Uterine fibroids and current clinical challenges

Uterine fibroids represent the most prevalent gynecological tumors in premenopausal women, with hysterectomy serving as the definitive treatment option despite the advantages of minimally invasive surgical techniques. Current pharmacological interventions are considered unsatisfactory because they typically target only a single pathway, such as estrogen or progesterone signaling, which limits their therapeutic efficacy. The authors argue that future investigations should focus on developing multi-target drugs capable of modulating multiple critical hubs within the signaling networks underlying fibroid pathogenesis to achieve more robust and durable effects. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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