WITHDRAWN: Drug use, costs, and outcomes of high-risk febrile neutropenia in a tertiary care centre in South India – A prospective cost analysis study
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This withdrawn prospective cost-analysis preprint aimed to evaluate drug use, healthcare costs, and outcomes for high-risk febrile neutropenia patients treated in a tertiary care centre in South India, but the platform does not provide the study methods, participant details, or results because the full text was removed. The only available information is the editorial note stating the authors withdrew the preprint due to disagreement with posting, and they requested it not be cited. A major limitation is that no substantive findings can be extracted or assessed from the withdrawn record. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.
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Abstract
Abstract Background Febrile Neutropenia (FN), a commonly encountered life-threatening complication of cancer chemotherapy, is a dose-limiting toxicity in the therapy of many cancers. The onset of FN demands dose reduction and usually temporary halting of chemotherapy, which could then affect the outcome of cancer treatment. The treatment of febrile neutropenia incurs significant expenses,and is itself regarded as an expensive side-effect of cancer chemotherapy. In our study, we wanted to quantify the drugs used in the treatment of febrile neutropenic episodes and the costs incurred as a result, as well as the outcomes of these episodes. Methods The study was a prospective observational study. Patients of either sex, of any age, diagnosed with cancer and classified as high-risk febrile neutropenia and hospitalised during the period of study were included in the study. A total of 46 patients with 50 episodes of FN were enrolled in the study. Data was collected from the department database and daily clinical notes and was entered into a pre-designed proforma. The drugs prescribed were classified as antibiotics and supportive medications. The drug cost of each episode was then calculated. The data was analysed using descriptive statistics. Results The mean age of participants was 26.66 (SD 13.28) years, with a median length of hospital stay of 10 (7–15) days. This study provides an estimate into the drug-related costs of management of febrile neutropenia. A total of Rs. 8,21,731 was spent on drugs for the management of fifty episodes, and the average cost of an episode was Rs. 16,434. Of the total cost, Rs. 7,00,300 (85.22%) was spent on antimicrobials. Conclusion Considering the complexities medical decision making and quality of care, the role of cost needs to take a major role in therapeutic options. There is a need to develop value-based policies, which strive to achieve the best clinical outcomes while also accounting for cost-effectiveness, polypharmacy and development of antimicrobial resistance.
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WITHDRAWN: Drug use, costs, and outcomes of high-risk febrile neutropenia in a tertiary care centre in South India – A prospective cost analysis study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Short Report WITHDRAWN: Drug use, costs, and outcomes of high-risk febrile neutropenia in a tertiary care centre in South India – A prospective cost analysis study Sairam B V S N, Mirunalini R, Smita Kayal This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4531858/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Editorial Note The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Full Text The authors have withdrawn this preprint from Research Square. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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