Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture

Abstract In this brief report, we evaluated various macrophage coculture systems for their CLL-feeding potential, phagocytosis capacity, induction of treatment resistance in CLL cells, and their impact on the transcriptional profiles of CLL cells. Competing Interest Statement The authors have declared no competing interest. Footnotes ↵* Joint first authors Funding statement This study is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) grant SFB1530–455784452 to P.-H.N and M.H. (sub-project B01) and V.K. (postdoc advancement grant), and by the research network CANcer TARgeting (CANTAR) of the Ministry of Culture and Science of the State of North Rhine-Westphalia (MKW NRW) to P.-H.N. and M.H. Ethics approval statement All ethics approvals and patient consents are provided in the manuscript. Disclosure All authors declare no conflict of interest. Manuscript revised; Figures revised; Supplemental file revised; Author list updated.