Identification of common electrochemical oxidation pathways and mass spectrometry fragmentation patterns of the fluoroquinolones difloxacin, norfloxacin, ofloxacin and pefloxacin

Identification of common electrochemical oxidation pathways and mass spectrometry fragmentation patterns of the fluoroquinolones difloxacin, norfloxacin, ofloxacin and pefloxacin | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Identification of common electrochemical oxidation pathways and mass spectrometry fragmentation patterns of the fluoroquinolones difloxacin, norfloxacin, ofloxacin and pefloxacin Melanie Voigt, Tobias Weißberg, Jana Boehm, Alexandra Schoentag, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8368141/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 5 You are reading this latest preprint version Abstract Among other fluoroquinolones, difloxacin, norfloxacin, ofloxacin, and pefloxacin are regularly detected in various bodies of water around the world. Advanced oxidation processes such as the electrochemical oxidation are employed to eliminate these micropollutants. Using a microflow cell and a synthesis cell, the four fluoroquinolones were submitted to electrochemical oxidation through a boron-doped electrode. They were subsequently analyzed using high-performance liquid chromatography coupled with high-resolution mass spectrometry. Electrochemical oxidation occurred above 800 mV. Products were formed according to common mechanisms: hydrogen and ethylene elimination, methylene/methyl cleavage, hydroxylation in combination with methyl cleavage. To facilitate future identification of electrochemical oxidation products of the fluoroquinolone class, fragmentation patterns in higher-order mass spectrometry were investigated deriving typical motives. A total of 17 products were identified, 13 of which were novel. Quantitative structure-activity relationship analysis suggested that the electrochemical oxidation products would be less ecotoxic than the initial drugs. Electrochemical Oxidation BDD-Electrode Fluoroquinolones structure elucidation MSn pathway QSAR Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 1. Introduction Fluoroquinolones are detected in surface waters worldwide. The active ingredients, norfloxacin, ofloxacin, and pefloxacin are used in human medicine, difloxacin in veterinary medicine. sewage treatment plants that are not equipped with advanced treatment stages to remove these substances from wastewater have been reported as main sources of contamination (Patel et al. 2019 ; Matesun et al. 2024 ). Norfloxacin and ofloxacin have been detected in surface waters with concentrations ranging from several hundred µg/L to mg/L (Dusi et al. 2019 ). Several fluoroquinolones also enter the aquatic ecosystem since they are administered to animals (Riaz et al. 2018 ; Bhatt and Chatterjee 2022 ). Among them, difloxacin was mainly detected in livestock sewage. Reported concentrations were 14.2 µg/L (Dusi et al. 2019 ). In other surface waters, the concentration of difloxacin was in the ng/L range. These contaminations threaten ecosystems by promoting the development of antibiotic resistance and posing risks to aquatic life (Bhatt and Chatterjee 2022 ; Thai et al. 2023 ). While it is currently not authorized for medical use in Germany, perfloxacin has been approved in some countries of the EU for the prevention of infection after urological treatments. Yet due to serious and long-lasting side effects, its authorization has been severely restricted. In China, pefloxacin was detected in surface waters with concentrations of up to 34 µg/L (Dusi et al. 2019 ). In order to eliminate these substances from water bodies and prevent their entry into the aquatic environment, intense research has been conducted for years into a new, enhanced purification stage in wastewater treatment plants. Advanced oxidation processes (AOPs) such as ozonation, UV treatment, and the electrochemical oxidation used in this study have first become promising and later established processes (Mazivila et al. 2019 ; Voigt et al. 2020 ). A common feature of AOPs is the formation of hydroxyl radicals from the water, the hydroxyl radicals deconstruct the substances via the indirect pathway. The substances may be degraded directly e,g,, through anodic electrochemical oxidation (Sirés et al. 2014 ; Voigt et al. 2023 ). The boron-doped diamond (BDD) electrode has established itself as one of the most efficient anodes, also allowing the formation of hydroxyl radicals. At a potential of greater than 1.23 V, an electrochemical oxidation transfer reaction (EOTR) takes place (Kapałka et al. 2007 ). During this EOTR, the process of water oxidation occurs first,, resulting in the adsorption of hydroxyl radicals onto the BDD anode surface, see Eq. 1 (Kapałka et al. 2007 ; Vargas et al. 2016 ; Wang et al. 2025 ). BDD[ ] + H 2 O → BDD[OH.] + H + + e − (1) These hydroxyl radicals can subsequently attack organic substances R . Ideally, these will be completely mineralized according to Eq. 2. x BDD[OH.] + R (aq) → x BDD[ ] + mineralization products + y H + + y e − (2) where x and y are stoichiometric coefficients (Kapałka et al. 2007 ; Vargas et al. 2016 ). High-performance liquid chromatography (HPLC) coupled with high resolution mass spectrometry (HRMS) is often used to identify transformation products (Knoche et al. 2022 ; Hollender et al. 2023 ). Multifragmenting mass spectrometry (MS n ) experiments were employed to elucidate the molecular structures. Typical fragmentations of fluoroquinolones were reported to be hydrogen fluoride cleavage (-20 Da), decarboxylation (-44 Da) and/or water cleavage (-18 Da). In addition, the piperazine ring may be fragmented and eliminated partially or completely (Calza et al. 2008 ; Niessen and Correa C. 2017; Fan et al. 2024 ; Wang et al. 2025 ). High-resolution higher-order mass spectrometry showed that electrochemical oxidation of selected fluoroquinolones occurred via the pathways hydrogen elimination, hydroxyl radical addition, and methyl or methylene cleavage (Voigt et al. 2024 ). Reactions via the combined pathways were observed as well. The structural investigation of the electrochemical transformation products of the studied fluoroquinolones revealed that the reactions preferentially took place at the piperazine ring. The indirect pathway i.e., hydroxyl radical reactions from water oxidation, was found active. Yet, direct anodic oxidation was also recognized through the TPs as hydrogen elimination and methyl/methylene cleavage. To date, typical mass spectrometric fragmentation pathways of electrochemical oxidation products have not been published on the fluoroquinolones difloxacin, pefloxacin, ofloxacin and norfloxacin. This study aims among other aspects to close this gap. It will also be investigated whether the known pathways can be extended to the fluoroquinolone class. In addition the required voltages for initiating the degradation shall be compared to the previous study. While fluoroquinolones act on bacteria and microorganisms, the application of AOPs can change the effect. First-generation fluoroquinolones, such as norfloxacin, are primarily used against Gram-negative pathogens. Second-generation fluoroquinolones, such as difloxacin, pefloxacin, and ofloxacin, are also effective against Gram-positive and atypical pathogens (Bhatt and Chatterjee 2022 ). An overview of the fluoroquinolones used in this study is shown in Fig. 1 , where the pharmacophores are color-coded. Ecotoxicological studies rely on in vivo and in vitro assays. Electrochemical oxidation produces a mixture of transformation products that are difficult to isolate in quantities sufficient for ecotoxicity testing. The synthesis and procurement of the products is also challenging and associated with high costs. For this reason, Quantitative Structure-Activity Relationship (QSAR) analysis is often used as an alternative for assessment. Here, ecotoxicity is predicted for individual substances based on structural similarity and mathematical models (Voigt and Jaeger 2023 ). In this study, the four fluoroquinolones difloxacin, pefloxacin, ofloxacin, and norfloxacin are degraded by electrochemical oxidation. Firstly, the conditions and voltage for the electrochemical oxidation are investigated. To this purpose, two electrolysis cells are used: a synthesis cell, which is operated in batch mode, and a microfluidic cell for a continuous process. The products are identified using HRMS. The comparison of the fragmentation products during structure elucidation, typical fragmentation pathways are derived. By means of the elucidated structures, the electrochemically induced degradation mechanisms of the fluoroquinolones are investigated. Finally, QSAR analysis is applied to predict the ecotoxicity of the individual products based on the molecular structures. The study shall contribute to the optimization of the potential use of electrochemical AOPs in advanced wastewater treatment. 2. Materials and Methods 2.1 Chemicals and reagents Difloxacin hydrochloride (> 98%), norfloxacin (> 98%), ofloxacin (> 98%) and pefloxacine methanesulphonate dihydrate (99.5%) were purchased from BLD Pharmatech GmbH (Kaiserslautern, Germany). Formic acid (98–100%, EMSURE® Reag. Ph. Eur., ACS for analysis, Supelco®, Merck, Darmstadt, Germany) was used to acidify the fluoroquinolone solution for electrochemical oxidation. Thus, sufficient conductivity of the solution was also ensured. The eluents used for HPLC-HRMS were ultrapure water, as eluent A, and acetonitrile (Carl Roth, Karlsruhe, Germany) as eluent B. To both eluents 0.1% formic acid were added. 2.2 Electrochemical Oxidation In order to determine the optimal voltage, where the maximum number of products was formed, mass voltammograms were recorded using an electrochemical micro-flow cell (µPrepCell, Antec Scientific, Zoeterwoude, The Netherland). Solutions with a final concentration of 20 ± 2 mg/L fluoroquinolone and ultrapure water were prepared. The pH value was adjusted to 3 using formic acid. The experiments were conducted in a ROXY™ system (Antec Scientific, Zoeterwoude, The Netherland) consisting of the micro-flow cell and a potentiostat. The system was controlled via Dialogue Elite™ software (Antec Scientific, Zoeterwoude, The Netherland) version 2.21.8.1. The oven temperature was set to 35°C and the polarity was selected as positive. A BDD electrode was used as the working electrode. The ROXY™ system was coupled directly to a high-resolution orbital ion trap hybrid mass spectrometer (Orbitrap IDX, ThermoFisher Scientific, Waltham, USA). Mass spectra were recorded between m/z 100 to 1000. The scan rate of 5 mV/s from 0 to 3500 mV were chosen. The solutions were pumped through the flow cell at a rate of 50 µL/min. The mass voltammograms were recorded with 15 accumulations. The scans were averaged. They were also smoothed and normalized. For this purpose, the mean value from 0 to 500 mV was calculated as the starting value. The electrochemical oxidation experiments in a synthesis cell were also performed in the ROXY™ system. The micro-cell was exchanged for a small electrosynthesis chamber (SynthesisCell, Antec Scientific, Zoeterwoude, Netherlands). Electrolysis of the solutions prepared as described above was performed using again the BDD electrode. Samples were taken at various time intervals of 0, 10, 20, 30, 45, 60, 75, 90, 120, 150, 180, 210, 240, 300, and 360 minutes using a syringe. The voltage was kept constant at 0.75 V, 1.00 V, 1.25 V, or 1.50 V. The samples were then analyzed using HPLC-HRMS. 2.3 HPLC-HRMS The samples in the vials were analyzed using a (U)HPLC (Vanquish Core, ThermoFisher Scientific, Waltham, USA) coupled to an orbital ion trap hybrid mass spectrometer. The mass range was set to 100 to 1000 m/z. The mass spectra were recorded at a resolution of 60000. MS n fragmentation was performed in the high-energy collision cell (HCD) with a normalized collision energy of 30% for MS² and 45% for MS³. Thermo Scientific XCalibur version 4.3.73.11 was used for instrument control. A Polaris 3 Amide C18 column (150 mm x 2 mm, Agilent, Waldbronn, Germany) was used for reversed-phase chromatography analysis. Chromatographic separation was performed in isocratic mode with an eluent ratio of 90:10 (A:B) both acidified with 0.1% formic acid. The flow rate was set to 0.3 mL/min. The duration of the analysis was 20 minutes. Accurate mass and isotope patterns were recorded for structure elucidation, allowing the molecular formula to be derived. Tentative structures were generated using ACD/ChemSketch 2016.1.1 software (ACDLabs, Toronto, ON, Canada). Based on the initial chemical structure, plausible structures were identified. The next step was to inspect the MS/MS and MS 3 spectra. The observed m/z values and differences were then compared with the expected values of the fragments created from the plausible structures, according to the standard fragmentation rules (Niessen 2011 ; Niessen and Honing 2015 ; Schymanski et al. 2015 ). The best matches with respect to the fragmentation pathway and the m/z values were considered to be structurally confirmed. 2.4 QSAR QSAR analysis was achieved using the software QSAR Toolbox Version 4.4.1. (LMC Oasis, Pourgas, Bulgaria). Chemicals structures were drawn with the software ACD/ChemSketch 2016.1.1 (ACDLabs, Toronto, ON, Canada) and entered into the QSAR toolbox. For in silico determination of ecotoxicity of individual substances ECOSAR (Ecological Structure-Activity Relationship), which is implemented in the QSAR Toolbox, was used. As Class, Vinyl/Allyl Ketones (1.0). Acute (median lethal concentration LC 50 and half maximal effective concentration (EC 50 )) were chosen and chronic toxicity (ChV) were thus predicted for the aquatic organism branchiopoda, actinopterygii and green algae. All fluoroquinolones and their observed transformation products were ranked from ecotoxic to non-ecotoxic based on the LC 50 , EC 50 and ChV values obtained (Voigt et al. 2024 ). 3. Results and Discussion 3.1 Mass voltammograms and concentration-time curves of the four fluoroquinolones The effect on the electrochemical oxidation of fluoroquinolones in the microflow cell or synthesis cell as a function of voltage can be determined using the mass voltammograms or concentration-time curves, see Fig. 2 . The mass voltammograms of the four fluoroquinolones showed the absence of electrochemical oxidation below approximately 800 mV. Then a continuous decrease of the substances occurred with voltages increasing to approximately 1500 mV. At that voltage, the the mass voltammograms reached a constant level, as the fluoroquinolones were continuously flowed into the cell. An analogous observation was obtained from the normalized concentration-time diagrams recorded during oxidation in the synthesis cell. At 750 mV, no degradation of the substances occurred, while decomposition became apparent at 1000 mV. Ofloxacin degraded fastest, followed by difloxacin and finally pefloxacin, which decreased at the same rate as norfloxacin. The degradation of pefloxacin and norfloxacin was exhibited this similarity, since both compounds possess similar structures with pefloxacin having a methyl substituent at the piperazine ring, while difloxacin and ofloxacin differ significantly with respect to their structures. The concentration-time curves showed similar behavior at 1250 mV. At 1500 mV, the decays finally converged. Hence, at voltages of 1500 mV and above, the degradation rate was observed independent of the fluoroquinolone structure. As indicated in Fig. 2 , the voltage range between 800 and 1500 mV is particularly interesting. While below that range degradation was absent, no transformation products were to be expected. 3.2 Identification of electrochemical oxidation products Table 1 provides an overview of the identified electrochemical oxidation products of difloxacin, pefloxacin, ofloxacin, and norfloxacin, which were formed in both the microflow and the synthesis cell. As both cells were equipped with BDD electrodes, TPs were identical. Table 1 Difloxacin, norfloxacin, ofloxacin, pefloxacin and their identified electrochemical oxidation products with their and exact accurate masses and corresponding m/z values from MS/MS and MS 3 Substance [M + H] + exact [M + H] + accurate ∆ ppm m/z MS/MS m/z MS 3 Reference Difloxacin 400.1467 400.1465 0.4998 356.1569; 299.0990 299.0990 285.0832 70.0653; - D402 402.1260 402.1258 0.4974 371.0820; 327.0924; 299.0974 327.0926 299.0989 279.0913; 299.0985 279.0913 238.0950; 279.0913 216.0608 173.5031 (Hubicka et al. 2013 ) D398 398.1311 398.1309 0.5024 354.1412; 311.0969; 70.0646 311.0974 283.0660 256.0553; 283.0662 256.0553 242.0762; 55.0415 54.0336 D384 384.1154 384.1155 0.2603 340.1254 283.0660 256.0568 D374 374.1311 374.1308 0.8019 354.1228; 317.0713; 299.0971 336.1127 308.1177 280.1228; 299.0610 271.0660 243.0713; 255.0712 243.0713 216.0606 (Linke et al. 2010 ) Norfloxacin 320.1405 320.1406 0.3124 276.1507; 256.1445; 233.1085 233.1085 219.0929 205.0773; 227.1053 212.0818 201.1023; 218.0850 205.0773 185.0710 N354 354.1460 354.1459 0.2824 336.1341; 318.1236 318.1234 298.1172 250.0734; - (Carneiro et al. 2020 ) N322 322.1198 322.1195 0.9313 305.0913; 261.1035; 233.1086 233.1073 205.0762 72.0441; 233.1072 205.0761 176.0736; 205.0771 185.0702 176.0744 (Carneiro et al. 2020 ) N318 318.1249 318.1247 0.6287 274.1331; 245.1068; 219.0914 226.0962 219.0916 190.0663; 217.0761 190.0654 162.0342; 204.0655 191.0608 163.0422 N294 294.1249 294.1245 1.3600 274.1167; 251.0810; 233.1085 256.1066 227.0678 200.1173; 233.0708 223.0502 205.0397; 205.0761 176.0735 149.0502 Ofloxacin 362.1510 362.1515 1.3806 318.1616; 261.1034 261.1036 221.0722 70.0654; 219.0567 205.0410 179.0379 O364 364.1303 364.1310 1.9224 333.0865; 289.0983; 86.0596 289.0968 261.1019 221.0710; 261.1018 221.0709 205.0397; 58.0650 56.0493 O360 360.1354 360.1358 1.1107 316.1440; 273.1016; 70.0647 301.1221 245.0706 70.0649; 245.0715 205.0397 175.0293; 55.0415 54.0337 O348 348.1354 348.1360 1.7235 304.1437; 284.1375; 261.1015 284.1380 261.1020 173.5015; -; 221.0721 205.0397 179.0369 O346 346.1198 346.1203 1.4446 302.1280 260.0815 220.0631 84.0805 O336 336.1354 336.1362 2.3800 316.1276; 279.0758; 235.0862 298.1170 270.1219 242.1274; 261.0653 238.0371 220.0267; 193.0877 173.5013 Pefloxacin 334.1562 334.1562 0.0000 290.1660; 233.1082; 219.0926 233.1084 205.0771 70.0653; 205.0772 203.0616 185.0710; 219.0928 217.0771 191.0616 P336 336.1354 336.1353 0.2975 305.0928; 261.1030 261.1030; 233.1084 205.0772 P332 332.1405 332.1407 0.6021 245.1080; 217.0767; 70.0649 190.0661 173.5021 162.0348; 190.0660 162.0347 134.0399; - P318 318.1249 318.1245 1.2574 274.1342; 245.0952; 217.1003 245.0957 217.1009; 217.1010 174.0587 160.0431; - P308 308.1405 308.1404 0.3245 288.1339; 251.0821; 207.0924 270.1231 241.0842 214.1339; 233.0718 149.0508 137.0508; 179.0612 173.5028 As listed in Table 1 , TPs were formed according to the same mechanism. As examples, a mass difference of -2 Da could be recognized in TPs D398, N318, O360 and P332, indicating a loss of di-hydrogen, typical for electrochemical oxidation. The mass difference of a hydroxylation in combination with methyl cleavage is + 2 Da, as occurring with D402, N322, O364 and P336. Figure 3 shows the structure of all TPs that were observed. They are arranged according to the formation pathways. A total of four different reactions were observed. First, the typical hydrogen cleavage at the piperazine ring was seen. Then, hydrogen cleavage in combination with the methyl elimination at the piperazine ring was identified. Since norfloxacin does not have a methyl substituent at the piperazine ring, this transformation product was absent in the norfloxacin experiment. The elimination of ethene from the piperazine ring was identified as the third reaction. A fourth reaction pathway was the cleavage of the methine-group in combination hydrogen elimination and addition of a hydroxyl group. Furthermore, two transformation products were identified and elucidated that could not be assigned to any of these four reaction schemes. In the transformation product of norfloxacin N354, two hydroxyl groups were added to the piperazine moiety. In the conversion product of ofloxacin O348, the methyl group was eliminated from the piperazine ring. It should be noted that all changes and mechanisms observed during the electrochemical oxidation of the four fluoroquinolones occurred at the piperazine ring. Hence, the observations made in a previous study on ciprofloxacin, danofloxacin, enoxacin, levofloxacin, and lomefloxacin were confirmed for the fluoroquinolones of this study (Voigt et al. 2024 ). 3.3 Fragmentation pathways of electrochemical oxidation products of danofloxacin, norfloxacin, ofloxacin and pefloxacin starting from electrospray ionization The mass fragmentation of TPs D398, O360, and P332 i.e., hydrogen elimination, resulted in four main fragments through losses of CO 2 (-44 Da), CO 2 CH 3 (-59 Da), CO 2 CH 3 NH 2 (-87 Da), and CO 2 C 4 H 6 NH 2 (-115 Da), cf. Figure 4 . Since a methyl group was absent in TP N318, the corresponding loss could not be observed on fragmentation, while the other typical fragmentations could. Yet, the common hydrogen fluoride cleavage was not observed. On MS³ fragmentation, no typical fragments were found. The piperazine ring and the remaining substituents were further fragmented. MS/MS fragmentation of the three TPs D398, O360, and P332 revealed an additional fragment with m/z = 70.0646 that was not formed from N318 (Fig. 4 ). The fragment originates from the methylated piperazine ring. For the two TPs N318 and P322, one fragment was structurally identical and MS 3 fragmentation was found identical. MS/MS spectra of D398 and O360 are given in the supplemental information Fig. S1 and S2. The TPs, where, further to hydrogen elimination, the methylene group in the piperazine ring was cleaved, exhibited a fragment with a mass difference of -44 Da. Apart from the decarboxylation, no other fragmentation occurred. For TP P318, the fragment with m/z = 245.0949 was also observed, stemming from carboxyl and methyl cleavage. No consistent trend could be found in the subsequent fragmentation. The MS/MS and MS 3 -spectra are shown in the supplemental materials in Fig. S3. For substances in which a hydroxyl group was added to ring and demethylation occurred at the piperazine, five fragment types were observed. They showed mass differences of -31 Da, -44 Da, -75 Da, -103 Da, and − 129 Da, cf. Fig. S4 – S7 in supplemental information. Again, TP N322 deviated due to the absence of the methyl group on the piperazine ring, leading to one fragment less. Yet, the fragmentation pathways were analogous to the other TPs. A small fragment with m/z = 86.0600 was observed with TPs D402, P336, and O364 due to the additional methyl group on the piperazine ring, leading to two fragments of m/z = 58.0651 and 56.0495 by MS 3 for the latter TPs. Due to the structural similarity of N322 and P336, equal fragments were observed here as well with m/z = 261.1034 and 233.1079. These fragments yielded identical fragments on MS 3 . All MS/MS and MS 3 -spectra are shown in the supplemental information Figs. S4 to S7. Ethylene elimination from the piperazine ring occurred as common motive as well. Five fragments were observed for the TPs D374, P308, N294, and O336. A mass difference of -20 Da was detected in one fragment i.e., hydrogen fluoride elimination. The electrochemical oxidation product of norfloxacin (N294) stood out again due to the absence of the methyl group. Still, the fragmentations remained similar. Mass differences of -31 Da, -57 Da, -75 Da, and − 101 Da were observed. All fragments indicated an alteration of the piperazine ring. One fragment showed additionally dehydrogenation. In the MS 3 spectra, it is noticeable that one fragment has a difference of -18 Da i.e., water elimination. Otherwise, no consistent trend could be identified. The MS/MS spectra and their MS 3 -spectra are shown in Fig. S8 – S11 in supplemental materials. In summary, MS/MS fragmentation of the electrochemical oxidation products of difloxacin, norfloxacin, ofloxacin, and pefloxacin yielded common fragments and hence common fragmentation motives. The piperazine ring was preferentially fragmented. Yet, the carboxyl and fluorine cleavage also occurred. The main quinolone skeleton was not fragmented in MS/MS experiments. While some special features where observed in MS³ experiments, no consistent trend could be identified. In a preceding study, the electrochemical oxidation of the five fluoroquinolones ciprofloxacin, danofloxacin, enoxacin, levofloxacin, and lomefloxacin showed hydrogen elimination for four of them (Voigt et al. 2024 ). Danofloxacin possesses a methylene bridge at the piperazine ring, thus blocking the hydrogen elimination. Methyl cleavage was observed for danofloxacin and enoxacin. Ethylene cleavage from the piperazine ring was observed for enoxacin. Hydroxyl addition to the piperazine ring was also identified as in this study with N354. Figure 5 illustrates the main three electrochemical oxidation motives of fluoroquinoloes i.e., hydrogene elimination, ethylene elimination and hydroxylation in combination with methyl or R 1 cleavage followed by the typical MS/MS fragmentation pattern of these TPs. 3.4 QSAR-Analysis Since structures have been assigned to the transformation products observed, potential ecotoxic effects were predicted. To this purpose, QSAR analysis was performed. All obtained data are presented in Table 2 . Table 2 QSAR-Analysis of difloxacin, pefloxacin, ofloxacin, norfloxacin and their electrochemical oxidation products All observed and structurally proposed electrochemical oxidation products were assessed to be less ecotoxic than their parent substance, suggesting that electrochemical oxidation of fluoroquinolones reduces the ecotoxicity of fluoroquinolones. In detail, the transformation products of difloxacin appeared more ecotoxic than the other described products, since the second floxacin group remained intact. This moiety is a pharmacological essential group and exercises a strong effect. The elimination of hydrogen in the piperazine ring only showed a slight reduction of ecotoxicity. This can be explained as due to the presence of the other functional groups, cf. Figure 1 . Still the piperazine ring was modified, which affects the spectrum of antibacterial activity. A significant reduction in ecotoxicity was yet observed on the addition of a hydroxyl group in combination with the hydrogen and methyl group elimination. In that case, the piperazine ring, including the residual groups, was fragmented, causing the pharmacological and apparently the ecotoxicological effect to be diminished. The same effect was predicted for the ethylene elimination, where the piperazine ring was fragmented as well. Thus, the ecotoxicity was predicted lower as compared to other structures where the ring remained intact. In summary, electrochemical oxidation seemed beneficial for the aquatic environment in case of fluoroquinolones. Even though the oxidation products formed mainly involved destruction of the piperazine ring of the fluoroquinolones, the ecotoxicological effect of the compound class was found reduced. 4. Conclusion In this study, the four fluoroquinolones difloxacin, norfloxacin, ofloxacin, and pefloxacin were electrochemically oxidized using a BDD electrode in both a synthesis cell and a µPrep-cell. The fluoroquinolones did not undergo oxidation below 800 mV. Voltage increase led to TPs that were identified using HPLC-MS/MS. Four oxidation products were identified for difloxacin, norfloxacin and perfloxacin, five for ofloxacin. Analysis demonstrated the typical motives, mechanisms, the oxidized and transformed regions of the fluoroquinolones. A general fragmentation pathway for the electrochemical oxidation products of difloxacin, norfloxacin, pefloxacin, and ofloxacin could be deduced applicable to the fluoroquinolone compound class. On second order fragmentation, decarboxylation, methylene/ methyl cleavage, dehydrogenation and decomposition with deamination of the piperazine ring occur. From an ecotoxicological perspective, in silico QSAR suggested that the resulting electrochemical oxidation products had lower ecotoxicity than their parent substances. Yet, difloxacin and its electrochemical oxidation products appeared more ecotoxic than the other investigated substances due to the second floxacin moiety. The findings are expected to contribute to the understanding and optimization of electrochemical wastewater treatment for the removal of pharmaceutical micropollutants. Statements & Declarations Acknowledgements Not applicable Funding Open Access funding enabled and organized by Projekt DEAL. Open Access funding enabled and organized by Project DEAL. We acknowledge support for the publication costs by the Open Access Publication Fund of Niederrhein University of Applied Sciences. Competing Interests The authors have no relevant financial or non-financial interests to disclose Author Contributions Melanie Voigt: conceptualization, validation, data curation, experiments, writing - original draft. Tobias Weißberg, Jana Boehm and Alexandra Schoentag: data curation, preparation, experiments. Martin Jaeger: formal analysis, writing - review and editing, supervision. Ethical Approval Not applicable. Consent to Participate Not applicable Consent to Publish Not applicable Data Availability Statement Data can be obtained upon request from the corresponding author. References Bhatt S, Chatterjee S (2022) Fluoroquinolone antibiotics: Occurrence, mode of action, resistance, environmental detection, and remediation – A comprehensive review. 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Microchem J 213:113814. https://doi.org/10.1016/j.microc.2025.113814 Supplementary Files FQ2025SI.docx Cite Share Download PDF Status: Under Review Version 1 posted Reviewers agreed at journal 06 Jan, 2026 Reviewers invited by journal 06 Jan, 2026 Editor invited by journal 06 Jan, 2026 Editor assigned by journal 22 Dec, 2025 First submitted to journal 18 Dec, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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10:38:33","extension":"xml","order_by":32,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":124717,"visible":true,"origin":"","legend":"","description":"","filename":"ESPRD25094520structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/eacdb12a7b4777cce65a33b4.xml"},{"id":99799326,"identity":"fcb679f7-be03-495b-8523-1d958ab2ab6d","added_by":"auto","created_at":"2026-01-08 13:49:28","extension":"html","order_by":33,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":131901,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/f3d631f38916c2733a362a39.html"},{"id":99798845,"identity":"18048d4a-65ea-40de-99b5-67492680f866","added_by":"auto","created_at":"2026-01-08 13:48:57","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":89481,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eStructures of a) difloxacin, b) pefloxacin, c) norfloxacin and d) ofloxacin. The principal pharmacophore is given in black. The fluorine atom (blue) improves the potency against Gram-negative bacteria and cell penetration. The piperazine ring (green) increases antibacterial activity and half-life of the drug. The methyl group (red) is again responsible for cell penetration. The essential substituent is the pink area. It increases the overall potency, the volume of distribution and bioavailability. The ether (orange) enhances bioavailability (Bhatt and Chatterjee 2022; Leyva et al. 2025).\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Fig1.png","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/e6e1cc5fd724e465efe4efdb.png"},{"id":99780694,"identity":"f85fc7d5-4b99-4705-8894-5ab5c620a3d3","added_by":"auto","created_at":"2026-01-08 10:38:31","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":524744,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003ea) Normalized mass voltammograms of difloxacin (red), pefloxacin (yellow), ofloxacin (green) and norfloxacin (blue), and normalized concentration-time curves at voltages of b) 750 mV, c) 1000 mV, d) 1250 mV and e) 1500 mV\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Fig2.png","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/07c0f0fd818b053c359e3e95.png"},{"id":99780613,"identity":"37a067ca-e321-4e86-b676-9cf1c6e11689","added_by":"auto","created_at":"2026-01-08 10:38:29","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":511915,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eChemical structures of the identified electrochemical oxidation products. The colors in the structures represent the pharmaceutically active moieties. TPs were formed via: hydroxylation in combination with methyl cleavage (+OH -CH\u003c/strong\u003e\u003csub\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003c/sub\u003e\u003cstrong\u003e, red), dehydrogenation (-H₂, green), methyl (-H\u003c/strong\u003e\u003csub\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003c/sub\u003e\u003cstrong\u003e-CH\u003c/strong\u003e\u003csub\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003c/sub\u003e\u003cstrong\u003e, blue)/ methylene (-2 CH\u003c/strong\u003e\u003csub\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003c/sub\u003e\u003cstrong\u003e, purple) cleavage and non-common types (black).\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Fig3.png","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/ea7967c7b95d3f3c2fefd1bc.png"},{"id":99799473,"identity":"4b7910b9-9fe5-4bd3-9ef8-2dbdf1b58c43","added_by":"auto","created_at":"2026-01-08 13:49:37","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":721924,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eMS/MS spectra of a) N318 and b) P332; MS\u003c/strong\u003e\u003csup\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003c/sup\u003e\u003cstrong\u003e spectra of the fragment m/z = 245.1085 (inserts).\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Fig4.png","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/e5947d15bf95ec6d9fb7d77f.png"},{"id":99780649,"identity":"1af70665-3195-40d9-8e53-9075a7c494bd","added_by":"auto","created_at":"2026-01-08 10:38:30","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":587924,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eGeneral main transformation motives of electrochemical oxidation products (blue boxes) of fluoroquinolones (black box), electrochemical oxidation (black arrows), MS/MS fragmentation (blue arrows), and fragments (green boxes).\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Fig5.png","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/8212759e05b507aba4a2f06c.png"},{"id":100421868,"identity":"699c5ca2-c09c-46b6-8979-18fc0fcf3002","added_by":"auto","created_at":"2026-01-16 13:59:02","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":4058585,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/d3b8d83f-685e-44c5-8324-023860f89e73.pdf"},{"id":99799297,"identity":"0656acfe-b844-4a0c-b215-522bd7abf9c6","added_by":"auto","created_at":"2026-01-08 13:49:26","extension":"docx","order_by":10,"title":"","display":"","copyAsset":false,"role":"supplement","size":2841816,"visible":true,"origin":"","legend":"","description":"","filename":"FQ2025SI.docx","url":"https://assets-eu.researchsquare.com/files/rs-8368141/v1/d35f01d9a464437a571332bf.docx"}],"financialInterests":"","formattedTitle":"Identification of common electrochemical oxidation pathways and mass spectrometry fragmentation patterns of the fluoroquinolones difloxacin, norfloxacin, ofloxacin and pefloxacin","fulltext":[{"header":"1. Introduction","content":"\u003cp\u003eFluoroquinolones are detected in surface waters worldwide. The active ingredients, norfloxacin, ofloxacin, and pefloxacin are used in human medicine, difloxacin in veterinary medicine. sewage treatment plants that are not equipped with advanced treatment stages to remove these substances from wastewater have been reported as main sources of contamination (Patel et al. \u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e2019\u003c/span\u003e; Matesun et al. \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e2024\u003c/span\u003e). Norfloxacin and ofloxacin have been detected in surface waters with concentrations ranging from several hundred \u0026micro;g/L to mg/L (Dusi et al. \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). Several fluoroquinolones also enter the aquatic ecosystem since they are administered to animals (Riaz et al. \u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e2018\u003c/span\u003e; Bhatt and Chatterjee \u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e2022\u003c/span\u003e). Among them, difloxacin was mainly detected in livestock sewage. Reported concentrations were 14.2 \u0026micro;g/L (Dusi et al. \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). In other surface waters, the concentration of difloxacin was in the ng/L range. These contaminations threaten ecosystems by promoting the development of antibiotic resistance and posing risks to aquatic life (Bhatt and Chatterjee \u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e2022\u003c/span\u003e; Thai et al. \u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e2023\u003c/span\u003e). While it is currently not authorized for medical use in Germany, perfloxacin has been approved in some countries of the EU for the prevention of infection after urological treatments. Yet due to serious and long-lasting side effects, its authorization has been severely restricted. In China, pefloxacin was detected in surface waters with concentrations of up to 34 \u0026micro;g/L (Dusi et al. \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e2019\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eIn order to eliminate these substances from water bodies and prevent their entry into the aquatic environment, intense research has been conducted for years into a new, enhanced purification stage in wastewater treatment plants. Advanced oxidation processes (AOPs) such as ozonation, UV treatment, and the electrochemical oxidation used in this study have first become promising and later established processes (Mazivila et al. \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e2019\u003c/span\u003e; Voigt et al. \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e2020\u003c/span\u003e). A common feature of AOPs is the formation of hydroxyl radicals from the water, the hydroxyl radicals deconstruct the substances via the indirect pathway. The substances may be degraded directly e,g,, through anodic electrochemical oxidation (Sir\u0026eacute;s et al. \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e2014\u003c/span\u003e; Voigt et al. \u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e2023\u003c/span\u003e). The boron-doped diamond (BDD) electrode has established itself as one of the most efficient anodes, also allowing the formation of hydroxyl radicals. At a potential of greater than 1.23 V, an electrochemical oxidation transfer reaction (EOTR) takes place (Kapałka et al. \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e2007\u003c/span\u003e). During this EOTR, the process of water oxidation occurs first,, resulting in the adsorption of hydroxyl radicals onto the BDD anode surface, see Eq.\u0026nbsp;1 (Kapałka et al. \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e2007\u003c/span\u003e; Vargas et al. \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e2016\u003c/span\u003e; Wang et al. \u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e2025\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eBDD[ ]\u0026thinsp;+\u0026thinsp;H\u003csub\u003e2\u003c/sub\u003eO \u0026rarr; BDD[OH.]\u0026thinsp;+\u0026thinsp;H\u003csup\u003e+\u003c/sup\u003e + e\u003csup\u003e\u0026minus;\u003c/sup\u003e (1)\u003c/p\u003e \u003cp\u003eThese hydroxyl radicals can subsequently attack organic substances \u003cem\u003eR\u003c/em\u003e. Ideally, these will be completely mineralized according to Eq.\u0026nbsp;2.\u003c/p\u003e \u003cp\u003e \u003cem\u003ex\u003c/em\u003e BDD[OH.]\u0026thinsp;+\u0026thinsp;R\u003csub\u003e(aq)\u003c/sub\u003e \u0026rarr; \u003cem\u003ex\u003c/em\u003e BDD[ ]\u0026thinsp;+\u0026thinsp;mineralization products\u0026thinsp;+\u0026thinsp;\u003cem\u003ey\u003c/em\u003e H\u003csup\u003e+\u003c/sup\u003e + \u003cem\u003ey\u003c/em\u003e e\u003csup\u003e\u0026minus;\u003c/sup\u003e (2)\u003c/p\u003e \u003cp\u003ewhere \u003cem\u003ex\u003c/em\u003e and \u003cem\u003ey\u003c/em\u003e are stoichiometric coefficients (Kapałka et al. \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e2007\u003c/span\u003e; Vargas et al. \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e2016\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eHigh-performance liquid chromatography (HPLC) coupled with high resolution mass spectrometry (HRMS) is often used to identify transformation products (Knoche et al. \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e2022\u003c/span\u003e; Hollender et al. \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e2023\u003c/span\u003e). Multifragmenting mass spectrometry (MS\u003csup\u003en\u003c/sup\u003e) experiments were employed to elucidate the molecular structures. Typical fragmentations of fluoroquinolones were reported to be hydrogen fluoride cleavage (-20 Da), decarboxylation (-44 Da) and/or water cleavage (-18 Da). In addition, the piperazine ring may be fragmented and eliminated partially or completely (Calza et al. \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2008\u003c/span\u003e; Niessen and Correa C. 2017; Fan et al. \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e2024\u003c/span\u003e; Wang et al. \u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e2025\u003c/span\u003e). High-resolution higher-order mass spectrometry showed that electrochemical oxidation of selected fluoroquinolones occurred via the pathways hydrogen elimination, hydroxyl radical addition, and methyl or methylene cleavage (Voigt et al. \u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e2024\u003c/span\u003e). Reactions via the combined pathways were observed as well. The structural investigation of the electrochemical transformation products of the studied fluoroquinolones revealed that the reactions preferentially took place at the piperazine ring. The indirect pathway i.e., hydroxyl radical reactions from water oxidation, was found active. Yet, direct anodic oxidation was also recognized through the TPs as hydrogen elimination and methyl/methylene cleavage.\u003c/p\u003e \u003cp\u003eTo date, typical mass spectrometric fragmentation pathways of electrochemical oxidation products have not been published on the fluoroquinolones difloxacin, pefloxacin, ofloxacin and norfloxacin. This study aims among other aspects to close this gap. It will also be investigated whether the known pathways can be extended to the fluoroquinolone class. In addition the required voltages for initiating the degradation shall be compared to the previous study.\u003c/p\u003e \u003cp\u003eWhile fluoroquinolones act on bacteria and microorganisms, the application of AOPs can change the effect. First-generation fluoroquinolones, such as norfloxacin, are primarily used against Gram-negative pathogens. Second-generation fluoroquinolones, such as difloxacin, pefloxacin, and ofloxacin, are also effective against Gram-positive and atypical pathogens (Bhatt and Chatterjee \u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e2022\u003c/span\u003e). An overview of the fluoroquinolones used in this study is shown in Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e, where the pharmacophores are color-coded.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eEcotoxicological studies rely on \u003cem\u003ein vivo\u003c/em\u003e and \u003cem\u003ein vitro\u003c/em\u003e assays. Electrochemical oxidation produces a mixture of transformation products that are difficult to isolate in quantities sufficient for ecotoxicity testing. The synthesis and procurement of the products is also challenging and associated with high costs. For this reason, Quantitative Structure-Activity Relationship (QSAR) analysis is often used as an alternative for assessment. Here, ecotoxicity is predicted for individual substances based on structural similarity and mathematical models (Voigt and Jaeger \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e2023\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eIn this study, the four fluoroquinolones difloxacin, pefloxacin, ofloxacin, and norfloxacin are degraded by electrochemical oxidation. Firstly, the conditions and voltage for the electrochemical oxidation are investigated. To this purpose, two electrolysis cells are used: a synthesis cell, which is operated in batch mode, and a microfluidic cell for a continuous process. The products are identified using HRMS. The comparison of the fragmentation products during structure elucidation, typical fragmentation pathways are derived. By means of the elucidated structures, the electrochemically induced degradation mechanisms of the fluoroquinolones are investigated. Finally, QSAR analysis is applied to predict the ecotoxicity of the individual products based on the molecular structures. The study shall contribute to the optimization of the potential use of electrochemical AOPs in advanced wastewater treatment.\u003c/p\u003e"},{"header":"2. Materials and Methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003e2.1 Chemicals and reagents\u003c/h2\u003e \u003cp\u003eDifloxacin hydrochloride (\u0026gt;\u0026thinsp;98%), norfloxacin (\u0026gt;\u0026thinsp;98%), ofloxacin (\u0026gt;\u0026thinsp;98%) and pefloxacine methanesulphonate dihydrate (99.5%) were purchased from BLD Pharmatech GmbH (Kaiserslautern, Germany). Formic acid (98\u0026ndash;100%, EMSURE\u0026reg; Reag. Ph. Eur., ACS for analysis, Supelco\u0026reg;, Merck, Darmstadt, Germany) was used to acidify the fluoroquinolone solution for electrochemical oxidation. Thus, sufficient conductivity of the solution was also ensured. The eluents used for HPLC-HRMS were ultrapure water, as eluent A, and acetonitrile (Carl Roth, Karlsruhe, Germany) as eluent B. To both eluents 0.1% formic acid were added.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003e2.2 Electrochemical Oxidation\u003c/h2\u003e \u003cp\u003eIn order to determine the optimal voltage, where the maximum number of products was formed, mass voltammograms were recorded using an electrochemical micro-flow cell (\u0026micro;PrepCell, Antec Scientific, Zoeterwoude, The Netherland). Solutions with a final concentration of 20\u0026thinsp;\u0026plusmn;\u0026thinsp;2 mg/L fluoroquinolone and ultrapure water were prepared. The pH value was adjusted to 3 using formic acid. The experiments were conducted in a ROXY\u0026trade; system (Antec Scientific, Zoeterwoude, The Netherland) consisting of the micro-flow cell and a potentiostat. The system was controlled via Dialogue Elite\u0026trade; software (Antec Scientific, Zoeterwoude, The Netherland) version 2.21.8.1. The oven temperature was set to 35\u0026deg;C and the polarity was selected as positive. A BDD electrode was used as the working electrode. The ROXY\u0026trade; system was coupled directly to a high-resolution orbital ion trap hybrid mass spectrometer (Orbitrap IDX, ThermoFisher Scientific, Waltham, USA). Mass spectra were recorded between m/z 100 to 1000. The scan rate of 5 mV/s from 0 to 3500 mV were chosen. The solutions were pumped through the flow cell at a rate of 50 \u0026micro;L/min. The mass voltammograms were recorded with 15 accumulations. The scans were averaged. They were also smoothed and normalized. For this purpose, the mean value from 0 to 500 mV was calculated as the starting value.\u003c/p\u003e \u003cp\u003eThe electrochemical oxidation experiments in a synthesis cell were also performed in the ROXY\u0026trade; system. The micro-cell was exchanged for a small electrosynthesis chamber (SynthesisCell, Antec Scientific, Zoeterwoude, Netherlands). Electrolysis of the solutions prepared as described above was performed using again the BDD electrode. Samples were taken at various time intervals of 0, 10, 20, 30, 45, 60, 75, 90, 120, 150, 180, 210, 240, 300, and 360 minutes using a syringe. The voltage was kept constant at 0.75 V, 1.00 V, 1.25 V, or 1.50 V. The samples were then analyzed using HPLC-HRMS.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003e2.3 HPLC-HRMS\u003c/h2\u003e \u003cp\u003eThe samples in the vials were analyzed using a (U)HPLC (Vanquish Core, ThermoFisher Scientific, Waltham, USA) coupled to an orbital ion trap hybrid mass spectrometer. The mass range was set to 100 to 1000 m/z. The mass spectra were recorded at a resolution of 60000. MS\u003csup\u003en\u003c/sup\u003e fragmentation was performed in the high-energy collision cell (HCD) with a normalized collision energy of 30% for MS\u0026sup2; and 45% for MS\u0026sup3;. Thermo Scientific XCalibur version 4.3.73.11 was used for instrument control. A Polaris 3 Amide C18 column (150 mm x 2 mm, Agilent, Waldbronn, Germany) was used for reversed-phase chromatography analysis. Chromatographic separation was performed in isocratic mode with an eluent ratio of 90:10 (A:B) both acidified with 0.1% formic acid. The flow rate was set to 0.3 mL/min. The duration of the analysis was 20 minutes.\u003c/p\u003e \u003cp\u003eAccurate mass and isotope patterns were recorded for structure elucidation, allowing the molecular formula to be derived. Tentative structures were generated using ACD/ChemSketch 2016.1.1 software (ACDLabs, Toronto, ON, Canada). Based on the initial chemical structure, plausible structures were identified. The next step was to inspect the MS/MS and MS\u003csup\u003e3\u003c/sup\u003e spectra. The observed m/z values and differences were then compared with the expected values of the fragments created from the plausible structures, according to the standard fragmentation rules (Niessen \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e2011\u003c/span\u003e; Niessen and Honing \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e2015\u003c/span\u003e; Schymanski et al. \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e2015\u003c/span\u003e). The best matches with respect to the fragmentation pathway and the m/z values were considered to be structurally confirmed.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003e2.4 QSAR\u003c/h2\u003e \u003cp\u003eQSAR analysis was achieved using the software QSAR Toolbox Version 4.4.1. (LMC Oasis, Pourgas, Bulgaria). Chemicals structures were drawn with the software ACD/ChemSketch 2016.1.1 (ACDLabs, Toronto, ON, Canada) and entered into the QSAR toolbox. For \u003cem\u003ein silico\u003c/em\u003e determination of ecotoxicity of individual substances ECOSAR (Ecological Structure-Activity Relationship), which is implemented in the QSAR Toolbox, was used. As Class, Vinyl/Allyl Ketones (1.0). Acute (median lethal concentration LC\u003csub\u003e50\u003c/sub\u003e and half maximal effective concentration (EC\u003csub\u003e50\u003c/sub\u003e)) were chosen and chronic toxicity (ChV) were thus predicted for the aquatic organism branchiopoda, actinopterygii and green algae. All fluoroquinolones and their observed transformation products were ranked from ecotoxic to non-ecotoxic based on the LC\u003csub\u003e50\u003c/sub\u003e, EC\u003csub\u003e50\u003c/sub\u003e and ChV values obtained (Voigt et al. \u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e2024\u003c/span\u003e).\u003c/p\u003e \u003c/div\u003e"},{"header":"3. Results and Discussion","content":"\u003cdiv id=\"Sec8\" class=\"Section2\"\u003e\n \u003ch2\u003e3.1 Mass voltammograms and concentration-time curves of the four fluoroquinolones\u003c/h2\u003e\n \u003cp\u003eThe effect on the electrochemical oxidation of fluoroquinolones in the microflow cell or synthesis cell as a function of voltage can be determined using the mass voltammograms or concentration-time curves, see Fig. \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e.\u003c/p\u003e\n \u003cp\u003eThe mass voltammograms of the four fluoroquinolones showed the absence of electrochemical oxidation below approximately 800 mV. Then a continuous decrease of the substances occurred with voltages increasing to approximately 1500 mV. At that voltage, the the mass voltammograms reached a constant level, as the fluoroquinolones were continuously flowed into the cell.\u003c/p\u003e\n \u003cp\u003eAn analogous observation was obtained from the normalized concentration-time diagrams recorded during oxidation in the synthesis cell. At 750 mV, no degradation of the substances occurred, while decomposition became apparent at 1000 mV. Ofloxacin degraded fastest, followed by difloxacin and finally pefloxacin, which decreased at the same rate as norfloxacin. The degradation of pefloxacin and norfloxacin was exhibited this similarity, since both compounds possess similar structures with pefloxacin having a methyl substituent at the piperazine ring, while difloxacin and ofloxacin differ significantly with respect to their structures. The concentration-time curves showed similar behavior at 1250 mV. At 1500 mV, the decays finally converged. Hence, at voltages of 1500 mV and above, the degradation rate was observed independent of the fluoroquinolone structure.\u003c/p\u003e\n \u003cp\u003eAs indicated in Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e, the voltage range between 800 and 1500 mV is particularly interesting. While below that range degradation was absent, no transformation products were to be expected.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec9\" class=\"Section2\"\u003e\n \u003ch2\u003e3.2 Identification of electrochemical oxidation products\u003c/h2\u003e\n \u003cp\u003eTable\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e provides an overview of the identified electrochemical oxidation products of difloxacin, pefloxacin, ofloxacin, and norfloxacin, which were formed in both the microflow and the synthesis cell. As both cells were equipped with BDD electrodes, TPs were identical.\u003c/p\u003e\n \u003cdiv class=\"gridtable\"\u003e\u0026nbsp;\u003ctable id=\"Tab1\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eDifloxacin, norfloxacin, ofloxacin, pefloxacin and their identified electrochemical oxidation products with their and exact accurate masses and corresponding m/z values from MS/MS and MS\u003csup\u003e3\u003c/sup\u003e\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003ccolgroup cols=\"7\"\u003e\u003c/colgroup\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eSubstance\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e[M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e\u003csub\u003eexact\u003c/sub\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e[M\u0026thinsp;+\u0026thinsp;H]\u003csup\u003e+\u003c/sup\u003e\u003csub\u003eaccurate\u003c/sub\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e∆ ppm\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003em/z\u003c/p\u003e\n \u003cp\u003eMS/MS\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003em/z\u003c/p\u003e\n \u003cp\u003eMS\u003csup\u003e3\u003c/sup\u003e\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eReference\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eDifloxacin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e400.1467\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e400.1465\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.4998\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e356.1569;\u003c/p\u003e\n \u003cp\u003e299.0990\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e299.0990\u003c/p\u003e\n \u003cp\u003e285.0832\u003c/p\u003e\n \u003cp\u003e70.0653;\u003c/p\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eD402\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e402.1260\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e402.1258\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.4974\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e371.0820;\u003c/p\u003e\n \u003cp\u003e327.0924;\u003c/p\u003e\n \u003cp\u003e299.0974\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e327.0926\u003c/p\u003e\n \u003cp\u003e299.0989\u003c/p\u003e\n \u003cp\u003e279.0913;\u003c/p\u003e\n \u003cp\u003e299.0985\u003c/p\u003e\n \u003cp\u003e279.0913\u003c/p\u003e\n \u003cp\u003e238.0950;\u003c/p\u003e\n \u003cp\u003e279.0913\u003c/p\u003e\n \u003cp\u003e216.0608\u003c/p\u003e\n \u003cp\u003e173.5031\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e(Hubicka et al. \u003cspan class=\"CitationRef\"\u003e2013\u003c/span\u003e)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eD398\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e398.1311\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e398.1309\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.5024\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e354.1412;\u003c/p\u003e\n \u003cp\u003e311.0969;\u003c/p\u003e\n \u003cp\u003e70.0646\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e311.0974\u003c/p\u003e\n \u003cp\u003e283.0660\u003c/p\u003e\n \u003cp\u003e256.0553;\u003c/p\u003e\n \u003cp\u003e283.0662\u003c/p\u003e\n \u003cp\u003e256.0553\u003c/p\u003e\n \u003cp\u003e242.0762;\u003c/p\u003e\n \u003cp\u003e55.0415\u003c/p\u003e\n \u003cp\u003e54.0336\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eD384\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e384.1154\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e384.1155\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.2603\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e340.1254\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e283.0660\u003c/p\u003e\n \u003cp\u003e256.0568\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eD374\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e374.1311\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e374.1308\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.8019\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e354.1228;\u003c/p\u003e\n \u003cp\u003e317.0713;\u003c/p\u003e\n \u003cp\u003e299.0971\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e336.1127\u003c/p\u003e\n \u003cp\u003e308.1177\u003c/p\u003e\n \u003cp\u003e280.1228;\u003c/p\u003e\n \u003cp\u003e299.0610\u003c/p\u003e\n \u003cp\u003e271.0660\u003c/p\u003e\n \u003cp\u003e243.0713;\u003c/p\u003e\n \u003cp\u003e255.0712\u003c/p\u003e\n \u003cp\u003e243.0713\u003c/p\u003e\n \u003cp\u003e216.0606\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e(Linke et al. \u003cspan class=\"CitationRef\"\u003e2010\u003c/span\u003e)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNorfloxacin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e320.1405\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e320.1406\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.3124\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e276.1507;\u003c/p\u003e\n \u003cp\u003e256.1445;\u003c/p\u003e\n \u003cp\u003e233.1085\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e233.1085\u003c/p\u003e\n \u003cp\u003e219.0929\u003c/p\u003e\n \u003cp\u003e205.0773;\u003c/p\u003e\n \u003cp\u003e227.1053\u003c/p\u003e\n \u003cp\u003e212.0818\u003c/p\u003e\n \u003cp\u003e201.1023;\u003c/p\u003e\n \u003cp\u003e218.0850\u003c/p\u003e\n \u003cp\u003e205.0773\u003c/p\u003e\n \u003cp\u003e185.0710\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eN354\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e354.1460\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e354.1459\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.2824\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e336.1341;\u003c/p\u003e\n \u003cp\u003e318.1236\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e318.1234\u003c/p\u003e\n \u003cp\u003e298.1172\u003c/p\u003e\n \u003cp\u003e250.0734;\u003c/p\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e(Carneiro et al. \u003cspan class=\"CitationRef\"\u003e2020\u003c/span\u003e)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eN322\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e322.1198\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e322.1195\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.9313\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e305.0913;\u003c/p\u003e\n \u003cp\u003e261.1035;\u003c/p\u003e\n \u003cp\u003e233.1086\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e233.1073\u003c/p\u003e\n \u003cp\u003e205.0762\u003c/p\u003e\n \u003cp\u003e72.0441;\u003c/p\u003e\n \u003cp\u003e233.1072\u003c/p\u003e\n \u003cp\u003e205.0761\u003c/p\u003e\n \u003cp\u003e176.0736;\u003c/p\u003e\n \u003cp\u003e205.0771\u003c/p\u003e\n \u003cp\u003e185.0702\u003c/p\u003e\n \u003cp\u003e176.0744\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e(Carneiro et al. \u003cspan class=\"CitationRef\"\u003e2020\u003c/span\u003e)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eN318\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e318.1249\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e318.1247\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.6287\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e274.1331;\u003c/p\u003e\n \u003cp\u003e245.1068;\u003c/p\u003e\n \u003cp\u003e219.0914\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e226.0962\u003c/p\u003e\n \u003cp\u003e219.0916\u003c/p\u003e\n \u003cp\u003e190.0663;\u003c/p\u003e\n \u003cp\u003e217.0761\u003c/p\u003e\n \u003cp\u003e190.0654\u003c/p\u003e\n \u003cp\u003e162.0342;\u003c/p\u003e\n \u003cp\u003e204.0655\u003c/p\u003e\n \u003cp\u003e191.0608\u003c/p\u003e\n \u003cp\u003e163.0422\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eN294\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e294.1249\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e294.1245\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.3600\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e274.1167;\u003c/p\u003e\n \u003cp\u003e251.0810;\u003c/p\u003e\n \u003cp\u003e233.1085\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e256.1066\u003c/p\u003e\n \u003cp\u003e227.0678\u003c/p\u003e\n \u003cp\u003e200.1173;\u003c/p\u003e\n \u003cp\u003e233.0708\u003c/p\u003e\n \u003cp\u003e223.0502\u003c/p\u003e\n \u003cp\u003e205.0397;\u003c/p\u003e\n \u003cp\u003e205.0761\u003c/p\u003e\n \u003cp\u003e176.0735\u003c/p\u003e\n \u003cp\u003e149.0502\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOfloxacin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e362.1510\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e362.1515\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.3806\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e318.1616;\u003c/p\u003e\n \u003cp\u003e261.1034\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e261.1036\u003c/p\u003e\n \u003cp\u003e221.0722\u003c/p\u003e\n \u003cp\u003e70.0654;\u003c/p\u003e\n \u003cp\u003e219.0567\u003c/p\u003e\n \u003cp\u003e205.0410\u003c/p\u003e\n \u003cp\u003e179.0379\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eO364\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e364.1303\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e364.1310\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.9224\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e333.0865;\u003c/p\u003e\n \u003cp\u003e289.0983;\u003c/p\u003e\n \u003cp\u003e86.0596\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e289.0968\u003c/p\u003e\n \u003cp\u003e261.1019\u003c/p\u003e\n \u003cp\u003e221.0710;\u003c/p\u003e\n \u003cp\u003e261.1018\u003c/p\u003e\n \u003cp\u003e221.0709\u003c/p\u003e\n \u003cp\u003e205.0397;\u003c/p\u003e\n \u003cp\u003e58.0650\u003c/p\u003e\n \u003cp\u003e56.0493\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eO360\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e360.1354\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e360.1358\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.1107\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e316.1440;\u003c/p\u003e\n \u003cp\u003e273.1016;\u003c/p\u003e\n \u003cp\u003e70.0647\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e301.1221\u003c/p\u003e\n \u003cp\u003e245.0706\u003c/p\u003e\n \u003cp\u003e70.0649;\u003c/p\u003e\n \u003cp\u003e245.0715\u003c/p\u003e\n \u003cp\u003e205.0397\u003c/p\u003e\n \u003cp\u003e175.0293;\u003c/p\u003e\n \u003cp\u003e55.0415\u003c/p\u003e\n \u003cp\u003e54.0337\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eO348\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e348.1354\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e348.1360\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.7235\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e304.1437;\u003c/p\u003e\n \u003cp\u003e284.1375;\u003c/p\u003e\n \u003cp\u003e261.1015\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e284.1380\u003c/p\u003e\n \u003cp\u003e261.1020\u003c/p\u003e\n \u003cp\u003e173.5015;\u003c/p\u003e\n \u003cp\u003e-;\u003c/p\u003e\n \u003cp\u003e221.0721\u003c/p\u003e\n \u003cp\u003e205.0397\u003c/p\u003e\n \u003cp\u003e179.0369\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eO346\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e346.1198\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e346.1203\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.4446\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e302.1280\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e260.0815\u003c/p\u003e\n \u003cp\u003e220.0631\u003c/p\u003e\n \u003cp\u003e84.0805\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eO336\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e336.1354\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e336.1362\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e2.3800\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e316.1276;\u003c/p\u003e\n \u003cp\u003e279.0758;\u003c/p\u003e\n \u003cp\u003e235.0862\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e298.1170\u003c/p\u003e\n \u003cp\u003e270.1219\u003c/p\u003e\n \u003cp\u003e242.1274;\u003c/p\u003e\n \u003cp\u003e261.0653\u003c/p\u003e\n \u003cp\u003e238.0371\u003c/p\u003e\n \u003cp\u003e220.0267;\u003c/p\u003e\n \u003cp\u003e193.0877\u003c/p\u003e\n \u003cp\u003e173.5013\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003ePefloxacin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e334.1562\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e334.1562\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.0000\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e290.1660;\u003c/p\u003e\n \u003cp\u003e233.1082;\u003c/p\u003e\n \u003cp\u003e219.0926\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e233.1084\u003c/p\u003e\n \u003cp\u003e205.0771\u003c/p\u003e\n \u003cp\u003e70.0653;\u003c/p\u003e\n \u003cp\u003e205.0772\u003c/p\u003e\n \u003cp\u003e203.0616\u003c/p\u003e\n \u003cp\u003e185.0710;\u003c/p\u003e\n \u003cp\u003e219.0928\u003c/p\u003e\n \u003cp\u003e217.0771\u003c/p\u003e\n \u003cp\u003e191.0616\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP336\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e336.1354\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e336.1353\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.2975\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e305.0928;\u003c/p\u003e\n \u003cp\u003e261.1030\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e261.1030;\u003c/p\u003e\n \u003cp\u003e233.1084\u003c/p\u003e\n \u003cp\u003e205.0772\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP332\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e332.1405\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e332.1407\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.6021\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e245.1080;\u003c/p\u003e\n \u003cp\u003e217.0767;\u003c/p\u003e\n \u003cp\u003e70.0649\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e190.0661\u003c/p\u003e\n \u003cp\u003e173.5021\u003c/p\u003e\n \u003cp\u003e162.0348;\u003c/p\u003e\n \u003cp\u003e190.0660\u003c/p\u003e\n \u003cp\u003e162.0347\u003c/p\u003e\n \u003cp\u003e134.0399;\u003c/p\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP318\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e318.1249\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e318.1245\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e1.2574\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e274.1342;\u003c/p\u003e\n \u003cp\u003e245.0952;\u003c/p\u003e\n \u003cp\u003e217.1003\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e245.0957\u003c/p\u003e\n \u003cp\u003e217.1009;\u003c/p\u003e\n \u003cp\u003e217.1010\u003c/p\u003e\n \u003cp\u003e174.0587\u003c/p\u003e\n \u003cp\u003e160.0431;\u003c/p\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP308\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e308.1405\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e308.1404\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.3245\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e288.1339;\u003c/p\u003e\n \u003cp\u003e251.0821;\u003c/p\u003e\n \u003cp\u003e207.0924\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e270.1231\u003c/p\u003e\n \u003cp\u003e241.0842\u003c/p\u003e\n \u003cp\u003e214.1339;\u003c/p\u003e\n \u003cp\u003e233.0718\u003c/p\u003e\n \u003cp\u003e149.0508\u003c/p\u003e\n \u003cp\u003e137.0508;\u003c/p\u003e\n \u003cp\u003e179.0612\u003c/p\u003e\n \u003cp\u003e173.5028\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/div\u003e\n \u003cp\u003eAs listed in Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e, TPs were formed according to the same mechanism. As examples, a mass difference of -2 Da could be recognized in TPs D398, N318, O360 and P332, indicating a loss of di-hydrogen, typical for electrochemical oxidation. The mass difference of a hydroxylation in combination with methyl cleavage is +\u0026thinsp;2 Da, as occurring with D402, N322, O364 and P336. Figure \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e shows the structure of all TPs that were observed. They are arranged according to the formation pathways.\u003c/p\u003e\n \u003cp\u003eA total of four different reactions were observed. First, the typical hydrogen cleavage at the piperazine ring was seen. Then, hydrogen cleavage in combination with the methyl elimination at the piperazine ring was identified. Since norfloxacin does not have a methyl substituent at the piperazine ring, this transformation product was absent in the norfloxacin experiment. The elimination of ethene from the piperazine ring was identified as the third reaction. A fourth reaction pathway was the cleavage of the methine-group in combination hydrogen elimination and addition of a hydroxyl group. Furthermore, two transformation products were identified and elucidated that could not be assigned to any of these four reaction schemes. In the transformation product of norfloxacin N354, two hydroxyl groups were added to the piperazine moiety. In the conversion product of ofloxacin O348, the methyl group was eliminated from the piperazine ring.\u003c/p\u003e\n \u003cp\u003eIt should be noted that all changes and mechanisms observed during the electrochemical oxidation of the four fluoroquinolones occurred at the piperazine ring. Hence, the observations made in a previous study on ciprofloxacin, danofloxacin, enoxacin, levofloxacin, and lomefloxacin were confirmed for the fluoroquinolones of this study (Voigt et al. \u003cspan class=\"CitationRef\"\u003e2024\u003c/span\u003e).\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003e3.3 Fragmentation pathways of electrochemical oxidation products of danofloxacin, norfloxacin, ofloxacin and pefloxacin starting from electrospray ionization\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003eThe mass fragmentation of TPs D398, O360, and P332 i.e., hydrogen elimination, resulted in four main fragments through losses of CO\u003csub\u003e2\u003c/sub\u003e (-44 Da), CO\u003csub\u003e2\u003c/sub\u003e CH\u003csub\u003e3\u003c/sub\u003e (-59 Da), CO\u003csub\u003e2\u003c/sub\u003e CH\u003csub\u003e3\u003c/sub\u003e NH\u003csub\u003e2\u003c/sub\u003e (-87 Da), and CO\u003csub\u003e2\u003c/sub\u003e C\u003csub\u003e4\u003c/sub\u003eH\u003csub\u003e6\u003c/sub\u003e NH\u003csub\u003e2\u003c/sub\u003e (-115 Da), cf. Figure \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e. Since a methyl group was absent in TP N318, the corresponding loss could not be observed on fragmentation, while the other typical fragmentations could. Yet, the common hydrogen fluoride cleavage was not observed. On MS\u0026sup3; fragmentation, no typical fragments were found. The piperazine ring and the remaining substituents were further fragmented. MS/MS fragmentation of the three TPs D398, O360, and P332 revealed an additional fragment with m/z\u0026thinsp;=\u0026thinsp;70.0646 that was not formed from N318 (Fig. \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e). The fragment originates from the methylated piperazine ring. For the two TPs N318 and P322, one fragment was structurally identical and MS\u003csup\u003e3\u003c/sup\u003e fragmentation was found identical. MS/MS spectra of D398 and O360 are given in the supplemental information Fig. \u003cspan class=\"InternalRef\"\u003eS1\u003c/span\u003e and S2.\u003c/p\u003e\n \u003cp\u003eThe TPs, where, further to hydrogen elimination, the methylene group in the piperazine ring was cleaved, exhibited a fragment with a mass difference of -44 Da. Apart from the decarboxylation, no other fragmentation occurred. For TP P318, the fragment with m/z\u0026thinsp;=\u0026thinsp;245.0949 was also observed, stemming from carboxyl and methyl cleavage. No consistent trend could be found in the subsequent fragmentation. The MS/MS and MS\u003csup\u003e3\u003c/sup\u003e-spectra are shown in the supplemental materials in Fig. S3.\u003c/p\u003e\n \u003cp\u003eFor substances in which a hydroxyl group was added to ring and demethylation occurred at the piperazine, five fragment types were observed. They showed mass differences of -31 Da, -44 Da, -75 Da, -103 Da, and \u0026minus;\u0026thinsp;129 Da, cf. Fig. S4 \u0026ndash; S7 in supplemental information. Again, TP N322 deviated due to the absence of the methyl group on the piperazine ring, leading to one fragment less. Yet, the fragmentation pathways were analogous to the other TPs. A small fragment with m/z\u0026thinsp;=\u0026thinsp;86.0600 was observed with TPs D402, P336, and O364 due to the additional methyl group on the piperazine ring, leading to two fragments of m/z\u0026thinsp;=\u0026thinsp;58.0651 and 56.0495 by MS\u003csup\u003e3\u003c/sup\u003e for the latter TPs. Due to the structural similarity of N322 and P336, equal fragments were observed here as well with m/z\u0026thinsp;=\u0026thinsp;261.1034 and 233.1079. These fragments yielded identical fragments on MS\u003csup\u003e3\u003c/sup\u003e. All MS/MS and MS\u003csup\u003e3\u003c/sup\u003e-spectra are shown in the supplemental information Figs. S4 to S7.\u003c/p\u003e\n \u003cp\u003eEthylene elimination from the piperazine ring occurred as common motive as well. Five fragments were observed for the TPs D374, P308, N294, and O336. A mass difference of -20 Da was detected in one fragment i.e., hydrogen fluoride elimination. The electrochemical oxidation product of norfloxacin (N294) stood out again due to the absence of the methyl group. Still, the fragmentations remained similar. Mass differences of -31 Da, -57 Da, -75 Da, and \u0026minus;\u0026thinsp;101 Da were observed. All fragments indicated an alteration of the piperazine ring. One fragment showed additionally dehydrogenation. In the MS\u003csup\u003e3\u003c/sup\u003e spectra, it is noticeable that one fragment has a difference of -18 Da i.e., water elimination. Otherwise, no consistent trend could be identified. The MS/MS spectra and their MS\u003csup\u003e3\u003c/sup\u003e-spectra are shown in Fig. S8 \u0026ndash; S11 in supplemental materials.\u003c/p\u003e\n \u003cp\u003eIn summary, MS/MS fragmentation of the electrochemical oxidation products of difloxacin, norfloxacin, ofloxacin, and pefloxacin yielded common fragments and hence common fragmentation motives. The piperazine ring was preferentially fragmented. Yet, the carboxyl and fluorine cleavage also occurred. The main quinolone skeleton was not fragmented in MS/MS experiments. While some special features where observed in MS\u0026sup3; experiments, no consistent trend could be identified.\u003c/p\u003e\n \u003cp\u003eIn a preceding study, the electrochemical oxidation of the five fluoroquinolones ciprofloxacin, danofloxacin, enoxacin, levofloxacin, and lomefloxacin showed hydrogen elimination for four of them (Voigt et al. \u003cspan class=\"CitationRef\"\u003e2024\u003c/span\u003e). Danofloxacin possesses a methylene bridge at the piperazine ring, thus blocking the hydrogen elimination. Methyl cleavage was observed for danofloxacin and enoxacin. Ethylene cleavage from the piperazine ring was observed for enoxacin. Hydroxyl addition to the piperazine ring was also identified as in this study with N354.\u003c/p\u003e\n \u003cp\u003eFigure \u003cspan class=\"InternalRef\"\u003e5\u003c/span\u003e illustrates the main three electrochemical oxidation motives of fluoroquinoloes i.e., hydrogene elimination, ethylene elimination and hydroxylation in combination with methyl or R\u003csup\u003e1\u003c/sup\u003e cleavage followed by the typical MS/MS fragmentation pattern of these TPs.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec10\" class=\"Section2\"\u003e\n \u003ch2\u003e3.4 QSAR-Analysis\u003c/h2\u003e\n \u003cp\u003eSince structures have been assigned to the transformation products observed, potential ecotoxic effects were predicted. To this purpose, QSAR analysis was performed. All obtained data are presented in Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e.\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003eTable 2 \u0026nbsp;QSAR-Analysis of difloxacin, pefloxacin, ofloxacin, norfloxacin and their electrochemical oxidation products\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cimg 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\"\u003e\u003c/strong\u003e\u003cbr\u003e\u003c/p\u003e\n \u003cdiv class=\"gridtable\"\u003e\n \u003cdiv align=\"left\" class=\"colspec\"\u003eAll observed and structurally proposed electrochemical oxidation products were assessed to be less ecotoxic than their parent substance, suggesting that electrochemical oxidation of fluoroquinolones reduces the ecotoxicity of fluoroquinolones. In detail, the transformation products of difloxacin appeared more ecotoxic than the other described products, since the second floxacin group remained intact. This moiety is a pharmacological essential group and exercises a strong effect. The elimination of hydrogen in the piperazine ring only showed a slight reduction of ecotoxicity. This can be explained as due to the presence of the other functional groups, cf. Figure \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e. Still the piperazine ring was modified, which affects the spectrum of antibacterial activity.\u003c/div\u003e\n \u003c/div\u003e\n \u003cp\u003eA significant reduction in ecotoxicity was yet observed on the addition of a hydroxyl group in combination with the hydrogen and methyl group elimination. In that case, the piperazine ring, including the residual groups, was fragmented, causing the pharmacological and apparently the ecotoxicological effect to be diminished. The same effect was predicted for the ethylene elimination, where the piperazine ring was fragmented as well. Thus, the ecotoxicity was predicted lower as compared to other structures where the ring remained intact.\u003c/p\u003e\n \u003cp\u003eIn summary, electrochemical oxidation seemed beneficial for the aquatic environment in case of fluoroquinolones. Even though the oxidation products formed mainly involved destruction of the piperazine ring of the fluoroquinolones, the ecotoxicological effect of the compound class was found reduced.\u003c/p\u003e\n\u003c/div\u003e"},{"header":"4. Conclusion","content":"\u003cp\u003eIn this study, the four fluoroquinolones difloxacin, norfloxacin, ofloxacin, and pefloxacin were electrochemically oxidized using a BDD electrode in both a synthesis cell and a \u0026micro;Prep-cell. The fluoroquinolones did not undergo oxidation below 800 mV. Voltage increase led to TPs that were identified using HPLC-MS/MS. Four oxidation products were identified for difloxacin, norfloxacin and perfloxacin, five for ofloxacin. Analysis demonstrated the typical motives, mechanisms, the oxidized and transformed regions of the fluoroquinolones. A general fragmentation pathway for the electrochemical oxidation products of difloxacin, norfloxacin, pefloxacin, and ofloxacin could be deduced applicable to the fluoroquinolone compound class. On second order fragmentation, decarboxylation, methylene/ methyl cleavage, dehydrogenation and decomposition with deamination of the piperazine ring occur.\u003c/p\u003e \u003cp\u003eFrom an ecotoxicological perspective, \u003cem\u003ein silico\u003c/em\u003e QSAR suggested that the resulting electrochemical oxidation products had lower ecotoxicity than their parent substances. Yet, difloxacin and its electrochemical oxidation products appeared more ecotoxic than the other investigated substances due to the second floxacin moiety. The findings are expected to contribute to the understanding and optimization of electrochemical wastewater treatment for the removal of pharmaceutical micropollutants.\u003c/p\u003e"},{"header":"Statements \u0026 Declarations","content":"\u003ch2\u003eAcknowledgements\u003c/h2\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003ch2\u003eFunding\u003c/h2\u003e\n\u003cp\u003eOpen Access funding enabled and organized by Projekt DEAL. Open Access funding enabled and organized by Project DEAL. We acknowledge support for the publication costs by the Open Access Publication Fund of Niederrhein University of Applied Sciences.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting Interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors have no relevant financial or non-financial interests to disclose\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor Contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMelanie Voigt: conceptualization, validation, data curation, experiments, writing - original draft. Tobias Weißberg, Jana Boehm and Alexandra Schoentag: data curation, preparation, experiments. Martin Jaeger: formal analysis, writing - review and editing, supervision.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical Approval\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to Participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to Publish\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData Availability Statement\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eData can be obtained upon request from the corresponding author.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n \u003cli\u003eBhatt S, Chatterjee S (2022) Fluoroquinolone antibiotics: Occurrence, mode of action, resistance, environmental detection, and remediation \u0026ndash; A comprehensive review. 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AIMS Environ Sci 7:69\u0026ndash;98. https://doi.org/10.3934/environsci.2020005\u003c/li\u003e\n \u003cli\u003eWang L, Yan H, Jiang L, Cai S, Liu H (2025) Avoiding false positives in the analysis of quinolones residues using liquid chromatography/triple quadrupole mass spectrometry. Microchem J 213:113814. https://doi.org/10.1016/j.microc.2025.113814\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"environmental-science-and-pollution-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"espr","sideBox":"Learn more about [Environmental Science and Pollution Research](https://www.springer.com/journal/11356)","snPcode":"11356","submissionUrl":"https://submission.nature.com/new-submission/11356/3","title":"Environmental Science and Pollution Research","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Electrochemical Oxidation, BDD-Electrode, Fluoroquinolones, structure elucidation, MSn pathway, QSAR","lastPublishedDoi":"10.21203/rs.3.rs-8368141/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8368141/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAmong other fluoroquinolones, difloxacin, norfloxacin, ofloxacin, and pefloxacin are regularly detected in various bodies of water around the world. Advanced oxidation processes such as the electrochemical oxidation are employed to eliminate these micropollutants. Using a microflow cell and a synthesis cell, the four fluoroquinolones were submitted to electrochemical oxidation through a boron-doped electrode. They were subsequently analyzed using high-performance liquid chromatography coupled with high-resolution mass spectrometry. Electrochemical oxidation occurred above 800 mV. Products were formed according to common mechanisms: hydrogen and ethylene elimination, methylene/methyl cleavage, hydroxylation in combination with methyl cleavage. To facilitate future identification of electrochemical oxidation products of the fluoroquinolone class, fragmentation patterns in higher-order mass spectrometry were investigated deriving typical motives. A total of 17 products were identified, 13 of which were novel. Quantitative structure-activity relationship analysis suggested that the electrochemical oxidation products would be less ecotoxic than the initial drugs.\u003c/p\u003e","manuscriptTitle":"Identification of common electrochemical oxidation pathways and mass spectrometry fragmentation patterns of the fluoroquinolones difloxacin, norfloxacin, ofloxacin and pefloxacin","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-01-08 10:38:06","doi":"10.21203/rs.3.rs-8368141/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"reviewerAgreed","content":"","date":"2026-01-07T01:27:48+00:00","index":0,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2026-01-06T13:55:30+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"Environmental Science and Pollution Research","date":"2026-01-06T13:12:41+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-12-22T05:31:15+00:00","index":"","fulltext":""},{"type":"submitted","content":"Environmental Science and Pollution Research","date":"2025-12-18T09:55:01+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"environmental-science-and-pollution-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"espr","sideBox":"Learn more about [Environmental Science and Pollution Research](https://www.springer.com/journal/11356)","snPcode":"11356","submissionUrl":"https://submission.nature.com/new-submission/11356/3","title":"Environmental Science and Pollution Research","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"efa983a2-428b-4f8a-8a01-5a8b8ff9d194","owner":[],"postedDate":"January 8th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-01-08T10:38:06+00:00","versionOfRecord":[],"versionCreatedAt":"2026-01-08 10:38:06","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8368141","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8368141","identity":"rs-8368141","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}