Expression of MMP-2 and VEGF in endometriosis

Objective:To investigate the expression of MMP-2 and VEGF in different endometrium tissues.Methods:The expressions of MMP-2 and VEGF protein were evaluated by immunohistochemistry(S-P method) in 76 ectopic endometrium and 64 eutopic endometrium and 72 normal endometrium.Results:①The expression of MMP-2 in ectopic endometrium was significantly higher than that in eutopic and normal endometrium;The expression of MMP-2 protein in ectopic endometrium was significantly higher than that in eutopic and normal endometrium at proliferative phase;In eutopic and normal endometrium,the expression of MMP-2 protein at secretory phase was significantly higher than that at proliferative phase.②The expression of VEGF protein became lower and lower in ectopic,eutopic and normal endometrium;At proliferative phase,the expression of VEGF protein in ectopic endometrium was significantly higher than that in eutopic and normal endometrium,while at secretory phase,it was higher in ectopic and eutopic endometrium than that in normal endometrium;In ectopic and eutopic endometrium,the expression of VEGF protein at secretory phase was all significantly higher than that at proliferative phase;but in normal endometrium there was no significance and they were low both at secretory and proliferative phase.③There was correlation between VEGF and MMP-2.Conclusion:MMP-2 and VEGF are obviously overexpressed in ectopic endometrium and they may play an important role in the development of endometriosis.