biopsy for females with disease-causing mutations and a limited number of oocytes in PGT-M. preimplantation genetic testing PGT monogenic disease polar body a limited number of oocytes single nucleotide polymorphism linkage analysis Figures Figure 1 Figure 2 Figure 3 Introduction Preimplantation genetic testing for monogenic disorders (PGT-M) is an assisted reproductive technology that helps high-risk parents to reduce the chance of having affected babies with genetic disorders by identifying inherited pathogenic mutations in the embryos prior to transfer [1] . Biopsy is the first step in PGT-M and can be performed at different embryo development stages. Polar body (PB) biopsy is carried out at the earliest stage. The first and second PBs (PB1 and PB2) are typically biopsied post-oocyte retrieval and fertilization via intracytoplasmic sperm injection (ICSI), respectively. Laser energy is commonly employed for zona pellucida opening, with aspiration utilized for the removal of a single PB. PB biopsy can be used to evaluate maternal genetic variants and conventionally applied in only a minority of centers [2] . Cleavage-stage embryo biopsy is mostly performed on day 3 of preimplantation development. Only one single cell of the blastomere has been recommended for aspiration [3] . In the context of blastocyst or trophectoderm (TE) biopsy, the zona pellucida is typically breached either on day 3/4 or on day 5. TE cells are extracted through a combination of aspiration and laser excision from protruding blastocysts, or through aspiration combined with mechanical dissection from blastocysts on day 5/6. Presently, TE biopsy is the predominant technique utilized in PGT procedures [3] . In comparison to cleavage-stage embryo biopsy, TE biopsy offers two primary benefits. Firstly, cleavage-stage biopsy notably diminishes the potential for human embryonic implantation, whereas TE biopsy does not. It has indicated that the sustained implantation rate of biopsied blastomeres on day 3 decreased by approximately 39% when compared with unbiopsied controls. Conversely, equivalent sustained implantation rates were observed in biopsied and unbiopsied blastocysts [4] . The reduced susceptibility of blastocysts to potential embryo damage may be attributed to the preservation of the inner cell mass, from which the fetus develops. Additionally, more cells (ideally five to eight cells) can be biopsied at blastocyst stage while only one single cell is recommended to remove at cleavage-stage. A two-cell removal at the cleavage-stage was shown to be more harmful for the embryonic development and implantation potential than the removal of one cell [5] . The damage of TE biopsy was largely determined by the TE quality and experience of different embryologists. When fewer than 41 cells were biopsied, increasing the number of biopsied TE cells did not have a significant impact on the survival and implantation rates of blastocysts with a grade A TE score. However, a higher number of biopsied cells resulted in improved accuracy of genetic analysis [6] . These advantages contribute to the widespread use of TE biopsy as the preferred method for obtaining samples from preimplantation embryos in PGT. A primary issue faced by patients undergoing TE biopsy in PGT is the relatively low rate of blastocyst formation. Various factors were involved in blastocyst development such as female age, body mass index (BMI), number of retrieved oocytes, fertilization method, embryo culture conditions, number of blastomeres, and embryo quality. Reported blastocyst formation rates typically fall within the range of 40% to 60% [7-9] . TE biopsy may result in the wastage of a portion of embryos, as not all embryos progress to the blastocyst stage. The genetically unaffected embryos degenerated in blastomere-blastocyst tranformation also have the potential of bringing live birth if transferred. These wasted embryos may have great value for females with disease-causing mutations and a limited number of oocytes in PGT-M cycles. PB biopsy is a safe and efficient way to detect maternal genetic variants in PGT [10] . PBs are by-products formed during the process of oocytes meiotic division and are not required for successful fertilization or normal embryonic development. PB1 obtains a subset of bivalent chromosomes after homologous chromosome separation in the first meiosis, whereas PB2 contains a haploid set of chromatids after separation of sister chromosome monomers in the second meiosis. Whether the embryo carries the maternal mutation could be deduced by detecting PB1 and PB2 [11] . PB biopsy may offer greater benefits for females with a low number of oocytes in PGT-M. In comparison to TE biopsy, PB biopsy has the potential to conserve a higher number of genetically unaffected embryos and enhance oocyte utilization by identifying mutation carrier status prior to blastocyst formation. Additionally, PB biopsy is less detrimental to embryos when compared with blastomere biopsy. These advantages make PB biopsy a more promising approach. In this research, a novel PB biopsy-based strategy (Figure 1) was employed to perform PGT-M on three couples, where the females carried disease-causing mutations in autosomal dominant ( IRF6 ) or X-linked monogenic genes ( FMR1 and EDA ). Each female had ≤6 retrieved oocytes per cycle. Using this strategy, two of the three families had given birth to healthy babies. This study demonstrated the efficacy of utilizing PB1 and PB2 for detecting maternal mutations in PGT-M, suggesting potential benefits for females with a limited number of oocytes. Materials and methods Patients Three couples, in which the females were carriers of autosomal dominant or X-linked monogenic disease-causing mutations, were recruited from the Reproductive Medicine Center of Jiangxi Maternal and Child Health Hospital for this study conducted from August 2020 to July 2023. Genetic testing revealed that the three females carried pathogenic mutations in IRF6 , FMR1 , and EDA , respectively (Figure 2). Additionally, poor ovarian reserve was noted, with each female expected to retrieve ≤6 oocytes per cycle. After genetic counseling, all of the three couples refused to transfer embryos carrying the disease-causing mutations and decided to participate in our study of PGT-M using PB biopsy. Case 1 and 3 underwent a single cycle of PGT-M, while Case 2 underwent two cycles. All couples provided written informed consents at their first consulation. The study was approved by the Ethics Committee of Jiangxi Maternal and Child Health Hospital. Genetic variation detection Genomic DNA was extracted from peripheral blood samples using the QIAamp DNA Blood Mini kit (Qiangen, Germany). Trio-based and proband-only whole exome sequencing (WES) approaches were employed to identify genetic mutations in cases 1 and 3, respectively. The sequencing and analysis protocols were executed according to established methods [12] . Candidate mutations were detected in the probands and confirmed in other family members through Sanger sequencing. The pathogenic criteria of the detected mutations were interpretated according to ACMG [13, 14] and ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/). In case 2, the quantification of FMR1 CGG repeats was conducted using GC-rich PCR and Triplet-primed (TP) PCR, as described by Gao et al. 2020 [15] . The GC-rich PCR was employed for the direct determination of CGG repeat counts based on allele size, while TP-PCR allowed for qualitative detection of the expanded allele [16] . Workflow of analysis The workflow of the strategy is depicted in Figure 1. Initially, disease-causing mutations were identified in family members. Subsequently, for females carrying inherited mutations, single nucleotide polymorphisms (SNPs) flanking the mutation were examined in the genomic DNA of selected family members. Linkage analysis was carried out to identify the haplotype of chromsome segment carrying the mutation. For females with de novo mutations, the PB1 and PB2 of each oocyte were biopsied. Each individual PB underwent whole genome amplification (WGA) through multiple displacement amplification (MDA) methodology. The mutation was detected directly in the MDA product of each PB. The SNPs surrounding the mutation were examined in the genotyped proband and PBs to determine the haplotype. Following oocyte fertilization and PB biopsy, the embryos were cryopreserved through vitrification on Day 3. The mutation carrier status of the corresponding embryo was deduced by direct mutation detection and haplotyping analysis of the PB1 and PB2. Embryos not carrying the mutation were chosen for frozen-thawed embryo transfer (FET). PB biopsy Controlled ovarian hyperstimulation and oocyte retrieval procedures were performed on the female subjects. In vitro fertilization using ICSI was utilized to fertilize the oocytes. Biopsies of PB1 were conducted 2-3 hours post oocyte retrieval using laser assistance, while biopsies of PB2 were performed 5-6 hours after ICSI. Single PB WGA and mutation detection The single PB was adapted MDA (Qiagen, REPLI-g Single Cell Kit) for WGA. The resulting MDA DNA was diluted fivefold with nuclease-free ultra-pure water for mutation detection. The methods employed for mutation detection in blood-derived genomic DNA were similarly applied to the MDA DNA obtained from PB samples. Haplotype analysis SNPs with the minor allele frequency of 0.3~0.5 were selected within 2Mb upstream and downstream of the IRF6 , FMR1 , and EDA gene mutations, respectively. The primers targeted the SNPs were designed and synthesized (Twist Bioscience, USA). DNA samples from family members and the MDA products of PBs were subjected to multiplex PCR using the targeted primers. The amplified DNA was purified by XP beads (Thermo Fisher Scientific, USA) and the concentration of each DNA sample was measured. A total of 200ng purified DNA was utilized to prepare the library, employing the AmpSeq Library Prep Kit V2 (Vazyme Biotech, Nanjing, China). Subsequently, the library was sequenced using Miseq Dx sequencer (Illumina, USA). In case 1, the genomic DNA of the proband and the MDA products of the selected PBs underwent targeted SNP amplification following successful genotyping by Sanger sequencing. The resulting products of SNP amplification were then subjected to sequencing analysis in order to acquire information on the SNPs. The heterozygous SNPs identified in the proband were deemed as effective SNPs and utilized for haplotype analysis. Through linkage analysis, the haplotype associated with the IRF6 mutation was determined. In case 2 and 3, the genomic DNA of selected genotyped family members was used to identify the haplotypes by targeted SNPs sequencing. Specific PBs were chosen to conduct haplotyping. The mutation carrier statuses of the embryos were inferred and validated through the haplotypes of PB1 and PB2 derived from each oocyte. FET and validation of the results Mutation-free embryos were selected to transfer in FET cycles. The accuracy of PGT-M was verified by genetic test of amniotic fluid at 18 gestational weeks or umbilical cord blood at birth. Results Mutation detection in the probands and family members The proband in Case 1 (II:1, Figure 2A) was a 33-year-old female afflicted with congenital orofacial clefts. No discernible phenotypic abnormalities were noted in her parents or spouse. Following the conception of a fetus with cleft lip and palate, the couple opted to terminate the pregnancy. Trio-WES of the proband and her parents revealed the presence of a de novo variant c.784C>T (p.Gln262*) in IRF6 (NM_006147.3). Sanger sequencing of the family members confirmed the de novo variant (Figure 2B). The IRF6 gene, which encodes interferon regulatory transcription factor 6, is implicated in Van der Woude Syndrome (VWS), an autosomal dominantly inherited developmental disorder characterized by cleft lip and/or palate. The IRF6 c.784C>T variant was reported in a patient with VWS [17] . According to the recommendation on sequence variants interpretation by the 2015 ACMG guidelines [13] , the IRF6 c.784C>T variant would be classified as “pathogenic”, meeting the criteria PVS1+PS2+PM2_Supporting, and was recognized as the disease-causing factor of the proband. The proband in Case 2 (II:1, Figure 2C) was a 32-year-old female with premature ovarian failure. Her follicle-stimulating hormone (FSH) level was 59.32 mIU/mL, and anti-mullerian hormone (AMH) level was 0.052ng/ml. She was revealed as a premutation carrier of FMR1 with the CGG repeats of 29 and 90. The FMR1 CGG repeats of the proband’s father, mother and husband were 90/Y, 29/29, and 24/Y, respectively (Figure 2C, D). In Case 3, the couple remained unaffected, yet they had given birth to two boys afflicted with hypohidrotic ectodermal dysplasia (HED). The little son had passed away. A hemizygous missense variant c.1045G>A (p.Ala349Thr) of the EDA gene (NM_001399.5) was found in the proband (II:1, Figure 2E) by WES. Defects in the EDA gene cause X-linked HED which is characterized by hypotrichosis, hypohidrosis, and hypodontia. The EDA c.1045G>A (p.Ala349Thr) variant had been reported in several patients with X-linked HED [18-21] and was interpretated as “pathogenic” by ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/, Variation ID: 11040). Sanger sequencing of the family members revealed that the proband’s mother carrying the heterozygous variant of EDA c.1045G>A (Figure 2E, F). Direct mutation detection in PBs A total of 15 PB1s/PB2s from 4 PGT-M cycles were biopsied in the three couples. The mutations were detected in the MDA products of PBs by Sanger sequencing for Case 1 and 3, GC-rich PCR and TP-PCR for Case 2. The mutation carrier statuses of the corresponding embryos were deduced by the test results of PB1s and PB2s. The detection chromatograms were shown in Figure 3 and the results were presented in Table 1. In Case 1, 6 oocytes were retrieved in one cycle. PB1 and PB2 of each oocyte were biopsied and examined by Sanger sequencing (Figure 3A, Table 1). In oocyte 1, only the wildtype genotype was detected in PB1 (F1-1-PB1) and PB2 (F1-1-PB2), suggesting that the corresponding embryo carried the mutant allele. The F1-1-PB1 should contain one wildtype allele and one mutant allele. The absence of the mutant allele in F1-1-PB1 suggests that the mutant allele was dropped out during the detection. PBs from oocyte 3 and 5 had similar test results with PBs in oocyte 1, with the exception of the absence of allele drop-out (ADO) in the detection of PB1s (F1-3-PB1 and F1-5-PB1). In oocyte 2 and 6, homozygous mutant genotype was detected in the PB1s (F1-2-PB1 and F1-6-PB1) and the wildtype was detected in the PB2s (F1-2-PB2 and F1-6-PB2). The mutation carrier statuses of these embryos were uncertain due to the possibility of ADO during the detection of the PB1s. The ADO rate for detecting genetic markers in PB1 was reported to be approximately 5.9%-9.6% [22] . Given the relatively low ADO rate, the corresponding embryos of oocyte 2 and 6 probably inherited the wildtype allele. A similar approach was taken to assess the mutation carrier status of the embryo from oocyte 4, suggesting that it likely carried the mutant allele. Haplotype analysis was conducted to determine whether the Sanger sequencing results of the PB1s (F1-2-PB1, F1-4-PB1, and F1-6-PB1) had been affected by ADO. In Case 2, three oocytes were retrieved from two cycles. The CGG mutation of FMR1 was detected in PBs by GC-rich PCR and TP-PCR (Figure 3B, Table 1). In the first cycle, a solitary oocyte was retrieved. Only the expanded CGG allele was detected in the PB1 (F2-C1-1-PB1) by TP-PCR, suggesting that it carried the homozygous FMR1 CGG mutant allele and no ADO occurred during the detection. Because it was unlikely that the expanded allele was kept while the unexpanded allele was dropped out. The failure of GC-rich PCR to directly detect the CGG repeat in PB1 (F2-C1-1-PB1) was primarily attributed to the large size of the expanded allele, which hindered amplification by the MDA technique. The unexpanded CGG allele was detected in the PB2 (F2-C1-1-PB2) by both GC-rich PCR and TP-PCR. These results suggested that the corresponding embryo inherited the normal FMR1 allele. In the second cycle, two oocytes were retrieved. Analysis of the detection results of PB1s and PB2s (Figure 3B and Table 1) suggested that the embryo from oocyte 1 (F2-C2-1) exhibited a normal allele, whereas the embryo from oocyte 2 (F2-C2-2) displayed an expanded allele. The detection failure of PB2 in oocyte 1 may have been due to DNA degradation during the biopsy or amplification failure in the MDA procedure, but this did not impact the deduction made. In Case 3, a total of six oocytes were retrieved in one cycle. Similar detection and analysis methods were applied (Figure 3C, Table 1). The embryos from oocytes 2 and 5 were determined to carry the mutant allele, while the mutation carrier statuses of the remaining embryos were indeterminate. Specifically, the embryos from oocytes 1, 4, and 6 were likely to have inherited the normal allele, while the embryo from oocyte 3 was likely to carry the mutant allele, assuming absence of ADO. Haplotype analysis was conducted on the corresponding PB1s (F3-1-PB1, F3-3-PB1, F3-4-PB1, and F3-6-PB1) to assess the occurrence of any ADO. Haplotype analysis of family members and PBs In Case 1, the proband and the specific PBs (PB1s and PB2s from oocyte 2, 4 and 6) were selected to conduct linkage analysis. The SNP haplotypes of PB1s and PB2s from oocyte 2 and 4 were presented in Table 2. The haplotypes of PB1 and PB2 in oocyte 6 were found to be identical to those in oocyte 2 (data not shown due to redundancy). The haplotypes of PBs were found to be consistent with the results obtained from direct mutation detection. These findings indicated that the embryos from oocyte 2 and 6 inherited the wildtype allele, whereas the embryo from oocyte 4 was carrying the IRF6 c.784C>T mutant allele. In Case 2, the proband and her father were selected for linkage analysis in order to determine the SNP haplotype surrounding the FMR1 mutation. Haplotyping of the corresponding PBs of low-risk embryos was conducted to validate the mutation detection findings in the PBs (Table 1 and 3). The consistency between the haplotypes and the direct mutation detection results of PBs confirmed the low pathogenicity of the embryos from oocytes F2-C1-1 and F2-C2-1. In Case 3, the proband and his mother were chosen for linkage analysis to investigate the SNP haplotype flanking the EDA c.1045G>A mutation. The specific PBs (PB1s and PB2s from oocyte 1, 3, 4 and 6) were haplotyped to determine the mutation carrier statuses of the embryos (Table 1 and 4). The haplotypes of PB1 and PB2 in oocyte 6 were found to be identical to those in oocyte 4 (data not shown due to redundancy). The haplotypes of the PBs were consistent with the results of mutation detection and deduced that embryos from oocyte 1, 4, and 6 inherited the wildtype allele, whereas the emrbyo from oocyte 3 carried the EDA c.1045G>A mutation. Embryo selection and transfer The mutation-free embryos deduced by the direct mutation detection and haplotype analysis were selected to transfer. Considering the morphology of these embryos, Case 1 chose the embryo from oocyte 2, Case 2 chose the embryo from oocyte 1 in the second cycle, Case 3 chose the embryo from oocyte 1, to transfer at the first time. The couples in Case 1 and 2 were clinically pregnant, while the couple in Case 3 were not. Validation of the PGT-M results In Case 1, no cleft lip or palate was detected in the fetus by ultrasound methods throughout the pregnancy. A healthy baby girl was born and the IRF6 c.784C>T mutation was not detected in the genomic DNA from the umbilical cord blood at birth (data not shown). In Case 2, the amniocentesis of the couple was performed at 18 weeks of the gestation. The PGT-M result was reconfirmed by the mutation detection of genomic DNA in amnion cells (data not shown). A healthy baby girl was achieved after a normal period of gestation. The Case 3 was waiting for another embryo transfer cycle. Discussion Since the first report of a human live birth after blastocyst biopsy for PGT by Kokkali et al in 2005 [23] , the mainstream biopsy method of PGT had gradually shifted from a biopsy of PBs or cleavage-stage embryos to TE cells in the blastocyst stage [24] . While TE biopsy offers numerous benefits, it may not be the optimal approach for individuals with a limited number of oocytes. Blastocyst formation rates exhibit variability across different centers, typically falling within the range of 40% to 60% [7-9] . A subset of genetically unaffected embryos may fail to reach the blastocyst stage in the in vitro culture system, resulting in their inability to be transferred. To increase the availability of transferable embryos for females with diminished oocyte reserves, we employed a novel PB-based testing strategy to perform PGT-M for three couples in which the female partners harbored pathogenic mutations. In Case 1, six oocytes were retrieved from the female proband afflicted with autosomal dominant orofacial clefts caused by the IRF6 c.784C>T mutation, two unaffected embryos were identified. The female in Case 2, diagnosed with premature ovarian failure caused by the FMR1 premutation, underwent two cycles resulting in the retrieval of three oocytes and preservation of two unaffected embryos. In Case 3, three out of six embryos were determined to not carry the EDA c.1045G>A mutation in the female who had previously given birth to two boys with X-linked HED. The PB-based method accurately deduced the mutation carrier status of each oocyte, resulting in the retention of genetically unaffected embryos to the fullest extent possible. To ensure the precision of the deduction, a methodology combining mutation detection and haplotype analysis was employed to analyze PBs. The utilization of PB-based testing in PGT-M was first documented in 1990 [25] . Initially, only PB1 was directly tested for mutations, allowing for the determination of the mutation-carrier status of the oocyte in cases where a homozygous genotype was identified [25] . However, this PB1 approach was unable to predict the eventual genotype of the oocyte in instances of a heterozygous genotype, and the potential impact of ADO on the results of PB1 detection remained unclear. Then, polymorphic markers flanking mutations were tested in PB1 and PB2 [11, 26] . A large experience of 938 PB-based PGT-M cycles performed by a simultaneous detection of the mutation together with polymorphic markers for 146 different monogenic diseases revealed an extremely high accuracy rate of over 99% [11] . In our study, a comparable methodology was employed with alterations, utilizing SNPs instead of short tandem repeats as polymorphic markers. This adjustment was made in order to potentially enhance the efficacy of identifying a sufficient number of informative markers, as targeted next-generation sequencing has the capacity to detect hundreds of SNPs simultaneously. Furthermore, haplotype analysis was conducted only when a homozygous genotype of PB1 was detected and uncertainty regarding ADO was present in the direct mutation test (Table 1-4). This approach has the potential to reduce testing expenses for patients. Due to the unsuccessful detection of CGG repeat sizes in the PB1s (F2-C1-1-PB1 and F2-C2-1-PB1) (Figure 3B), haplotype analysis was utilized in these samples to validate the inference. Performing PGT-M in females with premature ovarian failure due to FMR1 premutation presents challenges is challenging. Besides the poor reservation of oocytes, the other obstacle is to determine the CGG expansion status of FMR1 alleles in preimplantation samples [27] . Linkage analysis by polymorphic markers was widely used to trace the transmission of the risk allele [28] . However, the effectiveness of this approach depends on the availability of informative markers and their proximity to the FMR1 CGG repeat. The reliability is doubtful when few informative markers are available in the designated region. This deficiency could be addressed by direct detection of the FMR1 CGG repeat. In our study, the GC-rich PCR and the TP-PCR were used to directly test the FMR1 CGG repeats. The normal CGG allele was successfully detected in the PBs (F2-C1-1-PB2, F2-C2-2-PB1 and F2-C2-2-PB2) by GC-rich PCR. Although the repeat sizes of the mutant alleles were not detected in the samples (F2-C1-1-PB1 and F2-C2-2-PB1), the results of TP-PCR in these samples determined the expansion statuses (Figure 3B). It was reported that the TP-PCR reliably detected presence of FMR1 CGG expansion mutations in single cells biopsied in the Day 3 embryos [29] . Our study verified the useful of TP-PCR in PB samples. The PB-based PGT-M strategy also have some limitations. Firstly, it is unable to detect paternal mutations. Secondly, deducing genotype of embryo by detecting PBs is presumed that the chromatin in which the disease-causing genes located is replicating and separating smoothly during meiosis. The aneuploidy of these chromosomes will disrupt the detection. Thirdly, compared with biopsy methods performed on cleavage- or blastocyst-stage embryos, the PB-based strategy requires more manual interventions and testing of additional samples. Additionally, it is supported by evidence that blastocyst-stage embryo transfer yields higher clinical pregnancy rates and live birth rates compared with cleavage-stage embryo transfer [30] . Further clinical trials are necessary to elucidate whether the PB-based strategy offers greater benefits than TE biopsy for females with a limited number of oocytes undergoing PGT-M for maternal mutations. Conclusions We performed PGT-Ms on three couples in which the females harbored pathogenic mutations and exhibited diminished oocyte reserves, utilizing a novel PB-based testing approach. Among these couples, two successfully achieved the birth of unaffected offspring. Our study indicated that the PB-based strategy is feasible and effective to detect the mutation carrier statuses of embryos in PGT-M for maternal mutations. Further clinic trials are warranted to verify whether PB biopsy offers greater benefits than TE cell biopsy for females with disease-causing mutations and a limited number of oocytes in PGT-M. Abbreviations TE Trophectoderm PGT Preimplantation genetic testing PGT-M Preimplantation genetic testing for monogenic disorders PB Polar body PB1 The first polar body PB2 The second polar body MDA Multiple displacement amplification ICSI Intracytoplasmic sperm injection BMI Body mass index WES Whole exome sequencing TP Triplet-primed SNP Single nucleotide polymorphism WGA Whole genome amplification FET Frozen-thawed embryo transfer VWS Van der Woude Syndrome FSH Follicle-stimulating hormone AMH Anti-mullerian hormone HED Hypohidrotic ectodermal dysplasia ADO Allele drop-out Declarations Ethics approval and consent to participate The study was approved by the Ethics Committee of Jiangxi Maternal and Child Health Hospital (Nanchang, China) and conducted in accordance with the tenets of the Declaration of Helsinki. All couples provided written informed consents at their first consulation. Consent for publication All the patients included signed the consent for publication. Availability of data and materials The data of this study are available from the corresponding author on reasonable request. The data are not publicly available due to privacy or ethical restrictions. Competing interests The authors declare that they have no competing interests. Funding This work was supported by National Natural Science Foundation of China (Grant No. 82160317), Jiangxi Provincial Natural Science Foundation (Grant No. 20224BAB206018 and 20232BAB216097), Jiangxi Province Key Research and Development Project (Grant No. 20232BBG70023), and Jiangxi Provincial Health Commission Science and Technology Innovation Key Project (Grant No. 2023ZD006). Authors’ contributions J.C., Y.L., Q.W., and Z.L. designed and performed the experiments, collected and analyzed data, and wrote the manuscript. X.W., Q.X., T.D., G.C., H.C., and Y.Zou conducted the experiment. J.H., Z.Z., L.T., and Y.Zhao conceived, designed, supervised the experiments, and revised the manuscript. R.D. contributed to the interpretation of the results. All authors contributed to the article and approved the submitted version. All authors read and approved by the final manuscript. Acknowledgments We thank the family members involved in this study. References De Rycke M, Berckmoes V. Preimplantation Genetic Testing for Monogenic Disorders. Genes (Basel). 2020. 11(8): 871. Wei Y, Zhang T, Wang YP, Schatten H, Sun QY. Polar bodies in assisted reproductive technology: current progress and future perspectives. Biol Reprod. 2015. 92(1): 19. Kokkali G, Coticchio G, Bronet F, et al. ESHRE PGT Consortium and SIG Embryology good practice recommendations for polar body and embryo biopsy for PGT. Hum Reprod Open. 2020. 2020(3): hoaa020. Scott RT Jr, Upham KM, Forman EJ, Zhao T, Treff NR. Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Fertil Steril. 2013. 100(3): 624-30. De Vos A, Staessen C, De Rycke M, et al. Impact of cleavage-stage embryo biopsy in view of PGD on human blastocyst implantation: a prospective cohort of single embryo transfers. Hum Reprod. 2009. 24(12): 2988-96. Zhang S, Luo K, Cheng D, et al. Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality. Fertil Steril. 2016. 105(5): 1222-1227.e4. Comstock IA, Kim S, Behr B, Lathi RB. Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization. J Assist Reprod Genet. 2015. 32(9): 1299-304. Deng J, Zhao Q, Cinnioglu C, Kayali R, Lathi RB, Behr B. The impact of culture conditions on blastocyst formation and aneuploidy rates: a comparison between single-step and sequential media in a large academic practice. J Assist Reprod Genet. 2020. 37(1): 161-169. Kermack AJ, Fesenko I, Christensen DR, et al. Incubator type affects human blastocyst formation and embryo metabolism: a randomized controlled trial. Hum Reprod. 2022. 37(12): 2757-2767. Schenk M, Groselj-Strele A, Eberhard K, et al. Impact of polar body biopsy on embryo morphokinetics-back to the roots in preimplantation genetic testing. J Assist Reprod Genet. 2018. 35(8): 1521-1528. Kuliev A, Rechitsky S. Polar body-based preimplantation genetic diagnosis for Mendelian disorders. Mol Hum Reprod. 2011. 17(5): 275-85. Chen J, Yuan H, Xie K, et al. A novel TAB2 nonsense mutation (p.S149X) causing autosomal dominant congenital heart defects: a case report of a Chinese family. BMC Cardiovasc Disord. 2020. 20(1): 27. Richards S, Aziz N, Bale S, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015. 17(5): 405-24. Biesecker LG, Harrison SM. The ACMG/AMP reputable source criteria for the interpretation of sequence variants. Genet Med. 2018. 20(12): 1687-1688. Gao F, Huang W, You Y, et al. Development of Chinese genetic reference panel for Fragile X Syndrome and its application to the screen of 10,000 Chinese pregnant women and women planning pregnancy. Mol Genet Genomic Med. 2020. 8(6): e1236. Dean DD, Agarwal S, Kapoor D, Singh K, Vati C. Molecular Characterization of FMR1 Gene by TP-PCR in Women of Reproductive Age and Women with Premature Ovarian Insufficiency. Mol Diagn Ther. 2018. 22(1): 91-100. de Lima RL, Hoper SA, Ghassibe M, et al. Prevalence and nonrandom distribution of exonic mutations in interferon regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome. Genet Med. 2009. 11(4): 241-7. Monreal AW, Zonana J, Ferguson B. Identification of a new splice form of the EDA1 gene permits detection of nearly all X-linked hypohidrotic ectodermal dysplasia mutations. Am J Hum Genet. 1998. 63(2): 380-9. Lexner MO, Bardow A, Juncker I, et al. X-linked hypohidrotic ectodermal dysplasia. Genetic and dental findings in 67 Danish patients from 19 families. Clin Genet. 2008. 74(3): 252-9. Liu Y, Huang Y, Hua R, et al. Mutation Screening of the EDA Gene in Seven Chinese Families with X-Linked Hypohidrotic Ectodermal Dysplasia. Genet Test Mol Biomarkers. 2018. 22(8): 487-491. Körber L, Schneider H, Fleischer N, Maier-Wohlfart S. No evidence for preferential X-chromosome inactivation as the main cause of divergent phenotypes in sisters with X-linked hypohidrotic ectodermal dysplasia. Orphanet J Rare Dis. 2021. 16(1): 98. Rechitsky S, Strom C, Verlinsky O, et al. Allele dropout in polar bodies and blastomeres. J Assist Reprod Genet. 1998. 15(5): 253-7. Kokkali G, Vrettou C, Traeger-Synodinos J, et al. Birth of a healthy infant following trophectoderm biopsy from blastocysts for PGD of beta-thalassaemia major. Hum Reprod. 2005. 20(7): 1855-9. Mao D, Xu J, Sun L. Impact of trophectoderm biopsy for preimplantation genetic testing on obstetric and neonatal outcomes: a meta-analysis. Am J Obstet Gynecol. 2024. 230(2): 199-212.e5. Verlinsky Y, Ginsberg N, Lifchez A, Valle J, Moise J, Strom CM. Analysis of the first polar body: preconception genetic diagnosis. Hum Reprod. 1990. 5(7): 826-9. Verlinsky Y, Rechitsky S, Verlinsky O, et al. Polar body-based preimplantation diagnosis for X-linked disorders. Reprod Biomed Online. 2002. 4(1): 38-42. Persico T, Tranquillo ML, Seracchioli R, Zuccarello D, Sorrentino U. PGT-M for Premature Ovarian Failure Related to CGG Repeat Expansion of the FMR1 Gene. Genes (Basel). 2023. 15(1): 6. Chen M, Zhao M, Lee CG, Chong SS. Identification of microsatellite markers <1 Mb from the FMR1 CGG repeat and development of a single-tube tetradecaplex PCR panel of highly polymorphic markers for preimplantation genetic diagnosis of fragile X syndrome. Genet Med. 2016. 18(9): 869-75. Rajan-Babu IS, Lian M, Cheah F, et al. FMR1 CGG repeat expansion mutation detection and linked haplotype analysis for reliable and accurate preimplantation genetic diagnosis of fragile X syndrome. Expert Rev Mol Med. 2017. 19: e10. Glujovsky D, Quinteiro Retamar AM, Alvarez Sedo CR, Ciapponi A, Cornelisse S, Blake D. Cleavage-stage versus blastocyst-stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2022. 5(5): CD002118. Tables Table 1 Direct detection results of the disease-causing mutations in polar bodies. Case No. Maternal mutations Oocyte retrieval cycle No. Oocyte No. Cell type (Sample NO.) Direct detection results of the variants in polar bodies Deduced risk of embryos carrying the mutations The number of low-risk embryos 1 IRF6 c.784C>T Het. 1 1 PB1 (F1-1-PB1) Wt. (Mutant allele drop-out) High 2 PB2 (F1-1-PB2) Wt. 2 PB1 (F1-2-PB1) IRF6 c.784C>T Homo. Uncertain (Probably Low) PB2 (F1-2-PB2) Wt. 3 PB1 (F1-3-PB1) IRF6 c.784C>T Het. High PB2 (F1-3-PB2) Wt. 4 PB1 (F1-4-PB1) Wt. Uncertain (Probably High) PB2 (F1-4-PB2) IRF6 c.784C>T Hemi. 5 PB1 (F1-5-PB1) IRF6 c.784C>T Het. High PB2 (F1-5-PB2) Wt. 6 PB1 (F1-6-PB1) IRF6 c.784C>T Homo. Uncertain (Probably Low) PB2 (F1-6-PB2) Wt. 2 FMR1 CGG repeat number 29/90 1 1 PB1 (F2-C1-1-PB1) Mutant allele Homo. Low 1 PB2 (F2-C1-1-PB2) Normal allele Hemi. 2 1 PB1 (F2-C2-1-PB1) Mutant allele Homo. Low 1 PB2 (F2-C2-1-PB2) Detection failure 2 PB1 (F2-C2-2-PB1) Normal allele Homo. (Mutant allele drop-out) High PB2 (F2-C2-2-PB2) Normal allele Hemi. 3 EDA c.784C>T Het. 1 1 PB1 (F3-1-PB1) EDA c.1045G>A Homo. Uncertain (Probably Low) 3 PB2 (F3-1-PB2) Detection failure 2 PB1 (F3-2-PB1) Wt. (Mutant allele drop-out) High PB2 (F3-2-PB2) Wt. 3 PB1 (F3-3-PB1) Wt. Uncertain (Probably High) PB2 (F3-3-PB2) EDA c.1045G>A Hemi. 4 PB1 (F3-4-PB1) EDA c.1045G>A Homo. Uncertain (Probably Low) PB2 (F3-4-PB2) Wt. 5 PB1 (F3-5-PB1) EDA c.1045G>A Het. High PB2 (F3-5-PB2) Wt. 6 PB1 (F3-6-PB1) EDA c.1045G>A Homo. Uncertain (Probably Low) PB2 (F3-6-PB2) Wt. Table 2 The SNP haplotypes flanking the IRF6 gene (chr1:209,958,968-209,979,520) in case 1. Case 1 Chromosome SNP position (GRCH37/hg19) Proband ( II :1) Oocyte 2 Oocyte 4 F1-2-PB1 F1-2-PB2 F1-4-PB1 F1-4-PB2 Chr1 209656197 A G A A G G G A Chr1 209663226 C G C C G G G C Chr1 209700808 T A T T A A A T Chr1 209712889 T C T T ? C C T Chr1 209887369 C G C C G G G C Chr1 209965556 A T A A T T T A Chr1 210000282 C T C C T T T C Chr1 210005713 T C T T C C C T Chr1 210009372 A G A A G G G A Chr1 210020971 T C T T C C C T Chr1 210044393 C G C C G G G C Chr1 210104598 A G A A ? G G A Chr1 210134382 A G A A G ? ? A Chr1 210176904 A G A A G G G A Chr1 210194685 A G A A G G G ? Note: The deep orange marked haplotype indicates the chromosome segment carrying the mutant allele ( IRF6 c.784C>T) and the light orange marked haplotype indicates the chromosome segment carrying the normal allele. “?” indicates the genotype of the SNP was detected failure. Table 3 The SNP haplotypes flanking the FMR1 gene (chrX:146,993,437-147,032,645) in case 2. Case 2 Chromosome SNP position (GRCH37/hg19) Proband ( II :1) The proband’s father ( I :1) Oocyte 1 in cycle 1 Oocyte 1 in cycle 2 F2-C1-1-PB1 F2-C1-1-PB2 F2-C2-1-PB1 F2-C2-1-PB2 ChrX 146680236 T C T T T ? T T ? ChrX 146683786 C T C C C T C C ? ChrX 146684940 T C T T T C T T ? ChrX 146689817 G A G G G A G G ? ChrX 146919520 T G T T T G T T ? ChrX 146958977 T C T T T C T T ? ChrX 147401224 C G C C C G C C ? ChrX 147746704 G C G G G C G G ? ChrX 147945641 A G A A A G A A ? ChrX 148017272 A G A A A G A A ? ChrX 149497073 A G A A A G A A ? ChrX 149497116 C T C C C T C C ? Note: The deep orange marked haplotype indicates the chromosome segment carrying the mutant allele ( FMR1 CGG 90 ) and the light orange marked haplotype indicates the chromosome segment carrying the normal allele. “?” indicates the genotype of the SNP was detected failure. Table 4 The SNP haplotypes flanking the EDA gene (chrX:68,835,957-69,259,322) in case 3. Case 3 Chromosome SNP position (GRCH37/hg19) The proband’s mother ( I :2) Proband ( II :1) Oocyte 1 Oocyte 3 Oocyte 4 F3-1-PB1 F3-1-PB2 F3-3-PB1 F3-3-PB2 F3-4-PB1 F3-4-PB2 ChrX 68513890 G A G G G ? A A G G G A ChrX 68556523 T C T T T ? C C ? T T C ChrX 68556528 A G A A A ? G G A A A ? ChrX 68770723 T C T T T ? C C T T T C ChrX 68777145 G T G G G ? T T G ? ? T ChrX 68790706 G A G G G ? A A G G G A ChrX 69266212 G A G G G ? A A G G G A ChrX 69271943 T C T T T ? C C T T T C ChrX 69288187 A C A A A ? C C A A A ? ChrX 69291656 A G A A A ? G G A A A G ChrX 69308348 T C T T T ? C C T T T C ChrX 69409848 T C T T T ? C C ? T T C ChrX 69423721 T C T T T ? C C T T T C ChrX 69440241 A G A A A ? G G A A A G Note: The deep orange marked haplotype indicates the chromosome segment carrying the mutant allele ( EDA c.1045G>A) and the light orange marked haplotype indicates the chromosome segment carrying the normal allele. “?” indicates the genotype of the SNP was detected failure. Cite Share Download PDF Status: Published Journal Publication published 01 Apr, 2025 Read the published version in Orphanet Journal of Rare Diseases → Version 1 posted Editorial decision: Major revision 28 Jun, 2024 Reviewers agreed at journal 23 May, 2024 Reviewers invited by journal 20 May, 2024 Editor assigned by journal 09 May, 2024 First submitted to journal 18 Apr, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4286089","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":304773147,"identity":"8f95009c-2307-4f48-a1a8-7c1239cf2b3d","order_by":0,"name":"Jia Chen","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7ElEQVRIiWNgGAWjYDCCA0DM2ADj8djw8PM34FKLpoUHoiVNRnLGAZK0MBy2MWhIwK+D7/bhg59u7jicZ8/e+4Dhh8x5HgOGA4wfPubg1iJ5Li1ZOvfM4WIenuMGjD08t3nMmRuYJWduw63F4AyPgXRu2+HEHok0BmYGoBbLhgNszLx4tfB//g3WIv8MpOUcj8GBBEJaeNigtrCBtBwgrEXyDJuZdW5bemLPmTQGoF+SeSRnHGzG6xe+M8yPb+e2WSe2tx9jYPjZY2fPz9988MNHPFqQAfsPxh4QjUgMxIAfpCgeBaNgFIyCkQIAyilPOVw8i8sAAAAASUVORK5CYII=","orcid":"https://orcid.org/0009-0002-3211-1437","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":true,"prefix":"","firstName":"Jia","middleName":"","lastName":"Chen","suffix":""},{"id":304773148,"identity":"90d80fe0-d41c-4672-843d-0123f72a2577","order_by":1,"name":"Xingwu Wu","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Xingwu","middleName":"","lastName":"Wu","suffix":""},{"id":304773149,"identity":"086f4dc4-5c81-4282-b3c0-14cf7c1d05c7","order_by":2,"name":"Qiang Xu","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Qiang","middleName":"","lastName":"Xu","suffix":""},{"id":304773150,"identity":"ccc3afa9-9725-425c-a25b-bc2dc2425fcf","order_by":3,"name":"Tao Ding","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Tao","middleName":"","lastName":"Ding","suffix":""},{"id":304773151,"identity":"8d1ca78a-62cf-4aa8-b458-9fc52a4766dc","order_by":4,"name":"Ge Chen","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Ge","middleName":"","lastName":"Chen","suffix":""},{"id":304773152,"identity":"1aacf40a-6e63-4617-b680-d40ba03c4501","order_by":5,"name":"Houyang Chen","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Houyang","middleName":"","lastName":"Chen","suffix":""},{"id":304773153,"identity":"90d1f648-9668-4232-b044-55c5ebe6041a","order_by":6,"name":"Yongyi Zou","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Yongyi","middleName":"","lastName":"Zou","suffix":""},{"id":304773154,"identity":"0ba2b378-da58-4088-8a09-7d0e65f804db","order_by":7,"name":"Jialyu Huang","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Jialyu","middleName":"","lastName":"Huang","suffix":""},{"id":304773155,"identity":"92052ed9-6ff7-4452-b970-0e9971f0487a","order_by":8,"name":"Ziyu Zhang","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Ziyu","middleName":"","lastName":"Zhang","suffix":""},{"id":304773156,"identity":"03c2470b-2e48-4ec2-a8e4-45f6bc9e683f","order_by":9,"name":"Lifeng Tian","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Lifeng","middleName":"","lastName":"Tian","suffix":""},{"id":304773157,"identity":"6d2b96ad-7fda-4142-8bae-bc12c101b912","order_by":10,"name":"Yan Zhao","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Yan","middleName":"","lastName":"Zhao","suffix":""},{"id":304773158,"identity":"d702224e-4231-4c52-bb29-433f8e003b98","order_by":11,"name":"Ranhui Duan","email":"","orcid":"","institution":"Central South University","correspondingAuthor":false,"prefix":"","firstName":"Ranhui","middleName":"","lastName":"Duan","suffix":""},{"id":304773159,"identity":"60600744-c1ff-416a-bb00-90fb46d8bed9","order_by":12,"name":"Zengming Li","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Zengming","middleName":"","lastName":"Li","suffix":""},{"id":304773160,"identity":"e0d6d1d2-fd08-4753-abee-8754154008c2","order_by":13,"name":"Qiongfang Wu","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Qiongfang","middleName":"","lastName":"Wu","suffix":""},{"id":304773161,"identity":"53b9ff3e-301d-467c-9da4-6b97645dd36d","order_by":14,"name":"Yanqiu Liu","email":"","orcid":"","institution":"Jiangxi Maternal and Child Health Hospital","correspondingAuthor":false,"prefix":"","firstName":"Yanqiu","middleName":"","lastName":"Liu","suffix":""}],"badges":[],"createdAt":"2024-04-18 08:04:57","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4286089/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4286089/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s13023-025-03659-7","type":"published","date":"2025-04-01T15:56:51+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":57865297,"identity":"567ad548-2bdf-443e-a331-079a72a8075c","added_by":"auto","created_at":"2024-06-06 15:38:42","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":133914,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eWorkflow of analysis.\u003c/strong\u003e Females carrying with autosomal dominant or X-linked mutations and the number of expected retrieved oocytes ≤6 were recruited in the study. The mutations were detected in the family members. For females with inherited mutations, genotyped family members were selected to linkage analysis to get the haplotypes by targeted sequencing SNPs flanking the mutations. Then controlled ovarian hyperstimulation was conducted in the females. PB1 and PB2 of each oocyte were biopsied respectively following oocyte retrieval and ICSI. The zygotes were cultured \u003cem\u003ein vitro\u003c/em\u003e and the embryos were vitrified before blastocyst stage. The mutation-carrier status of each embryo was deduced by direct mutation detection and haplotype analysis in the corresponding PB1 and PB2. The mutation-free embryos were selected to FET. For females with \u003cem\u003ede novo\u003c/em\u003emutations, the only difference was that the haplotypes were obtained by linkage analysis of the females and PBs after genotyping by direct mutation detection.\u003c/p\u003e","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/rs-4286089/v1/a21d4c02b815a78d9272e4c8.png"},{"id":57865298,"identity":"e15b8f5c-8822-4e26-b3a2-ecea11d105dc","added_by":"auto","created_at":"2024-06-06 15:38:42","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":457701,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003ePedigrees and mutation detection results in family members. \u003c/strong\u003eA: The pedigree and genotypes of family members in case 1. B: Sanger sequence chromatograms of the family members in case 1 reveals the proband carrying a \u003cem\u003ede novo\u003c/em\u003e mutation of \u003cem\u003eIRF6\u003c/em\u003e c.784C\u0026gt;T. C: The pedigree and the number of \u003cem\u003eFMR1\u003c/em\u003e CGG repeats of family members in case 2. D: Fragment length analysis of GC-rich PCR products of indicating the number of \u003cem\u003eFMR1\u003c/em\u003e CGG repeats of family members in case 2. E: The pedigree and genotypes of family members in case 3. F: Sanger sequence chromatograms of the family members in case 3 reveals the proband carrying an inherited mutation of \u003cem\u003eEDA \u003c/em\u003ec.1045G\u0026gt;A. Open symbols, unaffected, filled symbols, affected, squares, male, circles, female, rhombuses, unkown gender, arrow, the proband, symbols with diagonals, death.\u003c/p\u003e","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-4286089/v1/8de489be2736c6c373ee0ad4.png"},{"id":57865299,"identity":"9120a2c5-2414-423d-a1bf-aa06f2f7bd5f","added_by":"auto","created_at":"2024-06-06 15:38:42","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":414779,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eDirect mutation detection results of PBs. \u003c/strong\u003eA: Sanger sequence chromatograms of \u003cem\u003eIRF6\u003c/em\u003e c.784 of PBs in case 1. B: GC-rich and TP-rich PCR results of \u003cem\u003eFMR1\u003c/em\u003e CGG mutation of PBs in case 2. C: Sanger sequence chromatograms of \u003cem\u003eEDA\u003c/em\u003e c.1045 of PBs in case 3.\u003c/p\u003e","description":"","filename":"Figure3.png","url":"https://assets-eu.researchsquare.com/files/rs-4286089/v1/a190a1b280aad42bfa83f5e1.png"},{"id":80082280,"identity":"0780b52a-2f76-4229-a219-661cadd6992d","added_by":"auto","created_at":"2025-04-07 16:08:16","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2593024,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4286089/v1/9238563f-9861-4275-99fd-a0ae5c272b05.pdf"}],"financialInterests":"","formattedTitle":"Clinical application of polar-body based preimplantation genetic testing for maternal mutations in females with a limited number of oocytes","fulltext":[{"header":"Introduction","content":"\u003cp\u003ePreimplantation genetic testing for monogenic disorders\u0026nbsp;(PGT-M) is an assisted reproductive technology that helps high-risk parents to reduce the chance of having affected babies with genetic disorders by identifying inherited pathogenic mutations in the embryos prior to transfer\u0026nbsp;\u003csup\u003e[1]\u003c/sup\u003e. Biopsy is the first step in PGT-M and can be performed at different embryo development stages. Polar body (PB) biopsy is carried out at the earliest stage. The first and second PBs (PB1 and PB2) are typically biopsied post-oocyte retrieval and fertilization via intracytoplasmic sperm injection (ICSI), respectively. Laser energy is commonly employed for zona pellucida opening, with aspiration utilized for the removal of a single PB. PB biopsy can be used to evaluate maternal genetic variants\u0026nbsp;and conventionally applied in only a minority of centers\u0026nbsp;\u003csup\u003e[2]\u003c/sup\u003e. Cleavage-stage embryo biopsy is mostly performed on day 3 of preimplantation development. Only one single cell of the blastomere has been recommended for aspiration\u0026nbsp;\u003csup\u003e[3]\u003c/sup\u003e. In the context of blastocyst or trophectoderm (TE) biopsy, the zona pellucida is typically breached either on day 3/4 or on day 5. TE cells are extracted through a combination of aspiration and laser excision from protruding blastocysts, or through aspiration combined with mechanical dissection from blastocysts on day 5/6.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ePresently, TE biopsy is the predominant technique utilized in PGT procedures\u0026nbsp;\u003csup\u003e[3]\u003c/sup\u003e. In comparison to cleavage-stage embryo biopsy, TE biopsy offers two primary benefits. Firstly, cleavage-stage biopsy notably diminishes the potential for human embryonic implantation, whereas TE biopsy does not. It has indicated that the sustained implantation rate of biopsied blastomeres on day 3 decreased by approximately 39% when compared with unbiopsied controls. Conversely, equivalent sustained implantation rates were observed in biopsied and unbiopsied blastocysts\u0026nbsp;\u003csup\u003e[4]\u003c/sup\u003e.\u0026nbsp;The reduced susceptibility of blastocysts to potential embryo damage may be attributed to the preservation of the inner cell mass, from which the fetus develops. Additionally, more cells (ideally five to eight cells) can be biopsied at\u0026nbsp;blastocyst\u0026nbsp;stage while only one single cell is recommended to remove at cleavage-stage. A two-cell removal at the cleavage-stage was shown to be more harmful for the embryonic development and implantation potential than the removal of one cell\u0026nbsp;\u003csup\u003e[5]\u003c/sup\u003e. The damage of TE biopsy was largely determined by the TE quality and experience of different embryologists. When fewer than 41 cells were biopsied, increasing the number of biopsied TE cells did not have a significant impact on the survival and implantation rates of blastocysts with a grade A TE score. However, a higher number of biopsied cells resulted in improved accuracy of genetic analysis\u0026nbsp;\u003csup\u003e[6]\u003c/sup\u003e. These advantages contribute to the widespread use of TE biopsy as the preferred method for obtaining samples from preimplantation embryos in PGT.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eA primary issue faced by patients undergoing TE biopsy in PGT is the relatively low rate of blastocyst formation.\u0026nbsp;Various factors were involved in blastocyst development such as female age, body mass index (BMI), number of retrieved oocytes, fertilization method, embryo culture conditions, number of blastomeres, and embryo quality. Reported blastocyst formation rates typically fall within the range of 40% to 60%\u0026nbsp;\u003csup\u003e[7-9]\u003c/sup\u003e.\u0026nbsp;TE biopsy may result in the wastage of a portion of embryos, as not all embryos progress to the blastocyst stage. The genetically unaffected embryos degenerated in blastomere-blastocyst tranformation also have the potential of bringing live birth if transferred. These wasted embryos may have great value for females with disease-causing mutations and a limited number of oocytes in PGT-M cycles.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ePB biopsy is a safe and efficient way to detect maternal genetic variants in PGT\u0026nbsp;\u003csup\u003e[10]\u003c/sup\u003e. PBs are by-products formed during the process of oocytes meiotic division and are not required for successful fertilization or normal embryonic development. PB1 obtains a subset of bivalent chromosomes after homologous chromosome separation in the first meiosis, whereas PB2 contains a haploid set of chromatids after separation of sister chromosome monomers in the second meiosis. Whether the embryo carries the maternal mutation could be deduced by detecting PB1 and PB2\u0026nbsp;\u003csup\u003e[11]\u003c/sup\u003e.\u0026nbsp;PB biopsy may offer greater benefits for females with a low number of oocytes in PGT-M. In comparison to TE biopsy, PB biopsy has the potential to conserve a higher number of genetically unaffected embryos and enhance oocyte utilization by identifying mutation carrier status prior to blastocyst formation. Additionally, PB biopsy is less detrimental to embryos when compared with blastomere biopsy. These advantages make PB biopsy a more promising approach.\u003c/p\u003e\n\u003cp\u003eIn this research, a novel PB biopsy-based strategy (Figure 1) was employed to perform PGT-M on three couples, where the females carried disease-causing mutations in autosomal dominant (\u003cem\u003eIRF6\u003c/em\u003e) or X-linked monogenic genes (\u003cem\u003eFMR1\u003c/em\u003e and \u003cem\u003eEDA\u003c/em\u003e). Each female had \u0026le;6 retrieved oocytes per cycle. Using this strategy, two of the three families had given birth to healthy babies. This study demonstrated the efficacy of utilizing PB1 and PB2 for detecting maternal mutations in PGT-M, suggesting potential benefits for females with a limited number of oocytes. \u0026nbsp;\u003c/p\u003e"},{"header":"Materials and methods","content":"\u003cp\u003e\u003cstrong\u003ePatients\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThree couples, in which the females were carriers of autosomal dominant or X-linked monogenic disease-causing mutations, were recruited from the Reproductive Medicine Center of Jiangxi Maternal and Child Health Hospital for this study conducted from August 2020 to July 2023. Genetic testing revealed that the three females carried pathogenic mutations in \u003cem\u003eIRF6\u003c/em\u003e, \u003cem\u003eFMR1\u003c/em\u003e, and \u003cem\u003eEDA\u003c/em\u003e, respectively (Figure 2). Additionally, poor ovarian reserve was noted, with each female expected to retrieve \u0026le;6 oocytes per cycle. After genetic counseling, all of the three couples refused to transfer embryos carrying the disease-causing mutations and decided to participate in our study of PGT-M using PB biopsy. Case 1 and 3 underwent a single cycle of PGT-M, while Case 2 underwent two cycles. All couples provided written informed consents at their first consulation. The study was approved by the Ethics Committee of Jiangxi Maternal and Child Health Hospital.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic variation detection\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGenomic DNA was extracted from peripheral blood samples using the QIAamp DNA Blood Mini kit (Qiangen, Germany). Trio-based and proband-only whole exome sequencing (WES) approaches were employed to identify genetic mutations in cases 1 and 3, respectively. The sequencing and analysis protocols were executed according to established methods \u003csup\u003e[12]\u003c/sup\u003e. Candidate mutations were detected in the probands and confirmed in other family members through Sanger sequencing. The pathogenic criteria of the detected mutations were interpretated according to ACMG \u003csup\u003e[13, 14]\u003c/sup\u003e and ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/). In case 2, the quantification of \u003cem\u003eFMR1\u003c/em\u003e CGG repeats was conducted using GC-rich PCR and Triplet-primed (TP) PCR, as described by Gao et al. 2020 \u003csup\u003e[15]\u003c/sup\u003e. The GC-rich PCR was employed for the direct determination of CGG repeat counts based on allele size, while TP-PCR allowed for qualitative detection of the expanded allele \u003csup\u003e[16]\u003c/sup\u003e. \u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eWorkflow of analysis\u003c/strong\u003e \u003c/p\u003e\n\u003cp\u003eThe workflow of the strategy is depicted in Figure 1. Initially, disease-causing mutations were identified in family members. Subsequently, for females carrying inherited mutations, single nucleotide polymorphisms (SNPs) flanking the mutation were examined in the genomic DNA of selected family members. Linkage analysis was carried out to identify the haplotype of chromsome segment carrying the mutation. For females with \u003cem\u003ede novo\u003c/em\u003e mutations, the PB1 and PB2 of each oocyte were biopsied. Each individual PB underwent whole genome amplification (WGA) through multiple displacement amplification (MDA) methodology. The mutation was detected directly in the MDA product of each PB. The SNPs surrounding the mutation were examined in the genotyped proband and PBs to determine the haplotype. Following oocyte fertilization and PB biopsy, the embryos were cryopreserved through vitrification on Day 3. The mutation carrier status of the corresponding embryo was deduced by direct mutation detection and haplotyping analysis of the PB1 and PB2. Embryos not carrying the mutation were chosen for frozen-thawed embryo transfer (FET).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePB biopsy\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eControlled ovarian hyperstimulation and oocyte retrieval procedures were performed on the female subjects. In vitro fertilization using ICSI was utilized to fertilize the oocytes. Biopsies of PB1 were conducted 2-3 hours post oocyte retrieval using laser assistance, while biopsies of PB2 were performed 5-6 hours after ICSI. \u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSingle PB WGA and mutation detection\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe single PB was adapted MDA (Qiagen, REPLI-g Single Cell Kit) for WGA. The resulting MDA DNA was diluted fivefold with nuclease-free ultra-pure water for mutation detection. The methods employed for mutation detection in blood-derived genomic DNA were similarly applied to the MDA DNA obtained from PB samples. \u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eHaplotype analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSNPs with the minor allele frequency of 0.3~0.5 were selected within 2Mb upstream and downstream of the \u003cem\u003eIRF6\u003c/em\u003e, \u003cem\u003eFMR1\u003c/em\u003e, and \u003cem\u003eEDA\u003c/em\u003e gene mutations, respectively. The primers targeted the SNPs were designed and synthesized (Twist Bioscience, USA). DNA samples from family members and the MDA products of PBs were subjected to multiplex PCR using the targeted primers. The amplified DNA was purified by XP beads (Thermo Fisher Scientific, USA) and the concentration of each DNA sample was measured. A total of 200ng purified DNA was utilized to prepare the library, employing the AmpSeq Library Prep Kit V2 (Vazyme Biotech, Nanjing, China). Subsequently, the library was sequenced using Miseq Dx sequencer (Illumina, USA). In case 1, the genomic DNA of the proband and the MDA products of the selected PBs underwent targeted SNP amplification following successful genotyping by Sanger sequencing. The resulting products of SNP amplification were then subjected to sequencing analysis in order to acquire information on the SNPs. The heterozygous SNPs identified in the proband were deemed as effective SNPs and utilized for haplotype analysis. Through linkage analysis, the haplotype associated with the \u003cem\u003eIRF6\u003c/em\u003e mutation was determined. In case 2 and 3, the genomic DNA of selected genotyped family members was used to identify the haplotypes by targeted SNPs sequencing. Specific PBs were chosen to conduct haplotyping. The mutation carrier statuses of the embryos were inferred and validated through the haplotypes of PB1 and PB2 derived from each oocyte.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFET and validation of the results\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMutation-free embryos were selected to transfer in FET cycles. The accuracy of PGT-M was verified by genetic test of amniotic fluid at 18 gestational weeks or umbilical cord blood at birth.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eMutation detection in the probands and family members\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe proband in Case 1 (II:1, Figure 2A) was a 33-year-old female afflicted with congenital orofacial clefts. No discernible phenotypic abnormalities were noted in her parents or spouse. Following the conception of a fetus with cleft lip and palate, the couple opted to terminate the pregnancy. Trio-WES of the proband and her parents revealed the presence of a \u003cem\u003ede novo\u003c/em\u003e variant c.784C\u0026gt;T (p.Gln262*) in \u003cem\u003eIRF6\u003c/em\u003e (NM_006147.3). Sanger sequencing of the family members confirmed the \u003cem\u003ede novo\u003c/em\u003e variant (Figure 2B).\u0026nbsp;The \u003cem\u003eIRF6\u003c/em\u003e gene, which encodes interferon regulatory transcription factor 6, is implicated in Van der Woude Syndrome (VWS), an autosomal dominantly inherited developmental disorder characterized by cleft lip and/or palate. The \u003cem\u003eIRF6\u003c/em\u003e c.784C\u0026gt;T variant was reported in a patient with VWS\u0026nbsp;\u003csup\u003e[17]\u003c/sup\u003e. According to the recommendation on sequence variants interpretation by the 2015 ACMG guidelines\u0026nbsp;\u003csup\u003e[13]\u003c/sup\u003e, the \u003cem\u003eIRF6\u003c/em\u003e c.784C\u0026gt;T variant would be classified as \u0026ldquo;pathogenic\u0026rdquo;, meeting the criteria PVS1+PS2+PM2_Supporting, and was recognized as the disease-causing factor of the proband.\u003c/p\u003e\n\u003cp\u003eThe proband in Case 2 (II:1, Figure 2C) was a 32-year-old female with premature ovarian failure. Her follicle-stimulating hormone (FSH) level was 59.32 mIU/mL, and anti-mullerian hormone (AMH) level was 0.052ng/ml. She was revealed as a premutation carrier of \u003cem\u003eFMR1\u003c/em\u003e with the CGG repeats of 29 and 90. The \u003cem\u003eFMR1\u003c/em\u003e CGG repeats of the proband\u0026rsquo;s father, mother and husband were 90/Y, 29/29, and 24/Y, respectively (Figure 2C, D).\u003c/p\u003e\n\u003cp\u003eIn Case 3, the couple remained unaffected, yet they had given birth to two boys afflicted with hypohidrotic ectodermal dysplasia (HED). The little son had passed away. A hemizygous missense variant c.1045G\u0026gt;A (p.Ala349Thr) of the \u003cem\u003eEDA\u003c/em\u003e gene (NM_001399.5) was found in the proband (II:1, Figure 2E) by WES. Defects in the \u003cem\u003eEDA\u003c/em\u003e gene cause X-linked HED which is characterized by hypotrichosis, hypohidrosis, and hypodontia. The \u003cem\u003eEDA\u003c/em\u003e c.1045G\u0026gt;A (p.Ala349Thr) variant had been reported in several patients with\u0026nbsp;X-linked HED\u0026nbsp;\u003csup\u003e[18-21]\u003c/sup\u003e and was interpretated as \u0026ldquo;pathogenic\u0026rdquo; by ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/, Variation ID: 11040). Sanger sequencing of the family members revealed that the proband\u0026rsquo;s mother carrying the heterozygous variant of \u003cem\u003eEDA\u003c/em\u003e c.1045G\u0026gt;A (Figure 2E, F).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirect mutation detection in PBs\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA total of 15 PB1s/PB2s from 4 PGT-M cycles were biopsied in the three couples. The mutations were detected in the MDA products of PBs by Sanger sequencing for Case 1 and 3, GC-rich PCR and TP-PCR for Case 2. The mutation carrier statuses of the corresponding embryos were deduced by the test results of PB1s and PB2s. The detection chromatograms were shown in Figure 3 and the results were presented in Table 1.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eIn Case 1, 6 oocytes were retrieved in one cycle. PB1 and PB2 of each oocyte were biopsied and examined by Sanger sequencing (Figure 3A, Table 1). In oocyte 1, only the wildtype genotype was detected in PB1 (F1-1-PB1) and PB2 (F1-1-PB2), suggesting that the corresponding embryo carried the mutant allele. The F1-1-PB1 should contain one wildtype allele and one mutant allele. The absence of the mutant allele in F1-1-PB1 suggests that the mutant allele was dropped out during the detection. PBs from oocyte 3 and 5 had similar test results with PBs in oocyte 1, with the exception of the absence of allele drop-out (ADO) in the detection of PB1s (F1-3-PB1 and F1-5-PB1). In oocyte 2 and 6, homozygous mutant genotype was detected in the PB1s (F1-2-PB1 and F1-6-PB1) and the wildtype was detected in the PB2s (F1-2-PB2 and F1-6-PB2). The mutation carrier statuses of these embryos were uncertain due to the possibility of ADO during the detection of the PB1s. The ADO rate for detecting genetic markers in PB1 was reported to be approximately 5.9%-9.6%\u0026nbsp;\u003csup\u003e[22]\u003c/sup\u003e. Given the relatively low ADO rate, the corresponding embryos of oocyte 2 and 6 probably inherited the wildtype allele. A similar approach was taken to assess the mutation carrier status of the embryo from oocyte 4, suggesting that it likely carried the mutant allele. Haplotype analysis was conducted to determine whether the Sanger sequencing results of the PB1s (F1-2-PB1, F1-4-PB1, and F1-6-PB1) had been affected by ADO.\u003c/p\u003e\n\u003cp\u003eIn Case 2, three oocytes were retrieved from two cycles. The CGG mutation of \u003cem\u003eFMR1\u003c/em\u003e was detected in PBs by GC-rich PCR and TP-PCR (Figure 3B, Table 1). In the first cycle, a solitary oocyte was retrieved. Only the expanded CGG allele was detected in the PB1 (F2-C1-1-PB1) by TP-PCR, suggesting that it carried the homozygous \u003cem\u003eFMR1\u003c/em\u003e CGG mutant allele and no ADO occurred during the detection. Because it was unlikely that the expanded allele was kept while the unexpanded allele was dropped out. The failure of GC-rich PCR to directly detect the CGG repeat in PB1 (F2-C1-1-PB1) was primarily attributed to the large size of the expanded allele, which hindered amplification by the MDA technique. The unexpanded CGG allele was detected in the PB2 (F2-C1-1-PB2) by both GC-rich PCR and TP-PCR. These results suggested that the corresponding embryo inherited the normal \u003cem\u003eFMR1\u003c/em\u003e allele. In the second cycle, two oocytes were retrieved. Analysis of the detection results of PB1s and PB2s (Figure 3B and Table 1) suggested that the embryo from oocyte 1 (F2-C2-1) exhibited a normal allele, whereas the embryo from oocyte 2 (F2-C2-2) displayed an expanded allele. The detection failure of PB2 in oocyte 1 may have been due to DNA degradation during the biopsy or amplification failure in the MDA procedure, but this did not impact the deduction made. \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eIn Case 3, a total of six oocytes were retrieved in one cycle. Similar detection and analysis methods were applied (Figure 3C, Table 1). The embryos from oocytes 2 and 5 were determined to carry the mutant allele, while the mutation carrier statuses of the remaining embryos were indeterminate. Specifically, the embryos from oocytes 1, 4, and 6 were likely to have inherited the normal allele, while the embryo from oocyte 3 was likely to carry the mutant allele, assuming absence of ADO. Haplotype analysis was conducted on the corresponding PB1s (F3-1-PB1, F3-3-PB1, F3-4-PB1, and F3-6-PB1) to assess the occurrence of any ADO. \u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eHaplotype analysis of family members and PBs\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn Case 1, the proband and the specific PBs (PB1s and PB2s from oocyte 2, 4 and 6) were selected to conduct linkage analysis. The SNP haplotypes of PB1s and PB2s from oocyte 2 and 4 were presented in Table 2. The haplotypes of PB1 and PB2 in oocyte 6 were found to be identical to those in oocyte 2 (data not shown due to redundancy). The haplotypes of PBs were found to be consistent with the results obtained from direct mutation detection. These findings indicated that the embryos from oocyte 2 and 6 inherited the wildtype allele, whereas the embryo from oocyte 4 was carrying the \u003cem\u003eIRF6\u003c/em\u003e c.784C\u0026gt;T mutant allele.\u003c/p\u003e\n\u003cp\u003eIn Case 2, the proband and her father were selected for linkage analysis in order to determine the SNP haplotype surrounding the \u003cem\u003eFMR1\u003c/em\u003e mutation. Haplotyping of the corresponding PBs of low-risk embryos was conducted to validate the mutation detection findings in the PBs (Table 1 and 3). The consistency between the haplotypes and the direct mutation detection results of PBs confirmed the low pathogenicity of the embryos from oocytes F2-C1-1 and F2-C2-1.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eIn Case 3, the proband and his mother were chosen for linkage analysis to investigate the SNP haplotype flanking the \u003cem\u003eEDA\u003c/em\u003e c.1045G\u0026gt;A mutation. The specific PBs (PB1s and PB2s from oocyte 1, 3, 4 and 6) were haplotyped to determine the mutation carrier statuses of the embryos (Table 1 and 4). The haplotypes of PB1 and PB2 in oocyte 6 were found to be identical to those in oocyte 4 (data not shown due to redundancy). The haplotypes of the PBs were consistent with the results of mutation detection and deduced that embryos from oocyte 1, 4, and 6 inherited the wildtype allele, whereas the emrbyo from oocyte 3 carried the \u003cem\u003eEDA\u003c/em\u003e c.1045G\u0026gt;A mutation.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEmbryo selection and transfer\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe mutation-free embryos deduced by the direct mutation detection and haplotype analysis were selected to transfer. Considering the morphology of these embryos, Case 1 chose the embryo from oocyte 2, Case 2 chose the embryo from oocyte 1 in the second cycle, Case 3 chose the embryo from oocyte 1, to transfer at the first time. The couples in Case 1 and 2 were clinically pregnant, while the couple in Case 3 were not. \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eValidation of the PGT-M results\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn Case 1, no cleft lip or palate was detected in the fetus by ultrasound methods throughout the pregnancy. A healthy baby girl was born and the \u003cem\u003eIRF6\u003c/em\u003e c.784C\u0026gt;T mutation was not detected in the genomic DNA from the umbilical cord blood at birth (data not shown). In Case 2, the amniocentesis of the couple was performed at 18 weeks of the gestation. The PGT-M result was reconfirmed by the mutation detection of genomic DNA in amnion cells (data not shown). A healthy baby girl was achieved after a normal period of gestation. The Case 3 was waiting for another embryo transfer cycle.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eSince the first report of a human live birth after blastocyst biopsy for PGT by\u0026nbsp;Kokkali et al\u0026nbsp;in 2005\u0026nbsp;\u003csup\u003e[23]\u003c/sup\u003e, the mainstream biopsy method of PGT had gradually shifted from a biopsy of PBs or cleavage-stage embryos to TE cells in the blastocyst stage\u0026nbsp;\u003csup\u003e[24]\u003c/sup\u003e. While TE biopsy offers numerous benefits, it may not be the optimal approach for individuals with a limited number of oocytes. Blastocyst formation rates exhibit variability across different centers, typically falling within the range of 40% to 60%\u0026nbsp;\u003csup\u003e[7-9]\u003c/sup\u003e. A subset of genetically unaffected embryos may fail to reach the blastocyst stage in the \u003cem\u003ein vitro\u003c/em\u003e culture system, resulting in their inability to be transferred. To increase the availability of transferable embryos for females with diminished oocyte reserves, we employed a novel PB-based testing strategy to perform PGT-M for three couples in which the female partners harbored pathogenic mutations. In Case 1, six oocytes were retrieved from the female proband afflicted with autosomal dominant orofacial clefts caused by the \u003cem\u003eIRF6\u003c/em\u003e c.784C\u0026gt;T mutation, two unaffected embryos were identified. The female in Case 2, diagnosed with premature ovarian failure caused by the \u003cem\u003eFMR1\u003c/em\u003e premutation, underwent two cycles resulting in the retrieval of three oocytes and preservation of two unaffected embryos. In Case 3, three out of six embryos were determined to not carry the \u003cem\u003eEDA\u003c/em\u003e c.1045G\u0026gt;A mutation in the female who had previously given birth to two boys with X-linked HED. The PB-based method accurately deduced the mutation carrier status of each oocyte, resulting in the retention of genetically unaffected embryos to the fullest extent possible.\u003c/p\u003e\n\u003cp\u003eTo ensure the precision of the deduction, a methodology combining mutation detection and haplotype analysis was employed to analyze PBs. The utilization of PB-based testing in PGT-M was first documented in 1990\u0026nbsp;\u003csup\u003e[25]\u003c/sup\u003e. Initially, only PB1 was directly tested for mutations, allowing for the determination of the mutation-carrier status of the oocyte in cases where a homozygous genotype was identified\u0026nbsp;\u003csup\u003e[25]\u003c/sup\u003e.\u0026nbsp;However, this PB1 approach was unable to predict the eventual genotype of the oocyte in instances of a heterozygous genotype, and the potential impact of ADO on the results of PB1 detection remained unclear. Then, polymorphic markers flanking mutations were tested in PB1 and PB2\u0026nbsp;\u003csup\u003e[11, 26]\u003c/sup\u003e. A large experience of 938 PB-based PGT-M cycles performed by a simultaneous detection of the mutation together with polymorphic markers for 146 different monogenic diseases revealed an extremely high accuracy rate of over 99%\u0026nbsp;\u003csup\u003e[11]\u003c/sup\u003e. In our study, a comparable methodology was employed with alterations, utilizing SNPs instead of short tandem repeats as polymorphic markers. This adjustment was made in order to potentially enhance the efficacy of identifying a sufficient number of informative markers, as targeted next-generation sequencing has the capacity to detect hundreds of SNPs simultaneously. Furthermore, haplotype analysis was conducted only when a homozygous genotype of PB1 was detected and uncertainty regarding ADO was present in the direct mutation test (Table 1-4). This approach has the potential to reduce testing expenses for patients. Due to the unsuccessful detection of CGG repeat sizes in the PB1s (F2-C1-1-PB1 and F2-C2-1-PB1) (Figure 3B), haplotype analysis was utilized in these samples to validate the inference.\u003c/p\u003e\n\u003cp\u003ePerforming PGT-M in females with premature ovarian failure due to FMR1 premutation presents challenges is challenging.\u0026nbsp;Besides the poor reservation of oocytes, the other obstacle is\u0026nbsp;to determine the CGG expansion status of \u003cem\u003eFMR1\u003c/em\u003e alleles in preimplantation samples\u0026nbsp;\u003csup\u003e[27]\u003c/sup\u003e. Linkage analysis by polymorphic markers was widely used to trace the transmission of the risk allele\u0026nbsp;\u003csup\u003e[28]\u003c/sup\u003e. However, the effectiveness of this approach depends on the availability of informative markers and their proximity to the \u003cem\u003eFMR1\u003c/em\u003e CGG repeat. The reliability is doubtful when few informative markers are available in the designated region. This deficiency could be addressed by direct detection of the \u003cem\u003eFMR1\u003c/em\u003e CGG repeat. In our study, the GC-rich PCR and the TP-PCR were used to directly test the \u003cem\u003eFMR1\u003c/em\u003e CGG repeats. The normal CGG allele was successfully detected in the PBs (F2-C1-1-PB2, F2-C2-2-PB1 and F2-C2-2-PB2) by GC-rich PCR. Although the repeat sizes of the mutant alleles were not detected in the samples (F2-C1-1-PB1 and F2-C2-2-PB1), the results of TP-PCR in these samples determined the expansion statuses (Figure 3B). It was reported that the TP-PCR reliably detected presence of \u003cem\u003eFMR1\u003c/em\u003e CGG expansion mutations in single cells biopsied in the Day 3 embryos\u0026nbsp;\u003csup\u003e[29]\u003c/sup\u003e. Our study verified the useful of TP-PCR in PB samples.\u003c/p\u003e\n\u003cp\u003eThe PB-based PGT-M strategy also have some\u0026nbsp;limitations. Firstly, it is unable to detect paternal mutations. Secondly, deducing genotype of embryo by detecting PBs is presumed that the chromatin in which the disease-causing genes located is replicating and separating smoothly during meiosis. The aneuploidy of these chromosomes will disrupt the detection. Thirdly, compared with biopsy methods performed on cleavage- or blastocyst-stage embryos, the PB-based strategy requires more manual interventions and testing of additional samples. Additionally, it is supported by evidence that blastocyst-stage embryo transfer yields higher clinical pregnancy rates and live birth rates compared with cleavage-stage embryo transfer\u0026nbsp;\u003csup\u003e[30]\u003c/sup\u003e. Further clinical trials are necessary to elucidate whether the PB-based strategy offers greater benefits than TE biopsy for females with a limited number of oocytes undergoing PGT-M for maternal mutations.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eWe performed PGT-Ms on three couples in which the females harbored pathogenic mutations and exhibited diminished oocyte reserves, utilizing a novel PB-based testing approach. Among these couples, two successfully achieved the birth of unaffected offspring. Our study indicated that the PB-based strategy is feasible and effective to detect the mutation carrier statuses of embryos in PGT-M for maternal mutations. Further clinic trials are warranted to verify whether PB biopsy offers greater benefits than TE cell biopsy for females with disease-causing mutations and a limited number of oocytes in PGT-M.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eTE\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eTrophectoderm\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003ePGT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003ePreimplantation genetic testing\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003ePGT-M\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003ePreimplantation genetic testing for monogenic disorders\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003ePB\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003ePolar body\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003ePB1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eThe first polar body\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003ePB2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eThe second polar body\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eMDA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eMultiple displacement amplification\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eICSI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eIntracytoplasmic sperm injection\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eBMI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eBody mass index\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eWES\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eWhole exome sequencing\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eTP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eTriplet-primed\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eSNP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eSingle nucleotide polymorphism\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eWGA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eWhole genome amplification\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eFET\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eFrozen-thawed embryo transfer\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eVWS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eVan der Woude Syndrome\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eFSH\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eFollicle-stimulating hormone\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eAMH\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eAnti-mullerian hormone\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eHED\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eHypohidrotic ectodermal dysplasia\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.806509945750452%\" valign=\"top\"\u003e\n \u003cp\u003eADO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"81.19349005424955%\" valign=\"top\"\u003e\n \u003cp\u003eAllele drop-out\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was approved by the Ethics Committee of Jiangxi Maternal and Child Health Hospital (Nanchang, China) and conducted in accordance with the tenets of the Declaration of Helsinki. All couples provided written informed consents at their first consulation.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll the patients included signed the consent for publication.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe data of this study are available from the corresponding author on reasonable request. The data are not publicly available due to privacy or ethical restrictions.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by National Natural Science Foundation of China (Grant No. 82160317), Jiangxi Provincial Natural Science Foundation (Grant No. 20224BAB206018 and 20232BAB216097), Jiangxi Province Key Research and Development Project (Grant No. 20232BBG70023), and Jiangxi Provincial Health Commission Science and Technology Innovation Key Project (Grant No. 2023ZD006).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors’ contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eJ.C., Y.L., Q.W., and Z.L. designed and performed the experiments, collected and analyzed data, and wrote the manuscript. X.W., Q.X., T.D., G.C., H.C., and Y.Zou conducted the experiment. J.H., Z.Z., L.T., and Y.Zhao conceived, designed, supervised the experiments, and revised the manuscript. R.D. contributed to the interpretation of the results. All authors contributed to the article and approved the submitted version. All authors read and approved by the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe thank the family members involved in this study. \u0026nbsp;\u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eDe Rycke M, Berckmoes V. Preimplantation Genetic Testing for Monogenic Disorders. Genes (Basel). 2020. 11(8): 871.\u003c/li\u003e\n\u003cli\u003eWei Y, Zhang T, Wang YP, Schatten H, Sun QY. Polar bodies in assisted reproductive technology: current progress and future perspectives. Biol Reprod. 2015. 92(1): 19.\u003c/li\u003e\n\u003cli\u003eKokkali G, Coticchio G, Bronet F, et al. ESHRE PGT Consortium and SIG Embryology good practice recommendations for polar body and embryo biopsy for PGT. Hum Reprod Open. 2020. 2020(3): hoaa020.\u003c/li\u003e\n\u003cli\u003eScott RT Jr, Upham KM, Forman EJ, Zhao T, Treff NR. Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Fertil Steril. 2013. 100(3): 624-30.\u003c/li\u003e\n\u003cli\u003eDe Vos A, Staessen C, De Rycke M, et al. Impact of cleavage-stage embryo biopsy in view of PGD on human blastocyst implantation: a prospective cohort of single embryo transfers. Hum Reprod. 2009. 24(12): 2988-96.\u003c/li\u003e\n\u003cli\u003eZhang S, Luo K, Cheng D, et al. Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality. Fertil Steril. 2016. 105(5): 1222-1227.e4.\u003c/li\u003e\n\u003cli\u003eComstock IA, Kim S, Behr B, Lathi RB. Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization. J Assist Reprod Genet. 2015. 32(9): 1299-304.\u003c/li\u003e\n\u003cli\u003eDeng J, Zhao Q, Cinnioglu C, Kayali R, Lathi RB, Behr B. The impact of culture conditions on blastocyst formation and aneuploidy rates: a comparison between single-step and sequential media in a large academic practice. J Assist Reprod Genet. 2020. 37(1): 161-169.\u003c/li\u003e\n\u003cli\u003eKermack AJ, Fesenko I, Christensen DR, et al. Incubator type affects human blastocyst formation and embryo metabolism: a randomized controlled trial. Hum Reprod. 2022. 37(12): 2757-2767.\u003c/li\u003e\n\u003cli\u003eSchenk M, Groselj-Strele A, Eberhard K, et al. Impact of polar body biopsy on embryo morphokinetics-back to the roots in preimplantation genetic testing. J Assist Reprod Genet. 2018. 35(8): 1521-1528.\u003c/li\u003e\n\u003cli\u003eKuliev A, Rechitsky S. Polar body-based preimplantation genetic diagnosis for Mendelian disorders. Mol Hum Reprod. 2011. 17(5): 275-85.\u003c/li\u003e\n\u003cli\u003eChen J, Yuan H, Xie K, et al. A novel TAB2 nonsense mutation (p.S149X) causing autosomal dominant congenital heart defects: a case report of a Chinese family. BMC Cardiovasc Disord. 2020. 20(1): 27.\u003c/li\u003e\n\u003cli\u003eRichards S, Aziz N, Bale S, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015. 17(5): 405-24.\u003c/li\u003e\n\u003cli\u003eBiesecker LG, Harrison SM. The ACMG/AMP reputable source criteria for the interpretation of sequence variants. Genet Med. 2018. 20(12): 1687-1688.\u003c/li\u003e\n\u003cli\u003eGao F, Huang W, You Y, et al. Development of Chinese genetic reference panel for Fragile X Syndrome and its application to the screen of 10,000 Chinese pregnant women and women planning pregnancy. Mol Genet Genomic Med. 2020. 8(6): e1236.\u003c/li\u003e\n\u003cli\u003eDean DD, Agarwal S, Kapoor D, Singh K, Vati C. Molecular Characterization of FMR1 Gene by TP-PCR in Women of Reproductive Age and Women with Premature Ovarian Insufficiency. Mol Diagn Ther. 2018. 22(1): 91-100.\u003c/li\u003e\n\u003cli\u003ede Lima RL, Hoper SA, Ghassibe M, et al. Prevalence and nonrandom distribution of exonic mutations in interferon regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome. Genet Med. 2009. 11(4): 241-7.\u003c/li\u003e\n\u003cli\u003eMonreal AW, Zonana J, Ferguson B. Identification of a new splice form of the EDA1 gene permits detection of nearly all X-linked hypohidrotic ectodermal dysplasia mutations. Am J Hum Genet. 1998. 63(2): 380-9.\u003c/li\u003e\n\u003cli\u003eLexner MO, Bardow A, Juncker I, et al. X-linked hypohidrotic ectodermal dysplasia. Genetic and dental findings in 67 Danish patients from 19 families. Clin Genet. 2008. 74(3): 252-9.\u003c/li\u003e\n\u003cli\u003eLiu Y, Huang Y, Hua R, et al. Mutation Screening of the EDA Gene in Seven Chinese Families with X-Linked Hypohidrotic Ectodermal Dysplasia. Genet Test Mol Biomarkers. 2018. 22(8): 487-491.\u003c/li\u003e\n\u003cli\u003eK\u0026ouml;rber L, Schneider H, Fleischer N, Maier-Wohlfart S. No evidence for preferential X-chromosome inactivation as the main cause of divergent phenotypes in sisters with X-linked hypohidrotic ectodermal dysplasia. Orphanet J Rare Dis. 2021. 16(1): 98.\u003c/li\u003e\n\u003cli\u003eRechitsky S, Strom C, Verlinsky O, et al. Allele dropout in polar bodies and blastomeres. J Assist Reprod Genet. 1998. 15(5): 253-7.\u003c/li\u003e\n\u003cli\u003eKokkali G, Vrettou C, Traeger-Synodinos J, et al. Birth of a healthy infant following trophectoderm biopsy from blastocysts for PGD of beta-thalassaemia major. Hum Reprod. 2005. 20(7): 1855-9.\u003c/li\u003e\n\u003cli\u003eMao D, Xu J, Sun L. Impact of trophectoderm biopsy for preimplantation genetic testing on obstetric and neonatal outcomes: a meta-analysis. Am J Obstet Gynecol. 2024. 230(2): 199-212.e5.\u003c/li\u003e\n\u003cli\u003eVerlinsky Y, Ginsberg N, Lifchez A, Valle J, Moise J, Strom CM. Analysis of the first polar body: preconception genetic diagnosis. Hum Reprod. 1990. 5(7): 826-9.\u003c/li\u003e\n\u003cli\u003eVerlinsky Y, Rechitsky S, Verlinsky O, et al. Polar body-based preimplantation diagnosis for X-linked disorders. Reprod Biomed Online. 2002. 4(1): 38-42.\u003c/li\u003e\n\u003cli\u003ePersico T, Tranquillo ML, Seracchioli R, Zuccarello D, Sorrentino U. PGT-M for Premature Ovarian Failure Related to CGG Repeat Expansion of the FMR1 Gene. Genes (Basel). 2023. 15(1): 6.\u003c/li\u003e\n\u003cli\u003eChen M, Zhao M, Lee CG, Chong SS. Identification of microsatellite markers \u0026lt;1\u0026thinsp;Mb from the FMR1 CGG repeat and development of a single-tube tetradecaplex PCR panel of highly polymorphic markers for preimplantation genetic diagnosis of fragile X syndrome. Genet Med. 2016. 18(9): 869-75.\u003c/li\u003e\n\u003cli\u003eRajan-Babu IS, Lian M, Cheah F, et al. FMR1 CGG repeat expansion mutation detection and linked haplotype analysis for reliable and accurate preimplantation genetic diagnosis of fragile X syndrome. Expert Rev Mol Med. 2017. 19: e10.\u003c/li\u003e\n\u003cli\u003eGlujovsky D, Quinteiro Retamar AM, Alvarez Sedo CR, Ciapponi A, Cornelisse S, Blake D. Cleavage-stage versus blastocyst-stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2022. 5(5): CD002118.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"margin:0in;text-align:left;font-size:14px;font-family:DengXian;line-height:11.0pt;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable 1 Direct detection results of the disease-causing mutations in polar bodies.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 6.3e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:42.55pt;border:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:6.8pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eCase No.\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;height:6.8pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eMaternal mutations\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;height:6.8pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eOocyte retrieval cycle No.\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.25pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;height:6.8pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eOocyte No.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;height:6.8pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eCell type\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e(Sample NO.)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;height:6.8pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eDirect detection results of the variants in polar bodies\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;height:6.8pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eDeduced risk of embryos carrying the mutations\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:106.3pt;border:solid windowtext 1.0pt;border-left: none;padding:0in 5.4pt 0in 5.4pt;height:6.8pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:10.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eThe number of low-risk embryos\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"12\" style=\"width:42.55pt;border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"12\" style=\"width:49.6pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eIRF6\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;c.784C\u0026gt;T\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHet.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"12\" style=\"width:49.65pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F1-1-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt. (Mutant allele drop-out)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"12\" style=\"width:106.3pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F1-1-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F1-2-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eIRF6\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ec.784C\u0026gt;T Homo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUncertain\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Probably Low)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F1-2-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F1-3-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eIRF6\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ec.784C\u0026gt;T Het.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F1-3-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F1-4-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUncertain\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Probably High)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F1-4-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eIRF6\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ec.784C\u0026gt;T Hemi.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F1-5-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eIRF6\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ec.784C\u0026gt;T Het.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F1-5-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F1-6-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eIRF6\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ec.784C\u0026gt;T Homo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUncertain\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Probably Low)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F1-6-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"6\" style=\"width:42.55pt;border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"6\" style=\"width:49.6pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eFMR1\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCGG repeat number\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e29/90\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:49.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F2-C1-1-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMutant allele Homo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:106.3pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F2-C1-1-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNormal allele Hemi.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"4\" style=\"width:49.65pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F2-C2-1-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMutant allele Homo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"4\" style=\"width:106.3pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F2-C2-1-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eDetection failure\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F2-C2-2-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNormal allele Homo.\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Mutant allele drop-out)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:28.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F2-C2-2-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNormal allele Hemi.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"12\" style=\"width:42.55pt;border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"12\" style=\"width:49.6pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eEDA\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;c.784C\u0026gt;T\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHet.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"12\" style=\"width:49.65pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F3-1-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eEDA\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;c.1045G\u0026gt;A Homo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUncertain\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Probably Low)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"12\" style=\"width:106.3pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:14.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F3-1-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eDetection failure\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F3-2-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Mutant allele drop-out)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F3-2-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F3-3-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUncertain\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Probably High)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F3-3-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eEDA\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;c.1045G\u0026gt;A Hemi.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F3-4-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eEDA\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;c.1045G\u0026gt;A Homo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUncertain\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Probably Low)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F3-4-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F3-5-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eEDA\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;c.1045G\u0026gt;A Het.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F3-5-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:42.25pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB1 (F3-6-PB1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eEDA\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;c.1045G\u0026gt;A Homo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:120.5pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eUncertain\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(Probably Low)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.2pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003ePB2 (F3-6-PB2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:120.5pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:3.35pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eWt.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;text-align:left;font-size:14px;font-family:DengXian;line-height:11.0pt;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable 2 The SNP haplotypes flanking the \u003cem\u003eIRF6\u003c/em\u003e gene (chr1:209,958,968-209,979,520) in case 1.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.8e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.7pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:127.55pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eCase 1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 127.8pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:62.35pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eChromosome\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 76.55pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eSNP position\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e(GRCH37/hg19)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" rowspan=\"2\" style=\"width:56.7pt;border:none;border-top: solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eProband\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e(\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eII\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e:1)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:14.15pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:127.55pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eOocyte 2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:14.15pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 127.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eOocyte 4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eF1-2-PB1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eF1-2-PB2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 56.7pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eF1-4-PB1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;border-right: none;border-bottom: none;border-left: none;border-image: initial;border-top: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eF1-4-PB2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e209656197\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e209663226\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e209700808\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e209712889\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e209887369\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e209965556\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210000282\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border: none;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: none;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border: none;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;border: none;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210005713\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210009372\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210020971\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210044393\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210104598\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210134382\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210176904\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:62.35pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChr1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e210194685\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: white;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.35pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(251, 228, 213);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;background: rgb(237, 125, 49);padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eNote: The deep orange marked haplotype indicates the chromosome segment carrying the mutant allele (\u003cem\u003eIRF6\u003c/em\u003e c.784C\u0026gt;T) and the light orange marked haplotype indicates the chromosome segment carrying the normal allele. \u0026ldquo;?\u0026rdquo; indicates the genotype of the SNP was detected failure.\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;text-align:left;font-size:14px;font-family:DengXian;line-height:11.0pt;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable 3 The SNP haplotypes flanking the \u003cem\u003eFMR1\u003c/em\u003e gene (chrX:146,993,437-147,032,645) in case 2.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"float: left;width: 5.9e+2pt;border-collapse:collapse;border:none;margin-left:6.75pt;margin-right:6.75pt;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"16\" style=\"width:588.05pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eCase 2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:63.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChromosome\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:75.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eSNP position\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(GRCH37/hg19)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" rowspan=\"2\" style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eProband\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eII\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e:1)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:14.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:54.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eThe proband\u0026rsquo;s father\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eI\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e:1)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:14.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:146.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eOocyte 1 in cycle 1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:148.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:26.15pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eOocyte 1 in cycle 2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:63.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF2-C1-1-PB1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF2-C1-1-PB2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:70.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF2-C2-1-PB1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF2-C2-1-PB2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e146680236\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e146683786\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e146684940\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e146689817\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e146919520\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e146958977\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;border:none;border-bottom:double windowtext 1.5pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e147401224\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e147746704\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e147945641\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e148017272\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e149497073\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.55pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:75.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e149497116\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.85pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:32.55pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.6pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.85pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.45pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:35.4pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u003cbr\u003e Note: The deep orange marked haplotype indicates the chromosome segment carrying the mutant allele (\u003cem\u003eFMR1\u003c/em\u003e CGG\u003csub\u003e90\u003c/sub\u003e) and the light orange marked haplotype indicates the chromosome segment carrying the normal allele. \u0026ldquo;?\u0026rdquo; indicates the genotype of the SNP was detected failure.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;text-align:left;font-size:14px;font-family:DengXian;line-height:11.0pt;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable 4 The SNP haplotypes flanking the \u003cem\u003eEDA\u003c/em\u003e gene (chrX:68,835,957-69,259,322) in case 3.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 6.5e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.7pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:118.4pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eCase 3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:116.8pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:121.1pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:63.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eChromosome\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:80.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eSNP position\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e(GRCH37/hg19)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" rowspan=\"2\" style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eThe proband\u0026rsquo;s mother\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e(\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eI\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e:2)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 12.3pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:45.35pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eProband\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e(\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eII\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e:1)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 14.15pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:118.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eOocyte 1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:116.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eOocyte 3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:121.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eOocyte 4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF3-1-PB1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF3-1-PB2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF3-3-PB1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF3-3-PB2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:56.7pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF3-4-PB1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eF3-4-PB2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e68513890\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e68556523\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e68556528\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e68770723\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e68777145\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e68790706\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;border:none;border-bottom:double windowtext 1.5pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt double windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:double windowtext 1.5pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:double windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;border:none;border-bottom:double windowtext 1.5pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e69266212\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;border: none;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;border:none;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e69271943\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e69288187\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e69291656\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e69308348\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e69409848\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e69423721\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eT\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:63.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eChrX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:80.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e69440241\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 12.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:right;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.15pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: bottom;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;margin-left:21.0pt;text-indent:-21.0pt;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:47.55pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e?\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.3pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 13.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;height: 2.85pt;vertical-align: top;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.35pt;border:none;border-bottom:solid windowtext 1.0pt;background:#ED7D31;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.15pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:50.25pt;border:none;border-bottom:solid windowtext 1.0pt;background:#FBE4D5;padding:0in 5.4pt 0in 5.4pt;height:2.85pt;\"\u003e\n \u003cp style=\"margin:0in;text-align:center;font-size:14px;font-family:DengXian;line-height:15.0pt;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eG\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;text-align:justify;font-size:14px;font-family:DengXian;\"\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eNote: The deep orange marked haplotype indicates the chromosome segment carrying the mutant allele (\u003cem\u003eEDA\u003c/em\u003e c.1045G\u0026gt;A) and the light orange marked haplotype indicates the chromosome segment carrying the normal allele. \u0026ldquo;?\u0026rdquo; indicates the genotype of the SNP was detected failure.\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"orphanet-journal-of-rare-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ojrd","sideBox":"Learn more about [Orphanet Journal of Rare Diseases](http://ojrd.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ojrd/default.aspx","title":"Orphanet Journal of Rare Diseases","twitterHandle":"@bmc","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"preimplantation genetic testing, PGT, monogenic disease, polar body, a limited number of oocytes, single nucleotide polymorphism, linkage analysis","lastPublishedDoi":"10.21203/rs.3.rs-4286089/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4286089/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Background\n\nTrophectoderm (TE) cell biopsy at the blastocyst stage is currently the predominant method used in preimplantation genetic testing for monogenic disorders (PGT-M). However, this approach may result in the discarding of genetically unaffected embryos due to the fact that not all embryos progress to the blastocyst stage. This study aimed to investigate the advantages of utilizing polar body (PB) biopsy in females with disease-causing mutations and a limited number of oocytes undergoing PGT-M.\n\nMethods\n\nThree couples with females carrying autosomal dominant or X-linked mutations in IRF6, FMR1, and EDA were recruited. The number of retrieved oocytes was no more than six per cycle. The first and second PBs (PB1 and PB2) of each oocyte were individually biopsied and subjected to multiple displacement amplification (MDA). The genotype of each embryo was deduced by analyzing the MDA products of corresponding PB1 and PB2 using a novel strategy that combined direct mutation testing and single nucleotide polymorphism linkage analysis. Mutation-free embryos cryopreserved before the blastocyst stage were selected to transfer.\n\nResults\n\nIn total, four cycles were conducted resulting in the retrieval of 15 oocytes for the three couples. The genotype of each embryo was successfully determined. Seven mutation-free embryos were identified. Three of them were transferred and resulted in two clinical pregnancies, culminating in the birth of two healthy babies. The accuracy of the embryo genotypes was validated through genetic testing of the fetuses in the second trimester or at birth.\n\nConclusions\n\nThe PB-based strategy is feasible and effective to detect the mutation carrier statuses of embryos in PGT-M for maternal mutations. Compared with blastocyst stage detection, this method may preserve a higher number of genetically unaffected embryos for the patients. Further clinic trials are warranted to verify whether PB biopsy offers greater benefits than TE cell biopsy for females with disease-causing mutations and a limited number of oocytes in PGT-M.","manuscriptTitle":"Clinical application of polar-body based preimplantation genetic testing for maternal mutations in females with a limited number of oocytes","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-06-06 15:38:37","doi":"10.21203/rs.3.rs-4286089/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2024-06-28T17:22:39+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2024-05-23T15:50:12+00:00","index":0,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-05-21T02:14:40+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-05-09T23:52:19+00:00","index":"","fulltext":""},{"type":"submitted","content":"Orphanet Journal of Rare Diseases","date":"2024-04-18T04:04:24+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"orphanet-journal-of-rare-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ojrd","sideBox":"Learn more about [Orphanet Journal of Rare Diseases](http://ojrd.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ojrd/default.aspx","title":"Orphanet Journal of Rare Diseases","twitterHandle":"@bmc","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4ae6d181-912c-4655-8071-c0c2db8dadec","owner":[],"postedDate":"June 6th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2025-04-07T16:05:44+00:00","versionOfRecord":{"articleIdentity":"rs-4286089","link":"https://doi.org/10.1186/s13023-025-03659-7","journal":{"identity":"orphanet-journal-of-rare-diseases","isVorOnly":false,"title":"Orphanet Journal of Rare Diseases"},"publishedOn":"2025-04-01 15:56:51","publishedOnDateReadable":"April 1st, 2025"},"versionCreatedAt":"2024-06-06 15:38:37","video":"","vorDoi":"10.1186/s13023-025-03659-7","vorDoiUrl":"https://doi.org/10.1186/s13023-025-03659-7","workflowStages":[]},"version":"v1","identity":"rs-4286089","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4286089","identity":"rs-4286089","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}