Effects of an extended-interval dosing regimen of gonadotropin releasing hormone agonist in the treatment of adenomyosis
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Abstract
目的 研究促性腺激素释放激素激动剂(GnRH-a)延长间隔给药方案治疗子宫腺肌病的疗效.方法 将子宫腺肌病要求保守治疗的患者20例随机分为两组(n=10).新方案作为观察组,每6周1剂(曲普瑞林3.75 mg/剂),共4剂的延长间隔给药方案;传统方案设为对照组,曲普瑞林每4周1剂,共6剂.观察治疗前后痛经程度及子宫体积的变化,并测定性激素水平.结果 治疗6个月后,两组痛经缓解率均达100%;观察组与对照组子宫体积平均分别缩小46.7%与47.5%;黄体生成素(LH)、卵泡刺激素(FSH)及雌二醇(E2)水平明显降低(P＜0.01),E2降至绝经期水平;两组疗效相等(P＞0.05).结论 应用GnRH-a延长间隔给药方案治疗子宫腺肌病同样能达到与传统方案相同的疗效,即低雌激素状态的抑制效应,但治疗费用显著降低。
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- last seen: 2026-06-10T17:14:06.276822+00:00
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