Predictive Value of Inflammatory Markers, Ca-125 Measurement, and Malignancy Risk Index Calculations in the Diagnosis of Endometrioma

Hilal Şerifoğlu
In: Haydarpasa Numune Training and Research Hospital Medical Journal · 2024 · pp. 472–478 · doi:10.14744/hnhj.2024.70456 · W4405109952
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This study investigated the predictive value of CA-125, malignancy risk index, and inflammatory markers for diagnosing endometrioma among 679 surgically treated adnexal mass patients.

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This retrospective study evaluated the diagnostic utility of CA-125 levels, inflammatory markers, and the RMI in distinguishing endometriomas from benign and malignant adnexal masses among 679 surgical patients. The results indicated that CA-125 values were significantly higher in endometrioma cases compared to both benign and malignant groups, although the marker demonstrated high sensitivity but low specificity for this condition. Additionally, neutrophil-related indices such as NLR showed significant differences between malignant and benign lesions, suggesting potential value in refining preoperative risk assessment models. This paper is centrally about endometriosis — specifically focusing on the diagnostic differentiation of endometriomas from other adnexal pathologies using biochemical and hematological predictors.

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Introduction

Adnexal mass is a frequently encountered problem in gynecology practice. Although ultrasonography is our main tool in distinguishing endometrioma cases, there is a need for methods that will provide preoperative prediction, especially in rare cases. For this reason, we aimed to investigate the predictive value of CA-125 level, inflammatory markers, and malignancy index calculations in the diagnosis of endometrioma.

Methods

In this study, 679 cases who were operated on, and diagnosed with an adnexal mass, at the Health Sciences University Haydarpaşa Numune Training and Research Hospital, Gynecology and Obstetrics Clinic, between 01.01.2010 and 30.06.2016, were retrospectively examined. The predictive value of CA-125, RMI, and inflammatory markers was investigated among these groups, which were divided into three groups: benign and malignant adnexal mass endometrioma patients.

Results

In the comparison of the three groups, CA-125 value, malignancy risk index calculations, and some hematological markers were found to be statistically significantly higher. In the subgroup analysis for CA-125; It was found in the comparison of endometrioma and benign masses (p=0.000), in the comparison of benign and malignant masses (p=0.000), and the distinction between endometrioma and malignant masses (p=0.004). In the subgroup analysis for inflammatory markers, the NLR value was found to be significantly different in malignant and benign cases (p=0.000). The neutrophil count was significantly different in malignant and benign cases (p=0.005).

Discussion

AND CONCLUSION: CA125 levels were found to be sensitive but not specific in the diagnosis of endometrioma. There is a need for studies on modeling in which new algorithms are developed in which TV-USG findings are combined with hematological markers.

Keywords

Adnex, endometriosis, RMI, CA-125. Corresponding Author: Hilal Şerifoğlu, Türkiye Manuscript Language: English Manuscript Language: English

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endometrioma

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