Expression of MMP9, TIMP1, VEGF in ectopic and eutopic endometrium in patients with endometriosis

To study the expression of MMP9 , TIMP1 and VEGF in eutopic endometrium in patients with endometriosis. The expressions of MMP9,TIMP1,MMP9/TIMP1,VEGF in eutopic endometrium were detected by immunohistochemistry SP method. Image dissector is used to determine that corresponding density. The expressions of MMP9,TIMP1,MMP9/TIMP1 and VEGF in eutopic and in the control group endometrium are 0.336,0.276;0.253,0.267 and 1.293,1.034;0.372,0.288 respectively. The expressions of MMP9,MMP9/TIMP1,VEGF are higher in eutopic endometrium than those of control group (P0.01 or P0.05). The high expressions of MMP9 and VEGF in eutopic endometrium in patients with EM may be related to the pathogenesis of EM. The expressions of high MMP9 and VEGF in eutopic endometrium are expected to create a diagnostic methods of EM.