Prognosis and Immune Cell Infiltration Analysis of OAS Family Genes in Pan-Cancer

2′-5′-oligoadenylate synthetases (OAS) family is interferon (IFN) -induced antiviral enzymes including OAS1, OAS2, OAS3, and OAS-like (OASL) is increasingly thought to play significant roles in human cancers. This study aims to explore the potential role of OAS family genes with a new clue to providing insights on tumor immune mechanisms implicated here. High expression levels of OAS family gene were observed in most cancer types. OAS family gene expression in tumor samples correlated with poor overall survival in several cancers such as Brain Lower Grade Glioma (LGG). OAS family genes were associated with M1 macrophages in cancers. Tumor mutation burden (TMB), microsatellite instability (MSI) correlated with OAS family genes dysregulation in cancers. OAS1/OAS3/OASL is a promising target for AP-26113, and OAS2/OASL is more likely to be an effective target for itraconazole. OAS1 and OASL were significantly correlated with their pathological stages in KIRC. OAS family genes were positively correlated with M1 macrophages. Gene set enrichment analysis (GSEA ) results demonstrated OAS1/OAS2/OASL have pathways commonly associated with immunity in KIRC such as natural killer cell mediated cytotoxicity. Our study suggests that OAS family genes may influence cancer development, particularly KIRC, by modulating M1 macrophages and NK cells.